Gilda Tachedjian

Adj Prof

1990 …2019
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Research Output 1990 2019

1990
56 Citations (Scopus)

Altered sensitivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndrome

Birch, C. J., Tachedjian, G., Doherty, R. R., Hayes, K. & Gust, I. D., 1 Jan 1990, In : Journal of Infectious Diseases. 162, 3, p. 731-734 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
57 Citations (Scopus)

Clinical effects and in vitro studies of trifluorothymidine combined with interferon-α for treatment of drug-resistant and -sensitive herpes simplex virus infections

Birch, C. J., Tyssen, D. P., Tachedjian, G., Doherty, R., Hayes, K., Mijch, A. & Lucas, C. R., 1 Jan 1992, In : Journal of Infectious Diseases. 166, 1, p. 108-112 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
9 Citations (Scopus)

Long‐term foscarnet therapy not associated with the development of foscarnet‐resistant human immunodeficiency virus type 1 in an acquired immunodeficiency syndrome patient

Tachedjian, G., Hoy, J., McGavin, K. & Birch, C., 1 Jan 1994, In : Journal of Medical Virology. 42, 2, p. 207-211 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1995
20 Citations (Scopus)

Reverse transcriptase mutations in sequential HIV‐1 isolates in a patient with AIDS

Gurusinghe, A. D., Land, S. A., Birch, C., McGavin, C., Hooker, D. J., Tachedjian, G., Doherty, R. & Deacon, N. J., 1 Jan 1995, In : Journal of Medical Virology. 46, 3, p. 238-243 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
39 Citations (Scopus)

The effect of NNRTIs on HIV reverse transcriptase dimerization

Tachedjian, G. & Goff, S. P., 1 Aug 2003, In : Current Opinion in Investigational Drugs. 4, 8, p. 966-973 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2004
3 Citations (Scopus)

Virological significance, prevalence and genetic basis of hypersusceptibility to nonnucleoside reverse transcriptase inhibitors

Tachedjian, G. & Mijch, A. M., 2004, In : Sexual Health. 1, 2, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
17 Citations (Scopus)

Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation

Buxton, P., Tachedjian, G. & Mak, J., 2005, In : Journal of Virology. 79, 10, p. 6338 - 6348 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1

Shehu-Xhilaga, M., Tachedjian, G., Crowe, S. M. & Kedzierska, K., 2005, In : Current Medicinal Chemistry. 12, 15, p. 1705 - 1719 14 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

Tachedjian, G., Moore, K. L., Goff, S. P. & Sluis-Cremer, N., 2005, In : FEBS Letters. 579, 2, p. 379 - 384 6 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Evaluation of a low cost reverse transcriptase assay for plasma HIV-1 viral load monitoring

Greengrass, V. L., Turnbull, S. P., Hocking, J., Dunne, A. L., Tachedjian, G., Corrigan, G. E. & Crowe, S. M., 2005, In : Current HIV Research. 3, 2, p. 183 - 190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer

Wapling, J. A., Moore, K. L., Sonza, S., Mak, J. & Tachedjian, G., 2005, In : Journal of Virology. 79, 16, p. 10247 - 10257 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Relationship between enzyme activity and dimeric structure of recombinant HTV-1 reverse transcriptase

Tachedjian, G., Radzio, J. & Sluis-Cremer, N., 2005, In : Proteins: Structure, Function, and Bioinformatics. 60, 1, p. 5 - 13 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

The packaging and maturation of the HIV-1 Pol proteins

Hill, M. K., Tachedjian, G. & Mak, J., 2005, In : Current HIV Research. 3, 1, p. 73 - 85 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
29 Citations (Scopus)

Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target

Srivastava, S., Sluis-Cremer, N. & Tachedjian, G., 2006, In : Current Pharmaceutical Design. 12, 15, p. 1879 - 1894 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.

Figueiredo, A., Moore, K. L., Mak, J., Sluis-Cremer, N., de Bethune, M-P. & Tachedjian, G., 2006, In : PLoS Pathogens. 2, 11, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

4th International AIDS Society Conference on HIV pathogenesis, treatment and prevention

Maher, L., Tachedjian, G., Hoy, J. F., Millwood, I., Guy, R. J., Walsh, N. M., Zaunders, J. J., Jaworowski, A. & Kaldor, J. M., 1 Dec 2007, In : Medical Journal of Australia. 187, 11-12, p. 610-612 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4th International AIDS society conference on HIV pathogenesis treatment and prevention (conference report)

Maher, L., Cooper, D. (ed.), Tachedjian, G., Hoy, J. F., Millwood, I., Guy, R. J., Walsh, N. M., Zaunders, J. J., Jaworowski, A. & Kaldor, J. M., 2007, p. 610 - 612. 3 p.

Research output: Contribution to conferenceOther

3 Citations (Scopus)

Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner

Hill, M. K., Bellamy-McIntyre, A. K., Vella, L. J., Campbell, S. M., Marshall, J. A., Tachedjian, G. & Mak, J., 2007, In : Current HIV Research. 5, 1, p. 69 - 78 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT

Nissley, D. V., Radzio, J., Ambrose, Z., Sheen, C-W., Hamamouch, N., Moore, K. L., Tachedjian, G. & Sluis-Cremer, N., 2007, In : Biochemical Journal. 404, 1, p. 151 - 157 7 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

Yap, S. H., Sheen, C-W., Fahey, J. P., Zanin, M., Tyssen, D., Dias Lima, V., Wynhoven, B., Kuiper, M., Sluis-Cremer, N., Harrigan, R. & Tachedjian, G., 2007, In : PLoS Medicine. 4, 12, p. e335-1 - e335-14 14 p.

Research output: Contribution to journalArticleOther

Targeting human immunodeficiency virus Type 1 assembly, maturation and budding

Wapling, J. A., Srivastava, S., Shehu-Xhilaga, M. & Tachedjian, G., 2007, In : Drug Target Insights. 2, p. 159 - 182 24 p.

Research output: Contribution to journalArticleResearchpeer-review

The mutation N3481 in the connection domain of the HIV-1 reverse transcriptase is selected in vivo and confers decreased susceptibility to zidovudine and nevirapine

Hope, T. (ed.), Yap, S. H., Wynhoven, B., Landau, N. (ed.), Lewis, J. A., Kuiper, M., Sheen, C-W., Zanin, M., Sluis-Cremer, N., Harrigan, R. & Tachedjian, G., 2007, p. 232 - 232. 1 p.

Research output: Contribution to conferenceAbstract

2008
18 Citations (Scopus)

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

Figueiredo, A., Zelina, S., Sluis-Cremer, N. & Tachedjian, G., 2008, In : Current HIV Research. 6, 2, p. 130 - 137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

Sluis-Cremer, N. & Tachedjian, G., 2008, In : Virus Research. 134, 1-2, p. 147 - 156 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
4 Citations (Scopus)

Effect of reverse transcriptase inhibitors and mutations on the low-cost Cavidi reverse transcriptase viral load assay

van Rooijen, L., Greengrass, V., Morris, L. M., Plate, M., Gouillou, M., Tachedjian, G., Sluis-Cremer, N., Hearps, A. & Crowe, S. M., 2009, In : JAIDS. 52, 4, p. 527 - 529 3 p.

Research output: Contribution to journalLetterOther

8 Citations (Scopus)

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Sonza, S., Johnson, A., Tyssen, D., Spelman, T. D., Lewis, G. R., Paull, J. R. A. & Tachedjian, G., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 8, p. 3565 - 3568 4 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Maturation of the HIV reverse transcription complex: Putting the jigsaw together

Warrilow, D., Tachedjian, G. & Harrich, D., 2009, In : Reviews in Medical Virology. 19, 6, p. 324 - 337 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs

Ambrose, Z., Herman, B. D., Sheen, C-W., Zelina, S., Moore, K. L., Tachedjian, G., Nissley, D. V. & Sluis-Cremer, N., 2009, In : Journal of Virology. 83, 8, p. 3826 - 3833 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
20 Citations (Scopus)

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

Sluis-Cremer, N., Moore, K., Radzio, J., Sonza, S. & Tachedjian, G., 2010, In : AIDS. 24, 2, p. 317 - 319 3 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

Radzio, J., Yap, S-H., Tachedjian, G. & Sluis-Cremer, N., 2010, In : AIDS. 24, 5, p. 659 - 667 9 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Structure activity relationship of dendrimer microbicides with dual action antiviral activity

Tyssen, D., Henderson, S. A., Johnson, A., Sterjovski, J., Moore, K., La, J., Zanin, M. P., Sonza, S., Karellas, P., Giannis, M., Krippner, G. Y., Wesselingh, S. L., McCarthy, T. D., Gorry, P. R., Ramsland, P. A., Cone, R., Paull, J. RA., Lewis, G. R. & Tachedjian, G., 2010, In : PLoS ONE. 5, 8 (e12309), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Ubisol-AquaTM: Coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model

Cherry, C. L., Mobarok, M., Wesselingh, S. L., Fain, R., Weinstock, S., Tachedjian, G., Srivastava, S., Tyssen, D. P., Glass, J. D. & Hooker, D. J., 2010, In : Current HIV Research. 8, 3, p. 232 - 239 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
95 Citations (Scopus)

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

Henriques, S. T., Huang, Y-H., Rosengren, J., Franquelim, H., Carvalho, F., Johnson, A., Sonza, S., Tachedjian, G., Castanho, M. A. R. B., Daly, N. & Craik, D., 2011, In : Journal of Biological Chemistry. 286, 27, p. 24231 - 24241 11 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

SPL7013 Gel (VivaGel) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans

Price, C. F., Tyssen, D., Sonza, S., Davie, A., Evans, S., Lewis, G. R., Xia, S., Spelman, T. D., Hodsman, P., Moench, T. R., Humberstone, A. J., Paull, J. RA. & Tachedjian, G., 2011, In : PLoS ONE. 6, 9, 12 p., e24095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
64 Citations (Scopus)

Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1

Telwatte, S., Moore, K., Johnson, A., Tyssen, D., Sterjovski, J., Aldunate, M., Gorry, P. R., Ramsland, P., Lewis, G., Paull, J., Sonza, S. & Tachedjian, G., 2011, In : Antiviral Research. 90, 3, p. 195 - 199 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
5 Citations (Scopus)

Biology of mucosally transmitted sexual infection-translating the basic science into novel HIV intervention: a workshop summary

Purcell, D., Cunningham, A. L., Turville, S., Tachedjian, G. & Landay, A., 2012, In : AIDS Research and Human Retroviruses. 28, 11, p. 1389 - 1396 8 p.

Research output: Contribution to journalArticleOther

34 Citations (Scopus)

Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses

Cui, J., Tachedjian, M., Wang, L., Tachedjian, G., Wang, L-F. & Zhang, S., 2012, In : Journal of Virology. 86, 8, p. 4288 - 4293 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Host-pathogen interactions of retroviruses

Waheed, A., Brass, A. L., Gummuluru, S. & Tachedjian, G., 2012, In : Molecular Biology International. 2012, 648512, p. 1 - 4 4 p.

Research output: Contribution to journalLetterOther

33 Citations (Scopus)

Identification of diverse groups of endogenous gammaretroviruses in mega and microbats

Cui, J., Tachedjian, G., Tachedjian, M., Holmes, E. C., Zhang, S. & Wang, L-F., 2012, In : Journal of General Virology. 93, Pt 9, p. 2037 - 2045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Identification of residues involved in NS2 homodimerization and elucidation of their impact on the HCV life cycle

Gorzin, A. A., Ramsland, P. A., Tachedjian, G. & Gowans, E. J., 2012, In : Journal of Viral Hepatitis. 19, 3, p. 189 - 198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

N3481 in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine

Yap, S. H., Herman, B. D., Radzio, J., Sluis-Cremer, N. & Tachedjian, G., 2012, In : JAIDS. 61, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

Henriques, S. T., Huang, Y-H., Castanho, M. A. R. B., Bagatolli, L. A., Sonza, S., Tachedjian, G., Daly, N. L. & Craik, D. J., 2012, In : Journal of Biological Chemistry. 287, 40, p. 33629 - 33643 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
5 Citations (Scopus)

HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: A Nef-dependent phenomenon

Cornall, A. M., Mak, J., Greenway, A. & Tachedjian, G., 2013, In : Viruses. 5, 9, p. 2235 - 2252 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

Hayward, J. A., Tachedjian, M., Cui, J., Field, H., Holmes, E. C., Wang, L-F. & Tachedjian, G., 2013, In : Retrovirology. 10, 1, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients

Rezaei, S. D., Hearps, A. C., Mills, J., Pedersen, J. S. & Tachedjian, G., 2013, In : Virology Journal. 10, p. 1 - 9 9 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Role of RNase H activity in NRTI/NNRTI drug resistance

Tachedjian, G. & Sluis-Cremer, N., 1 Nov 2013, Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-Bedside Success. Springer, p. 281-303 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

13 Citations (Scopus)

Sensitive Assessment of the Virologic Outcomes of Stopping and Restarting Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy

Geretti, A. M., Fox, Z., Johnson, J. A., Booth, C., Lipscomb, J., Stuyver, L. J., Tachedjian, G., Baxter, J., Touloumi, G., Lehmann, C., Owen, A. R. & Phillips, A., 18 Jul 2013, In : PLoS ONE. 8, 7, e69266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes

Gray, L. R., Tachedjian, G., Ellett, A., Roche, M. J., Cheng, W-J., Guillemin, G. J., Brew, B. J., Turville, S., Wesselingh, S. L., Gorry, P. R. & Churchill, M., 2013, In : PLoS ONE. 8, 4, 7 p., e62196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

The seventh (and last?) International Microbicides Conference: from discovery to delivery

McGregor, S., Tachedjian, G., Haire, B. G. & Kaldor, J. M., 2013, In : Sexual Health. 10, 3, p. 240 - 245 6 p.

Research output: Contribution to journalArticleOther

68 Citations (Scopus)

Vaginal concentrations of lactic acid potently inactivate HIV

Aldunate, M. C., Tyssen, D., Johnson, A., Zakir, T. S., Sonza, S., Moench, T. R., Cone, R. & Tachedjian, G., 2013, In : Journal of Antimicrobial Chemotherapy. 68, 9, p. 2015 - 2025 11 p.

Research output: Contribution to journalArticleResearchpeer-review