Greg Tesch

Adj Assoc Prof

Accepting PhD Students

PhD projects

Therapeutic targeting of kidney tubular cells to inhibit tubulointerstitial fibrosis

1992 …2020

Research output per year

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Research Output

2020

Novel mineralocorticoid receptor mechanisms regulate cardiac tissue inflammation in male mice

Ong, G. S. Y., Cole, T. J., Tesch, G. H., Morgan, J., Dowling, J. K., Mansell, A., Fuller, P. J. & Young, M. J., 1 Aug 2020, In : Journal of Endocrinology. 246, 2, p. 123-134 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting apoptosis signal-regulating kinase 1 in acute and chronic kidney disease

Tesch, G. H., Ma, F. Y. & Nikolic-Paterson, D. J., 23 Jan 2020, (Accepted/In press) In : Anatomical Record. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2019

Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Pullen, N., Jesson, M. I., Schlerman, F. J. & Nikolic-Paterson, D. J., 1 Dec 2019, In : American Journal of Physiology-Renal Physiology. 317, 6, p. F1439-F1449 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Establishing equivalent diabetes in male and female Nos3-deficient mice results in a comparable onset of diabetic kidney injury

Tian, L., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Sep 2019, In : Physiological Reports. 7, 18, 8 p., e14197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis

Han, Y., Tian, L., Ma, F., Tesch, G., Vesey, D. A., Gobe, G. C., Lohman, R. J., Morais, C., Suen, J. Y., Fairlie, D. P. & Nikolic-Paterson, D. J., 1 May 2019, In : Clinical and Experimental Pharmacology and Physiology. 46, 5, p. 456-464 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin

Ly, N. D. K., Tesch, G. H., Nikolic-Paterson, D. J. & Poronnik, P., Jan 2019, In : Nephrology. 24, 1, p. 121-126 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

Amos, L. A., Ma, F. Y., Tesch, G. H., Liles, J. T., Breckenridge, D. G., Nikolic-Paterson, D. J. & Han, Y., 1 Sep 2018, In : Journal of Cellular and Molecular Medicine. 22, 9, p. 4522-4533 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney

Hou, W., Leong, K. G., Ozols, E., Tesch, G. H., Nikolic-Paterson, D. J. & Ma, F. Y., 1 Mar 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 3, p. 250-260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis

Abraham, A. P., Ma, F. Y., Mulley, W. R., Nikolic-Paterson, D. J. & Tesch, G. H., 1 Feb 2018, In : Nephrology. 23, 2, p. 183-189 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease

Han, Y., Ly, N. D. K., Tesch, G. H., Poronnik, P. & Nikolic-Paterson, D. J., 1 Mar 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 3, p. 241-249 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2017

Diabetic nephropathy - is this an immune disorder?

Tesch, G. H., 2017, In : Clinical Science. 131, 16, p. 2183-2199 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

55 Citations (Scopus)
6 Citations (Scopus)

Mineralocorticoid receptor signaling as a therapeutic target for renal and cardiac fibrosis

Tesch, G. H. & Young, M. J., 29 May 2017, In : Frontiers in Pharmacology. 8, MAY, 9 p., 313.

Research output: Contribution to journalShort SurveyOtherpeer-review

Open Access
26 Citations (Scopus)

miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling

Wang, B., Yao, K., Wise, A. F., Lau, R., Shen, H-H., Tesch, G. H. & Ricardo, S. D., 2017, In : Clinical Science. 131, 5, p. 411-423 13 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2016

ASK1: A new therapeutic target for kidney disease

Tesch, G. H., Ma, F. Y. & Nikolic-Paterson, D. J., 1 Aug 2016, In : American Journal of Physiology-Renal Physiology. 311, 2, p. F373-F381

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A. J., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase

Ryan, J., Ma, F. Y., Han, Y., Ozols, E., Kanellis, J., Tesch, G. H. & Nikolic-Paterson, D. J., 1 Jan 2016, In : Journal of Pathology. 238, 1, p. 10-20 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2015

ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice

Tesch, G. H., Ma, F., Han, Y., Liles, J. T., Breckenridge, D. G. & Nikolic-Paterson, D. J., 2015, In : Diabetes. 64, 11, p. 3903 - 3913 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Earlier onset of diabesity-Induced adverse cardiac remodeling in female compared to male mice

Bowden, M. A., Tesch, G. H., Julius, T. L., Rosli, S., Love, J. E. & Ritchie, R. H., 2015, In : Obesity. 23, 6, p. 1166 - 1177 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat

Ramessur, S., Tesch, G. H., Han, Y., Woodman, N., Mulley, W., Kanellis, J., Blease, K., Ma, F. & Nikolic-Paterson, D. J., 2015, In : International Journal of Experimental Pathology. 96, 1, p. 54 - 62 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Suppression of rapidly progressive mouse glomerulonephritis with the non-steroidal mineralocorticoid receptor antagonist BR-4628

Ma, F., Han, Y., Nikolic-Paterson, D. J., Kolkhof, P. & Tesch, G. H., 2015, In : PLoS ONE. 10, 12 (Art. No: e0145666), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)
2014
55 Citations (Scopus)
26 Citations (Scopus)

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Tesch, G. H., Sourris, K., Summers, S. A., McCarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A. R., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. & Forbes, J. M., 2014, In : Diabetologia. 57, 9, p. 1977 - 1985 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease

Huang, L., Nikolic-Paterson, D. J., Han, Y., Ozols, E., Ma, F., Young, M. J. & Tesch, G. H., 2014, In : Journal of the American Society of Nephrology. 25, 10, p. 2231 - 2240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2013

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

Zhang, C., Ibrahim, P. N., Zhang, J., Burton, E. A., Habets, G., Zhang, Y., Powell, B., West, B. L., Matusow, B., Tsang, G., Shellooe, R., Carias, H., Nguyen, H., Marimuthu, A., Zhang, K. Y. J., Oh, A., Bremer, R., Hurt, C. R., Artis, D. R., Wu, G. & 7 others, Nespi, M., Spevak, W., Lin, P., Nolop, K., Hirth, P., Tesch, G. H. & Bollag, G., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5689 - 5694 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis

Han, Y., Ma, F., Tesch, G. H., Manthey, C. L. & Nikolic-Paterson, D. J., 2013, In : American Journal of Physiology-Renal Physiology. 304, 8, p. 1043 - 1053 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2012
29 Citations (Scopus)

Inflammation in diabetic nephropathy

Lim, A. K. H. & Tesch, G. H., 2012, In : Mediators of Inflammation. 2012, Art. ID: 146154, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
240 Citations (Scopus)

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis

Bienvenue, L., Morgan, J., Rickard, A. J., Tesch, G. H., Cranston, G., Fletcher, E. V., Delbridge, L. M. D. & Young, M. J., 2012, In : Endocrinology. 153, 7, p. 3416 - 3425 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2011

c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

Han, Y., Ma, F., Tesch, G., Manthey, C. & Nikolic-Paterson, D., 2011, In : Laboratory Investigation. 91, 7, p. 978 - 991 14 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Evaluation of JNK Blockade As an Early Intervention Treatment For Type 1 Diabetic Nephropathy

Lim, A. K. H., Ma, F. Y., Nikolic-Paterson, D., Ozols, E., Young, M. J., Bennett, B. L., Friedman, G. C. & Tesch, G., Sep 2011, p. A30. 1 p.

Research output: Contribution to conferenceAbstract

Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats

Lim, A., Ma, F., Nikolic-Paterson, D., Ozols, E., Young, M., Bennett, B., Friedman, G. & Tesch, G., 2011, In : American Journal of Nephrology. 34, 4, p. 337 - 346 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy

Tesch, G. & Lim, A., 2011, In : American Journal of Physiology-Renal Physiology. 300, 2, p. F301 - F310 10 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

TGF-beta-1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney

Ma, F., Tesch, G., Ozols, E., Xie, M., Schneider, M. & Nikolic-Paterson, D., 2011, In : American Journal of Physiology-Renal Physiology. 300, 6, p. F1410 - F1421 12 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)
2010

Immunoglobulin Deposition in Diabetic Glomeruli: Is it a Pathological Feature of Disease?

Lan, L., Lim, A. K. H., Nikolic-Paterson, D., Dowling, J. P. G., Kerr, P. G., Kitching, R. & Tesch, G., Sep 2010, In : Nephrology. 15, S4, p. 53-53 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells

Mariasegaram, M., Tesch, G. H., Verhardt, S. L., Hurst, L. A., Lan, H. & Nikolic-Paterson, D. J., 2010, In : Biochemical and Biophysical Research Communications. 393, 4, p. 855 - 859 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
35 Citations (Scopus)

Macrophages and diabetic nephropathy

Tesch, G., 2010, In : Seminars in Nephrology. 30, 3, p. 290 - 301 12 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Tesch, G., 2010, In : Nephrology. 15, 6, p. 609 - 616 8 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Successes achieved and challenges ahead in translating biomarkers into clinical applications

Tesch, G., Amur, S., Schousboe, J. T., Siegel, J. N., Lesko, L. J. & Bai, J. P. F., 1 Sep 2010, In : The AAPS Journal. 12, 3, p. 243-253 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)
2009

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Lim, A. K. H., Ma, F., Nicolic-Paterson, D., Thomas, M., Hurst, L. A. & Tesch, G. H., 2009, In : Diabetologia. 52, 8, p. 1669 - 1679 11 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat

Ma, F., Flanc, R., Tesch, G. H., Bennett, B., Friedman, G. C. & Nicolic-Paterson, D., 2009, In : Laboratory Investigation. 89, 4, p. 470 - 484 15 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure

Rickard, A., Morgan, J., Tesch, G. H., Funder, J. W., Fuller, P. J. & Young, M. J., 2009, In : Hypertension. 54, 3, p. 537 - 543 7 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

Lim, A. K. H., Nikolic-Paterson, D. J., Ma, F., Ozols, E., Thomas, M. C., Flavell, R. A., Davis, R. J. & Tesch, G. H., 2009, In : Diabetologia. 52, 2, p. 347 - 358 12 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)
2008

c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury

Fukuda, K., Tesch, G. H. & Nikolic-Paterson, D. J., 2008, In : Biochemical and Biophysical Research Communications. 366, 3, p. 710 - 716 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

In vivo visualization of albumin degradation in the proximal tubule

Slattery, C., Lee, A., Zhang, Y., Kelly, D. J., Thorn, P., Nikolic-Paterson, D. J., Tesch, G. H. & Poronnik, P., 2008, In : Kidney International. 74, 11, p. 1480 - 1486 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)