Projects per year
Personal profile
Biography
Prof Georg Ramm is a Chan Zuckerberg Initiative Imaging Scientist and a group leader in the Department of Biochemistry at Monash University. Georg trained as a microscopist, cell biologist, and biochemist during a PhD at Utrecht University in the Netherlands, and during undergraduate and diploma degrees in Germany. He established the Monash Ramaciotti Centre for Cryo-EM, which enables both cell and structural biology EM with imaging expertise in immuno EM, correlative light and electron microscopy, volume imaging, single particle cryo-EM and cryo-electron tomography. The Ramaciotti Centre is now a major EM Centre in Australia with over 300 users from Australia and overseas including the US, UK, Germany, Israel, New Zealand, and Singapore. He has published in leading journals including in Science, Cell Metabolism, Nature Communications, Autophagy, and the Journal of Cell Biology.
Research interests
The Ramm lab is focused on high-resolution imaging of cellular architecture and intracellular trafficking. The lab uses cryo-electron tomography (on Titan Krios G4) in combination with cryo-focused ion beam milling to reveal cellular structures at the highest resolution. The major focus is on fundamental cell biological problems that are relevant to human diseases. This includes the intracellular degradation of organelles by autophagy and mitophagy, mitochondrial ultrastructure and dynamics in healthy and stressed cells, and cellular structural changes during cell death.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- microscopy
- imaging
- protein trafficking
- cryo EM
- cancer
- Structural Biology
Collaborations and top research areas from the last five years
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High-resolution cryo-transmission electron microscopy at 120kV with a Gatan Alpine Direct Electron Detector
Ramm, G. (Primary Chief Investigator (PCI))
1/11/24 → 30/04/26
Project: Research
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Understanding the metabolic landscape in the human kidney in diabetes
Coughlan, M. (Primary Chief Investigator (PCI)), Watt, M. (Associate Investigator (AI)), Stroud, D. A. (Associate Investigator (AI)), Ramm, G. (Associate Investigator (AI)), Schittenhelm, R. (Associate Investigator (AI)), Lazarou, M. (Associate Investigator (AI)), McLean, C. (Associate Investigator (AI)), Lawton, P. (Associate Investigator (AI)) & Ekinci, E. (Associate Investigator (AI))
1/01/24 → 31/12/28
Project: Research
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Correlative cryo-fluorescence and electron tomography in tissues (pt 2)
Ramm, G. (Primary Chief Investigator (PCI))
1/12/23 → 30/11/25
Project: Research
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Elucidating the mechanisms of mitochondrial DNA escape
Ramm, G. (Primary Chief Investigator (PCI)) & Kile, B. (Partner Investigator (PI))
30/12/20 → 20/06/27
Project: Research
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Correlative cryo-fluorescence microscopy and electron tomography in tissues
Ramm, G. (Primary Chief Investigator (PCI))
1/12/20 → 31/03/26
Project: Research
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High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub-200-keV direct electron detector
Venugopal, H., Mobbs, J., Taveneau, C., Fox, D. R., Vuckovic, Z., Gulati, S., Knott, G., Grinter, R., Thal, D., Mick, S., Czarnik, C. & Ramm, G., 3 Jan 2025, In: Science Advances. 11, 1, 11 p., eadr0438.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M. & Ramm, G. & 5 others, , 23 Feb 2018, In: Science. 359, 6378, 12 p., eaao6047.Research output: Contribution to journal › Article › Research › peer-review
723 Citations (Scopus) -
The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells
Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In: Autophagy. 9, 11, p. 1862 - 1875 14 p.Research output: Contribution to journal › Article › Research › peer-review
80 Citations (Scopus) -
An introduction to scanning transmission electron microscopy for the study of protozoans
Trépout, S., Sgarra, M. L., Marco, S. & Ramm, G., Apr 2024, In: Molecular Microbiology. 121, 4, p. 659-670 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access6 Citations (Scopus) -
Antiviral Wolbachia strains associate with Aedes aegypti endoplasmic reticulum membranes and induce lipid droplet formation to restrict dengue virus replication
Loterio, R. K., Monson, E. A., Templin, R., de Bruyne, J. T., Flores, H. A., Mackenzie, J. M., Ramm, G., Helbig, K. J., Simmons, C. P. & Fraser, J. E., 14 Feb 2024, In: mBio. 15, 2, 20 p., e0249523.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Activities
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2nd CRYOZ conference
Ramm, G. (Organiser)
5 Jun 2019 → 7 Jun 2019Activity: Participating in or organising an event types › Contribution to conference
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President CRYOZ
Ramm, G. (Fellow)
2018 → …Activity: External Academic Engagement › Professional association or peak discipline body
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1st AMMS Cryo EM Aus/NZ Meeting
Ramm, G. (Organiser)
2018Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
Equipment
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Ramaciotti Centre for Cryo-Electron Microscopy (CryoEM)
Ramm, G. (Manager), Crawford, S. A. (Operator), Venugopal, H. (Operator), Clark, J. M. (Operator) & Gervinskas, G. (Operator)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility