Gonzalo del Monte Nieto

Dr

Accepting PhD Students

20072022
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Dr Gonzalo del Monte-Nieto received his PhD in 2011 from the Autonoma University of Madrid (Spain), training in molecular and developmental biology supervised by Prof José Luis de la Pompa and on 3D image analysis by Prof Antoon Moorman (the Netherlands). During this time, he developed a protocol for monitoring the Notch1 activity during development that not only helped to describe for the first time the cells and tissues where the Notch pathway is active in the developing embryo and adult tissues, but also to decode complex developmental processes such as cardiac ventricular trabeculation, valvulogenesis and somitogenesis. Furthermore, his PhD work determined for the first time the role of the Notch pathway during epicardium and coronary artery formation. In 2011, he joined Prof Richard Harvey laboratory at Victor Chang Cardiac Research Institute (Sydney). His research focus lays in the study of the molecular mechanisms and developmental processes orchestrating heart development and the translation of this knowledge into congenital heart disease and cardiac regeneration. On this regard, his recent research has described a new revolutionary model for cardiac chamber development with special focus in trabeculation by integrating the cellular and extracellular components of the heart with important implications for better understanding congenital and adult heart disease.

Research interests

  • To study the molecular mechanisms and developmental processes controlling heart development.
  • To understand the molecular and cellular etiology of Congenital Heart Disease.
  • To study ECM composition/patterning during heart development, adulthood and disease/injury models.
  • To develop computational models for the different developmental processes in the heart.
  • To apply the knowledge generated from developmental biology to improve heart regeneration, organ-on-a-chip technologies and tissue engineering.

Education/Academic qualification

Molecular Biology, PhD Degree, Universidad Autonoma de Madrid (Autonomous University of Madrid)

Molecular Biology, Masters Degree, Universidad Autonoma de Madrid (Autonomous University of Madrid)

20052007

Biology, Bachelor Degree, Universidad Autonoma de Madrid (Autonomous University of Madrid)

20002005

Molecular Biology, PhD

External positions

Con-joint Senior Lecturer , The University of New South Wales

20152018

Senior Postdoctoral Scientist, Victor Chang Cardiac Research Institute

20152018

Postdoctoral Scientist, Victor Chang Cardiac Research Institute

20112015

PhD Student, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) (Spanish National Center for Cardiovascular Research)

20092011

Short-Stay PhD student, Amsterdam UMC

2008

PhD Student, Centro Nacional de Biotecnologia/CSIC, Madrid, Spain

20072009

Masters Student, Centro Nacional de Biotecnologia/CSIC, Madrid, Spain

20062007

Undergraduate training student, Centro Nacional de Biotecnologia/CSIC, Madrid, Spain

20032006

Keywords

  • Developmental Biology
  • Developmental Origins of Health and Disease
  • Congenital Disease
  • heart disease
  • Regenerative Medicine
  • Organ on chip
  • Genetic Models

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2022

Research Output 2007 2019

Gene-environment interaction impacts on heart development and embryo survival

Moreau, J. L. M., Kesteven, S., Martin, E. M. M. A., Lau, K. S., Yam, M. X., O'Reilly, V. C., Del Monte-Nieto, G., Baldini, A., Feneley, M. P., Moon, A. M., Harvey, R. P., Sparrow, D. B., Chapman, G. & Dunwoodie, S. L., 20 Feb 2019, In : Development. 146, 4, 13 p., dev172957.

Research output: Contribution to journalArticleResearchpeer-review

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation

del Monte-Nieto, G., Ramialison, M., Adam, A. A. S., Wu, B., Aharonov, A., D’uva, G., Bourke, L. M., Pitulescu, M. E., Chen, H., de la Pompa, J. L., Shou, W., Adams, R. H., Harten, S. K., Tzahor, E., Zhou, B. & Harvey, R. P., 9 May 2018, In : Nature. 557, 7705, p. 439-445 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

Conway, J. R. W., Warren, S. C., Herrmann, D., Murphy, K. J., Cazet, A. S., Vennin, C., Shearer, R. F., Killen, M. J., Magenau, A., Mélénec, P., Pinese, M., Nobis, M., Zaratzian, A., Boulghourjian, A., Da Silva, A. M., del Monte-Nieto, G., Adam, A. S. A., Harvey, R. P., Haigh, J. J., Wang, Y. & 6 othersCroucher, D. R., Sansom, O. J., Pajic, M., Caldon, C. E., Morton, J. P. & Timpson, P., 12 Jun 2018, In : Cell Reports. 23, 11, p. 3312-3326 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts

Nobis, M., Herrmann, D., Warren, S. C., Kadir, S., Leung, W., Killen, M., Magenau, A., Stevenson, D., Lucas, M. C., Reischmann, N., Vennin, C., Conway, J. R. W., Boulghourjian, A., Zaratzian, A., Law, A. M., Gallego-Ortega, D., Ormandy, C. J., Walters, S. N., Grey, S. T., Bailey, J. & 23 othersChtanova, T., Quinn, J. M. W., Baldock, P. A., Croucher, P. I., Schwarz, J. P., Mrowinska, A., Zhang, L., Herzog, H., Masedunskas, A., Hardeman, E. C., Gunning, P. W., del Monte-Nieto, G., Harvey, R. P., Samuel, M. S., Pajic, M., McGhee, E. J., Johnsson, A. K. E., Sansom, O. J., Welch, H. C. E., Morton, J. P., Strathdee, D., Anderson, K. I. & Timpson, P., 3 Oct 2017, In : Cell Reports. 21, 1, p. 274-288 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Elk1 in congenital and late onset heart disease: at the heart of the matter

Hallab, J., Bouveret, R., del Monte Nieto, G., Hesselson, D., Miles, L. B., Dworkin, S., Harvey, R. & Ramialison, M., Jul 2017, p. S30. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Open Access
File

Activities 2011 2019

  • 17 Peer review responsibility

Developmental Biology (Journal)

Gonzalo del Monte Nieto (Peer reviewer)
2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

Circulation Research (Journal)

Gonzalo del Monte Nieto (Peer reviewer)
2018

Activity: Publication peer-review and editorial work typesPeer review responsibility

Circulation Research (Journal)

Gonzalo del Monte Nieto (Peer reviewer)
2017

Activity: Publication peer-review and editorial work typesPeer review responsibility

PLoS ONE (Journal)

Gonzalo del Monte Nieto (Peer reviewer)
2017

Activity: Publication peer-review and editorial work typesPeer review responsibility

eLife (Journal)

Gonzalo del Monte Nieto (Peer reviewer)
2017

Activity: Publication peer-review and editorial work typesPeer review responsibility