Hatem Salem

Emeritus Prof

1986 …2014
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Research Output 1986 2014

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1986
20 Citations (Scopus)

Control of thrombin mediated cleavage of protein S

Mitchell, C. A., Hau, L. & Salem, H. H., 1986, In : Thrombosis and Haemostasis. 56, 2, p. 151-154 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1987
44 Citations (Scopus)

A fatal thrombotic disorder associated with an acquired inhibitor of protein C

Mitchell, C. A., Rowell, J. A., Hau, L., Young, J. P. & Salem, H. H., 1987, In : New England Journal of Medicine. 317, 26, p. 1638-1642 5 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Cleavage of protein S by a platelet membrane protease

Mitchell, C. A. & Salem, H. H., 1987, In : Journal of Clinical Investigation. 79, 2, p. 374-379 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1988
13 Citations (Scopus)

Inhibition of the anticoagulant activity of protein S by prothrombin

Mitchell, C. A., Jane, S. M. & Salem, H. H., 1988, In : Journal of Clinical Investigation. 82, 6, p. 2142-2147 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Malignant systemic mastocytosis

JANE, S. M., SUTHERLAND, R. & SALEM, H. H., 1 Jan 1988, In : Australian and New Zealand Journal of Medicine. 18, 4, p. 610-612 3 p.

Research output: Contribution to journalArticleOtherpeer-review

22 Citations (Scopus)

The anticoagulant properties of a modified form of protein S

Mitchell, C. A., Kelemen, S. M. & Salem, H. H., 1988, In : Thrombosis and Haemostasis. 60, 2, p. 298-304 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

TREATMENT OF RESISTANT WALDENSTROM'S MACROGLOBULINEMIA WITH HIGH DOSE GLUCOCORTICOSTEROIDS

JANE, S. M. & SALEM, H. H., 1 Jan 1988, In : Internal Medicine Journal. 18, 1, p. 77-78 2 p.

Research output: Contribution to journalArticleOtherpeer-review

1989
10 Citations (Scopus)

Arterial thrombosis associated with immune thrombocytopenia: Presence of a platelet aggregating IgG synergistic with thrombin and adrenalin

Jackson, S. P., Jane, S. M., Mitchell, C. A., Cortizo, W. F., Hau, L., Pfueller, S. L. & Salem, H. H., 1989, In : Thrombosis and Haemostasis. 62, 3, p. 846-849 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Inhibition of activated protein C by platelets

Jane, S. M., Mitchell, C. A., Hau, L. & Salem, H. H., 1989, In : Journal of Clinical Investigation. 83, 1, p. 222-226 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Thrombomodulin: A major regulator of blood coagulation

Jane, S. & Salem, H., 1 Dec 1989, In : Today's Life Science. 1, 2, p. 40-43 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1991
1 Citation (Scopus)

Extracts from malignant tissue reduce thrombomodulin expression on cultured human endothelial cells

Jane, S. M., Hau, L. & Salem, H. H., 1 Jan 1991, In : Hematology Reviews and Communications. 5, 2, p. 85-95 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Regulation of activated protein C by factor Xa.

Jane, S. M., Hau, L. & Salem, H. H., 1 Dec 1991, In : Blood Coagulation and Fibrinolysis. 2, 6, p. 723-729 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
10 Citations (Scopus)

Haematological profile of healthy elderly Australians

Salem, H. H., Campion, K., McNeil, J. J., Robert, J., Donnan, G. A., Tonkin, A. M. & Worsam, B., 1 Jan 1992, In : Medical Journal of Australia. 157, 2, p. 96-100 5 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Nucleolar and cytoplasmic localization of annexin V

Sun, J., Salem, H. H. & Bird, P., 21 Dec 1992, In : FEBS Letters. 314, 3, p. 425-429 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein S negates the activated protein C inhibitory activity of plasma

Jane, S. M., Hau, L. & Salem, H. H., 1 Jan 1992, In : Blood Coagulation and Fibrinolysis. 3, 3, p. 257-261 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1993
16 Citations (Scopus)

Association of annexin V with mitochondria

Sun, J., Bird, C. H., Salem, H. H. & Bird, P., 23 Aug 1993, In : FEBS Letters. 329, 1-2, p. 79-83 5 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Cloning and molecular characterization of a human intracellular serine proteinase inhibitor

Coughlin, P., Sun, J., Cerruti, L., Salem, H. H. & Bird, P., 3 Nov 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9417-9421 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Effects of annexin V on the activity of the anticoagulant proteins C and S

Sun, J., Bird, P. & Salem, H. H., 1 Feb 1993, In : Thrombosis Research. 69, 3, p. 279-287 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Interaction of annexin V and platelets: Effects on platelet function and protein S binding

Sun, J., Bird, P. & Salem, H. H., 1 Feb 1993, In : Thrombosis Research. 69, 3, p. 289-296 8 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

Yuan, Y., Jackson, S. P., Mitchell, C. A. & Salem, H. H., 15 Jun 1993, In : Thrombosis Research. 70, 6, p. 471-481 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
110 Citations (Scopus)

Adhesion receptor activation of phosphatidylinositol 3-Kinase: Von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

Jackson, S. P., Schoenwaelder, S. M., Yuan, Y., Rabinowitz, I., Salem, H. H. & Mitchell, C. A., 28 Oct 1994, In : Journal of Biological Chemistry. 269, 43, p. 27093-27099 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
3 Citations (Scopus)

Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

Jackson, D. E., Mitchell, C. A. & Salem, H. H., 1994, In : Thrombosis and Haemostasis. 72, 1, p. 70-73 4 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Purification and characterization of two forms of soluble thrombomodulin from human urine

Jackson, D. E., Tetaz, T. J., Salem, H. H. & Mitchell, C. A., 1994, In : European Journal of Biochemistry. 221, 3, p. 1079-1087 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Tyrosine Kinases Regulate the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Polymers

Schoenwaelder, S. M., Jackson, S. P., Yuan, Y., Teasdale, M. S., Salem, H. H. & Mitchell, C. A., 23 Dec 1994, In : Journal of Biological Chemistry. 269, 51, p. 32479-32487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1995
46 Citations (Scopus)

An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase A2

Yuan, Y., Jackson, S. P., Newnham, H. H., Mitchell, C. A. & Salem, H. H., 1995, In : Blood. 86, 11, p. 4166-4174 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization

Coughlin, P., Nicholl, J., Sun, J., Salem, H., Bird, P. & Sutherland, G. R., 1 Jan 1995, In : Genomics. 26, 2, p. 431-433 3 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Immunohistochemical localization of thrombomodulin in normal human skin and skin tumours

Jackson, D. E., Mitchell, C. A., Bird, P., Salem, H. H. & Hayman, J. A., 1995, In : Journal of Pathology. 175, 4, p. 421-432 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

Sun, J., Coughlin, P., Salem, H. H. & Bird, P., 27 Sep 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1252, 1, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
5 Citations (Scopus)

Altered thrombomodulin staining in blistering dermatoses

Jackson, D. E., Mitchell, C. A., Mason, G., Salem, H. H. & Hayman, J. A., 1996, In : Pathology. 28, 3, p. 225-228 4 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

Cooray, P., Yuan, Y., Schoenwaelder, S. M., Mitchell, C. A., Salem, H. H. & Jackson, S. P., 15 Aug 1996, In : Biochemical Journal. 318, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets

Yuan, Y., Dopheide, S. M., Ivanidis, C., Salem, H. H. & Jackson, S. P., 1997, In : Journal of Biological Chemistry. p. 21847 - 21854 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets

Schoenwaelder, S. M., Kulkarni, S., Salem, H. H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T. C. & Jackson, S. P., 1997, In : Journal of Biological Chemistry. p. 24876 - 24884 9 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Natural anticoagulants and the liver

Castelino, D. J. & Salem, H. H., 1997, In : Journal of Gastroenterology and Hepatology. p. 77 - 83 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
20 Citations (Scopus)

Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation

Bird, P. I., Cerruti, L., Scott, F. L., Coughlin, P. B., Salem, H. H. & Paddle-Ledinek, J. E., 1998, In : Experimental Cell Research. p. 263 - 271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
69 Citations (Scopus)

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPIb/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

Cranmer, S. L., Ulsemer, P., Cooke, B. M., Salem, H. H., De La Salle, C., Lanza, F. & Jackson, S. P., 1999, In : Journal of Biological Chemistry. p. 6097 - 6106 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I. S., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 1999, In : Journal of Biological Chemistry. p. 36241 - 36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
47 Citations (Scopus)

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction

Mistry, N., Cranmer, S. L., Yuan, Y., Mangin, P., Dopheide, S. M., Harper, I. S., Giuliano, S., Dunstan, D. E., Lanza, F., Salem, H. H. H. & Jackson, S. P., 2000, In : Blood. p. 3480 - 3489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. H. & Jackson, S. P., 2000, In : Journal of Biological Chemistry. p. 41377 - 41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965 - 2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin IIb3

Yap, C. L., Anderson, K. E., Hughan, S. C., Dopheide, S. M., Salem, H. H. & Jackson, S. P., 2002, In : Blood. 99, 1, p. 151 - 158 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction between Platelet Glycoprotein Ib and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear

Williamson, D., Pikovski, I., Cranmer, S. L., Mangin, P., Mistry, N., Domagala, T., Chehab, S., Lanza, F., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 3, p. 2151 - 2159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 17, p. 14738 - 14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

RhoA sustains integrin αIIbβ3 adhesion contacts under high shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 26 Apr 2002, In : Journal of Biological Chemistry. 277, 17, p. 14738-14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2004

SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 2004, In : Journal of Biological Chemistry. 279, 31, p. 32196 - 32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

SHIP1 and Lyn kinase negatively regulate integrin α IIbβ3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 30 Jul 2004, In : Journal of Biological Chemistry. 279, 31, p. 32196-32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access