• Ramaciotti Centre for Cryo EM, 15 Innovation Walk, room G90, Ramaciotti Centre for Cryo EM

    3800 Clayton

    Australia

20002020

Research output per year

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Personal profile

Biography

Our lab is focused on the regulation of autophagy, a major intracellular degradation process. In cancer, autophagy plays complex roles and can suppress tumours, but also helps tumour cells survive in other cases. Autophagy delivers cellular and cytoplasmic structures to the lysosome, where they are degraded. This process is tightly linked to the cellular metabolism and is an evolutionary conserved survival mechanism that helps cells to cope with nutrient starvation. We have recently discovered a link between metabolic control and the Serine/Threonine kinase ULK1, a key regulator of autophagy. We aim to get a detailed understanding of how these regulatory networks are causing changes in intracellular membrane trafficking during autophagy.

Research interests

Key interests are cell signalling, cellular trafficking, correlative microscopy, cryo EM, tomography, autophagy, mitophagy, mitochondria, cancer, diabetes.

Research area keywords

  • microscopy
  • imaging
  • protein trafficking
  • cryo EM
  • cancer
  • diabetes

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 others, Lessene, G., Ryan, M. T., Rogers, K. L., Van Delft, M. F. & Kile, B. T., 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

An improved procedure for subcellular spatial alignment during live-cell CLEM

Padman, B. S., Bach, M. & Ramm, G., 2014, In : PLoS ONE. 9, 4 (Art. No.: e95967), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells

Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In : Autophagy. 9, 11, p. 1862 - 1875 14 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Immuno correlative light and electron microscopy on tokuyasu cryosections

Oorschot, V. M., Sztal, T. E., Bryson-Richardson, R. J. & Ramm, G., 2014, In : Methods in Cell Biology. 124, p. 241 - 258 18 p.

Research output: Contribution to journalArticleOther

12 Citations (Scopus)

KBTBD13 is an actin-binding protein that modulates muscle kinetics

De Winter, J. M., Molenaar, J. P., Yuen, M., Van Der Pijl, R., Shen, S., Conijn, S., Van De Locht, M., Willigenburg, M., Bogaards, S. J. P., Van Kleef, E. S. B., Lassche, S., Persson, M., Rassier, D. E., Sztal, T. E., Ruparelia, A. A., Oorschot, V., Ramm, G., Hall, T. E., Xiong, Z., Johnson, C. N. & 21 others, Li, F., Kiss, B., Lozano-Vidal, N., Boon, R. A., Marabita, M., Nogara, L., Blaauw, B., Rodenburg, R. J., Küsters, B., Doorduin, J., Beggs, A. H., Granzier, H., Campbell, K., Ma, W., Irving, T., Malfatti, E., Romero, N. B., Bryson-Richardson, R. J., Van Engelen, B. G. M., Voermans, N. C. & Ottenheijm, C. A. C., 3 Feb 2020, In : Journal of Clinical Investigation. 130, 2, p. 754-767 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Activities

  • 1 Contribution to conference
  • 1 Contribution to workshop, seminar, course
  • 1 Professional association or peak discipline body

2nd CRYOZ conference

Georg Ramm (Organiser)

5 Jun 20197 Jun 2019

Activity: Participating in or organising an event typesContribution to conference

1st AMMS Cryo EM Aus/NZ Meeting

Georg Ramm (Organiser)

2018

Activity: Participating in or organising an event typesContribution to workshop, seminar, course

President CRYOZ

Georg Ramm (Fellow)

20182021

Activity: External Academic EngagementProfessional association or peak discipline body