Hatem Salem

Emeritus Prof

1981 …2014

Research output per year

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Research Output

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1981

Disseminated intravascular coagulation following peritoneo-venous (LeVeen) shunt

Gibson, P. R., Dudley, F. J., Jakobovits, A. W., Salem, H. H. & McInnes, I. E., 24 Jul 1981, In : Australian and New Zealand Journal of Medicine. 11, 1, p. 8-12 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
1986

Control of thrombin mediated cleavage of protein S

Mitchell, C. A., Hau, L. & Salem, H. H., 1986, In : Thrombosis and Haemostasis. 56, 2, p. 151-154 4 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
1987

A fatal thrombotic disorder associated with an acquired inhibitor of protein C

Mitchell, C. A., Rowell, J. A., Hau, L., Young, J. P. & Salem, H. H., 1987, In : The New England Journal of Medicine. 317, 26, p. 1638-1642 5 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Cleavage of protein S by a platelet membrane protease

Mitchell, C. A. & Salem, H. H., 1987, In : Journal of Clinical Investigation. 79, 2, p. 374-379 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
1988

Inhibition of the anticoagulant activity of protein S by prothrombin

Mitchell, C. A., Jane, S. M. & Salem, H. H., 1988, In : Journal of Clinical Investigation. 82, 6, p. 2142-2147 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Malignant systemic mastocytosis

JANE, S. M., SUTHERLAND, R. & SALEM, H. H., 1 Jan 1988, In : Australian and New Zealand Journal of Medicine. 18, 4, p. 610-612 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

The anticoagulant properties of a modified form of protein S

Mitchell, C. A., Kelemen, S. M. & Salem, H. H., 1988, In : Thrombosis and Haemostasis. 60, 2, p. 298-304 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

TREATMENT OF RESISTANT WALDENSTROM'S MACROGLOBULINEMIA WITH HIGH DOSE GLUCOCORTICOSTEROIDS

JANE, S. M. & SALEM, H. H., 1 Jan 1988, In : Internal Medicine Journal. 18, 1, p. 77-78 2 p.

Research output: Contribution to journalArticleOtherpeer-review

22 Citations (Scopus)
1989

Arterial thrombosis associated with immune thrombocytopenia: Presence of a platelet aggregating IgG synergistic with thrombin and adrenalin

Jackson, S. P., Jane, S. M., Mitchell, C. A., Cortizo, W. F., Hau, L., Pfueller, S. L. & Salem, H. H., 1989, In : Thrombosis and Haemostasis. 62, 3, p. 846-849 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Inhibition of activated protein C by platelets

Jane, S. M., Mitchell, C. A., Hau, L. & Salem, H. H., 1989, In : Journal of Clinical Investigation. 83, 1, p. 222-226 5 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Thrombomodulin: A major regulator of blood coagulation

Jane, S. & Salem, H., 1 Dec 1989, In : Today's Life Science. 1, 2, p. 40-43 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1991

Extracts from malignant tissue reduce thrombomodulin expression on cultured human endothelial cells

Jane, S. M., Hau, L. & Salem, H. H., 1 Jan 1991, In : Hematology Reviews and Communications. 5, 2, p. 85-95 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Regulation of activated protein C by factor Xa.

Jane, S. M., Hau, L. & Salem, H. H., 1 Dec 1991, In : Blood Coagulation and Fibrinolysis. 2, 6, p. 723-729 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
1992

Haematological profile of healthy elderly Australians

Salem, H. H., Campion, K., McNeil, J. J., Robert, J., Donnan, G. A., Tonkin, A. M. & Worsam, B., 1 Jan 1992, In : The Medical Journal of Australia. 157, 2, p. 96-100 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Nucleolar and cytoplasmic localization of annexin V

Sun, J., Salem, H. H. & Bird, P., 21 Dec 1992, In : FEBS Letters. 314, 3, p. 425-429 5 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Protein S negates the activated protein C inhibitory activity of plasma

Jane, S. M., Hau, L. & Salem, H. H., 1 Jan 1992, In : Blood Coagulation and Fibrinolysis. 3, 3, p. 257-261 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1993

Association of annexin V with mitochondria

Sun, J., Bird, C. H., Salem, H. H. & Bird, P., 23 Aug 1993, In : FEBS Letters. 329, 1-2, p. 79-83 5 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Cloning and molecular characterization of a human intracellular serine proteinase inhibitor

Coughlin, P., Sun, J., Cerruti, L., Salem, H. H. & Bird, P., 3 Nov 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9417-9421 5 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Effects of annexin V on the activity of the anticoagulant proteins C and S

Sun, J., Bird, P. & Salem, H. H., 1 Feb 1993, In : Thrombosis Research. 69, 3, p. 279-287 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Interaction of annexin V and platelets: Effects on platelet function and protein S binding

Sun, J., Bird, P. & Salem, H. H., 1 Feb 1993, In : Thrombosis Research. 69, 3, p. 289-296 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

