Projects per year
Personal profile
Biography
Our lab is focused on the regulation of autophagy, a major intracellular degradation process. In cancer, autophagy plays complex roles and can suppress tumours, but also helps tumour cells survive in other cases. Autophagy delivers cellular and cytoplasmic structures to the lysosome, where they are degraded. This process is tightly linked to the cellular metabolism and is an evolutionary conserved survival mechanism that helps cells to cope with nutrient starvation. We have recently discovered a link between metabolic control and the Serine/Threonine kinase ULK1, a key regulator of autophagy. We aim to get a detailed understanding of how these regulatory networks are causing changes in intracellular membrane trafficking during autophagy.
Research interests
Key interests are cell signalling, cellular trafficking, correlative microscopy, cryo EM, tomography, autophagy, mitophagy, mitochondria, cancer, diabetes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- microscopy
- imaging
- protein trafficking
- cryo EM
- cancer
- diabetes
Network
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A centre for structural cryo-electron microscopy
Whisstock, J., Dougan, D., Hoogenraad, N., Kvansakul, M., Lithgow, T., Puthalakath, H., Ramm, G., Rood, J., Stojanovski, D., Colman, P., Czabotar, P. E. & Lawrence, M. S.
1/01/12 → 31/12/13
Project: Research
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New generation direct electron detector for cryo-electron microscopy
Ramm, G., Whisstock, J., Lucet, I., Boecking, T., Landsberg, M. J., Alexandrov, K., Dunstone, M., Curmi, P. M. G., Lawrence, M. C., Lithgow, T., Watterson, D., Sexton, P. & Hankamer, B. D.
3/07/20 → 15/06/21
Project: Research
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Elucidating the mechanisms of mitochondrial DNA escape
Kile, B. & Ramm, G.
30/06/20 → 30/06/23
Project: Research
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High resolution digital camera for immuno EM; Installation cost for Joel 12200 EX; Ultracut UC7 with Cryochamber FC7
Ramm, G., Febbraio, M., Lackmann, M., Lithgow, T., Lyras, D., Mak, J., Mitchell, C., Rood, J., Smyth, I., Watt, M. & Whisstock, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/12/09 → 30/11/10
Project: Research
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 others, , 23 Feb 2018, In: Science. 359, 6378, 12 p., eaao6047.Research output: Contribution to journal › Article › Research › peer-review
305 Citations (Scopus) -
An improved procedure for subcellular spatial alignment during live-cell CLEM
Padman, B. S., Bach, M. & Ramm, G., 2014, In: PLoS ONE. 9, 4 (Art. No.: e95967), p. 1 - 13 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells
Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In: Autophagy. 9, 11, p. 1862 - 1875 14 p.Research output: Contribution to journal › Article › Research › peer-review
61 Citations (Scopus) -
Immuno correlative light and electron microscopy on tokuyasu cryosections
Oorschot, V. M., Sztal, T. E., Bryson-Richardson, R. J. & Ramm, G., 2014, In: Methods in Cell Biology. 124, p. 241 - 258 18 p.Research output: Contribution to journal › Article › Other
16 Citations (Scopus) -
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Rodgers, S. J., Ooms, L. M., Oorschot, V. M. J., Schittenhelm, R. B., Nguyen, E. V., Hamila, S. A., Rynkiewicz, N., Gurung, R., Eramo, M. J., Sriratana, A., Fedele, C. G., Caramia, F., Loi, S., Kerr, G., Abud, H. E., Ramm, G., Papa, A., Ellisdon, A. M., Daly, R. J., McLean, C. A. & 1 others, , 2021, In: Nature Communications. 12, 1, 19 p., 3140.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus)
Activities
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1st AMMS Cryo EM Aus/NZ Meeting
Georg Ramm (Organiser)
2018Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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2nd CRYOZ conference
Georg Ramm (Organiser)
5 Jun 2019 → 7 Jun 2019Activity: Participating in or organising an event types › Contribution to conference
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President CRYOZ
Georg Ramm (Fellow)
2018 → 2021Activity: External Academic Engagement › Professional association or peak discipline body
Equipment
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Ramaciotti Centre for Cryo-Electron Microscopy
Georg Ramm (Manager), Simon Andrew Crawford (Operator), Hariprasad Venugopal (Operator), Joan Marea Clark (Operator) & Gediminas Gervinskas (Operator)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility