Projects per year
Personal profile
Biography
Career Summary: Prof Glen Westall is a Consultant Chest Physician, and Head of the Paediatric Lung Transplant Program at the Alfred Hospital, Melbourne. He trained at King’s College London, and completed his respiratory training at the Alfred Hospital, Melbourne and Royal Brompton Hospital, London. Prof Westall successfully applied to the Australian Health Ministers’ Advisory Council (AHMAC) to have paediatric lung transplantation recognized as requiring National Funding Centre (NFC) status in Australia and for the service to be established at the Alfred Hospital. In addition, Prof Westall is a lead Consultant in Victoria’s largest dedicated Lung Fibrosis service that operates within the Department of Allergy, Immunology and Respiratory Medicine at the Alfred Hospital. Prof Westall has established and is principal investigator of open-access national tissue bank consisting of explanted lung tissue collected at the time of lung transplantation from patients with severe ILD. Prof Westall is an integral member of an Australian-wide network of ILD researchers that aims to establish lung cell lines derived from patients with ILD.
Research Support: Prof Westall oversees the research portfolio of the Alfred’s lung transplant service. As an academic clinician, he has established a number of translational projects with industry partners that have taken discoveries in basic science to the clinical interface. In particular he has established biorepositories that collect and store both normal lung tissue (from deceased patients whose families consent to release lung tissue for research) and fibrotic lungs. In addition, Prof Westall has established a biorepository of blood and BAL samples that are collected longitudinally on all patients undergoing lung transplantation. These transplant samples provide the basis of a research model that has resulted in a number of research collaborations whereby the immune response to infection (ever-present in the immunosuppressed host) and transplantation can be studied. Prof Westall has developed a wider interest into how activation of the innate immune system early post-lung transplant influences clinical outcomes. Establishing a research platform in pulmonary xenotransplantation has resulted in the award of an internationally competitive Career Development Award. Clinically, Prof Westall is a principal and co-investigator on numerous studies in viral immunity, lung fibrosis, and lung transplantation. Prof Westall is the principal investigator of a number of other transplant studies that have generated over $1 million in financial support over the past 5 years. Additionally, Prof Westall is a co-investigator in a large number of studies that have generated over $2 million research funding to The Alfred and Monash University.
External positions
Lung Transplant Physician, Alfred Health
1 Jun 2007 → 1 Dec 2020
Research area keywords
- lung transplant recipients
- Transplantation biology
- Lung Fibrosis
Network
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Functional Lung Imaging in the Assessment of Severe Lung Disease for Lung Transplantation: FIT Study
Snell, G., Westall, G., Whitford, H., Levin, K., Crowhurst, T., Vazirani, J., Kotecha, S. & Levvey, B.
4/10/21 → 31/12/24
Project: Research
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Free fatty acid receptors as novel bronchodilator targets in severe asthma
Bourke, J., Dubsky, S., Royce, S., Westall, G., Grainge, C., Oliver, B. G., Ulven, T. & Bardin, P.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/22
Project: Research
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NHMRC 2003 S/Ship - G Westall
National Health and Medical Research Council (NHMRC) (Australia)
3/02/03 → …
Project: Research
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Clinical imaging of CXCR4 in the development of an i-body therapy for idiopathic pulmonary fibrosis
Foley, M., Hagemeyer, C., Egan, G., Scott, A., Westall, G., Donnelly, P. S. & Alt, K.
1/02/20 → 31/12/21
Project: Research
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Establishing the best method for improving exercise capacity, symptoms and quality of life in IPF patients
Corte, T. J., Knight, D., Laurent, G., Holland, A., Chambers, D. C., Moodley, Y. P., Walters, E. H., Westall, G., Glaspole, I. & Palmer, A. J.
7/10/19 → 31/12/21
Project: Research
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CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
Hensen, L., Illing, P. T., Bridie Clemens, E., Nguyen, T. H. O., Koutsakos, M., van de Sandt, C. E., Mifsud, N. A., Nguyen, A. T., Szeto, C., Chua, B. Y., Halim, H., Rizzetto, S., Luciani, F., Loh, L., Grant, E. J., Saunders, P. M., Brooks, A. G., Rockman, S., Kotsimbos, T. C., Cheng, A. C. & 16 others, , 18 May 2021, In: Nature Communications. 12, 1, 20 p., 2931.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Nguyen, T. H. O., Rowntree, L. C., Petersen, J., Chua, B. Y., Hensen, L., Kedzierski, L., van de Sandt, C. E., Chaurasia, P., Tan, H. X., Habel, J. R., Zhang, W., Allen, L. F., Earnest, L., Mak, K. Y., Juno, J. A., Wragg, K., Mordant, F. L., Amanat, F., Krammer, F., Mifsud, N. A. & 22 others, , 11 May 2021, In: Immunity. 54, 5, p. 1066-1082.e5 23 p.Research output: Contribution to journal › Article › Research › peer-review
24 Citations (Scopus) -
Outcomes Following Extracorporeal Photopheresis for Chronic Lung Allograft Dysfunction Following Lung Transplantation: A Single-Center Experience
Vazirani, J., Routledge, D., Snell, G. I., Watson, D., Paraskeva, M., Westall, G. P. & Harrison, S. J., Jan 2021, In: Transplantation Proceedings. 53, 1, p. 296-302 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Physical activity decline is disproportionate to decline in pulmonary physiology in IPF
Prasad, J. D., Paul, E., Holland, A. E., Glaspole, I. N. & Westall, G. P., Dec 2021, In: Respirology. 26, 12, p. 1152-1159 8 p.Research output: Contribution to journal › Article › Research › peer-review
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A donor PaO2/FiO2 < 300 mm Hg does not determine graft function or survival after lung transplantation
Whitford, H., Kure, C. E., Henriksen, A., Hobson, J., Snell, G. I., Levvey, B. J., Marasco, S. F., Gooi, J. H., Zimmet, A., Negri, J., Pick, A., Buckland, M., Williams, T., Westall, G., Paraskeva, M. A., Martin, C. & McGiffin, D. C., 1 Jan 2020, In: The Journal of Heart and Lung Transplantation. 39, 1, p. 53-61 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus)