Gordon Dougan

Professor

1977 …2021
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Research Output 1977 2019

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2019

Antibiotic resistance and typhoid

Dyson, Z. A., Klemm, E. J., Palmer, S. & Dougan, G., 7 Mar 2019, In : Clinical Infectious Diseases. 68, p. S165-S170 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Davies, M. R., McIntyre, L., Mutreja, A., Lacey, J. A., Lees, J. A., Towers, R. J., Duchêne, S., Smeesters, P. R., Frost, H. R., Price, D. J., Holden, M. T. G., David, S., Giffard, P. M., Worthing, K. A., Seale, A. C., Berkley, J. A., Harris, S. R., Rivera-Hernandez, T., Berking, O., Cork, A. J. & 18 othersTorres, R. S. L. A., Lithgow, T., Strugnell, R. A., Bergmann, R., Nitsche-Schmitz, P., Chhatwal, G. S., Bentley, S. D., Fraser, J. D., Moreland, N. J., Carapetis, J. R., Steer, A. C., Parkhill, J., Saul, A., Williamson, D. A., Currie, B. J., Tong, S. Y. C., Dougan, G. & Walker, M. J., 1 Jun 2019, In : Nature Genetics. 51, 6, p. 1035-1043 9 p.

Research output: Contribution to journalArticleResearchpeer-review

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 5 Feb 2019, In : Proceedings of the National Academy of Sciences. 116, 6, p. 2265-2273 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis

Torres, V. V. L., Heinz, E., Stubenrauch, C. J., Wilksch, J. J., Cao, H., Yang, J., Clements, A., Dunstan, R. A., Alcock, F., Webb, C. T., Dougan, G., Strugnell, R. A., Hay, I. D. & Lithgow, T., Sep 2018, In : Molecular Microbiology. 109, 5, p. 584-599 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

Napolitani, G., Kurupati, P., Teng, K. W. W., Gibani, M. M., Rei, M., Aulicino, A., Preciado-Llanes, L., Wong, M. T., Becht, E., Howson, L., De Haas, P., Salio, M., Blohmke, C. J., Olsen, L. R., Pinto, D. M. S., Scifo, L., Jones, C., Dobinson, H., Campbell, D., Juel, H. B. & 10 othersThomaides-Brears, H., Pickard, D., Bumann, D., Baker, S., Dougan, G., Simmons, A., Gordon, M. A., Newell, E. W., Pollard, A. J. & Cerundolo, V., 20 Jun 2018, In : Nature Immunology. 19, 7, p. 742-754 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional analysis of Salmonella Typhi adaptation to survival in water

Kingsley, R. A., Langridge, G., Smith, S. E., Makendi, C., Fookes, M., Wileman, T. M., El Ghany, M. A., Keith Turner, A., Dyson, Z. A., Sridhar, S., Pickard, D., Kay, S., Feasey, N., Wong, V., Barquist, L. & Dougan, G., 1 Nov 2018, In : Environmental Microbiology. 20, 11, p. 4079-4090 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants

Grinter, R., Hay, I. D., Song, J., Wang, J., Teng, D., Dhanesakaran, V., Wilksch, J. J., Davies, M. R., Littler, D., Beckham, S. A., Henderson, I. R., Strugnell, R. A., Dougan, G. & Lithgow, T., 2 Aug 2018, In : PLoS Biology. 16, 8, 21 p., e2006026.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy

Britto, C. D., Dyson, Z. A., Duchene, S., Carter, M. J., Gurung, M., Kelly, D. F., Murdoch, D. R., Ansari, I., Thorson, S., Shrestha, S., Adhikari, N., Dougan, G., Holt, K. E. & Pollard, A. J., 23 Apr 2018, In : PLoS Neglected Tropical Diseases. 12, 4, 19 p., e0006408.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

Deo, P., Chow, S. H., Hay, I. D., Kleifeld, O., Costin, A., Elgass, K. D., Jiang, J-H., Ramm, G., Gabriel, K., Dougan, G., Lithgow, T., Heinz, E. & Naderer, T., 30 Mar 2018, In : PLoS Pathogens. 14, 3, 30 p., e1006945.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

