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Personal profile


Professor Helmut Butzkueven 

Department of Neuroscience research groups - Butzkueven Lab

Helmut is a Professor of Research, in the Van Cleef Centre for Nervous Diseases, Department of Neuroscience, within the Central Clinical School.

Professor Butzkueven is joint Director of the MS Service at The Royal Melbourne Hospital and Director of the MS service at Box Hill Hospital, Melbourne, Australia. He is the Chairman of the MSBase Foundation (www.msbase.org) that funds and administers a global online MS cohort study with more than 20 300 patients enrolled in 64 centres across 27 countries.

His research interests focus on two areas of Multiple Sclerosis Research; development of new biomarkers for axonal degeneration in MS and understanding the effects of MS risk genes.


  • Multiple Sclerosis (MS)
  • Glial Biology
  • Genetics

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Projects 2005 2022

Research Output 1999 2018

Association of Inflammation and Disability Accrual in Patients with Progressive-Onset Multiple Sclerosis

Hughes, J., Jokubaitis, V., Lugaresi, A., Hupperts, R., Izquierdo, G., Prat, A., Girard, M., Duquette, P., Grand'maison, F., Grammond, P., Sola, P., Ferraro, DI., Ramo-Tello, C., Trojano, M., Slee, M., Shaygannejad, V., Boz, C., Lechner-Scott, J., Van Pesch, V., Pucci, E. & 12 othersSolaro, C., Verheul, F., Terzi, M., Granella, F., Spitaleri, D., Alroughani, R., Jun, J. K., Fambiatos, A., Van Der Walt, A., Butzkueven, H., Kalincik, T. & for the MSBase Study Group, 1 Jan 2018, (Accepted/In press) In : JAMA Neurology. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cladribine versus fingolimod, natalizumab and interferon β for multiple sclerosis

Kalincik, T., Jokubaitis, V., Spelman, T., Horakova, D., Havrdova, E., Trojano, M., Lechner-Scott, J., Lugaresi, A., Prat, A., Girard, M., Duquette, P., Grammond, P., Solaro, C., Grand’Maison, F., Hupperts, R., Prevost, J., Sola, P., Ferraro, D., Terzi, M., Butler, E. & 9 othersSlee, M., Kermode, A., Fabis-Pedrini, M., McCombe, P., Barnett, M., Shaw, C., Hodgkinson, S., Butzkueven, H. & on behalf of the MSBase Study Group, Oct 2018, In : Multiple Sclerosis. 24, 12, p. 1617-1626 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS

Liu, Y., Duan, Y., Huang, J., Ren, Z., Liu, Z., Dong, H., Weiler, F., Hahn, H. K., Shi, F-D., Butzkueven, H., Barkhof, F. & Li, K., Jan 2018, In : European Radiology. 28, 1, p. 96-103 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Genotype and Phenotype in Multiple Sclerosis—Potential for Disease Course Prediction?

Jokubaitis, V. G., Zhou, Y., Butzkueven, H. & Taylor, B. V., 1 Jun 2018, In : Current Treatment Options in Neurology. 20, 6, 18.

Research output: Contribution to journalReview ArticleResearchpeer-review

Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

Signori, A., Izquierdo, G., Lugaresi, A., Hupperts, R., Grand’Maison, F., Sola, P., Horakova, D., Havrdova, E., Prat, A., Girard, M., Duquette, P., Boz, C., Grammond, P., Terzi, M., Singhal, B., Alroughani, R., Petersen, T., Ramo, C., Oreja-Guevara, C., Spitaleri, D. & 22 othersShaygannejad, V., Butzkueven, H., Kalincik, T., Jokubaitis, V., Slee, M., Fernandez Bolaños, R., Sanchez-Menoyo, J. L., Pucci, E., Granella, F., Lechner-Scott, J., Iuliano, G., Hughes, S., Bergamaschi, R., Taylor, B., Verheul, F., Edite Rio, M., Amato, M. P., Sajedi, S. A., Majdinasab, N., Van Pesch, V., Sormani, M. P. & Trojano, M., 1 Apr 2018, In : Multiple Sclerosis. 24, 5, p. 642-652 11 p.

Research output: Contribution to journalArticleResearchpeer-review