Gwo-Yaw Ho

Dr

20122019
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Personal profile

Biography

Dr Gwo Yaw Ho is a medical oncologist and a clinician-scientist investigating better ways to treat ovarian cancer. Dr Ho graduated from The University of Glasgow, Scotland, in 2004, before completing his medical oncology specialist training in Brisbane, Queensland, in 2014. He has completed laboratory-based, translational PhD at Walter and Eliza Hall Institute of Medical Research, Melbourne in ovarian and rare cancer research whilst undertaking a role of a medical oncologist at Peter McCallum Cancer Centre and Royal Women’s Hospital, Melbourne. Dr Ho is now a part of the medical oncology team at Monash Health treating patients with breast cancer.

Research interests

MYCN is an early embryonic developmental gene that is completely silenced following completion of embryogenesis, except in the context of malignancy or in spermatogonial stem cell population. It plays an important role in regulating cell growth and division (proliferation), self-destruction of cells (apoptosis), cell stemness and differentiation (cell fate), and cell migration. Twenty percent of high grade serous ovarian cancer (HGSOC) is associated with MYCN oncogene pathway activation, which is linked to stem cell like behaviour and confers a poor prognosis.

Dr Ho’s research focuses on understanding the role of the MYCN pathway in HGSOC tumorigenesis and developing robust pre-clinical models to explore novel therapeutics for this subset of HGSOC. His studies have demonstrated that activation of the MYCN pathway in the fallopian tube secretory epithelial cells can drive ovarian cancer development and he utilises this model to generate pre-clinical data to support clinical trial designs. Dr Ho has also demonstrated that human cancer tissue with MYCN pathway activation can be successfully grown in the laboratory and be used to study the effect of novel therapies targeting this pathway together with their mechanisms of activity and resistance.

Education/Academic qualification

Cancer Research, PhD, The Walter and Eliza Hall Institute of Medical Research (WEHI)

Medicine, MBChB, University of Glasgow

Molecular and Cellular Biology, BSc (Hon) , University of Glasgow

Research area keywords

  • Cancer
  • Cancer Biology
  • Biomarkers

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Research Output 2012 2019

Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study

Kondrashova, O., Ho, G-Y., Au-Yeung, G. H., Leas, L., Boughtwood, T., Alsop, K., Zapparoli, G. V., Dobrovic, A., Ko, Y-N., Hsu, A., Love, C. J., Lunke, S., Wakefield, M. J., McNally, O. M., Quinn, M., Ananda, S. S., Neesham, D., Hamilton, A., Grossi, M., Freimund, A. & 10 others, Kanjanapan, Y., Rischin, D., Traficante, N., Bowtell, D. D. L., Scott, C. L., Christie, M., Taylor, G. R., Mileshkin, L., Waring, P. M. & On behalf of the Australian Ovarian Cancer Study Group, 20 Jun 2019, In : JCO Precision Oncology. 3, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The molecular origin and taxonomy of mucinous ovarian carcinoma

Cheasley, D., Wakefield, M. J., Ryland, G. L., Allan, P. E., Alsop, K., Amarasinghe, K. C., Ananda, S., Anglesio, M. S., Au-Yeung, G., Böhm, M., Bowtell, D. D. L., Brand, A., Chenevix-Trench, G., Christie, M., Chiew, Y. E., Churchman, M., DeFazio, A., Demeo, R., Dudley, R., Fairweather, N. & 44 others, Fedele, C. G., Fereday, S., Fox, S. B., Gilks, C. B., Gourley, C., Hacker, N. F., Hadley, A. M., Hendley, J., Ho, G. Y., Hughes, S., Hunstman, D. G., Hunter, S. M., Jobling, T. W., Kalli, K. R., Kaufmann, S. H., Kennedy, C. J., Köbel, M., Le Page, C., Li, J., Lupat, R., McNally, O. M., McAlpine, J. N., Mes-Masson, A. M., Mileshkin, L., Provencher, D. M., Pyman, J., Rahimi, K., Rowley, S. M., Salazar, C., Samimi, G., Saunders, H., Semple, T., Sharma, R., Sharpe, A. J., Stephens, A. N., Thio, N., Torres, M. C., Traficante, N., Xing, Z., Zethoven, M., Antill, Y. C., Scott, C. L., Campbell, I. G. & Gorringe, K. L., 1 Dec 2019, In : Nature Communications. 10, 1, 11 p., 3935.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Kondrashova, O., Topp, M., Nesic, K., Lieschke, E., Ho, G. Y., Harrell, M. I., Zapparoli, G. V., Hadley, A., Holian, R., Boehm, E., Heong, V., Sanij, E., Pearson, R. B., Krais, J. J., Johnson, N., McNally, O., Ananda, S., Alsop, K., Hutt, K. J., Kaufmann, S. H. & 11 others, Lin, K. K., Harding, T. C., Traficante, N., Australian Ovarian Cancer Study (AOCS), deFazio, A., McNeish, I. A., Bowtell, D. D., Swisher, E. M., Dobrovic, A., Wakefield, M. J. & Scott, C. L., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 3970.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

SRA737, a novel Chk1 inhibitor, shows efficacy in CCNE1-amplified and MYCN-overexpressing high-grade serous ovarian cancer patient-derived xenograft models

Ho, G-Y., Barker, H. E., Vandenberg, C. J., Kondrashova, O., Lieschke, E., McNally, O. M., Hamilton, A., Heong, V., Hansen, R., Strousse, B., Milutinovic, S., Hedrick, M., Hassig, C., Bowtell, D. D. L., Wakefield, M. J. & Scott, C. L., Nov 2018, In : European Journal of Cancer. 103, S1, p. e98 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Targeting MYCN over-expression with BRD4 inhibition in the proliferative C5 subtype of high grade serous ovarian cancer (HGSOC)

Ho, G-Y., Kondrashova, O., Vandenberg, C. J., Kyran, E., Lieschke, E., Heong, V., Milevinskiy, M., Papenfuss, T. A., Weroha, J., Dawson, M., Bowtell, D. D. L., Barker, H. E., Wakefield, M. J. & Scott, C. L., Nov 2018.

Research output: Contribution to conferencePosterOtherpeer-review

Activities 2016 2018

  • 3 Contribution to conference

Combine Scientific Meeting of the Australia-New-Zealand-Gynaecology-Oncology-Group

Gwo-Yaw Ho (Speaker)
Apr 2018

Activity: Participating in or organising an event typesContribution to conference

Combine Scientific Meeting of the Australia-New-Zealand-Gynaecology-Oncology-Group

Gwo-Yaw Ho (Speaker)
Apr 2016

Activity: Participating in or organising an event typesContribution to conference

Royal Women Hospital Research week

Gwo-Yaw Ho (Speaker)
Nov 2016

Activity: Participating in or organising an event typesContribution to conference