Gavin Knott

Research output

Research output per year 2014 2017 2018 2019 2020 2021 2022 2024

• 30 Article
• 3 Review Article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes

  Adler, B. A., Trinidad, M. I., Bellieny-Rabelo, D., Zhang, E., Karp, H. M., Skopintsev, P., Thornton, B. W., Weissman, R. F., Yoon, P. H., Chen, L. X., Hessler, T., Eggers, A. R., Colognori, D., Boger, R., Doherty, E. E., Tsuchida, C. A., Tran, R. V., Hofman, L., Shi, H. & Wasko, K. M. & 33 others, Zhou, Z., Xia, C., Al-Shimary, M. J., Patel, J. R., Thomas, V. C. J. X., Pattali, R., Kan, M. J., Vardapetyan, A., Yang, A., Lahiri, A., Maxwell, M. F., Murdock, A. G., Ramit, G. C., Henderson, H. R., Calvert, R. W., Bamert, R. S., Knott, G. J., Lapinaite, A., Pausch, P., Cofsky, J. C., Sontheimer, E. J., Wiedenheft, B., Fineran, P. C., Brouns, S. J. J., Sashital, D. G., Thomas, B. C., Brown, C. T., Goltsman, D. S. A., Barrangou, R., Siksnys, V., Banfield, J. F., Savage, D. F. & Doudna, J. A., 5 Jan 2024, In: Nucleic Acids Research. 52, D1, p. D590-D596 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  16 Citations (Scopus)

• The C-terminal protein interaction domain of the chromatin reader Yaf9 is critical for pathogenesis of Candida albicans

  Lo, T. L., Wang, Q., Nickson, J., van Denderen, B. J. W., Lucas, D. D., Chai, H. X., Knott, G. J., Weerasinghe, H. & Traven, A., Mar 2024, In: mSphere. 9, 3, 20 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  1 Citation (Scopus)
• 2023

  Methods special issue: RNA-targeting technologies

  Knott, G. J., Lapinaite, A. & O'Connell, M. R., Apr 2023, In: Methods. 212, p. 10-11 2 p.

  Research output: Contribution to journal › Editorial › Other › peer-review
• 2022

  CRISPR–Cas9 bends and twists DNA to read its sequence

  Cofsky, J. C., Soczek, K. M., Knott, G. J., Nogales, E. & Doudna, J. A., Apr 2022, In: Nature Structural & Molecular Biology. 29, 4, p. 395-402 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  42 Citations (Scopus)

• Crystal structure of an RNA/DNA strand exchange junction

  Cofsky, J. C., Knott, G. J., Gee, C. L. & Doudna, J. A., Apr 2022, In: PLoS ONE. 17, 4, 15 p., e0263547.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains

  Lee, P. W., Marshall, A. C., Knott, G. J., Kobelke, S., Martelotto, L., Cho, E., McMillan, P. J., Lee, M., Bond, C. S. & Fox, A. H., Nov 2022, In: Journal of Biological Chemistry. 298, 11, 15 p., 102563.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  9 Citations (Scopus)

• Rapid detection of SARS-CoV-2 RNA in saliva via Cas13

  Chandrasekaran, S. S., Agrawal, S., Fanton, A., Jangid, A. R., Charrez, B., Escajeda, A. M., Son, S., Mcintosh, R., Tran, H., Bhuiya, A., de León Derby, M. D., Switz, N. A., Armstrong, M., Harris, A. R., Prywes, N., Lukarska, M., Biering, S. B., Smock, D. C. J., Mok, A. & Knott, G. J. & 17 others, Dang, Q., Van Dis, E., Dugan, E., Kim, S., Liu, T. Y., IGI Testing Consortium, Moehle, E. A., Kogut, K., Eskenazi, B., Harris, E., Stanley, S. A., Lareau, L. F., Tan, M. X., Fletcher, D. A., Doudna, J. A., Savage, D. F. & Hsu, P. D., Aug 2022, In: Nature Biomedical Engineering. 6, 8, p. 944–956 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  80 Citations (Scopus)

• Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1

  Knott, G. J., Chong, Y. S., Passon, D. M., Liang, X. H., Deplazes, E., Conte, M. R., Marshall, A. C., Lee, M., Fox, A. H. & Bond, C. S., 11 Jan 2022, In: Nucleic Acids Research. 50, 1, p. 522-535 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  15 Citations (Scopus)
• 2021

