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Personal profile

Biography

NHMRC Senior Research Fellow

Research Group Head, Implantation and Placental Development Laboratory

Co-Deputy Head, Centre for Reproductive Health

The Hudson Institute of Medical Research

Senior Research Fellow
Adjunct Professor, Department of Biochemistry and Molecular Biology, Monash University

Professor Guiying Nie is an authority on embryo implantation and placental development. Her research focuses on human uterus-embryo interaction for implantation, implantation failure in IVF, placental development and pregnancy complications, particularly preeclampsia. She is also interested in reproductive cancer and non-hormonal contraception.

She obtained her PhD from the University of Essex, UK, and then travelled to the United States where she completed postdoctoral training at the Brookhaven National Laboratory in New York. She subsequently joined Prince Henry’s Institute, now Hudson Institute of Medical Research, and embarked on a rewarding career in reproductive biology. Now a Fellow of the Society of Reproductive Biology, she remains committed to research in female reproductive health.

Prof Nie works closely with specialist clinicians to address key women’s health issues. Her current research program focuses on developing clinical tools that will enable IVF scientists and clinicians to accurately predict when a woman is most likely to achieve successful implantation, and will also enable them to select the best quality embryos for transfer. Her work also focuses on developing new strategies to diagnose and treat pregnancy complications, especially early onset preeclampsia.

Prof Nie’s research has resulted in over 100 peer-reviewed publications, the majority as first or senior author in top discipline-specific or high impact general journals. A sought after speaker, she has presented her work at numerous national and international conferences and is regularly asked to review major national and international grants. She has also served on a number of editorial boards, including a current position on the Editorial Board of Reproductive Sciences. She is an executive member of Australian and New Zealand Placental Research Association (ANZPRA). As well as the National Health and Medical Research Council of Australia, Prof Nie receives funding support from Monash IVF, the CASS Foundation and international funding bodies such as CONRAD/CICCR (USA), ESHRE (Europe), Ferring, and the Bill and Melinda Gates Foundation.

Keywords

  • Uterus
  • Embryo implantation
  • Placental development
  • Infertility
  • IVF
  • Pregnancy diseases
  • Preeclampsia

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Projects 2013 2018

Research Output 1990 2019

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin

Tseng, E., Yee Teoh, S. S., Wang, Y. & Nie, G., 15 Jan 2019, In : Placenta. 76, 15, p. 51-53 3 p.

Research output: Contribution to journalArticleResearchpeer-review

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR

Wang, Y., La, M., Pham, T., Lovrecz, G. O. & Nie, G., 1 Apr 2019, In : FASEB Journal. 33, 4, p. 5058-5066 9 p.

Research output: Contribution to journalArticleResearchpeer-review

HtrA1 alters endothelial tube formation characteristics in an in vitro model

Singh, H. & Nie, G., 2019, (Accepted/In press) 15 p. bioRxiv.

Research output: Other contributionOther

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

Teoh, S. S. Y., Wang, Y., Li, Y., Leemaqz, S. Y. L., Dekker, G. A., Roberts, C. T. & Nie, G., 1 Jan 2019, (Accepted/In press) In : Fetal Diagnosis and Therapy. 10 p.

Research output: Contribution to journalArticleResearchpeer-review