Yuan, Y., Jackson, S. P., Mitchell, C. A. & Salem, H. H., 15 Jun 1993, In : Thrombosis Research. 70, 6, p. 471-481 11 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)
1994

Adhesion receptor activation of phosphatidylinositol 3-Kinase: Von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

Jackson, S. P., Schoenwaelder, S. M., Yuan, Y., Rabinowitz, I., Salem, H. H. & Mitchell, C. A., 28 Oct 1994, In : The Journal of Biological Chemistry. 269, 43, p. 27093-27099 7 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)
2 Citations (Scopus)

Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

Jackson, D. E., Mitchell, C. A. & Salem, H. H., 1994, In : Thrombosis and Haemostasis. 72, 1, p. 70-73 4 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Purification and characterization of two forms of soluble thrombomodulin from human urine

Jackson, D. E., Tetaz, T. J., Salem, H. H. & Mitchell, C. A., 1994, In : European Journal of Biochemistry. 221, 3, p. 1079-1087 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Tyrosine Kinases Regulate the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Polymers

Schoenwaelder, S. M., Jackson, S. P., Yuan, Y., Teasdale, M. S., Salem, H. H. & Mitchell, C. A., 23 Dec 1994, In : The Journal of Biological Chemistry. 269, 51, p. 32479-32487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
1995

An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase A2

Yuan, Y., Jackson, S. P., Newnham, H. H., Mitchell, C. A. & Salem, H. H., 1995, In : Blood. 86, 11, p. 4166-4174 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization

Coughlin, P., Nicholl, J., Sun, J., Salem, H., Bird, P. & Sutherland, G. R., 1 Jan 1995, In : Genomics. 26, 2, p. 431-433 3 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Immunohistochemical localization of thrombomodulin in normal human skin and skin tumours

Jackson, D. E., Mitchell, C. A., Bird, P., Salem, H. H. & Hayman, J. A., 1995, In : Journal of Pathology. 175, 4, p. 421-432 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

Sun, J., Coughlin, P., Salem, H. H. & Bird, P., 27 Sep 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1252, 1, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)
1996

Altered thrombomodulin staining in blistering dermatoses

Jackson, D. E., Mitchell, C. A., Mason, G., Salem, H. H. & Hayman, J. A., 1996, In : Pathology. 28, 3, p. 225-228 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

Cooray, P., Yuan, Y., Schoenwaelder, S. M., Mitchell, C. A., Salem, H. H. & Jackson, S. P., 15 Aug 1996, In : Biochemical Journal. 318, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)
1997

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets

Yuan, Y., Dopheide, S. M., Ivanidis, C., Salem, H. H. & Jackson, S. P., 1997, In : The Journal of Biological Chemistry. p. 21847 - 21854 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets

Schoenwaelder, S. M., Kulkarni, S., Salem, H. H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T. C. & Jackson, S. P., 1997, In : The Journal of Biological Chemistry. p. 24876 - 24884 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Natural anticoagulants and the liver

Castelino, D. J. & Salem, H. H., 1997, In : Journal of Gastroenterology and Hepatology. p. 77 - 83 7 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
1998

Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation

Bird, P. I., Cerruti, L., Scott, F. L., Coughlin, P. B., Salem, H. H. & Paddle-Ledinek, J. E., 1998, In : Experimental Cell Research. p. 263 - 271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
1999

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPIb/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

Cranmer, S. L., Ulsemer, P., Cooke, B. M., Salem, H. H., De La Salle, C., Lanza, F. & Jackson, S. P., 1999, In : The Journal of Biological Chemistry. p. 6097 - 6106 10 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I. S., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 1999, In : The Journal of Biological Chemistry. p. 36241 - 36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : The Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)
2000

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction

Mistry, N., Cranmer, S. L., Yuan, Y., Mangin, P., Dopheide, S. M., Harper, I. S., Giuliano, S., Dunstan, D. E., Lanza, F., Salem, H. H. H. & Jackson, S. P., 2000, In : Blood. p. 3480 - 3489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : The Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. H. & Jackson, S. P., 2000, In : The Journal of Biological Chemistry. p. 41377 - 41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 4, p. 2965 - 2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : The Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin IIb3

Yap, C. L., Anderson, K. E., Hughan, S. C., Dopheide, S. M., Salem, H. H. & Jackson, S. P., 2002, In : Blood. 99, 1, p. 151 - 158 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction between Platelet Glycoprotein Ib and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear

Williamson, D., Pikovski, I., Cranmer, S. L., Mangin, P., Mistry, N., Domagala, T., Chehab, S., Lanza, F., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 3, p. 2151 - 2159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 17, p. 14738 - 14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA sustains integrin αIIbβ3 adhesion contacts under high shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 26 Apr 2002, In : The Journal of Biological Chemistry. 277, 17, p. 14738-14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
63 Citations (Scopus)
2004

SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 2004, In : The Journal of Biological Chemistry. 279, 31, p. 32196 - 32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review