Projects per year
Personal profile
Biography
NHMRC Senior Research Fellow
Research Group Head, Implantation and Placental Development Laboratory
Co-Deputy Head, Centre for Reproductive Health
The Hudson Institute of Medical Research
Senior Research Fellow
Adjunct Professor, Department of Biochemistry and Molecular Biology, Monash University
Professor Guiying Nie is an authority on embryo implantation and placental development. Her research focuses on human uterus-embryo interaction for implantation, implantation failure in IVF, placental development and pregnancy complications, particularly preeclampsia. She is also interested in reproductive cancer and non-hormonal contraception.
She obtained her PhD from the University of Essex, UK, and then travelled to the United States where she completed postdoctoral training at the Brookhaven National Laboratory in New York. She subsequently joined Prince Henry’s Institute, now Hudson Institute of Medical Research, and embarked on a rewarding career in reproductive biology. Now a Fellow of the Society of Reproductive Biology, she remains committed to research in female reproductive health.
Prof Nie works closely with specialist clinicians to address key women’s health issues. Her current research program focuses on developing clinical tools that will enable IVF scientists and clinicians to accurately predict when a woman is most likely to achieve successful implantation, and will also enable them to select the best quality embryos for transfer. Her work also focuses on developing new strategies to diagnose and treat pregnancy complications, especially early onset preeclampsia.
Prof Nie’s research has resulted in over 100 peer-reviewed publications, the majority as first or senior author in top discipline-specific or high impact general journals. A sought after speaker, she has presented her work at numerous national and international conferences and is regularly asked to review major national and international grants. She has also served on a number of editorial boards, including a current position on the Editorial Board of Reproductive Sciences. She is an executive member of Australian and New Zealand Placental Research Association (ANZPRA). As well as the National Health and Medical Research Council of Australia, Prof Nie receives funding support from Monash IVF, the CASS Foundation and international funding bodies such as CONRAD/CICCR (USA), ESHRE (Europe), Ferring, and the Bill and Melinda Gates Foundation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Uterus
- Embryo implantation
- Placental development
- Infertility
- IVF
- Pregnancy diseases
- Preeclampsia
Collaborations and top research areas from the last five years
Projects
- 3 Finished
-
The pathogenic role of a placenta-specific protease in early-onset preeclampsia
1/01/16 → 31/12/18
Project: Research
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Embryo implantation and Placental Development
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/18
Project: Research
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Endometrial receptivity for embryo implantation: Proprotein convertase 6 and plasma membrane remodeling
Nie, G., Paule, S. & Rombauts, L.
1/01/13 → 31/12/15
Project: Research
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A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts
Chen, J., Neil, J. A., Tan, J. P., Rudraraju, R., Mohenska, M., Sun, Y. B. Y., Walters, E., Bediaga, N. G., Sun, G., Zhou, Y., Li, Y., Drew, D., Pymm, P., Tham, W. H., Wang, Y., Rossello, F. J., Nie, G., Liu, X., Subbarao, K. & Polo, J. M., Aug 2023, In: Nature Cell Biology. 25, 8, p. 1223-1234 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in mice
Thach, B., Samarajeewa, N., Li, Y., Heng, S., Tsai, T., Pangestu, M., Catt, S. & Nie, G., Jun 2022, In: Biology of Reproduction. 106, 6, p. 1143-1158 16 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4
Mansilla, M., Wang, Y., Lim, R., Palmer, K. & Nie, G., 13 Jul 2021, In: Scientific Reports. 11, 1, 14 p., 14363.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Podocalyxin inhibits human embryo implantation in vitro and luminal podocalyxin in putative receptive endometrium is associated with implantation failure in fertility treatment
Heng, S., Samarajeewa, N., Aberkane, A., Essahib, W., Van de Velde, H., Scelwyn, M., Hull, M. L., Vollenhoven, B., Rombauts, L. J. & Nie, G., 1 Nov 2021, In: Fertility and Sterility. 116, 5, p. 1391-1401 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile10 Citations (Scopus) -
Podocalyxin is a key negative regulator of human endometrial epithelial receptivity for embryo implantation
Paule, S. G., Heng, S., Samarajeewa, N., Li, Y., Mansilla, M., Webb, A. I., Nebl, T., Young, S. L., Lessey, B. A., Hull, M. L., Scelwyn, M., Lim, R., Vollenhoven, B., Rombauts, L. J. & Nie, G., 20 Apr 2021, In: Human Reproduction. 36, 5, p. 1353-1366 14 p.Research output: Contribution to journal › Article › Research › peer-review
18 Citations (Scopus)