• Ramaciotti Centre for Cryo EM, 15 Innovation Walk, room G90, Ramaciotti Centre for Cryo EM

    3800 Clayton

    Australia

Accepting PhD Students

20002021
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Personal profile

Biography

Our lab is focused on the regulation of autophagy, a major intracellular degradation process. In cancer, autophagy plays complex roles and can suppress tumours, but also helps tumour cells survive in other cases. Autophagy delivers cellular and cytoplasmic structures to the lysosome, where they are degraded. This process is tightly linked to the cellular metabolism and is an evolutionary conserved survival mechanism that helps cells to cope with nutrient starvation. We have recently discovered a link between metabolic control and the Serine/Threonine kinase ULK1, a key regulator of autophagy. We aim to get a detailed understanding of how these regulatory networks are causing changes in intracellular membrane trafficking during autophagy.

Research interests

Key interests are cell signalling, cellular trafficking, correlative microscopy, cryo EM, tomography, autophagy, mitophagy, mitochondria, cancer, diabetes.

Keywords

  • microscopy, imaging, cryo EM, cancer, diabetes, protein trafficking

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2021

Research Output 2000 2018

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 othersLessene, G., Ryan, M. T., Rogers, K. L., Van Delft, M. F. & Kile, B. T., 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.

Research output: Contribution to journalArticleResearchpeer-review

An improved procedure for subcellular spatial alignment during live-cell CLEM

Padman, B. S., Bach, M. & Ramm, G., 2014, In : PLoS ONE. 9, 4 (Art. No.: e95967), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells

Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In : Autophagy. 9, 11, p. 1862 - 1875 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Immuno correlative light and electron microscopy on tokuyasu cryosections

Oorschot, V. M., Sztal, T. E., Bryson-Richardson, R. J. & Ramm, G., 2014, In : Methods in Cell Biology. 124, p. 241 - 258 18 p.

Research output: Contribution to journalArticleOther

Helicobacter pylori outer membrane vesicle size determines their mechanisms of host cell entry and protein content

Turner, L., Bitto, N. J., Steer, D. L., Lo, C., D'Costa, K., Ramm, G., Shambrook, M., Hill, A. F., Ferrero, R. L. & Kaparakis-Liaskos, M., 2 Jul 2018, In : Frontiers in Immunology. 9, 10 p., 1466.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activities 2018 2018

  • 1 Contribution to workshop, seminar, course

1st AMMS Cryo EM Aus/NZ Meeting

Georg Ramm (Organiser)
2018

Activity: Participating in or organising an event typesContribution to workshop, seminar, course