Projects per year
Personal profile
Biography
Research Interests. Diabetes and hypertension are major causes of end-stage kidney disease. Dr Tesch’s research focuses on identifying the underlying mechanisms of inflammation and fibrosis that are involved in kidney and heart injury in patients with diabetes and hypertension. In particular, his work focuses on the role of macrophages, tubular cells, fibroblasts and cell signalling pathways in progressive tissue injury. His studies utilize a variety of experimental techniques to examine the molecular mechanisms of disease, including conditional gene deletion, pharmacological blockade of receptors or intracellular signalling kinases, combination therapies, and cell culture studies. He is also engaged in a collaboration to develop novel drug delivery systems to target specific cell types. His previous work has led to clinical trials using an inhibitor of either a chemokine receptor (CCR2) or a specific kinase (ASK1) to treat diabetic kidney disease. This has been achieved through collaborations with local and overseas researchers, and with a number of commercial companies.
Research opportunities. We have a variety of projects available for PhD students and post-doctoral scientists examining novel mechanisms of inflammation and fibrosis in kidney disease. Our lab has an active PhD student program with 4 current students at different stages of their studies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Chronic Kidney Disease (CKD)
- Diabetic Kidney Disease (DKD)
- Glomerulonephritis
- Cell signalling
- Inflammation
- Diabetic complications
- Fibrosis
Collaborations and top research areas from the last five years
Projects
- 7 Finished
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Therapeutic targeting of cellular senescence to prevent progression of chronic kidney disease
Tesch, G., Nikolic-Paterson, D. & Ma, F.
3/05/21 → 31/03/22
Project: Research
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Use of an early urine biomarker to identify individuals who can best benefit from ASK1 inhibitor therapy during diabetes.
Tesch, G., Nikolic-Paterson, D. & Ma, F.
3/05/21 → 3/05/22
Project: Research
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Targeting Diabetic Kidney and Cardiac Disease Through Inhibition of SYK Signalling
Tesch, G., Nikolic-Paterson, D. & Robertson, T.
1/01/20 → 31/12/20
Project: Research
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Preventing and Limiting Acute Kidney Injury in High Risk Diabetic Patients
Nikolic-Paterson, D., Ma, F. & Tesch, G.
1/01/19 → 31/12/19
Project: Other
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Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
Tesch, G. (Primary Chief Investigator (PCI)), Nikolic-Paterson, D. (Chief Investigator (CI)) & Young, M. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury
Tesch, G. H., Ma, F. Y., Ozols, E. & Nikolic-Paterson, D. J., 6 Mar 2024, In: Clinical Science. 138, 5, p. 309-326 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis
Ding, C., Wang, B., Lai, X. F., Guo, Y., Tesch, G., Ding, X., Zheng, J., Tian, P. X., Ricardo, S., Shen, H.-H. & Xue, W., Aug 2023, In: Materials Today Bio. 21, 12 p., 100716.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Corrigendum: c-Jun amino terminal kinase signaling promotes aristolochic acid-induced acute kidney injury, (Front. Physiol, (2021), 12, (599114), 10.3389/fphys.2021.599114)
Yang, F., Ozols, E., Ma, F. Y., Leong, K. G., Tesch, G. H., Jiang, X. & Nikolic-Paterson, D. J., 4 Jan 2023, In: Frontiers in Physiology. 13, 1 p., 1123475.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death
Ogier, J. M., Gao, Y., Dunne, E. M., Wilson, M. A., Ranganathan, S. C., Tesch, G. H., Nikolic Paterson, D. J., Dabdoub, A., Burt, R. A., Nayagam, B. A. & Lockhart, P. J., May 2022, In: Journal of Molecular Medicine. 100, 5, p. 797-813 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Mice with Established Diabetes Show Increased Susceptibility to Renal Ischemia/Reperfusion Injury: Protection by Blockade of Jnk or Syk Signaling Pathways
Grynberg, K., Tian, L., Tesch, G., Ozols, E., Mulley, W. R., Nikolic-Paterson, D. J. & Ma, F. Y., Mar 2022, In: American Journal of Pathology. 192, 3, p. 441-453 13 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus)