20112020

Research output per year

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Research Output

2020

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Xie, Y., Tummala, P., Oakley, A. J., Deora, G. S., Nakano, Y., Rooke, M., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Casarotto, M. G., Board, P. G. & Baell, J. B., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 2894-2914 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

Varghese, S., Rahmani, R., Russell, S., Deora, G. S., Ferrins, L., Toynton, A., Jones, A., Sykes, M., Kessler, A., Eufrásio, A., Cordeiro, A. T., Sherman, J., Rodriguez, A., Avery, V. M., Piggott, M. J. & Baell, J. B., 2020, In : ACS Medicinal Chemistry Letters. 11, 3, p. 278-285 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Zhang, S., Sakuma, M., Deora, G. S., Levy, C. W., Klausing, A., Breda, C., Read, K. D., Edlin, C. D., Ross, B. P., Wright Muelas, M., Day, P. J., O’Hagan, S., Kell, D. B., Schwarcz, R., Leys, D., Heyes, D. J., Giorgini, F. & Scrutton, N. S., 1 Dec 2019, In : Communications Biology. 2, 1, p. 1-10 10 p., 271.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Derivatives and analogues of resveratrol: Recent advances in structural modification

Li, Q. S., Li, Y., Deora, G. S. & Ruan, B. F., 1 Jan 2019, In : Mini-Reviews in Medicinal Chemistry. 19, 10, p. 809-825 17 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Estrogen Receptor α (ERα)-targeting Compounds and Derivatives: Recent Advances in Structural Modification and Bioactivity

Guo, W. Y., Zeng, S. M. Z., Deora, G. S., Li, Q. S. & Ruan, B. F., 1 Jan 2019, In : Current Topics in Medicinal Chemistry. 19, 15, p. 1318-1337 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents

Sharma, K., Tanwar, O., Deora, G. S., Ali, S., Alam, M. M., Zaman, M. S., Krishna, V. S., Sriram, D. & Akhter, M., 1 Jan 2019, In : Bioorganic & Medicinal Chemistry. 27, 7, p. 1421-1429 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Deora, G. S., Qin, C. X., Vecchio, E. A., Debono, A. J., Priebbenow, D. L., Brady, R. M., Beveridge, J., Teguh, S. C., Deo, M., May, L. T., Krippner, G., Ritchie, R. H. & Baell, J. B., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5242-5248 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Synthesis of novel benzimidazole acrylonitriles for inhibition of Plasmodium falciparum growth by dual target inhibition

Sharma, K., Shrivastava, A., Mehra, R. N., Deora, G. S., Alam, M. M., Zaman, M. S. & Akhter, M., 1 Jan 2018, In : Archiv der Pharmazie. 351, 1, 13 p., 1700251.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2017

2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents

Marie Kirwen, E., Batra, T., Karthikeyan, C., Deora, G. S., Rathore, V., Mulakayala, C., Mulakayala, N., Nusbaum, A. C., Chen, J., Amawi, H., McIntosh, K., Sahabjada, Shivnath, N., Chowarsia, D., Sharma, N., Arshad, M., Trivedi, P. & Tiwari, A. K., 1 Jan 2017, In : Acta Pharmaceutica Sinica B. 7, 1, p. 73-79 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Antibacterial Nanoparticles Based on Fluorescent 3-Substituted Uridine Analogue

Reddy, E. R., Yaseen, A. M., Rizvi, A., Deora, G. S., Banerjee, S., Sevilimedu, A. & Rajadurai, M., 1 Jan 2017, In : ChemistrySelect. 2, 1, p. 557-561 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation

Kantham, S., Chan, S., McColl, G., Miles, J. A., Veliyath, S. K., Deora, G. S., Dighe, S. N., Khabbazi, S., Parat, M. O. & Ross, B. P., 20 Sep 2017, In : ACS Chemical Neuroscience. 8, 9, p. 1901-1912 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Geldanamycin-inspired compounds induce direct trans-differentiation of human mesenchymal stem cells to neurons

Jogula, S., Soorneedi, A. R., Gaddam, J., Chamakuri, S., Deora, G. S., Indarapu, R. K., Ramgopal, M. K., Dravida, S. & Arya, P., 2017, In : European Journal of Medicinal Chemistry. 135, p. 110-116 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies

Deora, G. S., Kantham, S., Chan, S., Dighe, S. N., Veliyath, S. K., McColl, G., Parat, M. O., McGeary, R. P. & Ross, B. P., 20 Dec 2017, In : ACS Chemical Neuroscience. 8, 12, p. 2667-2675 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2016

Discovery and Structure−Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

Dighe, S. N., Deora, G. S., De La Mora, E., Nachon, F., Chan, S., Parat, M-O., Brazzolotto, X. & Ross, B. P., 25 Aug 2016, In : Journal of Medicinal Chemistry. 59, 16, p. 7683-7689 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
39 Citations (Scopus)

