Projects per year
Personal profile
Biography
Professor Helmut Butzkueven is The The Van Cleef Roet Chair of Neuroscience and Head of the Department of Neuroscience, Monash University, and Director of Neurology, Alfred Health. He is also Chair of the Multiple Sclerosis and Neuroimmunology research unit in the Department of Neuroscience, School of Translational Medicine. He is an international leader in translational research in the neurological disease, Multiple Sclerosis (MS). He is Managing Director of the MSBase Foundation (www.msbase.org) that funds and administers a global online MS cohort study with more than 70,000 patients enrolled in 130 centres across 36 countries, which has resulted in multiple publications that have directly impacted on patient care worldwide.
He completed his PhD at the Walter and Eliza Hall Institute in 2003, and subsequently a post-doctoral fellowship at The Howard Florey Institute. He has received multiple awards for his research and medical leadership, including The Bethlehem Griffith Research Foundation Award, The Australian Museum and University of NSW Eureka Prize and the Research Australia Health and Medical Research Data Innovation Award. Currently, he holds a highly competitive NHMRC Research Leader Investigator Grant, recognising him as a leading medical researcher in Australia.
Research interests
His overarching research theme and clinical interest is the use of registry data, clinical MRI data, cognitive testing, genomics and patient self-monitoring devices and applications to evaluate treatment strategies to optimise the benefit and safety of MS therapies.
Clinical activities
In addition to his research leadership credentials, Prof. Butzkueven has over 20 years’ experience as a clinical neurologist, and is Head of the Multiple Sclerosis and Neuro Immunology (MSNI) Clinic at the Alfred Hospital, Melbourne, Australia. He is also a passionate teacher and mentor of young clinicians and researchers, and is Research Higher Degree Coordinator for the School of Translational Medicine, Monash University.
Community service
Professor Butzkueven also is a member on the Board of Directors at MS Research Australia. He has a long working history with MS Research Australia, initially awarded a Fellowship in 2006 to investigate protecting nerve cells from MS injury. Most recently he has been an active member on a number of working groups and collaborative platforms as well as volunteering as MS Research Australia’s Scientific Conference Convenor.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post-Doctoral Fellowship, Florey Institute of Neuroscience and Mental Health (FINMH)
Research Fellowship, Multiple Sclerosis Research Australia (trading as National Multiple Sclerosis Research Foundation Limited)
PhD, Walter and Eliza Hall Institute of Medical Research (WEHI)
External positions
Department of Neurology, Alfred Hospital
3 Aug 2020 → …
Board Member, Multiple Sclerosis Research Australia (trading as National Multiple Sclerosis Research Foundation Limited)
2018 → …
Research area keywords
- Multiple Sclerosis (MS)
- Clinical Outcomes
- Participatory research
- Pharmacogenomics
- vitamin D
- e-health
Collaborations and top research areas from the last five years
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Optimising treatment outcomes for multiple sclerosis and related demyelinating diseases
Yeh, W. (Primary Chief Investigator (PCI)), Butzkueven, H. (Supervisor) & Jokubaitis, V. (Supervisor)
27/10/25 → 26/10/28
Project: Research
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A randomized, open-label, parallel-group, non-inferiority study comparing efficacy, safety, and tolerability of remibrutinib after switching from ocrelizumab in participants living with relapsing multiple sclerosis, followed by open-label treatment with remibrutinib
Butzkueven, H. (Primary Chief Investigator (PCI))
21/07/25 → 20/07/27
Project: Research
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Descriptive cohort study of pregnancy, maternal, fetal, neonatal, and infant outcomes following maternal exposure to zilucoplan for treatment of myasthenia gravis (MG) during pregnancy and/or lactation.
Butzkueven, H. (Primary Chief Investigator (PCI))
31/01/25 → 31/03/36
Project: Research
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Descriptive cohort study of pregnancy, maternal, fetal, neonatal, and infant outcomes following maternal exposure to rozanolixizumab-noli for treatment of myasthenia gravis (MG) during pregnancy and/or lactation.
Butzkueven, H. (Primary Chief Investigator (PCI))
31/01/25 → 30/12/36
Project: Research
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The Multiple Sclerosis Australian Women’s Midlife Years (MS-AMY) study.
Davis, S. (Primary Chief Investigator (PCI)), Jokubaitis, V. (Chief Investigator (CI)), Islam, R. (Chief Investigator (CI)), Butzkueven, H. (Chief Investigator (CI)), Sanfilippo, P. (Associate Investigator (AI)), Van Der Walt, A. (Associate Investigator (AI)) & Ohman, L. E. (Associate Investigator (AI))
1/01/25 → 31/12/27
Project: Research
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Acute and Long-Term Immune-Treatment Strategies in Anti-LGI1 Antibody-Mediated Encephalitis: A Multicenter Cohort Study
Seery, N., Wesselingh, R., Beech, P., McLaughlin, L. M., Rushen, T., Halliday, A. J., Horst, L. T., Griffith, S. P., Forcadela, M., Tan, T. H., Kazzi, C., Nesbitt, C., Broadley, J., Buzzard, K., Duncan, A. J., D'Souza, W. J., Tran, Y. D., Van Der Walt, A., Skinner, G. & Taylor, B. V. & 17 others, , 19 Jun 2025, In: Neurology: Neuroimmunology and NeuroInflammation. 12, 4, 12 p., e200412.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Adaptive transformer modelling of density function for nonparametric survival analysis
Zhang, X., Mehta, D., Hu, Y., Zhu, C., Darby, D., Yu, Z., Merlo, D., Gresle, M., van der Walt, A., Butzkueven, H. & Ge, Z., 27 Jan 2025, In: Machine Learning. 114, 2, 24 p., 31.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2
Shipley, J., Beharry, J., Yeh, W., Seery, N., Foong, Y. C., Ayton, D., Siriratnam, P., Tan, T., Beadnall, H., Barton, J., Bridge, F., Wesselingh, R., Taylor, L., Rath, L., Haartsen, J., Gadi, M., Nesbitt, C., Zhong, M., Cushing, V. & McKay, F. & 31 others, , Apr 2025, In: The Medical Journal of Australia. 222, 7, p. 365-371 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 1
Shipley, J., Beharry, J., Yeh, W., Seery, N., Foong, Y. C., Ayton, D., Siriratnam, P., Tan, T., Beadnall, H., Barton, J., Bridge, F., Wesselingh, R., Taylor, L., Rath, L., Haartsen, J., Gadi, M., Nesbitt, C., Zhong, M., Cushing, V. & McKay, F. & 31 others, , Apr 2025, In: The Medical Journal of Australia. 222, 7, p. 356-364 9 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Correction to: Estimation of Transition Probabilities from a Large Cohort (> 6000) of Australians Living with Multiple Sclerosis (MS) for Changing Disability Severity Classifications, MS Phenotype, and Disease-Modifying Therapy Classifications (PharmacoEconomics, (2024), 10.1007/s40273-024-01417-4)
Campbell, J. A., Henson, G. J., Ngwa, V. F., Ahmad, H., Taylor, B. V., van der Mei, I., MSBase Australian Researchers & Palmer, A. J., Feb 2025, In: PharmacoEconomics. 43, 2, p. 241 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access
Activities
- 2 External HDR Supervision
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PhD Supervision: Dr Gustavo Noffs
Van Der Walt, A. (Supervisor), Vogel, A. P. (Supervisor), Butzkueven, H. (Supervisor) & Kolbe, S. (Supervisor)
2017 → Mar 2021Activity: External Academic Engagement › External HDR Supervision
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PhD Supervision - Dr Ai-Lan Nguyen
Kalincik, T. (Supervisor), Jokubaitis, V. (Supervisor), Van Der Walt, A. (Supervisor) & Butzkueven, H. (Supervisor)
2017 → 12 May 2021Activity: External Academic Engagement › External HDR Supervision