Projects per year
Personal profile
Biography
Our lab is focused on the regulation of autophagy, a major intracellular degradation process. In cancer, autophagy plays complex roles and can suppress tumours, but also helps tumour cells survive in other cases. Autophagy delivers cellular and cytoplasmic structures to the lysosome, where they are degraded. This process is tightly linked to the cellular metabolism and is an evolutionary conserved survival mechanism that helps cells to cope with nutrient starvation. We have recently discovered a link between metabolic control and the Serine/Threonine kinase ULK1, a key regulator of autophagy. We aim to get a detailed understanding of how these regulatory networks are causing changes in intracellular membrane trafficking during autophagy.
Research interests
Key interests are cell signalling, cellular trafficking, correlative microscopy, cryo EM, tomography, autophagy, mitophagy, mitochondria, cancer, diabetes.
Keywords
- microscopy, imaging, cryo EM, cancer, diabetes, protein trafficking
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2009 2021
3D Cryo Correlative Light and Electron Microscopy Facility
Ramm, G., Kile, B., Lithgow, T., O'Bryan, M. & Naderer, T.
1/01/18 → 31/12/19
Project: Other
Understanding how mitochondria divide
Ryan, M., Ramm, G. & Stroud, D.
Australian Research Council (ARC), Monash University
1/01/16 → 31/12/18
Project: Research
A Video-Rate Nanoscopy Facility for Super-Resolution Imaging
Lithgow, T., Carroll, J., Gleeson, P., Hanssen, E. G., Hartland, E., Hertzog, P., Jans, D., Ramm, G. & Strugnell, R. A.
Australian Research Council (ARC), The University of Melbourne, Monash University
1/01/15 → 31/12/15
Project: Research
3D Cryo-FIBSEM Imaging Facility for Biological and Material Sciences.
Ramm, G., Arns, C., Bhaskaran, M., Etheridge, J., Fu, J., Gaus, K., Manefield, M., McCulloch, D. G. & Whisstock, J.
Australian Research Council (ARC), RMIT University, The University of New South Wales, Monash University
1/01/15 → 31/12/17
Project: Research
Research Output 2000 2018
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 others, 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.Research output: Contribution to journal › Article › Research › peer-review
An improved procedure for subcellular spatial alignment during live-cell CLEM
Padman, B. S., Bach, M. & Ramm, G., 2014, In : PLoS ONE. 9, 4 (Art. No.: e95967), p. 1 - 13 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells
Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In : Autophagy. 9, 11, p. 1862 - 1875 14 p.Research output: Contribution to journal › Article › Research › peer-review
Immuno correlative light and electron microscopy on tokuyasu cryosections
Oorschot, V. M., Sztal, T. E., Bryson-Richardson, R. J. & Ramm, G., 2014, In : Methods in Cell Biology. 124, p. 241 - 258 18 p.Research output: Contribution to journal › Article › Other
Helicobacter pylori outer membrane vesicle size determines their mechanisms of host cell entry and protein content
Turner, L., Bitto, N. J., Steer, D. L., Lo, C., D'Costa, K., Ramm, G., Shambrook, M., Hill, A. F., Ferrero, R. L. & Kaparakis-Liaskos, M., 2 Jul 2018, In : Frontiers in Immunology. 9, 10 p., 1466.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Activities 2018 2018
- 1 Contribution to workshop, seminar, course
1st AMMS Cryo EM Aus/NZ Meeting
Georg Ramm (Organiser)2018
Activity: Participating in or organising an event types › Contribution to workshop, seminar, course