Projects per year
Personal profile
Biography
Professor Hayley Newton is a cellular microbiologist with a keen interest in understanding the ways in which intracellular bacterial pathogens can manipulate their human host cells. She has worked with a range of bacterial pathogens, but her main research impact has come from studies into the zoonotic pathogen Coxiella burnetii. As a pathogen of both humans and animals, C. burnetii, remains an important example of the need for a one health approach for research into human health and disease.
After completing her PhD, studying pathogenesis of Legionella pneumophila at Monash University, Hayley was awarded a NHMRC Training Fellowship to undertake postdoctoral research at Yale University. Here she applied pioneering techniques to genetically manipulate C. burnetii and discovered key virulence factors of this poorly understood human pathogen. This research has led to a significant shift in our understanding of this mysterious intracellular pathogen. Hayley moved to the Department of Microbiology and Immunology, University of Melbourne, in 2013 where she established her independent research program and a substantial teaching portfolio. In 2022, Hayley was recruited to the Infection Program, Department of Microbiology and Biomedicine Discovery Institute, at Monash University.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Intracellular Bacterial Pathogens
- Coxiella burnetii
- Legionella
- Type 4 Secretion System
- Bacterial Effector Proteins
- Lysosome biology
- Autophagy
- host-pathogen interactions
Collaborations and top research areas from the last five years
Projects
- 1 Active
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A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence
Hachani, A., Giulieri, S. G., Guérillot, R., Walsh, C. J., Herisse, M., Soe, Y. M., Baines, S. L., Thomas, D. R., Cheung, S. D., Hayes, A. S., Cho, E., Newton, H. J., Pidot, S., Massey, R. C., Howden, B. P. & Stinear, T. P., 8 Jun 2023, In: eLife. 12, 27 p., e84778.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Chlamydia and Coxiella
Jelocnik, M., Huston, W. M. & Newton, H. J., 2023, Pathogenesis of Bacterial Infections in Animals. Prescott, J. F., Boyce, J. D., MacInnes, J. I., Rycroft, A. N., Van Immersee, F. & Vázquez-Boland, J. A. (eds.). 5th ed. Hoboken, NJ, USA: Wiley-Blackwell, p. 433-455 23 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
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Complex Signaling Networks Control Coxiella burnetii
Thomas, D. R. & Newton, H. J., Mar 2023, In: Journal of Bacteriology. 205, 3, 4 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Coxiella co-opts the Glutathione Peroxidase 4 to protect the host cell from oxidative stress-induced cell death
Loterio, R. K., Thomas, D. R., Andrade, W., Lee, Y. W., Santos, L. L., Mascarenhas, D. P. A., Steiner, T. M., Chiaratto, J., Fielden, L. F., Lopes, L., Bird, L. E., Goldman, G. H., Stojanovski, D., Scott, N. E., Zamboni, D. S. & Newton, H. J., 5 Sept 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 36, 11 p., e2308752120.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Eat, prey, love: Pathogen-mediated subversion of lysosomal biology
Bird, L. E., Edgington-Mitchell, L. E. & Newton, H. J., Aug 2023, In: Current Opinion in Immunology. 83, 9 p., 102344.Research output: Contribution to journal › Review Article › Other › peer-review
1 Citation (Scopus)