Professor Cloud holds a joint appointment as Director of Stroke Services at Alfred Health and adjunct Professor of Stroke Medicine in the Department of Neuroscience at the School of Translational Medicine. Previously he worked as a full time Consultant Stroke Physician and Honorary Senior Lecturer in the Department of Clinical Neurosciences at St George’s Hospital in London.

Professor Cloud is current chair of the Australian Stroke Data (AuSDaT) monitoring and the Australian Stroke Registry (AuSCR) quality improvement committees, and an elected council member of the Stroke Society of Australasia and New Zealand. Professor Cloud adjudicates outcomes for the ASPirin in Reducing Events in the Elderly (ASPREE) study and chairs the stroke adjudication committee for the STAtins in Reducing Events in the Elderly (STAREE). 

Having been an investigator for more than 50 randomized controlled stroke trials, Professor Cloud is dedicated to researching all aspects of improving stroke care and has close collaborations with other School of Translational Medicine researchers, Professors Natasha Lannin and Robert Medcalf. 

Outside of stroke service quality improvement and large clinical trials, Professor Cloud's published research interests include posterior circulation stroke, novel interventions for motor recovery after stroke and understanding the needs of stroke carers. He is co-author of the Oxford University Press Handbook of Stroke Medicine.