Gilda Tachedjian

Adj Assoc Prof

1990 …2019
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Research Output 1990 2019

2019

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Combined oral contraceptive pill-exposure alone does not reduce the risk of bacterial vaginosis recurrence in a pilot randomised controlled trial

Vodstrcil, L. A., Plummer, M. E., Fairley, C. K., Tachedjian, G., Law, M. G., Hocking, J. S., Worthington, M. K., Grant, M. M., Okoko, N. & Bradshaw, C. S., 5 Mar 2019, In : Scientific Reports. 9, 1, 13 p., 3555.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission

McKinnon, L. R., Achilles, S. L., Bradshaw, C. S., Burgener, A., Crucitti, T., Fredricks, D. N., Jaspan, H. B., Kaul, R., Kaushic, C., Klatt, N., Kwon, D. S., Marrazzo, J. M., Masson, L., McClelland, R. S., Ravel, J., van de Wijgert, J. H. H. M., Vodstrcil, L. A. & Tachedjian, G., 1 Mar 2019, In : AIDS Research and Human Retroviruses. 35, 3, p. 219-228 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Differential evolution of antiretroviral restriction factors in pteropid bats as revealed by APOBEC3 gene complexity

Hayward, J. A., Tachedjian, M., Cui, J., Cheng, A. Z., Johnson, A., Baker, M. L., Harris, R. S., Wang, L. F. & Tachedjian, G., 1 Jan 2018, In : Molecular Biology and Evolution. 35, 7, p. 1626-1637 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Nonnucleoside reverse transcriptase inhibitors reduce HIV-1 production from latently infected resting CD4+ T cells following latency reversal

Zerbato, J. M., Tachedjian, G. & Sluis-Cremer, N., 1 Mar 2017, In : Antimicrobial Agents and Chemotherapy. 61, 3, 5 p., e01736.

Research output: Contribution to journalArticleResearchpeer-review

The role of lactic acid production by probiotic Lactobacillus species in vaginal health

Tachedjian, G., Aldunate, M., Bradshaw, C. S. & Cone, R. A., Nov 2017, In : Research in Microbiology. 168, 9-10, p. 782-792 11 p.

Research output: Contribution to journalArticleOtherpeer-review

Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition

Hearps, A. C., Tyssen, D., Srbinovski, D., Bayigga, L., Diaz, D. J. D., Aldunate, M., Cone, R. A., Gugasyan, R., Anderson, D. J. & Tachedjian, G., 1 Nov 2017, In : Mucosal Immunology. 10, 6, p. 1480-1490 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Combination anti-HIV therapy: Via tandem release of prodrugs from macromolecular carriers

Danial, M., Telwatte, S., Tyssen, D. P., Cosson, S., Tachedjian, G., Moad, G. & Postma, A., 28 Dec 2016, In : Polymer Chemistry. 7, 48, p. 7477-7487 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats

Zhou, P., Tachedjian, M., Wynne, J. W., Boyd, V., Cui, J., Smith, I., Cowled, C., Ng, J. H. J., Mok, L., Michalski, W. P., Mendenhall, I. H., Tachedjian, G., Wang, L-F. & Baker, M. L., 8 Mar 2016, In : Proceedings of the National Academy of Sciences. 113, 10, p. 2696-2701 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Current and emerging drug targets for human immunodeficiency virus

Waheed, A. A. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1072-1073 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Fragment based strategies for discovery of novel HIV-1 reverse transcriptase and integrase inhibitors

Latham, C. F., La, J., Tinetti, R. N., Chalmers, D. K. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1135-1153 19 p.

Research output: Contribution to journalArticleResearchpeer-review

High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo

Lloyd, S. B., Lichtfuss, M., Amarasena, T. H., Alcantara, S., De Rose, R., Tachedjian, G., Alinejad-Rokny, H., Venturi, V., Davenport, M. P., Winnall, W. R. & Kent, S. J., May 2016, In : Virology. 492, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase

Telwatte, S., Brumme, C. J., Hearps, A. C., Latham, C. F. M., Hayward, J. A., Sonza, S., Sluis-Cremer, N., Harrigan, P. R. & Tachedjian, G., 28 Nov 2016, In : AIDS. 30, 18, p. 2787-2793 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanisms of HIV transmission in Depo-Provera users: The likely role of Hypoestrogenism

Hickey, M., Marino, J. L. & Tachedjian, G., 1 Jan 2016, In : JAIDS. 71, 1, p. 1-7 7 p.

Research output: Contribution to journalScientific ReviewResearchpeer-review

Open Access
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Perspectives in medicinal chemistry: Why do we need new drug classes for HIV treatment and prevention?

