Projects per year
Personal profile
Biography
Brain maps reveal disease pathways
There is no cure for genetically inherited conditions, such as Huntington's disease, that cause the brain to degenerate. Neuroscientist Professor Gary Egan is working to change that. He is leading research to map the progress of these diseases using ultra-powerful imaging equipment, with the aim of developing treatments to slow or prevent the onset of brain degeneration.
Conditions such as Huntington's disease and Friedreich's ataxia are genetically inherited neurodegenerative diseases that affect motor coordination and lead to dementia. Part of the problem, Gary says, is that it can take 20 years before clearly identifiable clinical symptoms appear.
'The enormous frustration for neuroscientists is that while it is possible to identify people who will suffer from these diseases using genetic tests, we need to be able to clearly identify what is happening in the brain very early in the course of the disease in order to test potential cures or treatments.'
Gary leads the Monash Biomedical Imaging team using world-class magnetic resonance imaging (MRI) equipment to map the brain changes in those carrying the genes for such diseases. The maps provide a high level of detail, and at an early stage of the disease, before symptoms manifest. This is providing important information that could help develop preventive treatments and a possible cure.
'If we can map the path of the disease well before it starts to take hold then it may allow us to come up with and track the progress of experimental preventive therapies in the future.'
In one study, Gary and his team are using MRI on people carrying Huntington's disease to map its effect on the brain.
'What we are looking for are bio-markers such as high concentrations of metals associated with neurodegenerative diseases. These bio-markers track the death of brain cells and neural pathways as the disease progresses."
In a parallel study, Gary is planning on using ultra-high resolution X-ray imaging available at the Australian Synchrotron to track changes in the brains of mice that have been implanted with a human gene carrying a neurodegenerative disease. Gary says commonalities between the mouse brain and the human brain - especially in the motor function areas that relate to Huntington's disease - make this investigation invaluable.
'As the disease develops in the brain of a mouse it manifests very similar symptoms as it would in a human brain. But because we are able to use ultra-high strength imaging, we can look at cellular changes at a microscopic level allowing far higher resolution than would be possible in human studies.'
This understanding of the progress of the disease in the animal model can then be translated into an understanding of the human brain. Using this same technology, Gary and his team are also tracking the effect on the mice of experimental drugs that are aimed at halting the progress of the disease.
'If those drugs are shown to work, we may be able to initiate early clinical trials on human beings.'
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Commentary: biomedical imaging and neuroimaging
- Supervision: neuroscience
- imaging sciences
Network
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The effects of early exposure to bushfires on adult brain structure and function
Alizadeh Mansouri, F., Atapour, N., Carril Mundinano, I., Majka, P., Rosa, M., Egan, G. & Bourne, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/22 → 31/12/25
Project: Research
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National Mobile Magnetic Resonance Imaging Network
Chen, Z., Egan, G., Pawar, K., Zhong, S., Morris, A., Barth, M., Dwyer, A., Verjans, J. W., Law, M. & Parizel, P. M.
1/01/22 → 30/06/23
Project: Research
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Transcranial focused ultrasound neuromodulation system
Coxon, J., Egan, G., Bellgrove, M., Rosa, M., Fornito, A., Verdejo-Garcia, A., Chong, T., Alizadeh Mansouri, F., Hendrikse, J. & Biabani, M.
1/10/21 → 31/12/22
Project: Research
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An informatics approach to predict outcomes and monitor intervention efficacy following moderate to severe traumatic brain injury
Fitzgerald, M., Gabbe, B., Lannin, N., Vallmuur, K., Curtis, K., Harrison, J., Young, J. T., Menon, D. K., Cullen, J. C., Armstrong, E., Eades, S., Cameron, P., Cooper, J., Fitzgerald, M., Balogh, Z., Fatovich, D., Honeybul, S., Jeffree, R. L., McNamara, R., Mitchell, G., Delaney, A., Reade, M. C., Wells, A., Williams, J., Ponsford, J., McDonald, S., Kendall, E., Ownsworth , T., Simpson, G., Togher, L., Hassett, L., Fleming, J., Williams, G. P., Collins-Praino, L. E., Reeder, S., Mobbs, R., Vickers, J., Anderson, V., Barlow, K., Holland, A. J. A., Scheinberg, A., Semple, B., Parizel, P. M., O'Brien, T., Law, M., Rose, S. E., Varma, D., Nasrallah, F., Shultz, S., Hellewell, S., Bosio, E., King , K., Parr, M., Udy, A., Hill, A. F., Olver, J., Teague, W. J., Egan, G., Fisher, M., York, L., Bynevelt, M., Maas, A. I., O'Reilly, G., McDonald, S., Capell, J., Gilroy, J., Walsham, J., Newcombe, V., Geraghty, T. J., Joyce, C. J., Rosenfeld, J., Elcock, M., Ross, J., Bragge, P., Meka, S., Chai, K., Cowen, G., Hasseler, L., Ercole, A., Wagland , J., Alexander, T., Babl, F. E., Bidargaddi, N., Mahoney, A. J., Wright, D., Crowe, L. M., Robinson, S., Rushworth, N., Hansen, M., Ellis, D., Zeeman, H., Francis, R., Whiley, L. & Reid, C.
1/07/21 → 30/06/23
Project: Research
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Brain-predicted age difference is associated with cognitive processing in later-life
Wrigglesworth, J., Yaacob, N., Ward, P., Woods, R. L., McNeil, J., Storey, E., Egan, G., Murray, A., Shah, R. C., Jamadar, S. D., Trevaks, R., Ward, S., Harding, I. H. & Ryan, J., Jan 2022, In: Neurobiology of Aging. 109, p. 195-203 9 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Longitudinal investigation of brain activation during motor tasks in Friedreich ataxia: 24-month data from IMAGE-FRDA
Shishegar, R., Harding, I. H., Selvadurai, L. P., Corben, L. A., Delatycki, M. B., Egan, G. F. & Georgiou-Karistianis, N., Apr 2022, In: Brain Structure and Function. 227, 3, p. 809-819 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Magnetic resonance iron imaging in Amyotrophic Lateral Sclerosis
Bhattarai, A., Egan, G. F., Talman, P., Chua, P. & Chen, Z., May 2022, In: Journal of Magnetic Resonance Imaging. 55, 5, p. 1283-1300 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
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Neuroinflammation in the cerebellum and brainstem in Friedreich ataxia: an [18F]-FEMPA PET study
Khan, W., Corben, L. A., Bilal, H., Vivash, L., Delatycki, M. B., Egan, G. F. & Harding, I. H., Jan 2022, In: Movement Disorders. 37, 1, p. 218-224 7 p.Research output: Contribution to journal › Article › Research › peer-review
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Reduced Precision Underwrites Ego Dissolution and Therapeutic Outcomes Under Psychedelics
Stoliker, D., Egan, G. F. & Razi, A., 17 Mar 2022, In: Frontiers in Neuroscience. 16, 11 p., 827400.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Activities
- 2 Patents
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MONASH UNIVERSITY (Organisational unit)
Kamlesh Pawar (Inventor), Zhaolin Chen (Inventor), Jon Shah (Inventor) & Gary Egan (Inventor)
21 Nov 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Kamlesh Pawar (Inventor), Zhaolin Chen (Inventor), Jon Shah (Inventor) & Gary Egan (Inventor)
21 Nov 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Equipment
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Biomedical Imaging (MBI)
Gary Egan (Manager) & Kylie Reid (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility