Hatem Salem

Emeritus Prof

1981 …2014

Research output per year

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Research Output

2014

Low-molecular-weight heparin biosimilars: Potential implications for clinical practice

Nandurkar, H. H., Chong, B. H., Salem, H. H., Gallus, A., Ferro, V. & McKinnon, R. A., 2014, In : Internal Medicine Journal. 44, 5, p. 497 - 500 4 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)
2013

High-dose cytarabine (24g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia

Low, M., Lee, D., Coutsouvelis, J., Patil, S., Opat, S., Walker, P. A., Schwarer, A., Salem, H. H., Avery, S., Spencer, A. & Wei, A., 2013, In : Internal Medicine Journal. 43, 3, p. 294 - 297 4 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S. M., Ashworth, K. J., Westein, E., Hosseini, E., Salem, H. H., Slattery, R. M., McColl, S. R., Hickey, M. J., Ruggeri, Z. M., Yuan, Y-P. & Jackson, S., 2013, In : Blood. 121, 22, p. 4555 - 4566 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)
2011
29 Citations (Scopus)

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., Andrews, R. K., Mason, K. D., Salem, H. H., Huang, D. C. S., Kile, B. T., Roberts, A. W. & Jackson, S. P., 2011, In : Blood. 118, 6, p. 1663-1674 12 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Prothrombin complex concentrates used alone in urgent reversal of warfarin anticoagulation

Tran, H., Collecutt, M., Whitehead, S. & Salem, H. H., 2011, In : Internal Medicine Journal. 41, 4, p. 337 - 343 7 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2010

Acquired factor v inhibitor

Teh, P. P. G., Grigoriadis, G. & Salem, H. H., Sep 2010, In : Internal Medicine Journal. 40, 9, p. 667-668 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Clinical Scientific notes

Teh, T-C., Grigoriadis, G. & Salem, H., 2010, In : Internal Medicine Journal. 40, p. 667 - 670 4 p.

Research output: Contribution to journalLetterOther

The thienopyridine class of antiplatelet drugs

Kaplan, Z., Al-Daher, S. & Salem, H. H., Aug 2010, In : Medicine Today. 11, 8, p. 65-70 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2009

Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular Injury

Woollard, K. J., Sturgeon, S. A., Chin-Dusting, J. PF., Salem, H. H. & Jackson, S., 2009, In : The Journal of Biological Chemistry. 284, 19, p. 13110 - 13118 9 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Yuan, Y-P., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., O'Reilly, L. A., Henley, K. J., Ono, A., Hsiao, S. T-F., Willcox, A. E. H., Roberts, A. W., Huang, D. C. S., Salem, H. H., Kile, B. & Jackson, S., 2009, In : Blood. 114, 3, p. 663 - 666 4 p.

Research output: Contribution to journalArticleResearchpeer-review

193 Citations (Scopus)
2007

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin aIIb?3 adhesive function in platelets

Schoenwaelder, S. M., Ono, A., Sturgeon, S. A., Chan, S. M., Mangin, P., Maxwell, M. J., Turnbull, S., Mulchandani, M., Anderson, K. E., Kauffenstein, G., Rewcastle, G. W., Kendall, J., Gachet, C., Salem, H. H. & Jackson, S., 2007, In : The Journal of Biological Chemistry. 282, 39, p. 28648 - 28658 11 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)
2006

The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.

Nesbitt, W. S., Mangin, P., Salem, H. H. & Jackson, S., 2006, In : Journal of Molecular Medicine. 84, 12, p. 989 - 995 7 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2005

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha

Cranmer, S. L., Pikovski, I., Mangin, P. H., Thompson, P. E., Domagala, T., Frazzetto, M., Salem, H. H. & Jackson, S. P., 2005, In : Biochemical Journal. 387, 3, p. 849 - 858 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

PI 3-kinase p110beta: A new target for antithrombotic therapy

Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L-S., Wright, C. E., Kenche, V. B., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C. & 6 others, Lu, L., Giuliano, S., Hughan, S. C., Angus, J. A., Robertson, A. D. & Salem, H. H., 2005, In : Nature Medicine. 11, 5, p. 507 - 514 8 p.

Research output: Contribution to journalArticleResearchpeer-review

465 Citations (Scopus)

Warfarin reversal: Consensus guidelines, on behalf of the Australasian society of thrombosis and haemostasis (multiple letters) [3]

Blacker, D. J., Dear, A. E., Gray, F., Byron, K., Lubicz, S., Kamien, M. & Salem, H. H., 4 Apr 2005, In : The Medical Journal of Australia. 182, 7, p. 365-368 4 p.

Research output: Contribution to journalLetterResearchpeer-review

4 Citations (Scopus)
2004

SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 2004, In : The Journal of Biological Chemistry. 279, 31, p. 32196 - 32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

SHIP1 and Lyn kinase negatively regulate integrin α IIbβ3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 30 Jul 2004, In : The Journal of Biological Chemistry. 279, 31, p. 32196-32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
67 Citations (Scopus)

Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis

Baker, R. I., Coughlin, P. B., Gallus, A. S., Harper, P. L., Salem, H. H. & Wood, E. M., 2004, In : The Medical Journal of Australia. 181, 9, p. 492 - 497 6 p.

Research output: Contribution to journalArticleResearchpeer-review

271 Citations (Scopus)
2002

Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 4, p. 2965 - 2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : The Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin IIb3

Yap, C. L., Anderson, K. E., Hughan, S. C., Dopheide, S. M., Salem, H. H. & Jackson, S. P., 2002, In : Blood. 99, 1, p. 151 - 158 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction between Platelet Glycoprotein Ib and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear

Williamson, D., Pikovski, I., Cranmer, S. L., Mangin, P., Mistry, N., Domagala, T., Chehab, S., Lanza, F., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 3, p. 2151 - 2159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 17, p. 14738 - 14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

RhoA sustains integrin αIIbβ3 adhesion contacts under high shear

Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. & Jackson, S. P., 26 Apr 2002, In : The Journal of Biological Chemistry. 277, 17, p. 14738-14746 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
63 Citations (Scopus)
2000

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction

Mistry, N., Cranmer, S. L., Yuan, Y., Mangin, P., Dopheide, S. M., Harper, I. S., Giuliano, S., Dunstan, D. E., Lanza, F., Salem, H. H. H. & Jackson, S. P., 2000, In : Blood. p. 3480 - 3489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : The Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. H. & Jackson, S. P., 2000, In : The Journal of Biological Chemistry. p. 41377 - 41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPIb/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

Cranmer, S. L., Ulsemer, P., Cooke, B. M., Salem, H. H., De La Salle, C., Lanza, F. & Jackson, S. P., 1999, In : The Journal of Biological Chemistry. p. 6097 - 6106 10 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I. S., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 1999, In : The Journal of Biological Chemistry. p. 36241 - 36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : The Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)
1998

Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation

Bird, P. I., Cerruti, L., Scott, F. L., Coughlin, P. B., Salem, H. H. & Paddle-Ledinek, J. E., 1998, In : Experimental Cell Research. p. 263 - 271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
1997

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets

Yuan, Y., Dopheide, S. M., Ivanidis, C., Salem, H. H. & Jackson, S. P., 1997, In : The Journal of Biological Chemistry. p. 21847 - 21854 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets

Schoenwaelder, S. M., Kulkarni, S., Salem, H. H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T. C. & Jackson, S. P., 1997, In : The Journal of Biological Chemistry. p. 24876 - 24884 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Natural anticoagulants and the liver

Castelino, D. J. & Salem, H. H., 1997, In : Journal of Gastroenterology and Hepatology. p. 77 - 83 7 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
1996

Altered thrombomodulin staining in blistering dermatoses

Jackson, D. E., Mitchell, C. A., Mason, G., Salem, H. H. & Hayman, J. A., 1996, In : Pathology. 28, 3, p. 225-228 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Bleeding Disorders

Mitchell, C. A., Dear, A. & Salem, H., 1996, MIMs Disease Index. 2nd ed. p. 69-71 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

Cooray, P., Yuan, Y., Schoenwaelder, S. M., Mitchell, C. A., Salem, H. H. & Jackson, S. P., 15 Aug 1996, In : Biochemical Journal. 318, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)
1995

An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase A2

Yuan, Y., Jackson, S. P., Newnham, H. H., Mitchell, C. A. & Salem, H. H., 1995, In : Blood. 86, 11, p. 4166-4174 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization

Coughlin, P., Nicholl, J., Sun, J., Salem, H., Bird, P. & Sutherland, G. R., 1 Jan 1995, In : Genomics. 26, 2, p. 431-433 3 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Immunohistochemical localization of thrombomodulin in normal human skin and skin tumours

Jackson, D. E., Mitchell, C. A., Bird, P., Salem, H. H. & Hayman, J. A., 1995, In : Journal of Pathology. 175, 4, p. 421-432 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

Sun, J., Coughlin, P., Salem, H. H. & Bird, P., 27 Sep 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1252, 1, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Pulmonary chronic lymphocytic leukemia: Difficulty in establishing a tissue diagnosis

Dear, A., Goldstein, D. & Salem, H. H., 1995, In : European Journal of Haematology. 54, 2, p. 130-133 4 p.

Research output: Contribution to journalLetterOtherpeer-review

3 Citations (Scopus)
1994

Adhesion receptor activation of phosphatidylinositol 3-Kinase: Von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

Jackson, S. P., Schoenwaelder, S. M., Yuan, Y., Rabinowitz, I., Salem, H. H. & Mitchell, C. A., 28 Oct 1994, In : The Journal of Biological Chemistry. 269, 43, p. 27093-27099 7 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)
2 Citations (Scopus)

Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

Jackson, D. E., Mitchell, C. A. & Salem, H. H., 1994, In : Thrombosis and Haemostasis. 72, 1, p. 70-73 4 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Purification and characterization of two forms of soluble thrombomodulin from human urine

Jackson, D. E., Tetaz, T. J., Salem, H. H. & Mitchell, C. A., 1994, In : European Journal of Biochemistry. 221, 3, p. 1079-1087 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Tyrosine Kinases Regulate the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Polymers

Schoenwaelder, S. M., Jackson, S. P., Yuan, Y., Teasdale, M. S., Salem, H. H. & Mitchell, C. A., 23 Dec 1994, In : The Journal of Biological Chemistry. 269, 51, p. 32479-32487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
1993

Association of annexin V with mitochondria

Sun, J., Bird, C. H., Salem, H. H. & Bird, P., 23 Aug 1993, In : FEBS Letters. 329, 1-2, p. 79-83 5 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)