Projects per year
Personal profile
Biography
Professor Graham Lieschke is a clinical and research haematologist. He is internationally recognised for his research into blood disorders and cancer using zebrafish and mice. He is also a clinical haematologist at the Royal Melbourne Hospital, where he treats people with leukaemia and lymphoma.
Prof Lieschke received his medical science and medical degrees from the University of Melbourne in 1983. He undertook his specialist clinical training in medical oncology at the Royal Melbourne Hospital (RMH), obtaining his FRACP in 1991.
His undergraduate laboratory and clinical research cultivated his interest in haematology, and as the first Ludwig Institute/RMH Clinical Fellow, he was part of the team that introduced the white blood cell growth factors into clinical practice. In his PhD project at the Ludwig Institute for Cancer Research (Melbourne Branch), he undertook one of Australia’s first gene knockout projects, proving that G-CSF was a key physiological regulator of granulocyte production.
His postdoctoral training was at the Whitehead Institute in Cambridge, Massachusetts, USA, in tumour immunology. He returned to Australia in 1997 as an independent investigator. He established his zebrafish-based research program while at the Ludwig Institute for Cancer Research, and continued this as a Laboratory Head in the Cancer and Haematology Division of the Walter and Eliza Hall Institute.
His work seeks to exploit the unique strengths of the zebrafish model in genetics, embryology, and for visualizing cell behaviour in vivo to understand blood cell development and diseases.
His awards include: the John Maynard Hedstrom Research Fellowship of the Cancer Council of Victoria, a Howard Hughes Postdoctoral Research Fellowship for Physicians, a Wellcome Trust Senior Research Fellowship, and an NHMRC Senior Research Fellowship. The Ludwig Institute awarded him its inaugural George Hodgson Medal for Medical Science.
He has published over 100 scientific papers and co-edited 2 books. Prof. Lieschke is also passionate about the organ and choral music of J.S. Bach, an interest for which he was awarded the 2004 Dame Roma Mitchell Churchill Fellowship.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Haematologist, Peter MacCallum Cancer Centre
2016 → 2022
Clinical Haematologist, Royal Melbourne Hospital
2007 → 2022
Research area keywords
- Haematology
- haematological malignancies
- Zebrafish Development
- Innate Immunity
- Transcription factors
Collaborations and top research areas from the last five years
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Migration-Dependent Signalling in Macrophages
Stow, J., Lieschke, G., Murray, R. & Condon, N.
Australian Research Council (ARC)
17/05/23 → 16/05/26
Project: Research
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The macrophage nucleus - its form and function during migration in vivo
Lieschke, G. & Reyes-Aldasoro, C.
4/08/21 → 3/08/25
Project: Research
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Diagnosis, discovery and novel phenotype characterisation using multimodal genomics in patients with inherited bone marrow failure and related disorders
Blombery, P., Wood, E., Fox, L., Wall, M., James, P. A., Brown, A. L., Stevenson, W. C., Ritchie, D. S., Francis, J. & Lieschke, G.
Department of Health and Aged Care (Australia)
1/06/21 → 31/05/25
Project: Research
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Advanced lattice light sheet microscope optimised for biological imaging
Lieschke, G., Currie, P., Mitchell, C., Ryan, M., Zenker, J., Hogan, B. M., Smith, K. A. & Poon, I.
6/05/22 → 31/12/22
Project: Research
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Uncovering the earliest events leading to tophaceous gout
Hall, C. J., Dalbeth, N. D., Lieschke, G. & Linnerz, T.
Health Research Council of New Zealand, University of Auckland, Auckland Uniservices Limited
1/09/21 → 31/08/24
Project: Research
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Biallelic deleterious germline SH2B3 variants cause a novel syndrome of myeloproliferation and multi-organ autoimmunity
Blombery, P., Pazhakh, V., Albuquerque, A. S., Maimaris, J., Tu, L., Briones Miranda, B., Evans, F., Thompson, E. R., Carpenter, B., Proctor, I., Curtin, J. A., Lambert, J., Burns, S. & Lieschke, G. J., May 2023, In: ejHaem. 4, 2, p. 463-469 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes
Linder, M. I., Mizoguchi, Y., Hesse, S., Csaba, G., Tatematsu, M., Łyszkiewicz, M., Ziȩtara, N., Jeske, T., Hastreiter, M., Rohlfs, M., Liu, Y., Grabowski, P., Ahomaa, K., Maier-Begandt, D., Schwestka, M., Pazhakh, V., Isiaku, A. I., Briones Miranda, B., Blombery, P., Saito, M. K., & 13 others , 9 Feb 2023, In: Blood. 141, 6, p. 645-658 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification
Cao, H., Naik, S. H., Amann-Zalcenstein, D., Hickey, P., Salim, A., Cao, B., Nilsson, S. K., Keightley, M. C. & Lieschke, G. J., 14 Nov 2023, In: Blood Advances. 7, 21, p. 6506-6519 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus
Payne, J. A. E., Tailhades, J., Ellett, F., Kostoulias, X., Fulcher, A. J., Fu, T., Leung, R., Louch, S., Tran, A., Weber, S. A., Schittenhelm, R. B., Lieschke, G. J., Qin, C. H., Irima, D., Peleg, A. Y. & Cryle, M. J., Dec 2021, In: Nature Communications. 12, 1, 15 p., 6157.Research output: Contribution to journal › Article › Research › peer-review
Open Access19 Citations (Scopus) -
Macrophages provide a transient muscle stem cell niche via NAMPT secretion
Ratnayake, D., Nguyen, P. D., Rossello, F. J., Wimmer, V. C., Tan, J. L., Galvis, L. A., Julier, Z., Wood, A. J., Boudier, T., Isiaku, A. I., Berger, S., Oorschot, V., Sonntag, C., Rogers, K. L., Marcelle, C., Lieschke, G. J., Martino, M. M., Bakkers, J. & Currie, P. D., 11 Mar 2021, In: Nature. 591, 7849, p. 281-287 7 p.Research output: Contribution to journal › Article › Research › peer-review
139 Citations (Scopus)
Press/Media
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Faculty of Opinions recommendation
Jennifer Payne, Max Cryle, Julien Tailhades, Alex Fulcher, Felix Ellett, Daniel Irima, Xenia Kostoulias, Ryan Leung, Steph Louch, Amy Tran, Severin Weber, Ralf Schittenhelm, Graham Lieschke, Chengxue Helena Qin, Anton Peleg & Ting Fu
3/12/21
1 item of Media coverage
Press/Media: Article/Feature