20062020

Research output per year

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Personal profile

Research interests

Our lab uses cryogenic electron microscopy (cryo-EM) to elucidate the structure and dynamics of large macromolecules involved in processes of fundamental biological and medical importance. In addition, we develop new computational methods for solving the most challenging problems in cryo-EM image processing and integrative structural biology. Biological topics include cancer biology, transcription regulation and mRNA export. Cryo-EM images are acquired at the newly established Clive and Vera Ramaciotti Centre for Structural Cryo-EM, housing the world-class FEI Titan KRIOS instrument.

Biography

Hans Elmlund carried out his doctoral work at the Royal Institute of Technology, Sweden, using a 300,000-volt helium-cooled electron microscope (EM) to image molecules that operate as biological “machines” inside the cell. He was not satisfied with available software technology and started to write his own specialized computer code to transform EM data into three-dimensional images of the macromolecules he was studying. As a postdoctoral fellow in Roger Kornberg’s lab at Stanford University, his theoretical work grew into a complete program package for single-particle image processing—SIMPLE (Single-particle Image Processing Linux Engine). Today, A/Prof Elmlund is a group leader at the Biomedicine Discovery Institute, Monash University. His team develops computational methods for cryo-EM single-particle analysis and applies cryo-EM techniques to study the structure and dynamics of large macromolecular assemblies involved in transcription regulation.

Research area keywords

  • transcription
  • cryo-tem

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Projects

Research Output

Critical differences in 3D atomic structure of individual ligand-protected nanocrystals in solution

Kim, B. H., Heo, J., Kim, S., Reboul, C. F., Chun, H., Kang, D., Bae, H., Hyun, H., Lim, J., Lee, H., Han, B., Hyeon, T., Paul Alivisatos, A., Ercius, P., Elmlund, H. & Park, J., 3 Apr 2020, In : Science. 368, 6486, 8 p., aax3233.

Research output: Contribution to journalArticleResearchpeer-review

Point-group symmetry detection in three-dimensional charge density of biomolecules

Reboul, C. F., Kiesewetter, S., Elmlund, D. & Elmlund, H., 1 Apr 2020, In : Bioinformatics. 36, 7, p. 2237-2243 7 p.

Research output: Contribution to journalArticleResearchpeer-review

AgarFix: Simple and accessible stabilization of challenging single-particle cryo-EM specimens through crosslinking in a matrix of agar

Adamus, K., Le, S. N., Elmlund, H., Boudes, M. & Elmlund, D., 1 Sep 2019, In : Journal of Structural Biology. 207, 3, p. 327-331 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The TAFs of TFIID bind and rearrange the topology of the TATA-less RPS5 promoter

Le, S. N., Brown, C. R., Harvey, S., Boeger, H., Elmlund, H. & Elmlund, D., 4 Jul 2019, In : International Journal of Molecular Sciences. 20, 13, 12 p., 3290.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Rapid near-atomic resolution single-particle 3D reconstruction with SIMPLE

Reboul, C. F., Kiesewetter, S., Eager, M., Belousoff, M., Cui, T., De Sterck, H., Elmlund, D. & Elmlund, H., Nov 2018, In : Journal of Structural Biology. 204, 2, p. 172-181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)