Waheed, A. A. & Tachedjian, G., 1 May 2016, In : Current Topics in Medicinal Chemistry. 16, 12, p. 1343-1349 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2015

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Aldunate, M. C., Srbinovski, D., Hearps, A. C., Latham, C. F., Ramsland, P. A., Gugasyan, R., Cone, R. A. & Tachedjian, G., 2015, In : Frontiers in Physiology. 6, 23 p., 164.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Bats and rodents shape mammalian retroviral phylogeny

Cui, J., Tachedjian, G. & Wang, L-F., 2015, In : Scientific Reports. 5, 7 p., 16561.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

La, J., Latham, C. F. M., Tinetti, R. N., Johnson, A. P., Tyssen, D. P., Huber, K. D., Sluis-Cremer, N., Simpson, J. S., Headey, S. J., Chalmers, D. K. & Tachedjian, G., 2015, In : Proceedings of the National Academy of Sciences. 112, 22, p. 6979-6984 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

Telwatte, S., Hearps, A. C., Johnson, A. P., Latham, C. F., Moore, K. A., Agius, P. A., Tachedjian, M., Sonza, S., Sluis-Cremer, N., Harrigan, P. R. & Tachedjian, G., 2015, In : Nucleic Acids Research. 43, 6, p. 3256 - 3271 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Drug Resistant SIV Strains Carrying Higher-Fidelity K65R and Q151N Reverse Transcriptase Mutations Are Less Fit In Vivo

Lloyd, S. B., Batista, F. (ed.), Kramski, M., Amarasena, T. H., Alcantara, S., Gooneratne, S., Tachedjian, G., De Rose, R., Kent, S. J. & Winnall, W. R., 2014, p. 185 - 185. 1 p.

Research output: Contribution to conferenceAbstractOther

Lactic Acid, a Vaginal Microbiota Metabolite, Elicits an Anti-inflammatory Response from Vaginal and Cervical Epithelial Cells

Hearps, A. C., Batista, F. (ed.), Gugasyan, R., Srbinovski, D., Tyssen, D. P., Aldunate, M. C., Anderson, D. J., Cone, R. & Tachedjian, G., 2014, p. 238 - 239. 2 p.

Research output: Contribution to conferenceAbstractOther

Vaginal Concentrations of Lactic Acid Potently Inactivate HIV-1 Compared to Short Chain Fatty Acids Present During Bacterial Vaginosis

Aldunate, M. C., Batista, F. (ed.), Tyssen, D. P., Latham, C. F. M., Ramsland, P. A., Perlmutter, P., Moench, T. R., Cone, R. & Tachedjian, G., 2014, p. 228 - 228. 1 p.

Research output: Contribution to conferenceAbstractOther

2013

HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: A Nef-dependent phenomenon

Cornall, A. M., Mak, J., Greenway, A. & Tachedjian, G., 2013, In : Viruses. 5, 9, p. 2235 - 2252 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

Hayward, J. A., Tachedjian, M., Cui, J., Field, H., Holmes, E. C., Wang, L-F. & Tachedjian, G., 2013, In : Retrovirology. 10, 1, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients

Rezaei, S. D., Hearps, A. C., Mills, J., Pedersen, J. S. & Tachedjian, G., 2013, In : Virology Journal. 10, p. 1 - 9 9 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Role of RNase H activity in NRTI/NNRTI drug resistance

Tachedjian, G. & Sluis-Cremer, N., 1 Nov 2013, Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-Bedside Success. Springer, p. 281-303 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Sensitive Assessment of the Virologic Outcomes of Stopping and Restarting Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy

Geretti, A. M., Fox, Z., Johnson, J. A., Booth, C., Lipscomb, J., Stuyver, L. J., Tachedjian, G., Baxter, J., Touloumi, G., Lehmann, C., Owen, A. R. & Phillips, A., 18 Jul 2013, In : PLoS ONE. 8, 7, e69266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes

Gray, L. R., Tachedjian, G., Ellett, A., Roche, M. J., Cheng, W-J., Guillemin, G. J., Brew, B. J., Turville, S., Wesselingh, S. L., Gorry, P. R. & Churchill, M., 2013, In : PLoS ONE. 8, 4, 7 p., e62196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The seventh (and last?) International Microbicides Conference: from discovery to delivery

McGregor, S., Tachedjian, G., Haire, B. G. & Kaldor, J. M., 2013, In : Sexual Health. 10, 3, p. 240 - 245 6 p.

Research output: Contribution to journalArticleOther

Vaginal concentrations of lactic acid potently inactivate HIV

Aldunate, M. C., Tyssen, D., Johnson, A., Zakir, T. S., Sonza, S., Moench, T. R., Cone, R. & Tachedjian, G., 2013, In : Journal of Antimicrobial Chemotherapy. 68, 9, p. 2015 - 2025 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Biology of mucosally transmitted sexual infection-translating the basic science into novel HIV intervention: a workshop summary

Purcell, D., Cunningham, A. L., Turville, S., Tachedjian, G. & Landay, A., 2012, In : AIDS Research and Human Retroviruses. 28, 11, p. 1389 - 1396 8 p.

Research output: Contribution to journalArticleOther

Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses

Cui, J., Tachedjian, M., Wang, L., Tachedjian, G., Wang, L-F. & Zhang, S., 2012, In : Journal of Virology. 86, 8, p. 4288 - 4293 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Host-pathogen interactions of retroviruses

Waheed, A., Brass, A. L., Gummuluru, S. & Tachedjian, G., 2012, In : Molecular Biology International. 2012, 648512, p. 1 - 4 4 p.

