• Ramaciotti Centre for Cryo EM, 15 Innovation Walk, room G90, Ramaciotti Centre for Cryo EM

    3800 Clayton



Research activity per year

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Personal profile


Our lab is focused on the regulation of autophagy, a major intracellular degradation process. In cancer, autophagy plays complex roles and can suppress tumours, but also helps tumour cells survive in other cases. Autophagy delivers cellular and cytoplasmic structures to the lysosome, where they are degraded. This process is tightly linked to the cellular metabolism and is an evolutionary conserved survival mechanism that helps cells to cope with nutrient starvation. We have recently discovered a link between metabolic control and the Serine/Threonine kinase ULK1, a key regulator of autophagy. We aim to get a detailed understanding of how these regulatory networks are causing changes in intracellular membrane trafficking during autophagy.

Research interests

Key interests are cell signalling, cellular trafficking, correlative microscopy, cryo EM, tomography, autophagy, mitophagy, mitochondria, cancer, diabetes.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research area keywords

  • microscopy
  • imaging
  • protein trafficking
  • cryo EM
  • cancer
  • diabetes


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