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Research Output 1990 2019

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2019

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin

Tseng, E., Yee Teoh, S. S., Wang, Y. & Nie, G., 15 Jan 2019, In : Placenta. 76, 15, p. 51-53 3 p.

Research output: Contribution to journalArticleResearchpeer-review

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR

Wang, Y., La, M., Pham, T., Lovrecz, G. O. & Nie, G., 1 Apr 2019, In : FASEB Journal. 33, 4, p. 5058-5066 9 p.

Research output: Contribution to journalArticleResearchpeer-review

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

Teoh, S. S. Y., Wang, Y., Li, Y., Leemaqz, S. Y. L., Dekker, G. A., Roberts, C. T. & Nie, G., 3 Apr 2019, (Accepted/In press) In : Fetal Diagnosis and Therapy. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum podocalyxin at 11–13 weeks of gestation in the prediction of small for gestational age neonates

Rolnik, D. L., Wang, Y., Hyett, J., Silva Costa, F. D. & Nie, G., 1 Jun 2019, In : Journal of Perinatology. 39, 6, p. 784-790 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

HtrA3 Isoform-Specific ELISAs for Early Detection of Preeclampsia

Wang, Y., Li, Y., Hyett, J., Da Silva Costa, F. & Nie, G., 1 Dec 2018, In : SLAS Discovery. 23, 10, p. 1092-1099 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer

Lv, Q., Yang, B., Ning, C., Xie, B., Nie, G., Chen, X. & Chen, Q., 18 Sep 2018, In : Biochemical and Biophysical Research Communications. 503, 4, p. 2918-2923 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum podocalyxin for early detection of preeclampsia at 11–13 weeks of gestation

Mansilla, M. K. S., Wang, Y., Hyett, J., da Silva Costa, F. & Nie, G., 1 Nov 2018, In : Placenta. 71, p. 13-15 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood

Li, Y., Salamonsen, L. A., Hyett, J., Da Silva Costa, F. & Nie, G-Y., 4 Jul 2017, In : Scientific Reports. 7, 1, 4627.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Multiple soluble TGF-β receptors in addition to soluble endoglin are elevated in preeclamptic serum and they synergistically inhibit TGF-β signaling

Wang, Y., Chen, Q., Zhao, M., Walton, K., Harrison, C. & Nie, G., 1 Aug 2017, In : Journal of Clinical Endocrinology and Metablism. 102, 8, p. 3065-3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum podocalyxin is significantly increased in early-onset preeclampsia and may represent a novel marker of maternal endothelial cell dysfunction

Chen, Q., Wang, Y., Li, Y., Zhao, M. & Nie, G., Nov 2017, In : Journal of Hypertension. 35, 11, p. 2287-2294 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The significance of post-translational removal of α-DG-N in early stage endometrial cancer development

Heng, S., Evans, J., Salamonsen, L. A., Jobling, T. W. & Nie, G., 1 Jan 2017, In : Oncotarget. 8, 47, p. 81942-81952 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

A high-throughput assay for the detection of α-dystroglycan N-Terminus in human uterine fluid to determine uterine receptivity

Heng, S., Vollenhoven, B., Rombauts, L. J. & Nie, G., Apr 2016, In : Journal of Biomolecular Screening. 21, 4, p. 408 - 413 6 p.

Research output: Contribution to journalArticleResearchpeer-review

High levels of HtrA4 observed in preeclamptic circulation drastically alter endothelial gene expression and induce inflammation in human umbilical vein endothelial cells

Wang, Y. & Nie, G., 1 Nov 2016, In : Placenta. 47, p. 46-55 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Measuring PC activity in endocervical swab may provide a simple and non-invasive method to detect endometrial cancer in post-menopausal women

Heng, S., Stephens, A. N., Jobling, T. W. & Nie, G., 25 Jun 2016, In : Oncotarget. 7, 29, p. 46573-46578 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases

Chen, Q., Wang, Y., Zhao, M., Hyett, J., da Silva Costa, F. & Nie, G., 1 Jul 2016, In : Cytokine. 83, p. 226-230 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Total PC activity is increased in uterine lavage of post-menopausal endometrial but not ovarian cancer patients

Heng, S., Stephens, A. N., Jobling, T. & Nie, G-Y., 2016, In : Journal of Cancer. 7, 13, p. 1812 - 1814 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2015

Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity

Heng, S., Dynon, K., Li, Y., Edgell, T. A., Walton, K., Rombauts, L., Vollenhoven, B. J. & Nie, G., 15 Apr 2015, In : Analytical Biochemistry. 475, p. 14 - 21 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endometrial CRISP3 is regulated throughout the mouse estrous and human menstrual cycle and facilitates adhesion and proliferation of endometrial epithelial cells

Evans, J., D'Sylva, R. J., Volpert, M., Jamsai, D., Merriner, D. J., Nie, G., Salamonsen, L. A. & O'Bryan, M. K., 2015, In : Biology of Reproduction. 92, 4 (Art. No: 99), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Human HtrA4 expression is restricted to the placenta, is significantly up-regulated in early-onset preeclampsia, and high levels of HtrA4 cause endothelial dysfunction

Singh, H., Zhao, M., Chen, Q., Wang, Y., Li, Y., Kaitu'u-Lino, T. J., Tong, S. & Nie, G., 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 7, p. E936 - E945 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation

Paule, S. G., Nebl, T., Webb, A., Vollenhoven, B. J., Rombauts, L. & Nie, G., 2015, In : Molecular Human Reproduction. 21, 3, p. 262 - 270 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia

Teoh, S. Y. S., Zhao, M., Wang, Y., Chen, Q. & Nie, G., 2015, In : Placenta. 36, 9, p. 990 - 995 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities

Singh, H., Nero, T. L., Wang, Y., Parker, M. W. & Nie, G., 2014, In : PLoS ONE. 9, 9 (Art. ID: e108235), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

HTRA3 is reduced in ovarian cancers regardless of stage

Zhao, M., Ding, J-X., Nie, G., Wei, J., Li, Y., Yin, X. Y. & Chen, Q., 2014, In : Cancer Investigation. 32, 9, p. 464 - 469 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of embryo implantation in mice through vaginal administration of a proprotein convertase 6 inhibitor

Ho, H., Li, Y. & Nie, G., 2014, In : Reproductive biology. 14, 2, p. 155 - 159 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Htra3 is downregulated in cancer cell lines and significantly reduced in primary serous and granulosa cell ovarian tumors

Singh, H., Li, Y., Fuller, P. J., Harrison, C., Rao, J., Stephens, A. N. & Nie, G-Y., 2013, In : Journal of Cancer. 4, 2, p. 152-164 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer

Yin, Y., Wu, M., Nie, G., Wang, K., Wei, J., Zhao, M. & Chen, Q., 2013, In : Tumor Biology. 34, 6, p. 3611 - 3617 7 p.

Research output: Contribution to journalArticleResearchpeer-review

IFPA Meeting 2012 Workshop Report III: Trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis

Al-Khan, A., Bulmer, J. N., Chantraine, F., Chen, C. P., Chen, Q., Collins, S., Cotechini, T., Fitzgerald, J. S., He, M., Holland, O., Hung, T. H., Illsley, N. P., Ino, K., Iwaki, T., Kanayama, N., Kaneki, E., Katabuchi, H., Kobayashi, Y., Kondo, A., Masuzaki, H. & 13 othersMatjila, M., Miura, K., Mori, A., Murthi, P., Nagahashi, K., Nie, G., Ohba, T., Sood, R., Sugimura, M., Takizawa, T., Usui, H., Velicky, P. & Lash, G. E., 2013, In : Placenta. 34, SUPPL, p. S11 - S16 6 p.

Research output: Contribution to journalArticleOtherpeer-review

Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery

Salamonsen, L. A., Edgell, T., Rombauts, L., Stephens, A. N., Robertson, D., Rainczuk, A., Nie, G. & Hannan, N. J., 2013, In : Fertility and Sterility. 99, 4, p. 1086 - 1092 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation

Ho, H., Singh, H., Heng, S., Nero, T. L., Paule, S., Parker, M. W., Johnson, A. T., Jiao, G-S. & Nie, G., 2013, In : PLoS ONE. 8, 12 (e81380), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

A high-throughput in vitro model of human embryo attachment

Ho, H., Singh, H., Aljofan, M. & Nie, G., 2012, In : Fertility and Sterility. 97, 4, p. 974 - 978 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases

Singh, H., Makino, S., Endo, Y., Li, Y., Stephens, A. N. & Nie, G., Jan 2012, In : BioTechniques. 52, 1, p. 23-28 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cleavage of endometrial α-integrins into their functional forms is mediated by proprotein convertase 5/6

Paule, S. G., Aljofan, M., Simon, C., Rombauts, L. & Nie, G., 2012, In : Human Reproduction. 27, 9, p. 2766 - 2774 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzyme activity assays within microstructured optical fibers enabled by automated alignment

Warren-Smith, S. C., Nie, G., Schartner, E. P., Salamonsen, L. A. & Monro, T. M., 1 Dec 2012, In : Biomedical Optics Express. 3, 12, p. 3304-3313 10 p.

Research output: Contribution to journalArticleResearchpeer-review

HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening

Dynon, K., Heng, S., Puryer, M. A., Li, Y., Walton, K. L., Endo, Y. & Nie, G., 2012, In : PLoS ONE. 7, 9, 14 p., e45956.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Inhibition of proprotein convertase 5/6 activity: potential for nonhormonal women-centered contraception

Aljofan, M., Singh, H., Ho, H., Xie, S., Zhu, Y., Sun, Z., Guo, X., Wang, J. & Nie, G., 2012, In : Contraception. 85, 6, p. 602 - 610 9 p.

Research output: Contribution to journalArticleResearchpeer-review

PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: in vitro bioactivity, stability and in vivo pharmacokinetics

Ho, H., Nero, T. L., Singh, H., Parker, M. W. & Nie, G., 2012, In : Peptides. 38, 2, p. 266 - 274 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis

Singh, H., Heng, S., Nicholls, P., Li, Y., Tai, L. T., Jobling, T., Salamonsen, L. A. & Nie, G., 2012, In : Biochemical and Biophysical Research Communications. 419, 4, p. 809 - 814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Uterine lavage or aspirate: which view of the intrauterine environment?

Hannan, N. J., Nie, G., Rainzcuk, A., Rombauts, L. & Salamonsen, L. A., 2012, In : Reproductive Sciences. 19, 10, p. 1125 - 1132 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Combination of hydrogel nanoparticles and proteomics to reveal secreted proteins associated with decidualization of human uterine stromal cells

Paule, S., Meehan, K., Rainczuk, A., Stephens, A. N. & Nie, G-Y., 1 Sep 2011, In : Proteome Science. 9, 6 p., 50.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys

Paule, S., Li, Y. & Nie, G., Apr 2011, In : Journal of Molecular Histology. 42, 2, p. 161-166 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Decidual HtrA3 negatively regulates trophoblast invasion during human placentation

Singh, H., Endo, Y. & Nie, G., Apr 2011, In : Human Reproduction. 26, 4, p. 748-757 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Embryo implantation is closely associated with dynamic expression of proprotein convertase 5/6 in the rabbit uterus

Nicholls, P. K., Sun, Z., Heng, S., Li, Y., Wang, J. & Nie, G., 2011, In : Reproductive Biology and Endocrinology. 9, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility

Heng, S., Hannan, N., Rombauts, L., Salamonsen, L. & Nie, G., 2011, In : Human Reproduction. 26, 4, p. 840 - 846 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia

Li, Y., Puryer, M., Lin, E., Hale, K., Salamonsen, L., Manuelpillai, U., Tong, S., Chan, W., Wallace, E. & Nie, G., 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 2, p. 403 - 411 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Proprotein convertase 5/6 is critical for embryo implantation in women: Regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions

Heng, S., Cervero, A., Simon, C., Stephens, A. N., Li, Y., Zhang, J., Paule, S., Rainczuk, A., Singh, H., Quinonero, A., Tapia, A., Velasquez, L., Salamonsen, L., Rombauts, L. & Nie, G., 2011, In : Endocrinology. 152, 12, p. 5041 - 5052 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

High-temperature requirement factor A3 (Htra3): A novel serine protease and its potential role in ovarian function and ovarian cancers

Bowden, M., Drummond, A., Fuller, P., Salamonsen, L., Findlay, J. & Nie, G., 2010, In : Molecular and Cellular Endocrinology. 327, 1-2, p. 13 - 18 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of HTRA3 stimulates trophoblast invasion during human placental development

Singh, H., Makino, S., Endo, Y. & Nie, G., Dec 2010, In : Placenta. 31, 12, p. 1085-1092 8 p.

Research output: Contribution to journalArticleResearchpeer-review