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Personal profile

Biography

Professor Graham Lieschke is a clinical and research haematologist. He is internationally recognised for his research into blood disorders and cancer using zebrafish and mice. He is also a clinical haematologist at the Royal Melbourne Hospital, where he treats people with leukaemia and lymphoma.


Prof Lieschke received his medical science and medical degrees from the University of Melbourne in 1983. He undertook his specialist clinical training in medical oncology at the Royal Melbourne Hospital (RMH), obtaining his FRACP in 1991.


His undergraduate laboratory and clinical research cultivated his interest in haematology, and as the first Ludwig Institute/RMH Clinical Fellow, he was part of the team that introduced the white blood cell growth factors into clinical practice.  In his PhD project at the Ludwig Institute for Cancer Research (Melbourne Branch), he undertook one of Australia’s first gene knockout projects, proving that G-CSF was a key physiological regulator of granulocyte production.


His postdoctoral training was at the Whitehead Institute in Cambridge, Massachusetts, USA, in tumour immunology.  He returned to Australia in 1997 as an independent investigator. He established his zebrafish-based research program while at the Ludwig Institute for Cancer Research, and continued this as a Laboratory Head in the Cancer and Haematology Division of the Walter and Eliza Hall Institute.


His work seeks to exploit the unique strengths of the zebrafish model in genetics, embryology, and for visualizing cell behaviour in vivo to understand blood cell development and diseases.


His awards include: the John Maynard Hedstrom Research Fellowship of the Cancer Council of Victoria, a Howard Hughes Postdoctoral Research Fellowship for Physicians, a Wellcome Trust Senior Research Fellowship, and an NHMRC Senior Research Fellowship. The Ludwig Institute awarded him its inaugural George Hodgson Medal for Medical Science.


He has published over 100 scientific papers and co-edited 2 books. Prof. Lieschke is also passionate about the organ and choral music of J.S. Bach, an interest for which he was awarded the 2004 Dame Roma Mitchell Churchill Fellowship.

External positions

Honorary Haematologist, Peter MacCallum Cancer Centre

20162022

Clinical Haematologist, Royal Melbourne Hospital

20072022

Research area keywords

  • Haematology
  • haematological malignancies
  • Zebrafish Development
  • Innate Immunity
  • Transcription factors

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Projects 2007 2022

Research Output 1981 2019

3 Citations (Scopus)

Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation

Jiang, J-H., Bhuiyan, M. S., Shen, H-H., Cameron, D. R., Rupasinghe, T. W. T., Wu, C. M., Le Brun, A. P., Kostoulias, X., Domene, C., Fulcher, A. J., McConville, M. J., Howden, B. P., Lieschke, G. J. & Peleg, A. Y., 26 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3722-3727 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Β-Glucan–dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment

Pazhakh, V., Ellett, F., Croker, B. A., O’Donnell, J. A., Pase, L., Schulze, K. E., Greulich, R. S., Gupta, A., Reyes-Aldasoro, C. C., Andrianopoulos, A. & Lieschke, G. J., 4 Sep 2019, In : PLoS Biology. 17, 9, 33 p., e3000113.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation

Hall, C. J., Sanderson, L. E., Lawrence, L. M., Pool, B., Van Der Kroef, M., Ashimbayeva, E., Britto, D., Harper, J. L., Lieschke, G. J., Astin, J. W., Crosier, K. E., Dalbeth, N. & Crosier, P. S., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1752-1771 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoietic growth factors: the scenario in zebrafish

Pazhakh, V. & Lieschke, G. J., 2018, In : Growth Factors. 36, 5-6, p. 196-212 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo

Ellett, F., Pazhakh, V., Pase, L., Benard, E. L., Weerasinghe, H., Azabdaftari, D., Alasmari, S., Andrianopoulos, A. & Lieschke, G. J., 8 Jun 2018, In : PLoS Pathogens. 14, 6, 27 p., e1007063.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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