Projects per year
Personal profile
Biography
Better breath of life for premature babies
Babies born prematurely at less than 26 weeks of development have only a 10 per cent chance of surviving without brain damage. Some of this damage can be caused in their first 15 minutes by resuscitation efforts. Dr Graeme Polglase's research into respiration and blood flow is changing resuscitation procedures and improving the survival odds for these newborns.
An internationally recognised physiologist Dr Polglase is leading authority on the role of pulmonary, cardiovascular, and cerebral circulation in organ inflammation and injury in preterm and compromised infants. A Monash University Graduate, he completed his PhD in 2005. Dr Polglase was recruited to join the Department of Women's and Infants' Health, the University of Western Australia, Perth, WA, which was running the largest perinatal ovine research program in the world. Following his promotion to Manager in 2008, he took over primary responsibility for running all animal studies. In 2010, Dr Polglase joined The Ritchie Centre, Monash University and Hudson Institute of Medical Research, where he established the Perinatal Transition Research Group in 2011 to influence clinical practise in the management of preterm and compromised infant care. Translation of his findings continues to improve treatment outcomes as evidenced by his publications cited in Australian, European, and International resuscitation guidelines, and multiple invitations so speak at National and International clinical meetings.
Recognised by the NHMRC with Early Career and Career Development Fellowships, Dr Polglase was the inaugural recipient of the Rebecca L. Cooper Medical Research Fellowship and significant funding from the NIH. He has also received funding from the National Heart Foundation of Australia, Cerebral Palsy Alliance, and Financial Markets for Children.
Dr Polglase is working to improve respiratory, cardiovascular, and neurological outcomes of infants born preterm single greatest cause of neonatal morbidity and mortality. His findings continue to expand understanding of how key events during fetal development, birth, and post delivery influence the pulmonary, cardiovascular, and cerebral circulation lead to organ inflammation and injury to improve outcomes. As the single greatest cause of neonatal morbidity and mortality, he hopes this work will improve outcomes for some of our tiniest patients.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- fetal and neonatal circulation and brain injury
- fetal physiology
- neonatal physiology
- respiratory function
- cardiovascular function
- circulation
Collaborations and top research areas from the last five years
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Reducing the burden of respiratory distress after caesarean delivery.
Crossley, K. (Primary Chief Investigator (PCI)), Hooper, S. (Chief Investigator (CI)), Kitchen, M. (Chief Investigator (CI)), te Pas, A. B. (Chief Investigator (CI)), Wallace, M. (Associate Investigator (AI)), Tran, N. (Associate Investigator (AI)), Polglase, G. (Associate Investigator (AI)) & Thio, M. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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The Monash Partners Children’s Acute Care Data Project: Optimising the use of electronic medical records data to improve hospital care for children
Craig, S. (Primary Chief Investigator (PCI)), Williams, K. (Chief Investigator (CI)), Lovett, A. (Chief Investigator (CI)), Taylor, D. A. (Chief Investigator (CI)), Nixon, G. (Chief Investigator (CI)), Coleman, J. M. (Chief Investigator (CI)), Winderlich, J. (Chief Investigator (CI)), Noorman, J. (Chief Investigator (CI)), Parkhurst, K. (Chief Investigator (CI)), Fahey, M. (Chief Investigator (CI)), Nataraja, R. (Chief Investigator (CI)), Hunt, R. (Chief Investigator (CI)), Lamont, S. (Chief Investigator (CI)), Nold, M. (Chief Investigator (CI)), Polglase, G. (Chief Investigator (CI)), Jones, A. (Chief Investigator (CI)) & Pigott, C. (Chief Investigator (CI))
1/01/23 → …
Project: Research
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Phase-Contrast Neuroimaging for Early Detection of Brain Injury at Birth
Kitchen, M. (Primary Chief Investigator (PCI)), Croton, L. (Chief Investigator (CI)), Hooper, S. (Associate Investigator (AI)), Cheong, J. L. Y. (Associate Investigator (AI)), Miller, S. (Associate Investigator (AI)), Polglase, G. (Associate Investigator (AI)), Crossley, K. (Associate Investigator (AI)), Morgan, K. (Associate Investigator (AI)) & Galinsky, R. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
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Reducing Cerebrovascular Injury in Newborns Receiving Advanced Cardiopulmonary Resuscitation
Polglase, G. (Primary Chief Investigator (PCI)), Hooper, S. (Chief Investigator (CI)), Roberts, C. (Chief Investigator (CI)) & Tran, N. (Chief Investigator (CI))
1/01/23 → 31/12/23
Project: Research
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Anti-inflammatory protection of brainstem respiratory centres to help preterm babies breathe at birth and reduce perinatal brain injury
Polglase, G. (Primary Chief Investigator (PCI)), Stojanovska, V. (Primary Chief Investigator (PCI)) & Roberts, C. (Associate Investigator (AI))
1/01/21 → 31/12/22
Project: Research
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The interplay between birth weight and intraventricular hemorrhage in very preterm neonates—a retrospective cohort study
Piscopo, B. R., Malhotra, A., Hunt, R. W., Davies-Tuck, M. L., Palmer, K. R., Sutherland, A. E., Polglase, G. R., Allison, B. J. & Miller, S. L., Apr 2025, In: American Journal of Obstetrics and Gynecology MFM. 7, 4, 10 p., 101628.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Assessing the influence of abdominal compression on time to return of circulation during resuscitation of asphyxiated newborn lambs: a randomised preclinical study
Polglase, G. R. (Leading Author), Hwang, C., Blank, D. A., Badurdeen, S., Crossley, K. J., Kluckow, M., Gill, A. W., Camm, E., Galinsky, R., Brian, Y., Hooper, S. B. & Roberts, C. T. (Leading Author), 19 Jun 2024, In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 109, 4, p. 405-411 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Blood pressure and cerebral oxygenation with physiologically-based cord clamping: sub-study of the BabyDUCC trial
Badurdeen, S., Blank, D. A., Hoq, M., Wong, F. Y., Roberts, C. T., Hooper, S. B., Polglase, G. R. & Davis, P. G., 2024, In: Pediatric Research. 96, p. 124–131 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Cardiac Agents during Neonatal Cardiopulmonary Resuscitation
Ramsie, M., Cheung, P.-Y., O’Reilly, M., Roberts, C. T., Polglase, G. R. & Schmölzer, G. M., 16 Jan 2024, In: Neonatology. 121, 2, p. 157-166 10 p.Research output: Contribution to journal › Review Article › Other › peer-review
1 Citation (Scopus) -
Early administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale
Tran, N. T., Penny, T. R., Chan, K. Y. Y., Tang, T., Papagianis, P. C., Sepehrizadeh, T., Nekkanti, L., Zahra, V. A., Pham, Y., Yawno, T., Nitsos, I., Kelly, S. B., Thiel, A. M., de Veer, M., Alahmari, D. M., Fahey, M. C., Jenkin, G., Miller, S. L., Galinsky, R. & Polglase, G. R. & 1 others, , Dec 2024, In: Journal of Neuroinflammation. 21, 1, 17 p., 121.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Press/Media
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CPR while attached to mum reduces brain injury
16/10/20
2 Media contributions
Press/Media: Profile/Interview