Research output: Contribution to journalLetterOther

Identification of diverse groups of endogenous gammaretroviruses in mega and microbats

Cui, J., Tachedjian, G., Tachedjian, M., Holmes, E. C., Zhang, S. & Wang, L-F., 2012, In : Journal of General Virology. 93, Pt 9, p. 2037 - 2045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of residues involved in NS2 homodimerization and elucidation of their impact on the HCV life cycle

Gorzin, A. A., Ramsland, P. A., Tachedjian, G. & Gowans, E. J., 2012, In : Journal of Viral Hepatitis. 19, 3, p. 189 - 198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

N3481 in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine

Yap, S. H., Herman, B. D., Radzio, J., Sluis-Cremer, N. & Tachedjian, G., 2012, In : JAIDS. 61, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

Henriques, S. T., Huang, Y-H., Castanho, M. A. R. B., Bagatolli, L. A., Sonza, S., Tachedjian, G., Daly, N. L. & Craik, D. J., 2012, In : Journal of Biological Chemistry. 287, 40, p. 33629 - 33643 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

Henriques, S. T., Huang, Y-H., Rosengren, J., Franquelim, H., Carvalho, F., Johnson, A., Sonza, S., Tachedjian, G., Castanho, M. A. R. B., Daly, N. & Craik, D., 2011, In : Journal of Biological Chemistry. 286, 27, p. 24231 - 24241 11 p.

Research output: Contribution to journalArticleResearchpeer-review

SPL7013 Gel (VivaGel) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans

Price, C. F., Tyssen, D., Sonza, S., Davie, A., Evans, S., Lewis, G. R., Xia, S., Spelman, T. D., Hodsman, P., Moench, T. R., Humberstone, A. J., Paull, J. RA. & Tachedjian, G., 2011, In : PLoS ONE. 6, 9, 12 p., e24095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1

Telwatte, S., Moore, K., Johnson, A., Tyssen, D., Sterjovski, J., Aldunate, M., Gorry, P. R., Ramsland, P., Lewis, G., Paull, J., Sonza, S. & Tachedjian, G., 2011, In : Antiviral Research. 90, 3, p. 195 - 199 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

Sluis-Cremer, N., Moore, K., Radzio, J., Sonza, S. & Tachedjian, G., 2010, In : AIDS. 24, 2, p. 317 - 319 3 p.

Research output: Contribution to journalArticleResearchpeer-review

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

Radzio, J., Yap, S-H., Tachedjian, G. & Sluis-Cremer, N., 2010, In : AIDS. 24, 5, p. 659 - 667 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure activity relationship of dendrimer microbicides with dual action antiviral activity

Tyssen, D., Henderson, S. A., Johnson, A., Sterjovski, J., Moore, K., La, J., Zanin, M. P., Sonza, S., Karellas, P., Giannis, M., Krippner, G. Y., Wesselingh, S. L., McCarthy, T. D., Gorry, P. R., Ramsland, P. A., Cone, R., Paull, J. RA., Lewis, G. R. & Tachedjian, G., 2010, In : PLoS ONE. 5, 8 (e12309), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ubisol-AquaTM: Coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model

Cherry, C. L., Mobarok, M., Wesselingh, S. L., Fain, R., Weinstock, S., Tachedjian, G., Srivastava, S., Tyssen, D. P., Glass, J. D. & Hooker, D. J., 2010, In : Current HIV Research. 8, 3, p. 232 - 239 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Effect of reverse transcriptase inhibitors and mutations on the low-cost Cavidi reverse transcriptase viral load assay

van Rooijen, L., Greengrass, V., Morris, L. M., Plate, M., Gouillou, M., Tachedjian, G., Sluis-Cremer, N., Hearps, A. & Crowe, S. M., 2009, In : JAIDS. 52, 4, p. 527 - 529 3 p.

Research output: Contribution to journalLetterOther

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Sonza, S., Johnson, A., Tyssen, D., Spelman, T. D., Lewis, G. R., Paull, J. R. A. & Tachedjian, G., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 8, p. 3565 - 3568 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Maturation of the HIV reverse transcription complex: Putting the jigsaw together

Warrilow, D., Tachedjian, G. & Harrich, D., 2009, In : Reviews in Medical Virology. 19, 6, p. 324 - 337 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs

Ambrose, Z., Herman, B. D., Sheen, C-W., Zelina, S., Moore, K. L., Tachedjian, G., Nissley, D. V. & Sluis-Cremer, N., 2009, In : Journal of Virology. 83, 8, p. 3826 - 3833 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

Figueiredo, A., Zelina, S., Sluis-Cremer, N. & Tachedjian, G., 2008, In : Current HIV Research. 6, 2, p. 130 - 137 8 p.

Research output: Contribution to journalArticleResearchpeer-review