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Personal profile

Biography

After finishing her Master’s Degree at the University of Copenhagen, Dr Heidi Bildsoe worked at King’s College, London as a Research Assistant in Professor Simon Hughes’ Muscle Signalling Group.  She then undertook her PhD studies in 2008 with Professor Patrick Tam at the Children’s Medical Research Institute in Sydney investigating the function and downstream targets of the transcription factor Twist1 during craniofacial development.

In 2015 Dr. Bildsoe relocated to Melbourne to work as an EMBL Postdoctoral Research Fellow with Associate Professor Edwina McGlinn at ARMI (Monash University) elucidating genomic and epigenetic regulation of Hox gene expression during axial formation.

Dr. Bildsoe has recently joined A/Prof Patrick Western’s team at the Centre for Reproductive Health, Hudson Institute of Medical Research, to work on germ cells development and epigenetic inheritance.

Career Summary

Academic Positions

March 2018 - present: Postdoctoral Scientist, Germ Cell Development and Epigenetics Laboratory, Hudson Institute of Medical Research

March 2015 - March 2018:  EMBL Postdoctoral Research Fellow, McGlinn Group, Australian Regenerative Medicine Institute, Monash University

Education

Aug 2008 – March 2014 (Submission date): Postgraduate Research Degree in Biomedical Science

Supervisor: Professor Patrick Tam, Embryology Unit, The Children’s Medical Research Institute, University of Sydney

(Maternity leave: March 2009 – November 2009)

Prizes and Awards 

May 2012:  Awarded 1st prize for Student oral presentation at the NSW 13th ANZSCDB Meeting, Sydney, Australia.

September 2010: Awarded Student travel grant from ANZSCDB

January 2010: Awarded a NHMRC Biomedical Postgraduate Scholarship 

August 2008: Awarded a CMRI Postgraduate Scholarship

August 2008: Awarded UPA co-funded Postgraduate Research Scholarship

Publications

Book Chapters

  1. 1.     Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. (2011) Marking Cells for Imaging Analysis of Morphogenetic Behavior and Cell Fates in Mouse Embryos. Imagning in Developmental Biology: A Laboratory Manual,(p311-329). Woodbury, New York, USA: Cold Spring Harbor Laboratory Press

