Gilda Tachedjian

Adj Prof

1990 …2019

Research output per year

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Research Output

2008

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

Figueiredo, A., Zelina, S., Sluis-Cremer, N. & Tachedjian, G., 2008, In : Current HIV Research. 6, 2, p. 130 - 137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

Sluis-Cremer, N. & Tachedjian, G., 2008, In : Virus Research. 134, 1-2, p. 147 - 156 10 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)
2007

4th International AIDS Society Conference on HIV pathogenesis, treatment and prevention

Maher, L., Tachedjian, G., Hoy, J. F., Millwood, I., Guy, R. J., Walsh, N. M., Zaunders, J. J., Jaworowski, A. & Kaldor, J. M., 1 Dec 2007, In : Medical Journal of Australia. 187, 11-12, p. 610-612 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4th International AIDS society conference on HIV pathogenesis treatment and prevention (conference report)

Maher, L., Cooper, D. (ed.), Tachedjian, G., Hoy, J. F., Millwood, I., Guy, R. J., Walsh, N. M., Zaunders, J. J., Jaworowski, A. & Kaldor, J. M., 2007, p. 610 - 612. 3 p.

Research output: Contribution to conferenceOther

Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner

Hill, M. K., Bellamy-McIntyre, A. K., Vella, L. J., Campbell, S. M., Marshall, J. A., Tachedjian, G. & Mak, J., 2007, In : Current HIV Research. 5, 1, p. 69 - 78 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT

Nissley, D. V., Radzio, J., Ambrose, Z., Sheen, C-W., Hamamouch, N., Moore, K. L., Tachedjian, G. & Sluis-Cremer, N., 2007, In : Biochemical Journal. 404, 1, p. 151 - 157 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

Yap, S. H., Sheen, C-W., Fahey, J. P., Zanin, M., Tyssen, D., Dias Lima, V., Wynhoven, B., Kuiper, M., Sluis-Cremer, N., Harrigan, R. & Tachedjian, G., 2007, In : PLoS Medicine. 4, 12, p. e335-1 - e335-14 14 p.

Research output: Contribution to journalArticleOther

144 Citations (Scopus)

Targeting human immunodeficiency virus Type 1 assembly, maturation and budding

Wapling, J. A., Srivastava, S., Shehu-Xhilaga, M. & Tachedjian, G., 2007, In : Drug Target Insights. 2, p. 159 - 182 24 p.

Research output: Contribution to journalArticleResearchpeer-review

The mutation N3481 in the connection domain of the HIV-1 reverse transcriptase is selected in vivo and confers decreased susceptibility to zidovudine and nevirapine

Hope, T. (ed.), Yap, S. H., Wynhoven, B., Landau, N. (ed.), Lewis, J. A., Kuiper, M., Sheen, C-W., Zanin, M., Sluis-Cremer, N., Harrigan, R. & Tachedjian, G., 2007, p. 232 - 232. 1 p.

Research output: Contribution to conferenceAbstract

2006

Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target

Srivastava, S., Sluis-Cremer, N. & Tachedjian, G., 2006, In : Current Pharmaceutical Design. 12, 15, p. 1879 - 1894 16 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.

Figueiredo, A., Moore, K. L., Mak, J., Sluis-Cremer, N., de Bethune, M-P. & Tachedjian, G., 2006, In : PLoS Pathogens. 2, 11, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation

Buxton, P., Tachedjian, G. & Mak, J., 2005, In : Journal of Virology. 79, 10, p. 6338 - 6348 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1

Shehu-Xhilaga, M., Tachedjian, G., Crowe, S. M. & Kedzierska, K., 2005, In : Current Medicinal Chemistry. 12, 15, p. 1705 - 1719 14 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

Tachedjian, G., Moore, K. L., Goff, S. P. & Sluis-Cremer, N., 2005, In : FEBS Letters. 579, 2, p. 379 - 384 6 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Evaluation of a low cost reverse transcriptase assay for plasma HIV-1 viral load monitoring

Greengrass, V. L., Turnbull, S. P., Hocking, J., Dunne, A. L., Tachedjian, G., Corrigan, G. E. & Crowe, S. M., 2005, In : Current HIV Research. 3, 2, p. 183 - 190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer

Wapling, J. A., Moore, K. L., Sonza, S., Mak, J. & Tachedjian, G., 2005, In : Journal of Virology. 79, 16, p. 10247 - 10257 11 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Relationship between enzyme activity and dimeric structure of recombinant HTV-1 reverse transcriptase

Tachedjian, G., Radzio, J. & Sluis-Cremer, N., 2005, In : Proteins: Structure, Function, and Bioinformatics. 60, 1, p. 5 - 13 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The packaging and maturation of the HIV-1 Pol proteins

Hill, M. K., Tachedjian, G. & Mak, J., 2005, In : Current HIV Research. 3, 1, p. 73 - 85 13 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)
2004

Virological significance, prevalence and genetic basis of hypersusceptibility to nonnucleoside reverse transcriptase inhibitors

Tachedjian, G. & Mijch, A. M., 2004, In : Sexual Health. 1, 2, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2003

The effect of NNRTIs on HIV reverse transcriptase dimerization

Tachedjian, G. & Goff, S. P., 1 Aug 2003, In : Current Opinion in Investigational Drugs. 4, 8, p. 966-973 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

39 Citations (Scopus)
1995

Reverse transcriptase mutations in sequential HIV‐1 isolates in a patient with AIDS

Gurusinghe, A. D., Land, S. A., Birch, C., McGavin, C., Hooker, D. J., Tachedjian, G., Doherty, R. & Deacon, N. J., 1 Jan 1995, In : Journal of Medical Virology. 46, 3, p. 238-243 6 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
1994

Long‐term foscarnet therapy not associated with the development of foscarnet‐resistant human immunodeficiency virus type 1 in an acquired immunodeficiency syndrome patient

Tachedjian, G., Hoy, J., McGavin, K. & Birch, C., 1 Jan 1994, In : Journal of Medical Virology. 42, 2, p. 207-211 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
1992

Clinical effects and in vitro studies of trifluorothymidine combined with interferon-α for treatment of drug-resistant and -sensitive herpes simplex virus infections

Birch, C. J., Tyssen, D. P., Tachedjian, G., Doherty, R., Hayes, K., Mijch, A. & Lucas, C. R., 1 Jan 1992, In : Journal of Infectious Diseases. 166, 1, p. 108-112 5 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
1990

Altered sensitivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndrome

Birch, C. J., Tachedjian, G., Doherty, R. R., Hayes, K. & Gust, I. D., 1 Jan 1990, In : Journal of Infectious Diseases. 162, 3, p. 731-734 4 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)