Park, S. E., Pham, D. T., Boinett, C., Wong, V. K., Pak, G. D., Panzner, U., Espinoza, L. M. C., von Kalckreuth, V., Im, J., Schütt-Gerowitt, H., Crump, J. A., Breiman, R. F., Adu-Sarkodie, Y., Owusu-Dabo, E., Rakotozandrindrainy, R., Soura, A. B., Aseffa, A., Gasmelseed, N., Keddy, K. H., May, J. & 50 othersSow, A. G., Aaby, P., Biggs, H. M., Hertz, J. T., Montgomery, J. M., Cosmas, L., Olack, B., Fields, B., Sarpong, N., Razafindrabe, T. J. L., Raminosoa, T. M., Kabore, L. P., Sampo, E., Teferi, M., Yeshitela, B., El Tayeb, M. A., Sooka, A., Meyer, C. G., Krumkamp, R., Dekker, D. M., Jaeger, A., Poppert, S., Tall, A., Niang, A., Bjerregaard-Andersen, M., Løfberg, S. V., Seo, H. J., Jeon, H. J., Deerin, J. F., Park, J., Konings, F., Ali, M., Clemens, J. D., Hughes, P., Sendagala, J. N., Vudriko, T., Downing, R., Ikumapayi, U. N., Mackenzie, G. A., Obaro, S., Argimon, S., Aanensen, D. M., Page, A., Keane, J. A., Duchene, S., Dyson, Z., Holt, K. E., Dougan, G., Marks, F. & Baker, S., 1 Dec 2018, In : Nature Communications. 9, 1, 10 p., 5094.

Research output: Contribution to journalArticleResearchpeer-review

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2017

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever

Tran Vu Thieu, N., Trinh Van, T., Tran Tuan, A., Klemm, E. J., Nguyen Ngoc Minh, C., Voong Vinh, P., Pham Thanh, D., Ho Ngoc Dan, T., Pham Duc, T., Langat, P., Martin, L. B., Galan, J., Liang, L., Felgner, P. L., Davies, D. H., de Jong, H. K., Maude, R. R., Fukushima, M., Wijedoru, L., Ghose, A. & 9 othersSamad, R., Dondorp, A. M., Faiz, A., Darton, T. C., Pollard, A. J., Thwaites, G. E., Dougan, G., Parry, C. M. & Baker, S., Aug 2017, In : Journal of Infection. 75, 2, p. 104-114 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency

Kuijpers, T. W., Tool, A. T. J., van der Bijl, I., de Boer, M., Van Houdt, M., de Cuyper, I. M., Roos, D., van Alphen, F., van Leeuwen, K., Cambridge, E. L., Arends, M. J., Dougan, G., Clare, S., Ramirez-Solis, R., Pals, S. T., Adams, D. J., Meijer, A. B. & Van den Berg, T. K., 1 Jul 2017, In : Journal of Allergy and Clinical Immunology. 140, 1, p. 273-277.e10

Research output: Contribution to journalArticleResearchpeer-review

Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function

Stubenrauch, C. J., Dougan, G., Lithgow, T. & Heinz, E., 15 Nov 2017, In : Open Biology. 7, 11, 10 p., 170144.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genomic history of the seventh pandemic of cholera in Africa

Weill, F. X., Domman, D., Njamkepo, E., Tarr, C., Rauzier, J., Fawal, N., Keddy, K. H., Salje, H., Moore, S., Mukhopadhyay, A. K., Bercion, R., Luquero, F. J., Ngandjio, A., Dosso, M., Monakhova, E., Garin, B., Bouchier, C., Pazzani, C., Mutreja, A., Grunow, R. & 21 othersSidikou, F., Bonte, L., Breurec, S., Damian, M., Njanpop-Lafourcade, B. M., Sapriel, G., Page, A. L., Hamze, M., Henkens, M., Chowdhury, G., Mengel, M., Koeck, J. L., Fournier, J. M., Dougan, G., Grimont, P. A. D., Parkhill, J., Holt, K. E., Piarroux, R., Ramamurthy, T., Quilici, M. L. & Thomson, N. R., 10 Nov 2017, In : Science. 358, 6364, p. 785-789 5 p.

Research output: Contribution to journalArticleResearchpeer-review

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Global and regional dissemination and evolution of Burkholderia pseudomallei

Chewapreecha, C., Holden, M. T. G., Vehkala, M., Välimäki, N., Yang, Z., Harris, S. R., Mather, A. E., Tuanyok, A., De Smet, B., Le Hello, S., Bizet, C., Mayo, M., Wuthiekanun, V., Limmathurotsakul, D., Phetsouvanh, R., Spratt, B. G., Corander, J., Keim, P., Dougan, G., Dance, D. A. B. & 3 othersCurrie, B. J., Parkhill, J. & Peacock, S. J., 23 Jan 2017, In : Nature Microbiology. 2, 16263.

Research output: Contribution to journalArticleResearchpeer-review

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2

Tchasovnikarova, I. A., Timms, R. T., Douse, C. H., Roberts, R. C., Dougan, G., Kingston, R. E., Modis, Y. & Lehner, P. J., 1 Jul 2017, In : Nature Genetics. 49, 7, p. 1035-1044 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Phylogenetic analysis of Klebsiella pneumoniae from hospitalized children, Pakistan

Ejaz, H., Wang, N., Wilksch, J. J., Page, A. J., Cao, H., Gujaran, S., Keane, J. A., Lithgow, T., Ul-Haq, I., Dougan, G., Strugnell, R. A. & Heinz, E., 1 Nov 2017, In : Emerging infectious diseases. 23, 11, p. 1872-1875 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of sapA and yfgA in susceptibility to antibody-mediated complement-dependent killing and virulence of Salmonella enterica serovar Typhimurium

Ondari, E. M., Heath, J. N., Klemm, E. J., Langridge, G. C., Barquist, L., Goulding, D. A., Clare, S., Dougan, G., Kingsley, R. A. & MacLennan, C. A., 1 Sep 2017, In : Infection and Immunity. 85, 9, 15 p., e00419-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The type III secretion system effector SptP of Salmonella enterica serovar Typhi

Johnson, R., Byrne, A., Berger, C. N., Klemm, E., Crepin, V. F., Dougan, G. & Frankel, G., 2017, In : Journal of Bacteriology. 199, 4, 00647-16.

Research output: Contribution to journalArticleResearchpeer-review

2016

An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Wong, V. K., Baker, S., Connor, T. R., Pickard, D., Page, A. J., Dave, J., Murphy, N. C., Holliman, R., Sefton, A., Millar, M., Dyson, Z. A., Dougan, G., Holt, K. E. & International Typhoid Consortium, 5 Oct 2016, In : Nature Communications. 7, 11 p., 12827.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A novel ciprofloxacin-resistant subclade of h58. Salmonella typhi is associated with fluoroquinolone treatment failure

Thanh, D. P., Karkey, A., Dongol, S., Thi, N. H., Thompson, C. N., Rabaa, M. A., Arjyal, A., Holt, K. E., Wong, V., Thieu, N. T. V., Vinh, P. V., Thanh, T. H., Pradhan, A., Shrestha, S. K., Gajurel, D., Pickard, D., Parry, C. M., Dougan, G., Wolbers, M., Dolecek, C. & 3 othersThwaites, G. E., Basnyat, B. & Baker, S., 14 Mar 2016, In : eLife. 5, 13 p., e14003.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions

Makendi, C., Page, A. J., Wren, B. W., Le Thi Phuong, T., Clare, S., Hale, C., Goulding, D., Klemm, E. J., Pickard, D., Okoro, C., Hunt, M., Thompson, C. N., Phu Huong Lan, N., Tran Do Hoang, N., Thwaites, G. E., Le Hello, S., Brisabois, A., Weill, F. X., Baker, S. & Dougan, G., 11 Feb 2016, In : PLoS Neglected Tropical Diseases. 10, 2, 19 p., e0004446.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

Timms, R. T., Tchasovnikarova, I. A., Antrobus, R., Dougan, G. & Lehner, P. J., 11 Oct 2016, In : Cell Reports. 17, 3, p. 653-659 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Binding of plasmodium falciparum merozoite surface proteins DBLMSP and DBLMSP2 to human immunoglobulin M Is conserved among broadly diverged sequence variants

Crosnier, C., Iqbal, Z., Knuepfer, E., Maciuca, S., Perrin, A. J., Kamuyu, G., Goulding, D., Bustamante, L. Y., Miles, A., Moore, S. C., Dougan, G., Holder, A. A., Kwiatkowski, D. P., Rayner, J. C., Pleass, R. J. & Wright, G. J., 1 Jul 2016, In : Journal of Biological Chemistry. 291, 27, p. 14285-14299 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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C13orf31 (FAMIN) is a central regulator of immunometabolic function

Cader, M. Z., Boroviak, K., Zhang, Q., Assadi, G., Kempster, S. L., Sewell, G. W., Saveljeva, S., Ashcroft, J. W., Clare, S., Mukhopadhyay, S., Brown, K. P., Tschurtschenthaler, M., Raine, T., Doe, B., Chilvers, E. R., Griffin, J. L., Kaneider, N. C., Floto, R. A., D'Amato, M., Bradley, A. & 3 othersWakelam, M. J. O., Dougan, G. & Kaser, A., 1 Aug 2016, In : Nature Immunology. 17, 9, p. 1046-1056 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family

Heinz, E., Stubenrauch, C. J., Grinter, R., Croft, N. P., Purcell, A. W., Strugnell, R. A., Dougan, G. & Lithgow, T., 13 Jun 2016, In : Genome Biology and Evolution. 8, 6, p. 1690-1705 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Differential killing of Salmonella enterica serovar Typhi by antibodies targeting VI and lipopolysaccharide O:9 antigen

Hart, P. J., O'Shaughnessy, C. M., Siggins, M. K., Bobat, S., Kingsley, R. A., Goulding, D. A., Crump, J. A., Reyburn, H., Micoli, F., Dougan, G., Cunningham, A. F. & MacLennan, C. A., 7 Jan 2016, In : PLoS ONE. 11, 1, 17 p., e0145945.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Discovery and characterization of human-urine utilization by asymptomatic-bacteriuria-causing Streptococcus agalactiae

Ipe, D. S., Ben Zakour, N. L., Sullivan, M. J., Beatson, S. A., Ulett, K. B., Benjamin, W. H., Davies, M. R., Dando, S. J., King, N. P., Cripps, A. W., Schembri, M. A., Dougan, G. & Ulett, G. C., Jan 2016, In : Infection and Immunity. 84, 1, p. 307-319 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

Feasey, N. A., Hadfield, J., Keddy, K. H., Dallman, T. J., Jacobs, J., Deng, X., Wigley, P., Barquist Barquist, L., Langridge, G. C., Feltwell, T., Harris, S. R., Mather, A. E., Fookes, M., Aslett, M., Msefula, C., Kariuki, S., MacLennan, C. A., Onsare, R. S., Weill, F. X., Le Hello, S. & 27 othersSmith, A. M. A., McClelland, M., Desai, P., Parry, C. M., Cheesbrough, J., French, N., Campos, J., Chabalgoity, J. A., Betancor, L., Hopkins, K. L., Nair, S., Humphrey, T. J., Lunguya, O., Cogan, T. A., Tapia, M. D., Sow, S. O., Tennant, S. M., Bornstein, K., Levine, M. M., Lacharme-Lora, L., Everett, D. B., Kingsley, R. A., Parkhill, J., Heyderman, R. S., Dougan, G., Gordon, M. A. & Thomson, N. R., 1 Oct 2016, In : Nature Genetics. 48, 10, p. 1211-1217 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host

Klemm, E. J., Gkrania-Klotsas, E., Hadfield, J., Forbester, J. L., Harris, S. R., Hale, C., Heath, J. N., Wileman, T., Clare, S., Kane, L., Goulding, D., Otto, T. D., Kay, S., Doffinger, R., Cooke, F. J., Carmichael, A., Lever, A. M. L., Parkhill, J., MacLennan, C. A., Kumararatne, D. & 2 othersDougan, G. & Kingsley, R. A., 25 Jan 2016, In : Nature Microbiology. 1, 3, 6 p., 15023.

Research output: Contribution to journalArticleResearchpeer-review

Evolution of atypical enteropathogenic E. Coli by repeated acquisition of LEE pathogenicity island variants

Ingle, D. J., Tauschek, M., Edwards, D. J., Hocking, D. M., Pickard, D. J., Azzopardi, K. I., Amarasena, T. H., Bennett-Wood, V. R., Pearson, J. S., Tamboura, B., Antonio, M., Ochieng, J. B., Oundo, J., Mandomando, I., Qureshi, S. M., Ramamurthy, T., Hossain, A., Kotloff, K. L., Nataro, J. P., Dougan, G. & 3 othersLevine, M. M., Robins-Browne, R. M. & Holt, K. E., 18 Jan 2016, In : Nature Microbiology. 1, 2, 9 p., 15010.

Research output: Contribution to journalArticleResearchpeer-review

Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1

Holt, K., Kenyon, J. J., Hamidian, M., Schultz, M. B., Pickard, D. J., Dougan, G. & Hall, R., 9 Feb 2016, In : Microbial genomics. 2, 2, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

Timms, R. T., Menzies, S. A., Tchasovnikarova, I. A., Christensen, L. C., Williamson, J. C., Antrobus, R., Dougan, G., Ellgaard, L. & Lehner, P. J., 10 Jun 2016, In : Nature Communications. 7, 10 p., 11786.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence

Kumar, N., Miyajima, F., He, M., Roberts, P., Swale, A., Ellison, L., Pickard, D., Smith, G., Molyneux, R., Dougan, G., Parkhill, J., Wren, B. W., Parry, C. M., Pirmohamed, M. & Lawley, T. D., 15 Mar 2016, In : Clinical Infectious Diseases. 62, 6, p. 746-752 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Infection susceptibility in gastric intrinsic factor (Vitamin B12)- defective mice is subject to maternal influences

Mottram, L., Speak, A. O., Selek, R. M., Cambridge, E. L., McIntyre, Z., Kane, L., Mukhopadhyay, S., Grove, C., Colin, A., Brandt, C., Duque-Correa, M. A., Forbester, J. L., Nguyen, T. A. P., Hale, C., Vasilliou, G. S., Arends, M. J., Wren, B. W., Dougan, G. & Clare, S., May 2016, In : mBio. 7, 3, 10 p., e00830-16.

Research output: Contribution to journalArticleResearchpeer-review

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Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever

Blohmke, C. J., Darton, T. C., Jones, C., Suarez, N. M., Waddington, C. S., Angus, B., Zhou, L., Hill, J. W., Clare, S., Kane, L., Mukhopadhyay, S., Schreiber, F., Duque-Correa, M. A., Wright, J. C., Roumeliotis, T. I., Yu, L., Choudhary, J. S., Mejias, A., Ramilo, O., Shanyinde, M. & 7 othersSztein, M. B., Kingsley, R. A., Lockhart, S., Levine, M. M., Lynn, D. J., Dougan, G. & Pollard, A. J., 1 May 2016, In : Journal of Experimental Medicine. 213, 6, p. 1061-1077 17 p.

Research output: Contribution to journalArticleResearchpeer-review

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Invasive group a Streptococcus infection among children, rural Kenya

Seale, A. C., Davies, M. R., Anampiu, K., Morpeth, S. C., Nyongesa, S., Mwarumba, S., Smeesters, P. R., Efstratiou, A., Karugutu, R., Mturi, N., Williams, T. N., Scott, J. A. G., Kariuki, S., Dougan, G. & Berkley, J. A., 1 Feb 2016, In : Emerging infectious diseases. 22, 2, p. 224-232 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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Microevolution of monophasic Salmonella typhimurium during epidemic, United Kingdom, 2005–2010

Petrovska, L., Mather, A. E., Abuoun, M., Branchu, P., Harris, S. R., Connor, T. R., Hopkins, K. L., Underwood, A., Lettini, A. A., Page, A., Bagnall, M., Wain, J., Parkhill, J., Dougan, G., Davies, R. & Kingsley, R. A., 1 Apr 2016, In : Emerging infectious diseases. 22, 4, p. 617-624 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

Burr, S. P., Costa, A. S. H., Grice, G. L., Timms, R. T., Lobb, I. T., Freisinger, P., Dodd, R. B., Dougan, G., Lehner, P. J., Frezza, C. & Nathan, J. A., 8 Nov 2016, In : Cell Metabolism. 24, 5, p. 740-752 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa

International Typhoid Consortium, Wong, V. K., Holt, K. E., Okoro, C., Baker, S., Pickard, D. J., Marks, F., Page, A. J., Olanipekun, G., Munir, H., Alter, R., Fey, P. D., Feasey, N. A., Weill, F-X., Le Hello, S., Hart, P. J., Kariuki, S., Breiman, R. F., Gordon, M. A., Heyderman, R. S. & 12 othersJacobs, J., Lunguya, O., Msefula, C., MacLennan, C. A., Keddy, K. H., Smith, A. M. A., Onsare, R. S., De Pinna, E., Nair, S., Amos, B., Dougan, G. & Obaro, S., 22 Sep 2016, In : PLoS Neglected Tropical Diseases. 10, 9, 22 p., e0004781.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain

Pérez-Vázquez, M., Oteo, J., García-Cobos, S., Aracil, B., Harris, S. R., Ortega, A., Fontanals, D., Hernández, J. M., Solís, S., Campos, J., Dougan, G. & Kingsley, R. A., 1 Apr 2016, In : Journal of Antimicrobial Chemotherapy. 71, 4, p. 887-896 10 p., dkv458.

Research output: Contribution to journalArticleResearchpeer-review

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Quantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations

Maggiore, L., Yu, L., Omasits, U., Rossi, O., Dougan, G., Thomson, N. R., Saul, A., Choudhary, J. S. & Gerke, C., 1 Feb 2016, In : International Journal of Medical Microbiology. 306, 2, p. 99-108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process

Karlsson, S. L., Thomson, N. R., Mutreja, A., Connor, T. R., Sur, D., Ali, M., Clemens, J., Dougan, G., Holmgren, J. & Lebens, M., 5 Oct 2016, In : PLoS Neglected Tropical Diseases. 10, 10, 11 p., e0005044.

Research output: Contribution to journalArticleResearchpeer-review

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Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

Yu, Y., Tsang, J. C. H., Wang, Y-C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L. S., Lu, L., Belz, G. T., McKenzie, A. N. J., Teichmann, S. A., Dougan, G. & Liu, P., 29 Sep 2016, In : Nature. 539, 7627, p. 102-106 5 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell fate and clonality inference from single-cell transcriptomes

Stubbington, M. J. T., Lönnberg, T., Proserpio, V., Clare, S., Speak, A. O., Dougan, G. & Teichmann, S. A., Apr 2016, In : Nature Methods. 13, 4, p. 329-332 4 p.

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The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia

Pham Thanh, D., Thompson, C. N., Rabaa, M. A., Sona, S., Sopheary, S., Kumar, V., Moore, C., Tran Vu Thieu, N., Wijedoru, L., Holt, K. E., Wong, V., Pickard, D., Thwaites, G. E., Day, N., Dougan, G., Turner, P., Parry, C. M. & Baker, S., 22 Jun 2016, In : PLoS Neglected Tropical Diseases. 10, 6, 16 p., e0004785.

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Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a

Darton, T. C., Jones, C., Blohmke, C. J., Waddington, C. S., Zhou, L., Peters, A., Haworth, K., Sie, R., Green, C. A., Jeppesen, C. A., Moore, M., Thompson, B. A. V., John, T., Kingsley, R. A., Yu, L. M., Voysey, M., Hindle, Z., Lockhart, S., Sztein, M. B., Dougan, G. & 3 othersAngus, B., Levine, M. M. & Pollard, A. J., 17 Aug 2016, In : PLoS Neglected Tropical Diseases. 10, 8, 27 p., e0004926.

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2015

Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model

McArthur, M. A., Fresnay, S., Magder, L. S., Darton, T. C., Jones, C., Waddington, C. S., Blohmke, C. J., Dougan, G., Angus, B., Levine, M. M., Pollard, A. J. & Sztein, M. B., 22 May 2015, In : PLoS Pathogens. 11, 5, 18 p., e1004914.

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Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors

Joffré, E., von Mentzer, A., Abd El Ghany, M., Oezguen, N., Savidge, T., Dougan, G., Svennerholm, A. M. & Sjöling, Å., 2015, In : Journal of Bacteriology. 197, 2, p. 392-403 12 p.

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