Macrocyclic Toolbox from Epothilone Fragment Identifies a Compound Showing Molecular Interactions with Actin and Novel Promoters of Apoptosis in Patient-derived Brain Tumor Cells

Dasari, B., Fufa, T., Aeluri, M., Gaddam, J., Deora, G. S., Gaunitz, F., Kitambi, S. S. & Arya, P., 1 Aug 2016, In : Asian Journal of Organic Chemistry. 5, 8, p. 976-980 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

Alam, M. J., Alam, O., Khan, S. A., Naim, M. J., Islamuddin, M. & Deora, G. S., 31 Oct 2016, In : Drug Design, Development and Therapy. 10, p. 3529-3543 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)
2015

Stereoselective synthesis of rapamycin fragment to build a macrocyclic toolbox

Guduru, S. K. R., Jimmidi, R., Deora, G. S. & Arya, P., 6 Feb 2015, In : Organic Letters. 17, 3, p. 480-483 4 p.

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)
2014

Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: their evaluation as novel and potential insulin secretagogues

Reddy, S. V., Rao, G. M., Kumar, B. V., Reddy, K. N., Sravya, K., Goverdhan, P., Rathore, V., Deora, G. S. & Pal, M., 2014, In : MedChemComm. 5, 5, p. 587-592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

Kolli, S. K., Nakhi, A., Archana, S., Saridena, M., Deora, G. S., Yellanki, S., Medisetti, R., Kulkarni, P., Ramesh Raju, R. & Pal, M., 30 Oct 2014, In : European Journal of Medicinal Chemistry. 86, p. 270-278 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations

Tanwar, O., Deora, G. S., Tanwar, L., Kumar, G., Janardhan, S., Alam, M. M., Shaquiquzzaman, M. & Akhter, M., 2014, In : Journal of Molecular Modeling. 20, 4, 16 p., 2118.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Pd/C-mediated arylation followed by I2-catalyzed hydration strategy: preparation of functionalized novel indanone derivatives

Dulla, B., Kolli, S. K., Chamakura, U. R., Deora, G. S., Raju, R. R. & Pal, M., 19 May 2014, In : Synthetic Communications. 44, 10, p. 1466-1474 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Synthesis of 2,2,4-trimethyl-1,2-dihydroquinolinyl substituted 1,2,3-triazole derivatives: their evaluation as potential PDE 4B inhibitors possessing cytotoxic properties against cancer cells

Praveena, K. S. S., Durgadas, S., Suresh Babu, N., Akkenapally, S., Ganesh Kumar, C., Deora, G. S., Murthy, N. Y. S., Mukkanti, K. & Pal, S., Apr 2014, In : Bioorganic Chemistry. 53, p. 8-14 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Synthesis of N-(3-arylprop-2-ynyl)substituted olanzapine derivatives as potential inhibitors of PDE4B

Babu, P. V., Gorja, D. R., Meda, C. L. T., Deora, G. S., Kolli, S. K., Parsa, K. V. L., Mukkanti, K. & Pal, M., 14 May 2014, In : Tetrahedron Letters. 55, 20, p. 3176-3180 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2013

Cu-mediated 1,3-dipolar cycloaddition of azomethine ylides with dipolarophiles: a faster access to spirooxindoles of potential pharmacological interest

Singh, S. N., Regati, S., Paul, A. K., Layek, M., Jayaprakash, S., Reddy, K. V., Deora, G. S., Mukherjee, S. & Pal, M., 2 Oct 2013, In : Tetrahedron Letters. 54, 40, p. 5448-5452 5 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Design, synthesis and biological evaluation of novel arylidine-malononitrile derivatives as non-carboxylic inhibitors of protein tyrosine phosphatase 1B

Deora, G. S., Karthikeyan, C., Moorthy, N. S. H. N., Rathore, V., Rawat, A. K., Tamrakar, A. K., Srivastava, A. K. & Trivedi, P., Nov 2013, In : Medicinal Chemistry Research. 22, 11, p. 5344-5348 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B

Rakse, M., Karthikeyan, C., Deora, G. S., Moorthy, N. S. H. N., Rathore, V., Rawat, A. K., Srivastava, A. K. & Trivedi, P., 2013, In : European Journal of Medicinal Chemistry. 70, p. 469-476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Facile assembly of two 6-membered fused N-heterocyclic rings: a rapid access to novel small molecules via Cu-mediated reaction

Adepu, R., Sunke, R., Meda, C. L. T., Rambabu, D., Krishna, G. R., Reddy, C. M., Deora, G. S., Parsa, K. V. L. & Pal, M., 7 Jan 2013, In : Chemical Communications. 49, 2, p. 190-192 3 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Identification of ZINC02765569: a potent inhibitor of PTP1B by vHTS

Joshi, P., Deora, G. S., Rathore, V., Tanwar, O., Rawat, A. K., Srivastava, A. K. & Jain, D., Jan 2013, In : Medicinal Chemistry Research. 22, 1, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity

Ohlyan, R., Kandale, A., Deora, G. S., Rathore, V. & Chahal, J., Mar 2013, In : Medicinal Chemistry Research. 22, 3, p. 1365-1370 6 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo

Babu, P. V., Mukherjee, S., Deora, G. S., Chennubhotla, K. S., Medisetti, R., Yellanki, S., Kulkarni, P., Sripelly, S., Parsa, K. V. L., Chatti, K., Mukkanti, K. & Pal, M., 21 Oct 2013, In : Organic and Biomolecular Chemistry. 11, 39, p. 6680-6685 6 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Molecular modeling and synthesis of ZINC02765569 derivatives as protein tyrosine phosphatase 1B inhibitors: lead optimization study

Joshi, P., Deora, G. S., Rathore, V., Rawat, A. K., Srivastava, A. K. & Jain, D., Apr 2013, In : Medicinal Chemistry Research. 22, 4, p. 1618-1623 6 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Novel imidazophenoxazine-4-sulfonamides: their synthesis and evaluation as potential inhibitors of PDE4

Reddy, S. V., Rao, G. M., Kumar, B. V., Meda, C. L. T., Deora, G. S., Kumar, K. S., Parsa, K. V. L. & Pal, M., 1 Apr 2013, In : Bioorganic & Medicinal Chemistry. 21, 7, p. 1952-1963 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors

Gorja, D. R., Mukherjee, S., Meda, C. L. T., Deora, G. S., Lalith Kumar, K., Jain, A., Chaudhari, G. H., Chennubhotla, K. S., Banote, R. K., Kulkarni, P., Parsa, K. V. L., Mukkanti, K. & Pal, M., 7 Apr 2013, In : Organic and Biomolecular Chemistry. 11, 13, p. 2075-2079 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Pharmacophore modeling and 3D QSAR analysis of isothiazolidinedione derivatives as PTP1B inhibitors

Deora, G. S., Joshi, P., Rathore, V., Kumar, K. L., Ohlyan, R. & Kandale, A., Jul 2013, In : Medicinal Chemistry Research. 22, 7, p. 3478-3484 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2′-quinazolines

Rambabu, D., Raja, G., Yogi Sreenivas, B., Seerapu, G. P. K., Lalith Kumar, K., Deora, G. S., Haldar, D., Rao, M. V. B. & Pal, M., 1 Mar 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 5, p. 1351-1357 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

Dulla, B., Kirla, K. T., Rathore, V., Deora, G. S., Kavela, S., Maddika, S., Chatti, K., Reiser, O., Iqbal, J. & Pal, M., 2013, In : Organic and Biomolecular Chemistry. 11, 19, p. 3103-3107 5 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)
2012

AgNO3 mediated C-N bond forming reaction: synthesis of 3-substituted benzothiazines as potential COX inhibitors

Rambabu, D., Murthy, P. V. N. S., Prasad, K. R. S., Kandale, A., Deora, G. S., Basaveswara Rao, M. V. & Pal, M., 28 Nov 2012, In : Tetrahedron Letters. 53, 48, p. 6577-6583 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interest

Prasad, B., Adepu, R., Sandra, S., Rambabu, D., Krishna, G. R., Reddy, C. M., Deora, G. S., Misra, P. & Pal, M., 28 Oct 2012, In : Chemical Communications. 48, 84, p. 10434-10436 3 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents

Patel, K., Karthikeyan, C., Hari Narayana Moorthy, N. S., Deora, G. S., Solomon, V. R., Lee, H. & Trivedi, P., Aug 2012, In : Medicinal Chemistry Research. 21, 8, p. 1780-1784 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Modeling VEGFR kinase inhibition of aminopyrazolopyridine urea derivatives using topological and physicochemical descriptors: a quantitative structure activity analysis study

Pandey, A. K., Tanwar, O., Deora, G. S., Karthikeyan, C., Hari Narayana Moorthy, N. S. & Trivedi, P., 2012, In : Medicinal Chemistry Research. 21, 12, p. 3958–3964 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay

Nakhi, A., Rahman, M. S., Kishore, R., Meda, C. L. T., Deora, G. S., Parsa, K. V. L. & Pal, M., 15 Oct 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 20, p. 6433-6441 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents

Tonk, R. K., Bawa, S., Chawla, G., Deora, G. S., Kumar, S., Rathore, V., Mulakayala, N., Rajaram, A., Kalle, A. M. & Afzal, O., Nov 2012, In : European Journal of Medicinal Chemistry. 57, p. 176-184 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)
2011

Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines

Patel, K., Karthikeyan, C., Solomon, V. R., Moorthy, N. S. H. N., Lee, H., Sahu, K., Deora, G. S. & Trivedi, P., May 2011, In : Letters in Drug Design and Discovery. 8, 4, p. 308-311 4 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)