Greg Tesch

Adj Assoc Prof

Accepting PhD Students

PhD projects

Therapeutic targeting of kidney tubular cells to inhibit tubulointerstitial fibrosis

1992 …2020

Research output per year

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Research Output

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Article
2020

Novel mineralocorticoid receptor mechanisms regulate cardiac tissue inflammation in male mice

Ong, G. S. Y., Cole, T. J., Tesch, G. H., Morgan, J., Dowling, J. K., Mansell, A., Fuller, P. J. & Young, M. J., 1 Aug 2020, In : Journal of Endocrinology. 246, 2, p. 123-134 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting apoptosis signal-regulating kinase 1 in acute and chronic kidney disease

Tesch, G. H., Ma, F. Y. & Nikolic-Paterson, D. J., 23 Jan 2020, (Accepted/In press) In : Anatomical Record. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2019

Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Pullen, N., Jesson, M. I., Schlerman, F. J. & Nikolic-Paterson, D. J., 1 Dec 2019, In : American Journal of Physiology-Renal Physiology. 317, 6, p. F1439-F1449 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Establishing equivalent diabetes in male and female Nos3-deficient mice results in a comparable onset of diabetic kidney injury

Tian, L., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Sep 2019, In : Physiological Reports. 7, 18, 8 p., e14197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis

Han, Y., Tian, L., Ma, F., Tesch, G., Vesey, D. A., Gobe, G. C., Lohman, R. J., Morais, C., Suen, J. Y., Fairlie, D. P. & Nikolic-Paterson, D. J., 1 May 2019, In : Clinical and Experimental Pharmacology and Physiology. 46, 5, p. 456-464 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin

Ly, N. D. K., Tesch, G. H., Nikolic-Paterson, D. J. & Poronnik, P., Jan 2019, In : Nephrology. 24, 1, p. 121-126 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

Amos, L. A., Ma, F. Y., Tesch, G. H., Liles, J. T., Breckenridge, D. G., Nikolic-Paterson, D. J. & Han, Y., 1 Sep 2018, In : Journal of Cellular and Molecular Medicine. 22, 9, p. 4522-4533 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney

Hou, W., Leong, K. G., Ozols, E., Tesch, G. H., Nikolic-Paterson, D. J. & Ma, F. Y., 1 Mar 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 3, p. 250-260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis

Abraham, A. P., Ma, F. Y., Mulley, W. R., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Feb 2018, In : Nephrology. 23, 2, p. 183-189 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease

Han, Y., Ly, N. D. K., Tesch, G. H., Poronnik, P. & Nikolic-Paterson, D. J., 1 Mar 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 3, p. 241-249 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2017
6 Citations (Scopus)

miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling

Wang, B., Yao, K., Wise, A. F., Lau, R., Shen, H-H., Tesch, G. H. & Ricardo, S. D., 2017, In : Clinical Science. 131, 5, p. 411-423 13 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2016

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A. J., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase

Ryan, J., Ma, F. Y., Han, Y., Ozols, E., Kanellis, J., Tesch, G. H. & Nikolic-Paterson, D. J., 1 Jan 2016, In : Journal of Pathology. 238, 1, p. 10-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2015

ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Ma, F., Han, Y., Liles, J. T., Breckenridge, D. G. & Nikolic-Paterson, D. J., 2015, In : Diabetes. 64, 11, p. 3903 - 3913 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Earlier onset of diabesity-Induced adverse cardiac remodeling in female compared to male mice

Bowden, M. A., Tesch, G. H., Julius, T. L., Rosli, S., Love, J. E. & Ritchie, R. H., 2015, In : Obesity. 23, 6, p. 1166 - 1177 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat

Ramessur, S., Tesch, G. H., Han, Y., Woodman, N., Mulley, W., Kanellis, J., Blease, K., Ma, F. & Nikolic-Paterson, D. J., 2015, In : International Journal of Experimental Pathology. 96, 1, p. 54 - 62 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Suppression of rapidly progressive mouse glomerulonephritis with the non-steroidal mineralocorticoid receptor antagonist BR-4628

Ma, F., Han, Y., Nikolic-Paterson, D. J., Kolkhof, P. & Tesch, G. H., 2015, In : PLoS ONE. 10, 12 (Art. No: e0145666), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)
2014
55 Citations (Scopus)
26 Citations (Scopus)

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Tesch, G. H., Sourris, K., Summers, S. A., McCarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A. R., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. & Forbes, J. M., 2014, In : Diabetologia. 57, 9, p. 1977 - 1985 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease

Huang, L., Nikolic-Paterson, D. J., Han, Y., Ozols, E., Ma, F., Young, M. J. & Tesch, G. H., 2014, In : Journal of the American Society of Nephrology. 25, 10, p. 2231 - 2240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2013

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

Zhang, C., Ibrahim, P. N., Zhang, J., Burton, E. A., Habets, G., Zhang, Y., Powell, B., West, B. L., Matusow, B., Tsang, G., Shellooe, R., Carias, H., Nguyen, H., Marimuthu, A., Zhang, K. Y. J., Oh, A., Bremer, R., Hurt, C. R., Artis, D. R., Wu, G. & 7 others, Nespi, M., Spevak, W., Lin, P., Nolop, K., Hirth, P., Tesch, G. H. & Bollag, G., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5689 - 5694 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis

Han, Y., Ma, F., Tesch, G. H., Manthey, C. L. & Nikolic-Paterson, D. J., 2013, In : American Journal of Physiology-Renal Physiology. 304, 8, p. 1043 - 1053 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2012
29 Citations (Scopus)

Inflammation in diabetic nephropathy

Lim, A. K. H. & Tesch, G. H., 2012, In : Mediators of Inflammation. 2012, Art. ID: 146154, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
240 Citations (Scopus)

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis

Bienvenue, L., Morgan, J., Rickard, A. J., Tesch, G. H., Cranston, G., Fletcher, E. V., Delbridge, L. M. D. & Young, M. J., 2012, In : Endocrinology. 153, 7, p. 3416 - 3425 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2011

c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

Han, Y., Ma, F., Tesch, G., Manthey, C. & Nikolic-Paterson, D., 2011, In : Laboratory Investigation. 91, 7, p. 978 - 991 14 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats

Lim, A., Ma, F., Nikolic-Paterson, D., Ozols, E., Young, M., Bennett, B., Friedman, G. & Tesch, G., 2011, In : American Journal of Nephrology. 34, 4, p. 337 - 346 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy

Tesch, G. & Lim, A., 2011, In : American Journal of Physiology-Renal Physiology. 300, 2, p. F301 - F310 10 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

TGF-beta-1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney

Ma, F., Tesch, G., Ozols, E., Xie, M., Schneider, M. & Nikolic-Paterson, D., 2011, In : American Journal of Physiology-Renal Physiology. 300, 6, p. F1410 - F1421 12 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)
2010

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells

Mariasegaram, M., Tesch, G. H., Verhardt, S. L., Hurst, L. A., Lan, H. & Nikolic-Paterson, D. J., 2010, In : Biochemical and Biophysical Research Communications. 393, 4, p. 855 - 859 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
35 Citations (Scopus)

Macrophages and diabetic nephropathy

Tesch, G., 2010, In : Seminars in Nephrology. 30, 3, p. 290 - 301 12 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Tesch, G., 2010, In : Nephrology. 15, 6, p. 609 - 616 8 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)
2009

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Lim, A. K. H., Ma, F., Nicolic-Paterson, D., Thomas, M., Hurst, L. A. & Tesch, G. H., 2009, In : Diabetologia. 52, 8, p. 1669 - 1679 11 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat

Ma, F., Flanc, R., Tesch, G. H., Bennett, B., Friedman, G. C. & Nicolic-Paterson, D., 2009, In : Laboratory Investigation. 89, 4, p. 470 - 484 15 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure

Rickard, A., Morgan, J., Tesch, G. H., Funder, J. W., Fuller, P. J. & Young, M. J., 2009, In : Hypertension. 54, 3, p. 537 - 543 7 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

Lim, A. K. H., Nikolic-Paterson, D. J., Ma, F., Ozols, E., Thomas, M. C., Flavell, R. A., Davis, R. J. & Tesch, G. H., 2009, In : Diabetologia. 52, 2, p. 347 - 358 12 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)
2008

c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury

Fukuda, K., Tesch, G. H. & Nikolic-Paterson, D. J., 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 710 - 716 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

In vivo visualization of albumin degradation in the proximal tubule

Slattery, C., Lee, A., Zhang, Y., Kelly, D. J., Thorn, P., Nikolic-Paterson, D. J., Tesch, G. H. & Poronnik, P., 2008, In : Kidney International. 74, 11, p. 1480 - 1486 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

MCP-1/CCL2: A new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy

Tesch, G. H., 2008, In : American Journal of Physiology-Renal Physiology. 294, 4, p. 697 - 701 5 p.

Research output: Contribution to journalArticleResearchpeer-review

273 Citations (Scopus)

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model

Fukuda, K., Tesch, G. H., Yap, F., Forbes, J. M., Flavell, R. A., Davis, R. & Nikolic-Paterson, D. J., 2008, In : Laboratory Investigation. 88, 4, p. 398 - 407 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells

Giunti, S., Tesch, G. H., Pinach, S., Burt, D. J., Cooper, M. E., Cavallo-Perin, P., Camussi, G. & Gruden, G., 2008, In : Diabetologia. 51, 1, p. 198 - 207 10 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)
2007

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis

Ma, F., Flanc, R., Tesch, G. H., Han, Y., Atkins, R. C., Bennett, B. L., Friedman, G. C., Fan, J-H. & Nikolic-Paterson, D. J., 2007, In : Journal of the American Society of Nephrology. 18, 2, p. 472 - 484 13 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis

Flanc, R., Ma, F., Tesch, G. H., Han, Y., Atkins, R. C., Bennett, B. L., Friedman, G. C., Fan, J-H. & Nikolic-Paterson, D. J., 2007, In : Kidney International. 72, 6, p. 698 - 708 11 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Human peritoneal mesothelial cells isolated from spent dialysate fluid maintain contaminating macrophages via production of macrophage colony stimulating factor

Tee, M. M., Tesch, G. H., Nikolic-Paterson, D. J. & Brown, F. G., 2007, In : Nephrology. 12, 2, p. 160 - 165 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney

Ma, F., Tesch, G. H., Flavell, R. A., Davis, R. & Nikolic-Paterson, D. J., 2007, In : American Journal of Physiology-Renal Physiology. 293, 5, p. 1556 - 1563 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

Chow, F. YF., Nikolic-Paterson, D. J., Ma, F., Ozols, E., Rollins, B. J. & Tesch, G. H., 2007, In : Diabetologia. 50, 2, p. 471 - 480 10 p.

Research output: Contribution to journalArticleResearchpeer-review

168 Citations (Scopus)

Quantification of renal pathology by image analysis (Methods in Renal Research)

Rangan, G. K. & Tesch, G. H., 2007, In : Nephrology. 12, 6, p. 553 - 558 6 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)