Projects per year
Personal profile
Biography
A/Prof Georg Ramm is a Chan Zuckerberg Initiative Imaging Scientist and a group leader in the Department of Biochemistry at Monash University. Georg trained as a microscopist, cell biologist, and biochemist during a PhD at Utrecht University in the Netherlands, and during undergraduate and diploma degrees in Germany. He established the Monash Ramaciotti Centre for Cryo-EM, which enables both cell and structural biology EM with imaging expertise in immuno EM, correlative light and electron microscopy, volume imaging, single particle cryo-EM and cryo-tomography. The Ramaciotti Centre is now a major EM Centre in Australia with over 280 users from Australia and overseas including the US, UK, Germany, Israel, New Zealand, and Singapore. He has published in leading journals including in Science, Cell Metabolism, Nature Communications, Autophagy, and the Journal of Cell Biology.
Research interests
The Ramm lab is focused on high-resolution imaging of cellular architecture and intracellular trafficking. The lab uses cryo-tomography (on Titan Krios) in combination with cryo-focused ion beam milling (cryo-FIB on cryo-Helios) to reveal cellular structures at the highest resolution. The major focus is on fundamental cell biological problems that are relevant to human diseases. This includes the intracellular degradation of organelles by autophagy and mitophagy, mitochondrial ultrastructure and dynamics in healthy and stressed cells, and cellular structural changes during cell death.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- microscopy
- imaging
- protein trafficking
- cryo EM
- cancer
- diabetes
Network
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Correlative cryo-fluorescence microscopy and electron tomography in tissues
1/12/20 → 30/11/23
Project: Research
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Elucidating the mechanisms of mitochondrial DNA escape
Kile, B. & Ramm, G.
30/06/20 → 30/06/23
Project: Research
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New generation direct electron detector for cryo-electron microscopy
Ramm, G., Whisstock, J., Lucet, I., Boecking, T., Landsberg, M. J., Alexandrov, K., Dunstone, M., Curmi, P. M. G., Lawrence, M. C., Lithgow, T., Watterson, D., Sexton, P. & Hankamer, B. D.
3/07/20 → 15/06/21
Project: Research
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Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing
Naderer, T., Shen, H., Peleg, A., Mackay, C., Ramm, G. & Dougan, G.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/19 → 31/12/21
Project: Research
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3D Cryo Correlative Light and Electron Microscopy Facility
Ramm, G., Kile, B., Lithgow, T., O'Bryan, M. & Naderer, T.
1/01/18 → 31/12/19
Project: Other
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G., & 5 others , 23 Feb 2018, In: Science. 359, 6378, 12 p., eaao6047.Research output: Contribution to journal › Article › Research › peer-review
421 Citations (Scopus) -
An improved procedure for subcellular spatial alignment during live-cell CLEM
Padman, B. S., Bach, M. & Ramm, G., 2014, In: PLoS ONE. 9, 4 (Art. No.: e95967), p. 1 - 13 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells
Padman, B. S., Bach, M., Lucarelli, G., Prescott, M. & Ramm, G., 2013, In: Autophagy. 9, 11, p. 1862 - 1875 14 p.Research output: Contribution to journal › Article › Research › peer-review
70 Citations (Scopus) -
Immuno correlative light and electron microscopy on tokuyasu cryosections
Oorschot, V. M., Sztal, T. E., Bryson-Richardson, R. J. & Ramm, G., 2014, In: Methods in Cell Biology. 124, p. 241 - 258 18 p.Research output: Contribution to journal › Article › Other
17 Citations (Scopus) -
Autophagic lysosome reformation in health and disease
Nanayakkara, R., Gurung, R., Rodgers, S. J., Eramo, M. J., Ramm, G., Mitchell, C. A. & McGrath, M. J., 2022, (Accepted/In press) In: Autophagy. 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access3 Citations (Scopus)
Activities
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2nd CRYOZ conference
Georg Ramm (Organiser)
5 Jun 2019 → 7 Jun 2019Activity: Participating in or organising an event types › Contribution to conference
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1st AMMS Cryo EM Aus/NZ Meeting
Georg Ramm (Organiser)
2018Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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President CRYOZ
Georg Ramm (Fellow)
2018 → 2021Activity: External Academic Engagement › Professional association or peak discipline body
Equipment
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Ramaciotti Centre for Cryo-Electron Microscopy
Georg Ramm (Manager), Simon Andrew Crawford (Operator), Hariprasad Venugopal (Operator), Joan Marea Clark (Operator) & Gediminas Gervinskas (Operator)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility