Projects per year
Personal profile
Biography
Our lab is focused on the regulation of autophagy, a major intracellular degradation process. In cancer, autophagy plays complex roles and can suppress tumours, but also helps tumour cells survive in other cases. Autophagy delivers cellular and cytoplasmic structures to the lysosome, where they are degraded. This process is tightly linked to the cellular metabolism and is an evolutionary conserved survival mechanism that helps cells to cope with nutrient starvation. We have recently discovered a link between metabolic control and the Serine/Threonine kinase ULK1, a key regulator of autophagy. We aim to get a detailed understanding of how these regulatory networks are causing changes in intracellular membrane trafficking during autophagy.
Research interests
Key interests are cell signalling, cellular trafficking, correlative microscopy, cryo EM, tomography, autophagy, mitophagy, mitochondria, cancer, diabetes.
Research area keywords
- microscopy
- imaging
- protein trafficking
- cryo EM
- cancer
- diabetes
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
3D Cryo Correlative Light and Electron Microscopy Facility
Ramm, G., Kile, B., Lithgow, T., O'Bryan, M. & Naderer, T.
1/01/18 → 31/12/19
Project: Other
Understanding how mitochondria divide
Ryan, M., Ramm, G. & Stroud, D.
Australian Research Council (ARC), Monash University
1/01/16 → 31/12/18
Project: Research
3D Cryo-FIBSEM Imaging Facility for Biological and Material Sciences.
Ramm, G., Arns, C., Bhaskaran, M., Etheridge, J., Fu, J., Gaus, K., Manefield, M., McCulloch, D. G. & Whisstock, J.
Australian Research Council (ARC), RMIT University, University of New South Wales, Monash University
1/01/15 → 31/12/17
Project: Research
A Video-Rate Nanoscopy Facility for Super-Resolution Imaging
Lithgow, T., Carroll, J., Gleeson, P. A., Hanssen, E. G., Hartland, E. L., Hertzog, P., Jans, D., Ramm, G. & Strugnell, R. A.
Australian Research Council (ARC), University of Melbourne, Monash University
1/01/15 → 31/12/15
Project: Research
Research Output
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 others, , 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.Research output: Contribution to journal › Article › Research › peer-review
101
Citations
(Scopus)
An improved procedure for subcellular spatial alignment during live-cell CLEM
Padman, B. S., Bach, M. & Ramm, G., 2014, In : PLoS ONE. 9, 4 (Art. No.: e95967), p. 1 - 13 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
9
Citations
(Scopus)
The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells
Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In : Autophagy. 9, 11, p. 1862 - 1875 14 p.Research output: Contribution to journal › Article › Research › peer-review
50
Citations
(Scopus)
Immuno correlative light and electron microscopy on tokuyasu cryosections
Oorschot, V. M., Sztal, T. E., Bryson-Richardson, R. J. & Ramm, G., 2014, In : Methods in Cell Biology. 124, p. 241 - 258 18 p.Research output: Contribution to journal › Article › Other
12
Citations
(Scopus)
KBTBD13 is an actin-binding protein that modulates muscle kinetics
De Winter, J. M., Molenaar, J. P., Yuen, M., Van Der Pijl, R., Shen, S., Conijn, S., Van De Locht, M., Willigenburg, M., Bogaards, S. J. P., Van Kleef, E. S. B., Lassche, S., Persson, M., Rassier, D. E., Sztal, T. E., Ruparelia, A. A., Oorschot, V., Ramm, G., Hall, T. E., Xiong, Z., Johnson, C. N. & 21 others, , 3 Feb 2020, In : Journal of Clinical Investigation. 130, 2, p. 754-767 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
2
Citations
(Scopus)
Activities
2nd CRYOZ conference
Georg Ramm (Organiser)
5 Jun 2019 → 7 Jun 2019
Activity: Participating in or organising an event types › Contribution to conference
1st AMMS Cryo EM Aus/NZ Meeting
Georg Ramm (Organiser)
2018
Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
President CRYOZ
Georg Ramm (Fellow)
2018 → 2021
Activity: External Academic Engagement › Professional association or peak discipline body