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Better breath of life for premature babies

Babies born prematurely at less than 26 weeks of development have only a 10 per cent chance of surviving without brain damage. Some of this damage can be caused in their first 15 minutes by resuscitation efforts. Dr Graeme Polglase's research into respiration and blood flow is changing resuscitation procedures and improving the survival odds for these newborns.

An internationally recognised physiologist Dr Polglase is leading authority on the role of pulmonary, cardiovascular, and cerebral circulation in organ inflammation and injury in preterm and compromised infants. A Monash University Graduate, he completed his PhD in 2005. Dr Polglase was recruited to join the Department of Women's and Infants' Health, the University of Western Australia, Perth, WA, which was running the largest perinatal ovine research program in the world. Following his promotion to Manager in 2008, he took over primary responsibility for running all animal studies. In 2010, Dr Polglase joined The Ritchie Centre, Monash University and Hudson Institute of Medical Research, where he established the Perinatal Transition Research Group in 2011 to influence clinical practise in the management of preterm and compromised infant care. Translation of his findings continues to improve treatment outcomes as evidenced by his publications cited in Australian, European, and International resuscitation guidelines, and multiple invitations so speak at National and International clinical meetings.

Recognised by the NHMRC with Early Career and Career Development Fellowships, Dr Polglase was the inaugural recipient of the Rebecca L. Cooper Medical Research Fellowship and significant funding from the NIH. He has also received funding from the National Heart Foundation of Australia, Cerebral Palsy Alliance, and Financial Markets for Children.

Dr Polglase is working to improve respiratory, cardiovascular, and neurological outcomes of infants born preterm single greatest cause of neonatal morbidity and mortality. His findings continue to expand understanding of how key events during fetal development, birth, and post delivery influence the pulmonary, cardiovascular, and cerebral circulation lead to organ inflammation and injury to improve outcomes. As the single greatest cause of neonatal morbidity and mortality, he hopes this work will improve outcomes for some of our tiniest patients.

Research area keywords

  • fetal and neonatal circulation and brain injury
  • fetal physiology
  • neonatal physiology
  • respiratory function
  • cardiovascular function
  • circulation

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2024

Research Output 2004 2020

Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs

Malhotra, A., Castillo-Melendez, M., Allison, B. J., Sutherland, A. E., Nitsos, I., Pham, Y., McDonald, C. A., Fahey, M. C., Polglase, G. R., Jenkin, G. & Miller, S. L., 8 Jan 2020, In : Stem Cell Research and Therapy. 11, 1, 14 p., 17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Advanced MRI analysis to detect white matter brain injury in growth restricted newborn lambs

Malhotra, A., Sepehrizadeh, T., Dhollander, T., Wright, D., Castillo-Melendez, M., Sutherland, A. E., Pham, Y., Ditchfield, M., Polglase, G. R., de Veer, M., Jenkin, G., Pannek, K., Shishegar, R. & Miller, S. L., 1 Jan 2019, In : NeuroImage: Clinical. 24, 9 p., 101991.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Delivery of positive end-expiratory pressure to preterm lambs using common resuscitation devices

Thio, M., Dawson, J. A., Crossley, K. J., Moss, T. J., Roehr, C. C., Polglase, G. R., Davis, P. G. & Hooper, S. B., 1 Jan 2019, In : Archives of Disease in Childhood: Fetal and Neonatal Edition. 104, 1, p. F83-F88 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Dose-dependent exacerbation of ventilation-induced lung injury by erythropoietin in preterm newborn lambs

Allison, B. J., LaRosa, D. A., Barton, S. K., Hooper, S., Zahra, V., Tolcos, M., Chan, K. Y. Y., Barbuto, J., Inocencio, I. M., Moss, T. J. & Polglase, G. R., 1 Jan 2019, In : Journal of Applied Physiology. 126, 1, p. 44-50 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Effectiveness of stabilization of preterm infants with intact umbilical cord using a purpose-built resuscitation table-study protocol for a randomized controlled trial

Knol, R., Brouwer, E., Klumper, F. J. C. M., van den Akker, T., DeKoninck, P., Hutten, G. J., Lopriore, E., van Kaam, A. H., Polglase, G. R., Reiss, I. K. M., Hooper, S. B. & Pas, A. B., 1 Jan 2019, In : Frontiers in Pediatrics. 7, APR, 8 p., 134.

Research output: Contribution to journalArticleOtherpeer-review

Open Access