  Accelerated RNA detection using tandem CRISPR nucleases

  Liu, T. Y., Knott, G. J., Smock, D. C. J., Desmarais, J. J., Son, S., Bhuiya, A., Jakhanwal, S., Prywes, N., Agrawal, S., Díaz de León Derby, M., Switz, N. A., Armstrong, M., Harris, A. R., Charles, E. J., Thornton, B. W., Fozouni, P., Shu, J., Stephens, S. I., Kumar, G. R. & Zhao, C. & 15 others, Mok, A., Iavarone, A. T., Escajeda, A. M., McIntosh, R., Kim, S., Dugan, E. J., IGI Testing Consortium, Pollard, K. S., Tan, M. X., Ott, M., Fletcher, D. A., Lareau, L. F., Hsu, P. D., Savage, D. F. & Doudna, J. A., Sept 2021, In: Nature Chemical Biology. 17, 9, p. 982-988 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  160 Citations (Scopus)

• Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

  Fozouni, P., Son, S., Díaz de León Derby, M., Knott, G. J., Gray, C. N., D'Ambrosio, M. V., Zhao, C., Switz, N. A., Kumar, G. R., Stephens, S. I., Boehm, D., Tsou, C. L., Shu, J., Bhuiya, A., Armstrong, M., Harris, A. R., Chen, P. Y., Osterloh, J. M., Meyer-Franke, A. & Joehnk, B. & 12 others, Walcott, K., Sil, A., Langelier, C., Pollard, K. S., Crawford, E. D., Puschnik, A. S., Phelps, M., Kistler, A., DeRisi, J. L., Doudna, J. A., Fletcher, D. A. & Ott, M., 21 Jan 2021, In: Cell. 184, 2, p. 323-333.e9 20 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  658 Citations (Scopus)

• Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

  Amen, A. M., Fellmann, C., Soczek, K. M., Ren, S. M., Lew, R. J., Knott, G. J., Park, J. E., McKinney, A. M., Mancini, A., Doudna, J. A. & Costello, J. F., 30 Mar 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 13, 10 p., e2008772118.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  33 Citations (Scopus)

• Controlling and enhancing CRISPR systems

  Shivram, H., Cress, B. F., Knott, G. J. & Doudna, J. A., Jan 2021, In: Nature Chemical Biology. 17, 1, p. 10-19 10 p.

  Research output: Contribution to journal › Review Article › Research › peer-review
  128 Citations (Scopus)

• CRISPR Gets Its Origin Story

  Knott, G. J. & Lapinaite, A., Oct 2021, In: The CRISPR Journal. 4, 5, p. 631-633 3 p.

  Research output: Contribution to journal › Article › Other › peer-review
  1 Citation (Scopus)

• Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics

  Nalefski, E. A., Patel, N., Leung, P. J. Y., Islam, Z., Kooistra, R. M., Parikh, I., Marion, E., Knott, G. J., Doudna, J. A., Le Ny, A. L. M. & Madan, D., 24 Sept 2021, In: iScience. 24, 9, 23 p., 102996.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  70 Citations (Scopus)
• 2020

  CRISPR-CasΦ from huge phages is a hypercompact genome editor

  Pausch, P., Al-Shayeb, B., Bisom-Rapp, E., Tsuchida, C. A., Li, Z., Cress, B. F., Knott, G. J., Jacobsen, S. E., Banfield, J. F. & Doudna, J. A., 17 Jul 2020, In: Science. 369, 6501, p. 333-337 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  395 Citations (Scopus)

• DNA capture by a CRISPR-Cas9-guided adenine base editor

  Lapinaite, A., Knott, G. J., Palumbo, C. M., Lin-Shiao, E., Richter, M. F., Zhao, K. T., Beal, P. A., Liu, D. R. & Doudna, J. A., 31 Jul 2020, In: Science. 369, 6503, p. 566-571 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  133 Citations (Scopus)

• Machine learning predicts new anti-CRISPR proteins

  Eitzinger, S., Asif, A., Watters, K. E., Iavarone, A. T., Knott, G. J., Doudna, J. A. & Minhas, F. U. A. A., 21 May 2020, In: Nucleic Acids Research. 48, 9, p. 4698-4708 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  74 Citations (Scopus)

• Protein-Embedded Metalloporphyrin Arrays Templated by Circularly Permuted Tobacco Mosaic Virus Coat Proteins

  Dai, J., Knott, G. J., Fu, W., Lin, T. W., Furst, A. L., Britt, R. D. & Francis, M. B., 7 Dec 2020, In: ACS Nano. 15, 5, p. 8110-8119 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  12 Citations (Scopus)
• 2019

  Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

  Knott, G. J., Thornton, B. W., Lobba, M. J., Liu, J. J., Al-Shayeb, B., Watters, K. E. & Doudna, J. A., 1 Apr 2019, In: Nature Structural & Molecular Biology. 26, 4, p. 315-321 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  94 Citations (Scopus)

• CasX enzymes comprise a distinct family of RNA-guided genome editors

  Liu, J. J., Orlova, N., Oakes, B. L., Ma, E., Spinner, H. B., Baney, K. L. M., Chuck, J., Tan, D., Knott, G. J., Harrington, L. B., Al-Shayeb, B., Wagner, A., Brötzmann, J., Staahl, B. T., Taylor, K. L., Desmarais, J., Nogales, E. & Doudna, J. A., 14 Feb 2019, In: Nature. 566, 7743, p. 218-223 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  338 Citations (Scopus)

• Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

  Knott, G. J., Cress, B. F., Liu, J. J., Thornton, B. W., Lew, R. J., Al-Shayeb, B., Rosenberg, D. J., Hammel, M., Adler, B. A., Lobba, M. J., Xu, M., Arkin, A. P., Fellmann, C. & Doudna, J. A., 9 Aug 2019, In: eLife. 8, 25 p., e49110.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  41 Citations (Scopus)
• 2018

  CRISPR-Cas guides the future of genetic engineering

  Knott, G. J. & Doudna, J. A., 31 Aug 2018, In: Science. 361, 6405, p. 866-869 4 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access

  File
  1087 Citations (Scopus)

• NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

  Lahaye, X., Gentili, M., Silvin, A., Conrad, C., Picard, L., Jouve, M., Zueva, E., Maurin, M., Nadalin, F., Knott, G. J., Zhao, B., Du, F., Rio, M., Amiel, J., Fox, A. H., Li, P., Etienne, L., Bond, C. S., Colleaux, L. & Manel, N., 4 Oct 2018, In: Cell. 175, 2, p. 488-501 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  164 Citations (Scopus)

• RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a

  Tambe, A., East-Seletsky, A., Knott, G. J., Doudna, J. A. & O'Connell, M. R., 24 Jul 2018, In: Cell Reports. 24, 4, p. 1025-1036 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  99 Citations (Scopus)
• 2017

  A Broad-Spectrum Inhibitor of CRISPR-Cas9

  Harrington, L. B., Doxzen, K. W., Ma, E., Liu, J. J., Knott, G. J., Edraki, A., Garcia, B., Amrani, N., Chen, J. S., Cofsky, J. C., Kranzusch, P. J., Sontheimer, E. J., Davidson, A. R., Maxwell, K. L. & Doudna, J. A., 7 Sept 2017, In: Cell. 170, 6, p. 1224-1233 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  197 Citations (Scopus)

• Evidence for ancient origins of bowman-birk inhibitors from Selaginella moellendorffii

  James, A. M., Jayasena, A. S., Zhang, J., Berkowitz, O., Secco, D., Knott, G. J., Whelan, J., Bond, C. S. & Mylne, J. S., Mar 2017, In: The Plant Cell. 29, 3, p. 461-473 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

• Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme

  Knott, G. J., East-Seletsky, A., Cofsky, J. C., Holton, J. M., Charles, E., O'Connell, M. R. & Doudna, J. A., 5 Oct 2017, In: Nature Structural & Molecular Biology. 24, 10, p. 825-833 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  122 Citations (Scopus)

• RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes

  East-Seletsky, A., O'Connell, M. R., Burstein, D., Knott, G. J. & Doudna, J. A., 4 May 2017, In: Molecular Cell. 66, 3, p. 373-383 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  214 Citations (Scopus)

• Structures of the CRISPR genome integration complex

  Wright, A. V., Liu, J. J., Knott, G. J., Doxzen, K. W., Nogales, E. & Doudna, J. A., 15 Sept 2017, In: Science. 357, 6356, p. 1113-1118 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  111 Citations (Scopus)
• 2016

  A crystallographic study of human NONO (p54^nrb): Overcoming pathological problems with purification, data collection and noncrystallographic symmetry: Overcoming

  Knott, G. J., Panjikar, S., Thorn, A., Fox, A. H., Conte, M. R., Lee, M. & Bond, C. S., 2016, In: Acta Crystallographica Section D: Structural Biology. 72, 6, p. 761-769 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  11 Citations (Scopus)

• The DBHS proteins SFPQ, NONO and PSPC1: A multipurpose molecular scaffold

  Knott, G. J., Bond, C. S. & Fox, A. H., 19 May 2016, In: Nucleic Acids Research. 44, 9, p. 3989-4004 16 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  Open Access

  File
  230 Citations (Scopus)
• 2015

  Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function

  Knott, G. J., Lee, M., Passon, D. M., Fox, A. H. & Bond, C. S., Dec 2015, In: Protein Science. 24, 12, p. 2033-2043 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  21 Citations (Scopus)

• Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

  Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G. J., Iyer, S. S., Ho, D., Newcombe, E. A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C. S. & Fox, A. H., 17 Aug 2015, In: Journal of Cell Biology. 210, 4, p. 529-539 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  240 Citations (Scopus)
• 2014

  Crystal 'unengineering': Reducing the crystallisability of sulfolobus solfataricus hjc

  Middleton, C. L., Parker, J. L., Knott, G. J., White, M. F. & Bond, C. S., 18 Aug 2014, In: Australian Journal of Chemistry. 67, 12, p. 1818-1823 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)