Gilda Tachedjian

Adj Prof

1990 …2019
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Research Output 1990 2019

Abstract

Drug Resistant SIV Strains Carrying Higher-Fidelity K65R and Q151N Reverse Transcriptase Mutations Are Less Fit In Vivo

Lloyd, S. B., Batista, F. (ed.), Kramski, M., Amarasena, T. H., Alcantara, S., Gooneratne, S., Tachedjian, G., De Rose, R., Kent, S. J. & Winnall, W. R., 2014, p. 185 - 185. 1 p.

Research output: Contribution to conferenceAbstract

Lactic Acid, a Vaginal Microbiota Metabolite, Elicits an Anti-inflammatory Response from Vaginal and Cervical Epithelial Cells

Hearps, A. C., Batista, F. (ed.), Gugasyan, R., Srbinovski, D., Tyssen, D. P., Aldunate, M. C., Anderson, D. J., Cone, R. & Tachedjian, G., 2014, p. 238 - 239. 2 p.

Research output: Contribution to conferenceAbstract

The mutation N3481 in the connection domain of the HIV-1 reverse transcriptase is selected in vivo and confers decreased susceptibility to zidovudine and nevirapine

Hope, T. (ed.), Yap, S. H., Wynhoven, B., Landau, N. (ed.), Lewis, J. A., Kuiper, M., Sheen, C-W., Zanin, M., Sluis-Cremer, N., Harrigan, R. & Tachedjian, G., 2007, p. 232 - 232. 1 p.

Research output: Contribution to conferenceAbstract

Vaginal Concentrations of Lactic Acid Potently Inactivate HIV-1 Compared to Short Chain Fatty Acids Present During Bacterial Vaginosis

Aldunate, M. C., Batista, F. (ed.), Tyssen, D. P., Latham, C. F. M., Ramsland, P. A., Perlmutter, P., Moench, T. R., Cone, R. & Tachedjian, G., 2014, p. 228 - 228. 1 p.

Research output: Contribution to conferenceAbstract

Article

4th International AIDS Society Conference on HIV pathogenesis, treatment and prevention

Maher, L., Tachedjian, G., Hoy, J. F., Millwood, I., Guy, R. J., Walsh, N. M., Zaunders, J. J., Jaworowski, A. & Kaldor, J. M., 1 Dec 2007, In : Medical Journal of Australia. 187, 11-12, p. 610-612 3 p.

Research output: Contribution to journalArticleResearchpeer-review

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner

Hill, M. K., Bellamy-McIntyre, A. K., Vella, L. J., Campbell, S. M., Marshall, J. A., Tachedjian, G. & Mak, J., 2007, In : Current HIV Research. 5, 1, p. 69 - 78 10 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Altered sensitivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndrome

Birch, C. J., Tachedjian, G., Doherty, R. R., Hayes, K. & Gust, I. D., 1 Jan 1990, In : Journal of Infectious Diseases. 162, 3, p. 731-734 4 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation

Buxton, P., Tachedjian, G. & Mak, J., 2005, In : Journal of Virology. 79, 10, p. 6338 - 6348 11 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Aldunate, M. C., Srbinovski, D., Hearps, A. C., Latham, C. F., Ramsland, P. A., Gugasyan, R., Cone, R. A. & Tachedjian, G., 2015, In : Frontiers in Physiology. 6, 23 p., 164.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)

Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1

Shehu-Xhilaga, M., Tachedjian, G., Crowe, S. M. & Kedzierska, K., 2005, In : Current Medicinal Chemistry. 12, 15, p. 1705 - 1719 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Bats and rodents shape mammalian retroviral phylogeny

Cui, J., Tachedjian, G. & Wang, L-F., 2015, In : Scientific Reports. 5, 7 p., 16561.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Biology of mucosally transmitted sexual infection-translating the basic science into novel HIV intervention: a workshop summary

Purcell, D., Cunningham, A. L., Turville, S., Tachedjian, G. & Landay, A., 2012, In : AIDS Research and Human Retroviruses. 28, 11, p. 1389 - 1396 8 p.

