Hatem Salem

Emeritus Prof

1986 …2014
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Research Output 1986 2014

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110 Citations (Scopus)

Adhesion receptor activation of phosphatidylinositol 3-Kinase: Von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

Jackson, S. P., Schoenwaelder, S. M., Yuan, Y., Rabinowitz, I., Salem, H. H. & Mitchell, C. A., 28 Oct 1994, In : Journal of Biological Chemistry. 269, 43, p. 27093-27099 7 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

A fatal thrombotic disorder associated with an acquired inhibitor of protein C

Mitchell, C. A., Rowell, J. A., Hau, L., Young, J. P. & Salem, H. H., 1987, In : New England Journal of Medicine. 317, 26, p. 1638-1642 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Altered thrombomodulin staining in blistering dermatoses

Jackson, D. E., Mitchell, C. A., Mason, G., Salem, H. H. & Hayman, J. A., 1996, In : Pathology. 28, 3, p. 225-228 4 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase A2

Yuan, Y., Jackson, S. P., Newnham, H. H., Mitchell, C. A. & Salem, H. H., 1995, In : Blood. 86, 11, p. 4166-4174 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Arterial thrombosis associated with immune thrombocytopenia: Presence of a platelet aggregating IgG synergistic with thrombin and adrenalin

Jackson, S. P., Jane, S. M., Mitchell, C. A., Cortizo, W. F., Hau, L., Pfueller, S. L. & Salem, H. H., 1989, In : Thrombosis and Haemostasis. 62, 3, p. 846-849 4 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Association of annexin V with mitochondria

Sun, J., Bird, C. H., Salem, H. H. & Bird, P., 23 Aug 1993, In : FEBS Letters. 329, 1-2, p. 79-83 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
134 Citations (Scopus)

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., Andrews, R. K., Mason, K. D., Salem, H. H., Huang, D. C. S., Kile, B. T., Roberts, A. W. & Jackson, S. P., 2011, In : Blood. 118, 6, p. 1663-1674 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets

Yuan, Y., Dopheide, S. M., Ivanidis, C., Salem, H. H. & Jackson, S. P., 1997, In : Journal of Biological Chemistry. p. 21847 - 21854 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization

Coughlin, P., Nicholl, J., Sun, J., Salem, H., Bird, P. & Sutherland, G. R., 1 Jan 1995, In : Genomics. 26, 2, p. 431-433 3 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Cleavage of protein S by a platelet membrane protease

Mitchell, C. A. & Salem, H. H., 1987, In : Journal of Clinical Investigation. 79, 2, p. 374-379 6 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Cloning and molecular characterization of a human intracellular serine proteinase inhibitor

Coughlin, P., Sun, J., Cerruti, L., Salem, H. H. & Bird, P., 3 Nov 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9417-9421 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
20 Citations (Scopus)

Control of thrombin mediated cleavage of protein S

Mitchell, C. A., Hau, L. & Salem, H. H., 1986, In : Thrombosis and Haemostasis. 56, 2, p. 151-154 4 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction

Mistry, N., Cranmer, S. L., Yuan, Y., Mangin, P., Dopheide, S. M., Harper, I. S., Giuliano, S., Dunstan, D. E., Lanza, F., Salem, H. H. H. & Jackson, S. P., 2000, In : Blood. p. 3480 - 3489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965 - 2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets

Schoenwaelder, S. M., Kulkarni, S., Salem, H. H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T. C. & Jackson, S. P., 1997, In : Journal of Biological Chemistry. p. 24876 - 24884 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Effects of annexin V on the activity of the anticoagulant proteins C and S

Sun, J., Bird, P. & Salem, H. H., 1 Feb 1993, In : Thrombosis Research. 69, 3, p. 279-287 9 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular Injury

Woollard, K. J., Sturgeon, S. A., Chin-Dusting, J. PF., Salem, H. H. & Jackson, S., 2009, In : Journal of Biological Chemistry. 284, 19, p. 13110 - 13118 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin IIb3

Yap, C. L., Anderson, K. E., Hughan, S. C., Dopheide, S. M., Salem, H. H. & Jackson, S. P., 2002, In : Blood. 99, 1, p. 151 - 158 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Extracts from malignant tissue reduce thrombomodulin expression on cultured human endothelial cells

Jane, S. M., Hau, L. & Salem, H. H., 1 Jan 1991, In : Hematology Reviews and Communications. 5, 2, p. 85-95 11 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

Cooray, P., Yuan, Y., Schoenwaelder, S. M., Mitchell, C. A., Salem, H. H. & Jackson, S. P., 15 Aug 1996, In : Biochemical Journal. 318, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPIb/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

Cranmer, S. L., Ulsemer, P., Cooke, B. M., Salem, H. H., De La Salle, C., Lanza, F. & Jackson, S. P., 1999, In : Journal of Biological Chemistry. p. 6097 - 6106 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Haematological profile of healthy elderly Australians

Salem, H. H., Campion, K., McNeil, J. J., Robert, J., Donnan, G. A., Tonkin, A. M. & Worsam, B., 1 Jan 1992, In : Medical Journal of Australia. 157, 2, p. 96-100 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

High-dose cytarabine (24g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia

Low, M., Lee, D., Coutsouvelis, J., Patil, S., Opat, S., Walker, P. A., Schwarer, A., Salem, H. H., Avery, S., Spencer, A. & Wei, A., 2013, In : Internal Medicine Journal. 43, 3, p. 294 - 297 4 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin aIIb?3 adhesive function in platelets

Schoenwaelder, S. M., Ono, A., Sturgeon, S. A., Chan, S. M., Mangin, P., Maxwell, M. J., Turnbull, S., Mulchandani, M., Anderson, K. E., Kauffenstein, G., Rewcastle, G. W., Kendall, J., Gachet, C., Salem, H. H. & Jackson, S., 2007, In : Journal of Biological Chemistry. 282, 39, p. 28648 - 28658 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha

Cranmer, S. L., Pikovski, I., Mangin, P. H., Thompson, P. E., Domagala, T., Frazzetto, M., Salem, H. H. & Jackson, S. P., 2005, In : Biochemical Journal. 387, 3, p. 849 - 858 10 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Immunohistochemical localization of thrombomodulin in normal human skin and skin tumours

Jackson, D. E., Mitchell, C. A., Bird, P., Salem, H. H. & Hayman, J. A., 1995, In : Journal of Pathology. 175, 4, p. 421-432 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Inhibition of activated protein C by platelets

Jane, S. M., Mitchell, C. A., Hau, L. & Salem, H. H., 1989, In : Journal of Clinical Investigation. 83, 1, p. 222-226 5 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Inhibition of the anticoagulant activity of protein S by prothrombin

Mitchell, C. A., Jane, S. M. & Salem, H. H., 1988, In : Journal of Clinical Investigation. 82, 6, p. 2142-2147 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction between Platelet Glycoprotein Ib and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear

Williamson, D., Pikovski, I., Cranmer, S. L., Mangin, P., Mistry, N., Domagala, T., Chehab, S., Lanza, F., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 3, p. 2151 - 2159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Interaction of annexin V and platelets: Effects on platelet function and protein S binding

Sun, J., Bird, P. & Salem, H. H., 1 Feb 1993, In : Thrombosis Research. 69, 3, p. 289-296 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Low-molecular-weight heparin biosimilars: Potential implications for clinical practice

Nandurkar, H. H., Chong, B. H., Salem, H. H., Gallus, A., Ferro, V. & McKinnon, R. A., 2014, In : Internal Medicine Journal. 44, 5, p. 497 - 500 4 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Malignant systemic mastocytosis

JANE, S. M., SUTHERLAND, R. & SALEM, H. H., 1 Jan 1988, In : Australian and New Zealand Journal of Medicine. 18, 4, p. 610-612 3 p.

Research output: Contribution to journalArticleOtherpeer-review

41 Citations (Scopus)

Natural anticoagulants and the liver

Castelino, D. J. & Salem, H. H., 1997, In : Journal of Gastroenterology and Hepatology. p. 77 - 83 7 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Nucleolar and cytoplasmic localization of annexin V

Sun, J., Salem, H. H. & Bird, P., 21 Dec 1992, In : FEBS Letters. 314, 3, p. 425-429 5 p.

Research output: Contribution to journalArticleResearchpeer-review

455 Citations (Scopus)

PI 3-kinase p110beta: A new target for antithrombotic therapy

Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L-S., Wright, C. E., Kenche, V. B., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C. & 6 others, Lu, L., Giuliano, S., Hughan, S. C., Angus, J. A., Robertson, A. D. & Salem, H. H., 2005, In : Nature Medicine. 11, 5, p. 507 - 514 8 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

Sun, J., Coughlin, P., Salem, H. H. & Bird, P., 27 Sep 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1252, 1, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation

Bird, P. I., Cerruti, L., Scott, F. L., Coughlin, P. B., Salem, H. H. & Paddle-Ledinek, J. E., 1998, In : Experimental Cell Research. p. 263 - 271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

Jackson, D. E., Mitchell, C. A. & Salem, H. H., 1994, In : Thrombosis and Haemostasis. 72, 1, p. 70-73 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein S negates the activated protein C inhibitory activity of plasma

Jane, S. M., Hau, L. & Salem, H. H., 1 Jan 1992, In : Blood Coagulation and Fibrinolysis. 3, 3, p. 257-261 5 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Prothrombin complex concentrates used alone in urgent reversal of warfarin anticoagulation

Tran, H., Collecutt, M., Whitehead, S. & Salem, H. H., 2011, In : Internal Medicine Journal. 41, 4, p. 337 - 343 7 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

Yuan, Y., Jackson, S. P., Mitchell, C. A. & Salem, H. H., 15 Jun 1993, In : Thrombosis Research. 70, 6, p. 471-481 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Purification and characterization of two forms of soluble thrombomodulin from human urine

Jackson, D. E., Tetaz, T. J., Salem, H. H. & Mitchell, C. A., 1994, In : European Journal of Biochemistry. 221, 3, p. 1079-1087 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Regulation of activated protein C by factor Xa.

Jane, S. M., Hau, L. & Salem, H. H., 1 Dec 1991, In : Blood Coagulation and Fibrinolysis. 2, 6, p. 723-729 7 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 17, p. 14738 - 14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

RhoA sustains integrin αIIbβ3 adhesion contacts under high shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 26 Apr 2002, In : Journal of Biological Chemistry. 277, 17, p. 14738-14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 2004, In : Journal of Biological Chemistry. 279, 31, p. 32196 - 32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review