Projects per year
Personal profile
Biography
Better breath of life for premature babies
Babies born prematurely at less than 26 weeks of development have only a 10 per cent chance of surviving without brain damage. Some of this damage can be caused in their first 15 minutes by resuscitation efforts. Dr Graeme Polglase's research into respiration and blood flow is changing resuscitation procedures and improving the survival odds for these newborns.
An internationally recognised physiologist Dr Polglase is leading authority on the role of pulmonary, cardiovascular, and cerebral circulation in organ inflammation and injury in preterm and compromised infants. A Monash University Graduate, he completed his PhD in 2005. Dr Polglase was recruited to join the Department of Women's and Infants' Health, the University of Western Australia, Perth, WA, which was running the largest perinatal ovine research program in the world. Following his promotion to Manager in 2008, he took over primary responsibility for running all animal studies. In 2010, Dr Polglase joined The Ritchie Centre, Monash University and Hudson Institute of Medical Research, where he established the Perinatal Transition Research Group in 2011 to influence clinical practise in the management of preterm and compromised infant care. Translation of his findings continues to improve treatment outcomes as evidenced by his publications cited in Australian, European, and International resuscitation guidelines, and multiple invitations so speak at National and International clinical meetings.
Recognised by the NHMRC with Early Career and Career Development Fellowships, Dr Polglase was the inaugural recipient of the Rebecca L. Cooper Medical Research Fellowship and significant funding from the NIH. He has also received funding from the National Heart Foundation of Australia, Cerebral Palsy Alliance, and Financial Markets for Children.
Dr Polglase is working to improve respiratory, cardiovascular, and neurological outcomes of infants born preterm single greatest cause of neonatal morbidity and mortality. His findings continue to expand understanding of how key events during fetal development, birth, and post delivery influence the pulmonary, cardiovascular, and cerebral circulation lead to organ inflammation and injury to improve outcomes. As the single greatest cause of neonatal morbidity and mortality, he hopes this work will improve outcomes for some of our tiniest patients.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- fetal and neonatal circulation and brain injury
- fetal physiology
- neonatal physiology
- respiratory function
- cardiovascular function
- circulation
Network
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Reducing the burden of respiratory distress after caesarean delivery.
Crossley, K., Hooper, S., Kitchen, M., te Pas, A. B., Wallace, M., Tran, N., Polglase, G. & Thio, M.
1/01/23 → 31/12/26
Project: Research
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The Monash Partners Children’s Acute Care Data Project: Optimising the use of electronic medical records data to improve hospital care for children
Craig, S., Williams, K., Lovett, A., Taylor, D. A., Nixon, G., Coleman, J. M., Winderlich, J., Noorman, J., Parkhurst, K., Fahey, M., Nataraja, R., Hunt, R., Lamont, S., Nold, M., Polglase, G., Jones, A. & Pigott, C.
1/01/23 → …
Project: Research
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Phase-Contrast Neuroimaging for Early Detection of Brain Injury at Birth
Kitchen, M., Croton, L., Hooper, S., Cheong, J., Miller, S., Polglase, G., Crossley, K., Morgan, K. & Galinsky, R.
1/01/22 → 31/12/25
Project: Research
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Reducing the consequences of prematurity by improving the transition at birth
1/01/20 → 31/12/24
Project: Research
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Effect of clinical chorioamnionitis on breathing effort in premature infants at birth: A retrospective case-control study
Panneflek, T. J. R., Kuypers, K. L. A. M., Polglase, G. R., Hooper, S. B., Van Den Akker, T. & Te Pas, A. B., May 2023, In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 108, 3, 6 p., 324695.Research output: Contribution to journal › Article › Research › peer-review
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Cerebral haemodynamic response to somatosensory stimulation in preterm lambs and 7–10-day old lambs born at term: Direct synchrotron microangiography assessment
Inocencio, I. M., Tran, N. T., Nakamura, S., Khor, S. J., Wiersma, M., Stoecker, K., Maksimenko, A., Polglase, G. R., Walker, D. W., Pearson, J. T. & Wong, F. Y., Feb 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 2, p. 315-328 14 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs
Roberts, C. T., Klink, S., Schmölzer, G. M., Blank, D. A., Badurdeen, S., Crossley, K. J., Rodgers, K., Zahra, V., Moxham, A., Roehr, C. C., Kluckow, M., Gill, A. W., Hooper, S. B. & Polglase, G. R., May 2022, In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 107, 3, p. 311-316 6 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Hemodynamics of the Circulatory Transition
Polglase, G. R., Kluckow, M., Gill, A. W. & Hooper, S. B., 2022, Hypoxic Respiratory Failure in the Newborn: From Origins to Clinical Management. Dakshinamurti, S. (ed.). 1st ed. Boca Raton FL USA: CRC Press, p. 57-61 5 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
1 Citation (Scopus) -
Increased Prostaglandin E2 in Brainstem Respiratory Centers Is Associated With Inhibition of Breathing Movements in Fetal Sheep Exposed to Progressive Systemic Inflammation
Stojanovska, V., Atta, J., Kelly, S. B., Zahra, V. A., Matthews-Staindl, E., Nitsos, I., Moxham, A., Pham, Y., Hooper, S. B., Herlenius, E., Galinsky, R. & Polglase, G. R., 3 Mar 2022, In: Frontiers in Physiology. 13, 12 p., 841229.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)
Press/Media
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CPR while attached to mum reduces brain injury
16/10/20
2 Media contributions
Press/Media: Profile/Interview