20042019
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Personal profile

Biography

Francis Chiu leads the Bioanalytical section at the Centre for Drug Candidate Optimisation (CDCO). He joined the CDCO in 2003 with over twenty years' experience in the fields of medicinal chemistry, analytical chemistry and pharmaceutical science. Francis completed his Ph.D. in Pharmaceutical Chemistry at the University of Sydney and held roles at La Trobe University, Washington University, U.S.A. and the Chinese University, Hong Kong. His role at the CDCO involves leading a team responsible for the LCMS analyses of experimental drug candidates to determine their metabolic stability and their pharmacokinetics. He enjoys being involved in the large variety of research areas and collaborative projects; and being exposed to new research ideas and technologies. Frances' key projects include the Ozonide antimalarial project and the NHMRC project focussing on antibiotic resistance, which features in andlsquo;Ten of the Best Research Projects, 2015' by the National Health and Medical Research Council.

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Research Output 2004 2019

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 othersPrice, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

Katneni, K., Pham, T., Saunders, J., Chen, G., Patil, R., White, K. L., Abla, N., Chiu, F. C. K., Shackleford, D. M. & Charman, S. A., 1 Nov 2018, In : Pharmaceutical Research. 35, 11, 13 p., 210.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

Dong, Y., Wang, X., Kamaraj, S., Bulbule, V. J., Chiu, F. C. K., Chollet, J., Dhanasekaran, M., Hein, C. D., Papastogiannidis, P., Morizzi, J., Shackleford, D. M., Barker, H., Ryan, E., Scheurer, C., Tang, Y., Zhao, Q., Zhou, L., White, K. L., Urwyler, H., Charman, W. N. & 4 othersMatile, H., Wittlin, S., Charman, S. A. & Vennerstrom, J. L., 13 Apr 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2654-2668 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with improved drug-like properties for treatment and prevention of malaria

Phillips, M. A., White, K., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D., Chiu, F., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 1 othersCharman, S., 9 Dec 2016, In : ACS Infectious Diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Xie, S. C., Dogovski, C., Hanssen, E., Chiu, F., Yang, T., Crespo, M. P., Stafford, C., Batinovic, S., Teguh, S., Charman, S., Klonis, N. & Tilley, L., 2016, In : Journal of Cell Science. 129, 2, p. 406-416 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2011 2011

  • 1 Submissions to industry or govt committees, commissions and inquiries

Centre for Drug Candidate Optimisation

Francis Chiu (Member)
29 Nov 2011

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries