• 19 Innovation Walk, Level 3

    3800 Clayton

    Australia

Accepting PhD Students

1981 …2023
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Personal profile

Research interests

Unlike many cancers, prostate cancer develops over decades, but when it spreads beyond the gland to other parts of the body, and no longer responds to the usual hormone therapies, there are very limited treatment options for the patients. "That is where our research is focused; we are trying to develop something for men who have end-stage disease.' Androgen-deprivation therapy is used to treat prostate cancer that has spread. It is effectively castration by drugs, depriving the body of the hormones that fuel tumour growth. Although it's effective, some cells always remain. "In some patients, they eventually regrow and they are lethal,' Gail says. Those are the cells she wants to target. In the past, oestrogen therapy came with dreadful side effects but Gail sees great promise in the carefully designed hormones it is now possible to make. 'We have just found a way that oestrogens might be used to effectively target those cells, working differently to the old therapies, without the bad side effects.' With the collaboration of urologists, oncologists and other clinicians, the discovery is being tested on human tissue specimens. Work on benign disease is just as important because it affects so many men. Although current drugs can be effective, many men have surgery.'There is an irony in the focus on prostate cancer, because most men, if they live long enough, will develop benign disease and yet relatively less research dollars and time are devoted to this aspect of prostate health, and we could do much better.' In both diseases, for example, stopping regeneration is important: in benign disease to prevent enlargement of the prostate, and in cancer to prevent growth of tumour cells. 'In both of those instances, we think that oestrogens can be useful,' Gail says. Although she notes that many myths exist about the complementary (or herbal) medicines often taken for benign disease, some have components that function like oestrogens. More knowledge of the mechanisms involved could lead to better, more potent drugs. 'There will come a time when we have to marry what we're doing with new drugs and what is known in traditional medicine to be effective,' 'Can what we do give some validity to using these complementary medicines? "That's a tough question but we've thought a lot about it." Prostate disease predominantly affects older men, but work on it is very much a forward-looking enterprise and Gail puts much emphasis on the need to train the next generation of experts. "This is not a disease that's going to be cured overnight." "We need a workforce of scientists and clinicians to continue the research."

Biography

Professor Gail Risbridger gained her PhD in Monash University, Melbourne, Australia. Currently, Prof Risbridger holds the positions of Deputy Dean (Special Projects), Research Director of Monash Comprehensive Cancer Consortium (MCCC) and Chair, Faculty Research Centres & Institutes Committee as well as advisory roles in Andrology Australia and the Freemasons Foundation Centre for Men’s Health.  She is one of Australia’s leading prostate cancer researchers and has authored >200 publications. Her awards include an International Fulbright Senior Scholar Award, British Endocrine Society Asia-Oceania Medal and Honorary Life Member of Endocrine Society of Australia.

External positions

Head & Group Leader, Prostate Cancer Research Program, Research Division, Peter MacCallum Cancer Centre

2016 → …

Executive Committee, Member, Monash Health

2015 → …

Assigner’s Panel, Member , National Health & Medical Research Council (NHMRC)

20152016

Research Director, Cancer & Blood Diseases Theme, Monash Partners Academic Health Science Centre (known as MPCCC)

2015 → …

Scientific Advisory Board, Member, DoD-TIA

2014 → …

Laureate Awards Committee, Member, The Endocrine Society

2014 → …

Director, Epworth Research Institute

20132016

Research Translation Faculty Steering Group, Cancer Control, Member, National Health & Medical Research Council (NHMRC)

2013

Project Grants Grant Review Panel, Member, National Health & Medical Research Council (NHMRC)

2013

Board Member, Prostate Cancer Foundation of Australia

2013 → …

South Australian Health & Medical Research Institute (SAHMRI), Beat Cancer Advisory Group

2012 → …

Chair, Fulbright Scholarship Victorian Selection Panel

2012

Research Fellowship Review Panel Member, National Health & Medical Research Council (NHMRC)

2012

Southern Melbourne Integrated Cancer Service (SMICS) & Monash Comprehensive Cancer Consortium (MCCC) Joint Council, Member

20122014

Southern Melbourne Integrated Cancer Service (SMICS) Management Committee, Member

20122014

Ambassador for Promotion of Cancer Research, European Association for Cancer Research (EACR)

2012

Council Member, Monash Partners Academic Health Science Centre

2012 → …

Victorian Selection Panel, ANZ Trustees Medical Advisory Committee

2010 → …

Chair, Australian Women in Endocrinology

20102012

Member of ANZUP Committee: Prostate Cancer & Renal Cell Cancer, Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)

2010 → …

Project Grant Review Panel, Chair, National Health & Medical Research Council (NHMRC)

2010

Annual Meeting Steering Committee, Basic Science Chair for ENDO 2011, The Endocrine Society

20102011

Scientific and Educational Programs Core Committee (SCIED) as Basic Science Chair for ENDO 2011, Member, The Endocrine Society

20102011

Executive Committee, Chair, Monash Comprehensive Cancer Consortium (MCCC)

2009 → …

Academy Member, (Cancer Biology) , National Health & Medical Research Council (NHMRC)

2009 → …

CRC Asthma & Airways, Co-operative Research Centre for Asthma, Director & Board Member

20082014

Communications Committee, Member, Women in Endocrinology

20082010

Medical and Scientific Advisory Committee, Cancer Council Victoria

2007 → …

Co-Chair Scientific Advisory Group, Freemason's Foundation Centre for Men's Health

2007 → …

Member, Fulbright Scholarship Victorian Selection Panel

20072012

Career Development Awards Panel, Chair, National Health & Medical Research Council (NHMRC)

20062009

Annual Meeting Steering Committee, Member, The Endocrine Society

20062008

Executive Committee of Management, Australian Prostate Cancer Consortium (APCC)

2005 → …

Grant Review Panels: Endocrinology, Cancer Biology, Genetics & Development , Member, National Health & Medical Research Council (NHMRC)

20052008

Scientific Advisory Group, Executive Member, Prostate Cancer Foundation of Australia

20052007

Board Member, Chair, US Women in Endocrinogy

2005

Awards Committee, Member, Women in Endocrinology

20052011

Postgraduate Student Committee, Chair, Monash Institute for Medical Research

20012006

Andrology Australia, Centre for Excellence in Male Reproductive Health, Member of Board & Executive Management Committee

2000 → …

Discipline Panel for Endocrinology & Reproduction, Chair, National Health & Medical Research Council (NHMRC)

19982000

Advisory Board Subcommittee for Commercialisation, Member, Monash Institute for Medical Research

19972003

Strategic Planning Committee, Member, Monash Institute for Medical Research

19961998

Assigner’s Panel Member, National Health & Medical Research Council (NHMRC)

19951997

Council Member & Secretary, The Endocrine Society of Australia

19941998

NH&MRC Regional Grants Interviewing Committee , National Health & Medical Research Council (NHMRC)

19911997

Research area keywords

  • Activin
  • Differentiation
  • Inhibin
  • Leydig Cells
  • Tumours
  • Cancer
  • Cancer Biology
  • Cancer/Carcinogenesis
  • Stromal Cells
  • Experimental Models
  • Immune-Deficient Models
  • Endocrinology
  • Prostate
  • Oestrogen Action
  • Prostate cancer
  • Prostate stem cell

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2000 2023

Research Output 1981 2019

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

Taylor, R. A., Fraser, M., Livingstone, J., Espiritu, S. M. G., Thorne, H., Huang, V., Lo, W., Shiah, Y-J., Yamaguchi, T. N., Sliwinski, A., Horsburgh, S., Meng, A., Heisler, L. E., Yu, N., Yousif, F., Papargiris, M., Lawrence, M. G., Timms, L., Murphy, D. G., Frydenberg, M. & 8 others, Hopkins, J. F., Bolton, D., Clouston, D., McPherson, J. D., Van Der Kwast, T., Boutros, P. C., Risbridger, G. P. & Bristow, R. G., 9 Jan 2017, In : Nature Communications. 8, 10 p., 13671.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Intraductal carcinoma of the prostate can evade androgen deprivation, with emergence of castrate-tolerant cells

Porter, L. H., Hashimoto, K., Lawrence, M. G., Pezaro, C., Clouston, D., Wang, H., Papargiris, M., Thorne, H., Li, J., Investigators, K., Ryan, A., Norden, S., Moon, D., Bolton, D. M., Sengupta, S., Frydenberg, M., Murphy, D. G., Risbridger, G. P. & Taylor, R. A., 1 Jun 2018, In : BJU International. 121, 6, p. 971-978 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Enduring epigenetic landmarks define the cancer microenvironment

Pidsley, R., Lawrence, M. G., Zotenko, E., Niranjan, B., Statham, A., Song, J., Chabanon, R. M., Qu, W., Wang, H., Richards, M., Nair, S. S., Armstrong, N., Nim, H. T., Papargiris, M., Balanathan, P., French, H., Peters, T., Norden, S., Ryan, A., Pedersen, J. & 9 others, Kench, J. G., Daly, R. J., Horvath, L., Stricker, P., Frydenberg, M., Taylor, R. A., Stirzaker, C., Risbridger, G. P. & Clark, S. J., 1 May 2018, In : Genome Research. 28, 5, p. 625-638 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Breast and prostate cancer: more similar than different

Risbridger, G. P., Davis, I. D., Birrell, S. N. & Tilley, W. D., 2010, In : Nature Reviews Cancer. 10, 3, p. 205 - 212 8 p.

Research output: Contribution to journalArticleOther

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Lee, R. S., Zhang, L., Berger, A., Lawrence, M. G., Song, J., Niranjan, B., Davies, R. G., Lister, N. L., Sandhu, S. K., Rubin, M. A., Risbridger, G. P., Taylor, R. A., Rickman, D. S., Horvath, L. G. & Daly, R. J., 1 Apr 2019, In : Neoplasia. 21, 4, p. 389-400 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Academic Links and Interchange Scheme Award, British Council

Gail Risbridger (Recipient), 1991

Prize: Prize (including medals and awards)

Australian Academy of Science Royal Society Exchange Program Award

Gail Risbridger (Recipient), 1997

Prize: Prize (including medals and awards)

Endocrine Society of Australia (ESA) Senior Plenary Award

Gail Risbridger (Recipient), 2012

Prize: Prize (including medals and awards)

Finnish Academy Science Award - Visiting Scientist

Gail Risbridger (Recipient), 1991

Prize: Prize (including medals and awards)

Activities 1992 2018

  • 50 Contribution to workshop, seminar, course
  • 33 Contribution to conference
  • 15 Editorial responsibility

Vic VIP Trade 2018

Gail Risbridger (Invited speaker)
28 Mar 2018

Activity: Participating in or organising an event typesContribution to conference

18th International Congress of Endocirnology (ICE) 2018

Gail Risbridger (Keynote/plenary speaker)
1 Dec 20184 Dec 2018

Activity: Participating in or organising an event typesContribution to conference

Australian Diabetes Society (ADS) and the Australian Diabetes Educators Association (ADEA) Annual Scientific Meeting 2017: Bioscientific Symposium - Practical Publishing Advice

Gail Risbridger (Keynote/plenary speaker)
30 Aug 20171 Sep 2017

Activity: Participating in or organising an event typesContribution to conference

Victorian Government Program for Japan Agency for Medical Research and Development - AMED

Gail Risbridger (Invited speaker)
2 Oct 20174 Oct 2017

Activity: Participating in or organising an event typesContribution to workshop, seminar, course

The Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology 2017

Gail Risbridger (Speaker)
27 Aug 201730 Aug 2017

Activity: Participating in or organising an event typesContribution to conference