Gregory Moseley

Dr

  • 19 Innovation Walk (Bldg 76), (Bldg 76)

    3800 Monash

20032021
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Personal profile

Biography

Greg Moseley is head of the Viral Pathogenesis Laboratory. After graduating with BSc (Hons) from the University of York, UK, he undertook research toward a PhD at The University of Sheffield in the UK and the Walter & Eliza Hall Institute in Melbourne on the roles of tetraspanin proteins in immunology and infection.Greg was subsequently awarded a fellowship from The Royal Society (UK) which enabled him to undertake postdoctoral research in immunology at the Austin Research Institute (Melbourne). He later moved to the Department of Biochemistry and Molecular Biology at Monash University to pursue research investigating the mechanisms of subcellular protein trafficking. 

At Monash he established an independent research laboratory bringing together his research expertise in virology, protein trafficking and immunology to investigate the molecular mechanisms underlying viral immune evasion and pathogenicity. Greg also undertook fellowship research in CNRS (France) and Gifu University (Japan). In 2013 Greg was awarded the Grimwade Fellowship and relocated his laboratory to the Department of Biochemistry and Molecular Biology at the Bio21 Institute (The University of Melbourne).

In 2017, he was recruited back to Monash to join the Department of Microbiology within the Infection and Immunity theme in the Biomedicine Discovery Institute. His laboratory will build new capacity in the areas of Molecular Virology, Pathogen-Host Interactions, and the Molecular Basis of Infectious Disease. The overarching aim of the research is to define the fundamental processes underlying infection by highly lethal pathogens such as rabies virus, Australian bat lyssavirus, Nipah and Hendra viruses, and Ebola virus, and to use this knowledge to develop new vaccines and therapeutics for currently incurable viral diseases.

 

Research interests

Viruses pose one of the grand challenges to human and animal health globally and within Australia. Viral disease progression is critically dependent on the formation of specific interaction networks between viral proteins and host cell factors, which enable viral subversion of important processes such as antiviral immunity and cell survival.

 

The figure shows high resolution confocal images of viral protein targeting of microtubules and sub-nuclear structures within mammalian cells. These interactions enable viral reprograming of host cell biology, including important processes in innate immunity and stress responses.

 

Research in our laboratory seeks to elucidate these interactions at the molecular level and to understand their functions in diseases caused by highly lethal human viruses, including rhabdoviruses (e.g. rabies virus, Australian bat lyssavirus), paramyxoviruses (e.g. Nipah, Hendra, measles) and filoviruses (e.g. Ebola), as well as a number of agriculturally significant and potentially zoonotic animal viruses.

The overarching aim of the research is to identify novel targets and strategies for the development of new vaccines and therapeutics for currently incurable viral diseases. Our research involves extensive collaborations within Monash University, and with other leading national (e.g. CSIRO-AAHL, The University of Melbourne, The University of Sydney) and international institutes (e.g. The Pasteur Institute and CNRS, Paris; Gifu and Hokkaido Universities, Japan; University of Dundee (UK), enabling access to unique resources and technologies including novel and highly pathogenic viruses.

Research area keywords

  • Virus, Virology, Infectious disease, Pathogenesis, Immune Evasion, Host Manipulation, Virus-Host Interface, Vaccines, Antivirals, Structural Biology, Super-resolution Imaging, Live Cell Imaging, Microscopy, Genomics, Proteomics, Lyssavirus, Henipavirus, Filovirus, Rabies, Nipah, Hendra, Ebola, Zoonoses, Inflammation, Immunity, Innate Immunity, Interferon, Cytokines

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2021

Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis

Moseley, G., Gooley, P. R., Williams, S. J. & Bourhy, H.

1/04/1731/03/21

Project: Research

Viral targeting of STAT proteins: roles in disease

Moseley, G. & Sugiyama, M.

1/04/1730/06/18

Project: Research

Nucleolus targeting by negative strand RNA viruses

Moseley, G., Wang, L. & Lamond, A.

30/03/1731/12/18

Project: Research

Research Output 2003 2019

35 Citations (Scopus)

Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease

Wiltzer, L., Okada, K., Yamaoka, S., Larrous, F., Kuusisto, H. V., Sugiyama, M., Blondel, D., Bourhy, H., Jans, D. A., Ito, N. & Moseley, G. W., 2014, In : Journal of Infectious Diseases. 209, 11, p. 1744 - 1753 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Quantitative analysis of the microtubule interaction of rabies virus P3 protein: Roles in immune evasion and pathogenesis

Brice, A., Whelan, D. R., Ito, N., Shimizu, K., Wiltzer-Bach, L., Lo, C. Y., Blondel, D., Jans, D. A., Bell, T. D. M. & Moseley, G. W., 21 Sep 2016, In : Scientific Reports. 6, 12 p., 33493.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

Identification of a role for nucleolin in rabies virus infection

Oksayan, S., Nikolic, J., David, C. T., Blondel, D., Jans, D. A. & Moseley, G. W., 2015, In : Journal of Virology. 89, 3, p. 1939 - 1943 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
36 Citations (Scopus)

The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling

Lieu, K. G., Brice, A., Wiltzer, L., Hirst, B., Jans, D. A., Blondel, D. & Moseley, G. W., 2013, In : Journal of Virology. 87, 14, p. 8261 - 8265 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus

Wiltzer, L., Larrous, F., Oksayan, S., Ito, N., Marsh, G. A., Blondel, D., Bourhy, H., Jans, D. A. & Moseley, G. W., 2012, In : Journal of Virology. 86, 18, p. 10194 - 10199 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access