Research output: Contribution to journalArticleOther

22 Citations (Scopus)

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT

Nissley, D. V., Radzio, J., Ambrose, Z., Sheen, C-W., Hamamouch, N., Moore, K. L., Tachedjian, G. & Sluis-Cremer, N., 2007, In : Biochemical Journal. 404, 1, p. 151 - 157 7 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Clinical effects and in vitro studies of trifluorothymidine combined with interferon-α for treatment of drug-resistant and -sensitive herpes simplex virus infections

Birch, C. J., Tyssen, D. P., Tachedjian, G., Doherty, R., Hayes, K., Mijch, A. & Lucas, C. R., 1 Jan 1992, In : Journal of Infectious Diseases. 166, 1, p. 108-112 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Combination anti-HIV therapy: Via tandem release of prodrugs from macromolecular carriers

Danial, M., Telwatte, S., Tyssen, D. P., Cosson, S., Tachedjian, G., Moad, G. & Postma, A., 28 Dec 2016, In : Polymer Chemistry. 7, 48, p. 7477-7487 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Combined oral contraceptive pill-exposure alone does not reduce the risk of bacterial vaginosis recurrence in a pilot randomised controlled trial

Vodstrcil, L. A., Plummer, M. E., Fairley, C. K., Tachedjian, G., Law, M. G., Hocking, J. S., Worthington, M. K., Grant, M. M., Okoko, N. & Bradshaw, C. S., 5 Mar 2019, In : Scientific Reports. 9, 1, 13 p., 3555.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
68 Citations (Scopus)

Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats

Zhou, P., Tachedjian, M., Wynne, J. W., Boyd, V., Cui, J., Smith, I., Cowled, C., Ng, J. H. J., Mok, L., Michalski, W. P., Mendenhall, I. H., Tachedjian, G., Wang, L-F. & Baker, M. L., 8 Mar 2016, In : Proceedings of the National Academy of Sciences. 113, 10, p. 2696-2701 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
95 Citations (Scopus)

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

Henriques, S. T., Huang, Y-H., Rosengren, J., Franquelim, H., Carvalho, F., Johnson, A., Sonza, S., Tachedjian, G., Castanho, M. A. R. B., Daly, N. & Craik, D., 2011, In : Journal of Biological Chemistry. 286, 27, p. 24231 - 24241 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Differential evolution of antiretroviral restriction factors in pteropid bats as revealed by APOBEC3 gene complexity

Hayward, J. A., Tachedjian, M., Cui, J., Cheng, A. Z., Johnson, A., Baker, M. L., Harris, R. S., Wang, L. F. & Tachedjian, G., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 7, p. 1626-1637 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)

Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target

Srivastava, S., Sluis-Cremer, N. & Tachedjian, G., 2006, In : Current Pharmaceutical Design. 12, 15, p. 1879 - 1894 16 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses

Cui, J., Tachedjian, M., Wang, L., Tachedjian, G., Wang, L-F. & Zhang, S., 2012, In : Journal of Virology. 86, 8, p. 4288 - 4293 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

Tachedjian, G., Moore, K. L., Goff, S. P. & Sluis-Cremer, N., 2005, In : FEBS Letters. 579, 2, p. 379 - 384 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Sonza, S., Johnson, A., Tyssen, D., Spelman, T. D., Lewis, G. R., Paull, J. R. A. & Tachedjian, G., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 8, p. 3565 - 3568 4 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Evaluation of a low cost reverse transcriptase assay for plasma HIV-1 viral load monitoring

Greengrass, V. L., Turnbull, S. P., Hocking, J., Dunne, A. L., Tachedjian, G., Corrigan, G. E. & Crowe, S. M., 2005, In : Current HIV Research. 3, 2, p. 183 - 190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fragment based strategies for discovery of novel HIV-1 reverse transcriptase and integrase inhibitors

Latham, C. F., La, J., Tinetti, R. N., Chalmers, D. K. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1135-1153 19 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo

Lloyd, S. B., Lichtfuss, M., Amarasena, T. H., Alcantara, S., De Rose, R., Tachedjian, G., Alinejad-Rokny, H., Venturi, V., Davenport, M. P., Winnall, W. R. & Kent, S. J., May 2016, In : Virology. 492, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: A Nef-dependent phenomenon

Cornall, A. M., Mak, J., Greenway, A. & Tachedjian, G., 2013, In : Viruses. 5, 9, p. 2235 - 2252 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

Hayward, J. A., Tachedjian, M., Cui, J., Field, H., Holmes, E. C., Wang, L-F. & Tachedjian, G., 2013, In : Retrovirology. 10, 1, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Identification of diverse groups of endogenous gammaretroviruses in mega and microbats

Cui, J., Tachedjian, G., Tachedjian, M., Holmes, E. C., Zhang, S. & Wang, L-F., 2012, In : Journal of General Virology. 93, Pt 9, p. 2037 - 2045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

La, J., Latham, C. F. M., Tinetti, R. N., Johnson, A. P., Tyssen, D. P., Huber, K. D., Sluis-Cremer, N., Simpson, J. S., Headey, S. J., Chalmers, D. K. & Tachedjian, G., 2015, In : Proceedings of the National Academy of Sciences. 112, 22, p. 6979-6984 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Identification of residues involved in NS2 homodimerization and elucidation of their impact on the HCV life cycle

