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Personal profile


Professor Helmut Butzkueven 

Department of Neuroscience research groups - Butzkueven Lab

Helmut is a Professor of Research, in the Van Cleef Centre for Nervous Diseases, Department of Neuroscience, within the Central Clinical School.

Professor Butzkueven is joint Director of the MS Service at The Royal Melbourne Hospital and Director of the MS service at Box Hill Hospital, Melbourne, Australia. He is the Chairman of the MSBase Foundation (www.msbase.org) that funds and administers a global online MS cohort study with more than 20 300 patients enrolled in 64 centres across 27 countries.

His research interests focus on two areas of Multiple Sclerosis Research; development of new biomarkers for axonal degeneration in MS and understanding the effects of MS risk genes.


  • Multiple Sclerosis (MS)
  • Glial Biology
  • Genetics

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Projects 2005 2024

Research Output 1997 2019

Anti-inflammatory disease-modifying treatment and disability progression in primary progressive multiple sclerosis: a cohort study

Lorscheider, J., Kuhle, J., Izquierdo, G., Lugaresi, A., Havrdova, E., Horakova, D., Hupperts, R., Duquette, P., Girard, M., Prat, A., Grand'Maison, F., Grammond, P., Sola, P., Ferraro, D., Trojano, M., Ramo-Tello, C., Lechner-Scott, J., Pucci, E., Solaro, C., Slee, M. & 7 othersVan Pesch, V., Sanchez Menoyo, J. L., van der Walt, A., Butzkueven, H., Kappos, L., Kalincik, T. & on behalf of the MSBase Study Group, 1 Feb 2019, In : European Journal of Neurology. 26, 2, p. 363-370 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Association of Initial Disease-Modifying Therapy with Later Conversion to Secondary Progressive Multiple Sclerosis

Brown, J. W. L., Coles, A., Horakova, D., Havrdova, E., Izquierdo, G., Prat, A., Girard, M., Duquette, P., Trojano, M., Lugaresi, A., Bergamaschi, R., Grammond, P., Alroughani, R., Hupperts, R., McCombe, P., Van Pesch, V., Sola, P., Ferraro, D., Grand'Maison, F., Terzi, M. & 20 othersLechner-Scott, J., Flechter, S., Slee, M., Shaygannejad, V., Pucci, E., Granella, F., Jokubaitis, V., Willis, M., Rice, C., Scolding, N., Wilkins, A., Pearson, O. R., Ziemssen, T., Hutchinson, M., Harding, K., Jones, J., McGuigan, C., Butzkueven, H., Kalincik, T. & Robertson, N., 15 Jan 2019, In : JAMA. 321, 2, p. 175-187 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis

Kalincik, T., Kubala Havrdova, E., Horakova, D., Izquierdo, G., Prat, A., Girard, M., Duquette, P., Grammond, P., Onofrj, M., Lugaresi, A., Ozakbas, S., Kappos, L., Kuhle, J., Terzi, M., Lechner-Scott, J., Boz, C., Grand'Maison, F., Prevost, J., Sola, P., Ferraro, D. & 24 othersGranella, F., Trojano, M., Bergamaschi, R., Pucci, E., Turkoglu, R., McCombe, P. A., Pesch, V. V., Van Wijmeersch, B., Solaro, C., Ramo-Tello, C., Slee, M., Alroughani, R., Yamout, B., Shaygannejad, V., Spitaleri, D., Sánchez-Menoyo, J. L., Ampapa, R., Hodgkinson, S., Karabudak, R., Butler, E., Vucic, S., Jokubaitis, V., Spelman, T. & Butzkueven, H., 1 Apr 2019, In : Journal of Neurology, Neurosurgery and Psychiatry. 90, 4, p. 458-468 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis

Boonstra, F. M. C., Noffs, G., Perera, T., Jokubaitis, V. G., Vogel, A. P., Moffat, B. A., Butzkueven, H., Evans, A., van der Walt, A. & Kolbe, S. C., 25 Mar 2019, (Accepted/In press) In : Multiple Sclerosis Journal. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study

Nguyen, A. L., Havrdova, E. K., Horakova, D., Izquierdo, G., Kalincik, T., van der Walt, A., Terzi, M., Alroughani, R., Duquette, P., Girard, M., Prat, A., Boz, C., Sola, P., Ferraro, D., Lugaresi, A., Lechner-Scott, J., Barnett, M., Grand'Maison, F., Grammond, P., Ramo-Tello, C. & 26 othersTurkoglu, R., McCombe, P., Pucci, E., Trojano, M., Granella, F., Spitaleri, D., Van Pesch, V., Soysal, A., Oreja-Guevara, C., Verheul, F., Vucic, S., Hodgkinson, S., Slee, M., Ampapa, R., Prevost, J., Menoyo, J. L. S., Skibina, O., Solaro, C., Olascoaga, J., Shaw, C., Madsen, K. G., Naidoo, K., Hyde, R., Butzkueven, H., Jokubaitis, V. & on behalf of the MSBase Study Group, 1 Feb 2019, In : Multiple Sclerosis and Related Disorders. 28, p. 235-243 9 p.

Research output: Contribution to journalArticleResearchpeer-review