 Original research articles and reviews

  1. 2.     Jarred E.*, Bildsoe H*, Western PW. Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs. (* Equal contribution) F1000Research 2018, 7(F1000 Faculty Rev) PMID: 30613387 
  2. 3.     Casaca A*., Hauswirth GM*., Bildsoe H*., Mallo M. and McGlinn E. Regulatory landscape of the Hox Transcriptome. Int J Dev Biol.  (* equal contribution) Int J Dev Biol. 2018;62(11-12):693-704 PMID: 30604839
  3. 4.     Janz N., Keniry A., Trussart M., Bildsoe H., Beck T., Tonks ID., Mould AW., Hickey P., Breslin K., Iminitoff M., Ritchie ME., McGlinn E., Kay GF., Murphy JM. and Blewitt ME. Long-range chromatin interactions on the inactive X and at Hoxclusters are regulated by the non-canonical SMC protein Smchd1.Nat Struct Mol Biol. 2018 Sep;25(9):766-777 PMID: 30127357
  4. 5.     Bildsoe H., Fan X., Wilkie EE., Ashoti A., Jones VJ., Power M., Qin J., Wang J.,Tam PP and Loebel DAF. (2016). Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest. Data Brief. 2016 sep 12;9372-375 PMID:27699189
  5. 6.     Bildsoe H.,Fan X., Wilkie EE., Ashoti A., Jones VJ., Power M., Qin J., Wang J.,Tam PP and Loebel DAF. (2016). Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Dev Bio. 2016 Oct 1:418(1):189-203 PMID: 27546376
  6. 7.     Fan X., Loebel DAF., Bildsoe H.,Wilkie EE., Qin J., Wang J.,Tam PP and Loebel DAF. (2016). Tissue interactions, cell signalling and transcriptional control in the cranial mesoderm during craniofacial development. AIMS Genetics 
  7. 8.     Loebel DAF., Hor AC., Bildsoe H., and Tam PP (2014). Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugodpod patterning. PLoS One 2014 Jun 3;9(6):e98945 PMID: 24893291
  8. 9.     Bildsoe H.,Loebel DAF., Hor A., Jones VJ., Braithwaite A., C, Chen YT., Behringer RR., Tam PP (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Bio. 2013 Feb 15:374(2):295-307 PMID: 23261931
  9. 10.  Loebel DAF., Hor A., Bildsoe H.,Jones VJ., Chen YT., Behringer RR., Tam PP (2012). Regionalized Twist1 activity in the forelimb bud drives the Morphogenesis of the proximal and preaxial skeleton. Developmental Biology 362, 132-40. doi:10.1016/j.ydbio.2011.11.020
  10. 11.  Bildsoe H.,Loebel DAF., Jones VJ., Chen YT., Behringer RR., Tam PP (2009). Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Developmental Biology 331, 176-88. doi:10.1016/j.ydbio.2009.04.034
  11. 12.  Henriquez JP., Webb A., Bence M., Bildsoe H.,Sahores M., Hughes SM., Salinas PC (2008). Wnt signalling promotes AChR aggregation at the neuro-muscular synapse in collaboration with agrin. Proc Natl Acad Sci U S A. 105, 18812-7. doi: 10.1073/pnas.0806300105
  12. 13.  Franklin V., Khoo PL., Bildsoe H., Wong N., Lewis SL., Tam PP (2008). Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mechanisms of Development 125, 587-600. doi: 10.1016/j.mod.2008.04.001
  13. 14.  Franklin V., Bildsoe H.,Tam PP (2007). Fate-Mapping Technique: Grafting Fluorescent Cells into Gastrula-Stage Mouse Embryos at 7-7.5 Days Post-coitum. CSH Protocols pdb.prot4915, doi: 10.1101/pdb.prot4892           
  14. 15.  Bildsoe H.,Franklin V., Tam PP (2007). Fate-Mapping technique: Using Carbocyanine Dyes for Vital Labeling of Cells in Gatrula-Stage Mouse Embryos Cultured In Vitro. CSH Protocols pdb.prot, 4892, doi: 10.1101/pdb.prot4915
  15. 16.  Tam PP., Khoo PL., Lewis SL., Bildsoe H.,Wong N., Sang TE., Gad JM., Robb L. (2007). Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development 134, 251-60
  16. 17.  Lewis SL., Khoo PL., Andrea De Young R., Bildsoe H, Wakamiya M., Behringer RR., Mukhopadhyay M., Westphal H., Tam PP (2006). Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mechanism of Development 124, 157-165
  17. 18.  Brack AS., Bildsoe H., Hughes SM. (2005). Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy. Journal of Cell Science 118, 4813-21
  18. 19.  Schuierer M., Mann CJ., Bildsoe H., Huxley C., Hughes SM. (2005). Analyses of the differentiation potential of satellite cells from myoD-/-, mdx, and PMP22 C22 mice. BMC Musculoskelet Disord. 11;6:15 
  19. 20.  Li X.*, Blagden CS.*,Bildsoe H.*, Bonnin MA., Duprez D., Hughes SM (2004). Hedgehog can drive terminal differentiation of amniote slow skeletal muscle. BMC Developmental Biology 6; 4:9, doi:10.1186/1471-213X-4-9 (*Equal contribution)

Academic Standing

Conferences/Seminars

  1. 1.     Bildsoe H., Nefzger CM., Chen J., Wong SFL., Polo JM., McGlinn E. Elucidating mechanisms driving axis elongation and anterior posterior patterning. ComBio Adelaide 2017 (oral presentation)
  2. 2.     Bildsoe H.,Wong SFL., McGlinn E. Integrating novel targets of miR-196 in controlling axis elongation and vertebral patterning. ComBio Melbourne 2015 (oral presentation)
  3. 3.     Bildsoe H., Loebel DAF., Jones VJ., Hor A., Chen YT., Behringer RR., and Patrick Tam.  Twist1: a key regulator of craniofacial development” ComBio Adelaide 2012
  4. 4.     Bildsoe H.,Loebel DAF., Jones VJ., Hor A., Chen YT., Behringer RR., and Patrick Tam.  Twist1: a key regulator of craniofacial development” NSW 13thANZSCDB meeting Sydney (Oral presentation)
  5. 5.     Bildsoe H., Li X., Blagden CS., Bonnin MA., Duprez D., Hughes SM. “Hedgehog proteins and muscle differentiation”. The Randall Centre Retreat, Royal Holloway, London, UK September 2004 
  6. 6.    Bildsoe H., Li X., Blagden CS., Bonnin MA., Duprez D., Hughes SM “Hedgehog can drive the terminal differentiation of skeletal muscle”8thLimb Conference, Dundee, UK, July 2004 (Oral presentation). 

 Supervision & Mentoring

May 2017- present: Assisting A/Prof Edwina McGlinn in mentoring phD student Mr. Gabriel Hauswirth 

Feb. – May 2017: Co-supervisor to Ms. Hoang Phan (DEV3990 Student) in semester 1.

Nov.2015-Dec.2017: Assisting A/Prof Edwina McGlinn in supervising former UROP/Research Assistant Ms Laura Stein. 

2013-2014: Assisting Dr. David Loebel (CMRI) in supervising visting student Ms Ator Ashoti and phD student Ms Xiaochen Fan.

Professional Activities

2017                Session chair at the EMBL Australia PhD course, Monash University 

2017–Present NH&MRC Project grant reviewer, external

2016-2018       Chair of the Australian Regenerative Medicine Institute Postdoctoral Committee, ARMI, Monash University

2016–Present  Organizer of the ARMI Internal Seminar Series, ARMI

2016-Present Examiner, DEV3011 Oral presentations

I have reviewed for journals including Development, Developmental biology and Bioassays.


Keywords

  • epigenetic inheritance
  • embryonic development
  • germ cell epigenetics
  • bone development
  • transcriptional regulation
  • stem cell biology
  • mouse genetics

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Research Output 2004 2018

Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs [version 1; referees: 3 approved]

Jarred, E. G., Bildsoe, H. & Western, P. S., 1 Jan 2018, In : F1000Research. 7, 14 p., 1967.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access

Regulatory landscape of the hox transcriptome

Casaca, A. N. A., Hauswirth, G. M., Bildsoe, H., Mallo, M. & McGlinn, E., 1 Jan 2018, In : International Journal of Developmental Biology. 62, 11-12, p. 693-704 12 p., 62.

Research output: Contribution to journalArticleResearchpeer-review

Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters

Jansz, N., Keniry, A., Trussart, M., Bildsoe, H., Beck, T., Tonks, I. D., Mould, A. W., Hickey, P., Breslin, K., Iminitoff, M., Ritchie, M. E., McGlinn, E., Kay, G. F., Murphy, J. M. & Blewitt, M. E., 1 Sep 2018, In : Nature Structural Biology. 25, 9, p. 766-777 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest

Bildsoe, H., Fan, X., Wilkie, E. E., Ashoti, A., Jones, V. J., Power, M., Qin, J., Wang, J., Tam, P. P. L. & Loebel, D. A. F., 1 Dec 2016, In : Data in Brief. 9, p. 372-375 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance

Bildsoe, H., Fan, X., Wilkie, E. E., Ashoti, A., Jones, V. J., Power, M., Qin, J., Wang, J., Tam, P. P. L. & Loebel, D. A. F., 1 Oct 2016, In : Developmental Biology. 418, 1, p. 189-203 15 p.

Research output: Contribution to journalArticleResearchpeer-review