Gorzin, A. A., Ramsland, P. A., Tachedjian, G. & Gowans, E. J., 2012, In : Journal of Viral Hepatitis. 19, 3, p. 189 - 198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

Figueiredo, A., Zelina, S., Sluis-Cremer, N. & Tachedjian, G., 2008, In : Current HIV Research. 6, 2, p. 130 - 137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase

Telwatte, S., Brumme, C. J., Hearps, A. C., Latham, C. F. M., Hayward, J. A., Sonza, S., Sluis-Cremer, N., Harrigan, P. R. & Tachedjian, G., 28 Nov 2016, In : AIDS. 30, 18, p. 2787-2793 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Long‐term foscarnet therapy not associated with the development of foscarnet‐resistant human immunodeficiency virus type 1 in an acquired immunodeficiency syndrome patient

Tachedjian, G., Hoy, J., McGavin, K. & Birch, C., 1 Jan 1994, In : Journal of Medical Virology. 42, 2, p. 207-211 5 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Maturation of the HIV reverse transcription complex: Putting the jigsaw together

Warrilow, D., Tachedjian, G. & Harrich, D., 2009, In : Reviews in Medical Virology. 19, 6, p. 324 - 337 14 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

Sluis-Cremer, N. & Tachedjian, G., 2008, In : Virus Research. 134, 1-2, p. 147 - 156 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
46 Citations (Scopus)

Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer

Wapling, J. A., Moore, K. L., Sonza, S., Mak, J. & Tachedjian, G., 2005, In : Journal of Virology. 79, 16, p. 10247 - 10257 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

N3481 in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine

Yap, S. H., Herman, B. D., Radzio, J., Sluis-Cremer, N. & Tachedjian, G., 2012, In : JAIDS. 61, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

Sluis-Cremer, N., Moore, K., Radzio, J., Sonza, S. & Tachedjian, G., 2010, In : AIDS. 24, 2, p. 317 - 319 3 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

Radzio, J., Yap, S-H., Tachedjian, G. & Sluis-Cremer, N., 2010, In : AIDS. 24, 5, p. 659 - 667 9 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

Yap, S. H., Sheen, C-W., Fahey, J. P., Zanin, M., Tyssen, D., Dias Lima, V., Wynhoven, B., Kuiper, M., Sluis-Cremer, N., Harrigan, R. & Tachedjian, G., 2007, In : PLoS Medicine. 4, 12, p. e335-1 - e335-14 14 p.

Research output: Contribution to journalArticleOther

8 Citations (Scopus)

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients

Rezaei, S. D., Hearps, A. C., Mills, J., Pedersen, J. S. & Tachedjian, G., 2013, In : Virology Journal. 10, p. 1 - 9 9 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Nonnucleoside reverse transcriptase inhibitors reduce HIV-1 production from latently infected resting CD4+ T cells following latency reversal

Zerbato, J. M., Tachedjian, G. & Sluis-Cremer, N., 1 Mar 2017, In : Antimicrobial Agents and Chemotherapy. 61, 3, 5 p., e01736.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

Henriques, S. T., Huang, Y-H., Castanho, M. A. R. B., Bagatolli, L. A., Sonza, S., Tachedjian, G., Daly, N. L. & Craik, D. J., 2012, In : Journal of Biological Chemistry. 287, 40, p. 33629 - 33643 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.

Figueiredo, A., Moore, K. L., Mak, J., Sluis-Cremer, N., de Bethune, M-P. & Tachedjian, G., 2006, In : PLoS Pathogens. 2, 11, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Relationship between enzyme activity and dimeric structure of recombinant HTV-1 reverse transcriptase

Tachedjian, G., Radzio, J. & Sluis-Cremer, N., 2005, In : Proteins: Structure, Function, and Bioinformatics. 60, 1, p. 5 - 13 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Reverse transcriptase mutations in sequential HIV‐1 isolates in a patient with AIDS

Gurusinghe, A. D., Land, S. A., Birch, C., McGavin, C., Hooker, D. J., Tachedjian, G., Doherty, R. & Deacon, N. J., 1 Jan 1995, In : Journal of Medical Virology. 46, 3, p. 238-243 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Sensitive Assessment of the Virologic Outcomes of Stopping and Restarting Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy

Geretti, A. M., Fox, Z., Johnson, J. A., Booth, C., Lipscomb, J., Stuyver, L. J., Tachedjian, G., Baxter, J., Touloumi, G., Lehmann, C., Owen, A. R. & Phillips, A., 18 Jul 2013, In : PLoS ONE. 8, 7, e69266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access