Francine Coelho Marques

Assoc Professor

Accepting PhD Students

PhD projects

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20052020

Research output per year

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Research Output

2020

Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, Spector, T. D., Valdes, A. M., Mackay, C. R. & Marques, F. Z., 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Don't take it with a pinch of salt: How sodium increases blood pressure via the gut microbiota

Jama, H. A. & Marques, F. Z., 27 Mar 2020, In : Circulation Research. 126, 7, p. 854-856 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Highlights from the International Society of Hypertension's New Investigators Network during 2019

Kruger, R., Brunström, M., Burger, D., Charchar, F., Climie, R., Mirabito Colafella, K. M., Kempny, P., Korostovtseva, L., Marques, F. Z., Picone, D., Romero, C., Steckelings, U. M., Velkoska, E., Wainford, R., Wynne, B. M. & Zanuzzi, M. G., May 2020, In : Journal of Hypertension. 38, 5, p. 968-973 6 p.

Research output: Contribution to journalArticleOtherpeer-review

Impact, strategies, and opportunities for early and midcareer cardiovascular researchers during the COVID-19 pandemic

Climie, R. E. & Marques, F. Z., 9 Jun 2020, In : Circulation. 141, 23, p. 1838-1840 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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1 Citation (Scopus)

Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia

Climie, R. E., Wu, J. H. Y., Calkin, A. C., Chapman, N., Inglis, S. C., Mirabito Colafella, K. M., Picone, D. S., Tan, J. T. M., Thomas, E., Viola, H. M., Wise, S. G., Murphy, A. J., Nelson, M. R., Nicholls, S. J., Hool, L. C., Doyle, K., Figtree, G. A., Marques, F. Z. & on behalf of the Australian Cardiovascular Alliance, 21 Aug 2020, (Accepted/In press) In : Heart Lung and Circulation. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice

Jackson, K. L., Gueguen, C., Lim, K., Eikelis, N., Stevenson, E. R., Charchar, F. J., Lambert, G. W., Burke, S. L., Paterson, M. R., Marques, F. Z. & Head, G. A., 19 May 2020, (Accepted/In press) In : Hypertension Research. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The Emerging Role of Gut Dysbiosis in Cardio-metabolic Risk Factors for Heart Failure

Sata, Y., Marques, F. Z. & Kaye, D. M., 1 May 2020, In : Current Hypertension Reports. 22, 5, 8 p., 38.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)
2019

Circulating microRNAs, Vascular Risk, and Physical Activity in Spinal Cord-Injured Subjects

Paim, L. R., Schreiber, R., de Rossi, G., Matos-Souza, J. R., de A. Costa e Silva, A., Calegari, D. R., Cheng, S., Coelho Marques, F., Sposito, A. C., Gorla, J. I., Cliquet, Jr, A. & Nadruz, JR, W., 2019, In : Journal of Neurotrauma. 36, 6, p. 845-852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Deficiency of Either Prebiotic Dietary Fibre or Prebiotic-Responsive Gut Microbiota Result in High Blood Pressure

Marques, F. Z., Shihata, W. A., Jama, H., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Phillips, S. E., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W., Mackay, C. & Kaye, D. M., Sep 2019, p. A059-A059. 1 p.

Research output: Contribution to conferenceAbstract

Open Access

Global deletion of MicroRNA-181A results in increased salt sensitivity in mice

Head, G., Paterson, M., Jackson, K., Evans, R., Charchar, F. J. & Marques, F., Jul 2019, In : Journal of Hypertension. 37, p. e27-e28 2 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Guidelines for Transparency on Gut Microbiome Studies in Essential and Experimental Hypertension

Marques, F. Z., Jama, H. A., Tsyganov, K., Gill, P. A., Rhys-Jones, D., Muralitharan, R. R., Muir, J., Holmes, A. & Mackay, C. R., Dec 2019, In : Hypertension. 74, 6, p. 1279-1293 15 p.

Research output: Contribution to journalArticleOtherpeer-review

5 Citations (Scopus)

Intergenerational Prevention Of Heart Failure Through Maternal Intake Of High Fibre

Jama, H. A., Shihata, W., Ziemann, M. D., Donner, D. G., Kiriazis, H., Du, X-J., El-Osta, A., Mackay, C. R., Kaye, D. M. & Coelho Marques, F., Feb 2019. 1 p.

Research output: Contribution to conferenceAbstract

Mechanisms responsible for Genetic Hypertension in Schlager BPH/2 Mice

Jackson, K. L., Head, G. A., Gueguen, C., Stevenson, E. R., Lim, K. & Marques, F. Z., 2019, In : Frontiers in Physiology. 10, OCT, 1311.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

The effect of diet on hypertensive pathology: is there a link via gut microbiota-driven immune-metabolism?

Jama, H. A., Beale, A., Shihata, W. & Marques, F. Z., 2019, In : Cardiovascular Research. 115, 9, p. 1435-1447 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

The gut microbiota and blood pressure in experimental models

Jama, H. A., Kaye, D. M. & Marques, F. Z., 1 Mar 2019, In : Current Opinion in Nephrology and Hypertension. 28, 2, p. 97-104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The role of the gut microbiome in sex differences in arterial pressure

Beale, A. L., Kaye, D. M. & Marques, F. Z., 25 Apr 2019, In : Biology of Sex Differences. 10, 1, 22.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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10 Citations (Scopus)
2018

Age-related differential structural and transcriptomic responses in the hypertensive heart

Marques, F. Z., Chu, P. Y., Ziemann, M., Kaspi, A., Kiriazis, H., Du, X. J., El-Osta, A. & Kaye, D. M., 9 Jul 2018, In : Frontiers in Physiology. 9, JUL, 13 p., 817.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

A polymorphism in the noradrenaline transporter gene is associated with increased blood pressure in patients with resistant hypertension

Eikelis, N., Marques, F. Z., Hering, D., Marusic, P., Head, G. A., Walton, A. S., Lambert, E. A., Esler, M. D., Sari, C. I., Schlaich, M. P. & Lambert, G. W., 1 Jul 2018, In : Journal of Hypertension. 36, 7, p. 1571-1577 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Beyond gut feelings: How the gut microbiota regulates blood pressure

Marques, F. Z., Mackay, C. R. & Kaye, D. M., 1 Jan 2018, In : Nature Reviews Cardiology. 15, 1, p. 20-32 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

91 Citations (Scopus)

Circadian differences in the contribution of the brain renin-angiotensin system in genetically hypertensive mice

Jackson, K. L., Marques, F. Z., Lim, K., Davern, P. J. & Head, G. A., 19 Mar 2018, In : Frontiers in Physiology. 9, 15 p., 231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life

Booth, S. A., Wadley, G. D., Marques, F. Z., Wlodek, M. E. & Charchar, F. J., 1 Nov 2018, In : Physiological Genomics. 50, 11, p. 956-963 8 p.

Research output: Contribution to journalArticleResearchpeer-review

GLOBAL DELETION OF MICRORNA-181A RESULTS IN ELEVATED BLOOD PRESSURE IN MICE

Head, G., Peterson, M., Jackson, K., Lim, K., Evans, R., Davern, P., Charchar, F. J. & Marques, F. Z., Jun 2018, p. e20-e21. 2 p.

Research output: Contribution to conferenceAbstract

HIGHER MICRORNA-132 IS ASSOCIATED WITH BLOOD PRESSURE AND LIVER STEATOSIS IN OBESE INDIVIDUALS

Eikelis, N., Dixon, J., Lambert, E. A., Hanin, G., Greenberg, D. S., Soreq, H., Marques, F. Z., Schlaich, M. P. & Lambert, G. W., Jun 2018, p. e25-e25. 1 p.

Research output: Contribution to conferenceAbstract

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

Prestes, P. R., Marques, F. Z., Lopez-Campos, G., Lewandowski, P., Delbridge, L. M. D., Charchar, F. J. & Harrap, S. B., 1 Sep 2018, In : Physiological Genomics. 50, 9, p. 680-687 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Missing Heritability of Hypertension and Our Microbiome: Have we been searching in the wrong place?

Marques, F. Z., 2 Oct 2018, In : Circulation. 138, 14, p. 1381-1383 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

4 Citations (Scopus)

Population-Based Gut Microbiome Associations With Hypertension

Jama, H., Kaye, D. M. & Marques, F. Z., 9 Nov 2018, In : Circulation Research. 123, 11, p. 1185-1187 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

3 Citations (Scopus)

Regulation of the human placental (pro)renin receptor-prorenin-angiotensin system by microRNAs

Wang, Y., Lumbers, E. R., Arthurs, A. L., Corbisier de Meaultsart, C., Mathe, A., Avery-Kiejda, K. A., Roberts, C. T., Broughton Pipkin, F., Marques, F. Z., Morris, B. J. & Pringle, K. G., 1 Sep 2018, In : Molecular Human Reproduction. 24, 9, p. 453-464 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Renal nerves contribute to hypertension in Schlager BPH/2J mice

Gueguen, C., Jackson, K. L., Marques, F. Z., Eikelis, N., Phillips, S., Stevenson, E. R., Charchar, F. J., Lambert, G. W., Davern, P. J. & Head, G. A., 10 Dec 2018, In : Hypertension Research. 42, p. 306-318 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2017

A polymorphism in the norepinephrine transporter gene is associated with affective and cardiovascular disease through a microRNA mechanism

Marques, FZ., Eikelis, N., Bayles, R. G., Lambert, EA., Straznicky, N. E., Hering, D., Esler, MD., Head, GA., Barton, DA., Schlaich, MP. & Lambert, GW., 1 Jan 2017, In : Molecular Psychiatry. 22, 1, p. 134-141 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

DETERMINING THE ROLE OF FIBRE, THROUGH CHANGES IN THE GUT MICROBIOTA, IN BLOOD PRESSURE REGULATION

Marques, F. Z., Fiedler, A., Horlock, D., Mackay, C. & Kaye, D. M., Sep 2017, p. e345-e346. 2 p.

Research output: Contribution to conferencePoster

Open Access
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DYSREGULATION OF MICRORNA-181A CAUSED BY OVERACTIVE RENAL SYMPATHETIC NERVES CONTRIBUTES TO ELEVATED RENAL RENIN MRNA AND HYPERTENSION IN SCHLAGER BPH/2J MICE

Jackson, K., Gueguen, C., Lim, K., Eikelis, N., Charchar, F. J., Lambert, G. W., Davern, P. J., Marques, F. Z. & Head, G., Sep 2017, p. e41-e41. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
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Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Marques, F. Z., Prestes, P. R., Byars, S. G., Ritchie, S. C., Würtz, P., Patel, S. K., Booth, S. A., Rana, I., Minoda, Y., Berzins, S. P., Curl, C. L., Bell, J. R., Wai, B., Srivastava, P. M., Kangas, A. J., Soininen, P., Ruohonen, S., Kähönen, M., Lehtimäki, T., Raitoharju, E. & 15 others, Havulinna, A., Perola, M., Raitakari, O., Salomaa, V., Ala-Korpela, M., Kettunen, J., McGlynn, M., Kelly, J., Wlodek, M. E., Lewandowski, P. A., Delbridge, L. M., Burrell, L. M., Inouye, M., Harrap, S. B. & Charchar, F. J., 14 Jun 2017, In : Journal of the American Heart Association. 6, 6, 57 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., Mackay, C. R. & Kaye, D. M., 7 Mar 2017, In : Circulation. 135, 10, p. 964-977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

196 Citations (Scopus)

N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy

Giam, B., Kuruppu, S., Chu, P. Y., Smith, A. I., Marques, F. Z., Fiedler, A., Horlock, D., Kiriazis, H., Du, X-J., Kaye, D. M. & Rajapakse, N. W., 18 Dec 2017, In : Scientific Reports. 7, 1, 12 p., 17718.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

N-acetylcysteine Reverses Established Renal Fibrosis and Restores Renal Function in a Mouse Model of Dilated Cardiomyopathy

Giam, B., Kuruppu, S., Chu, P. Y., Smith, I., Marques, F. Z., Fiedler, A., Horlock, D., Kiriazis, H., Du, X-J., Kaye, D. M. & Rajapakse, N., 14 Nov 2017. 1 p.

Research output: Contribution to conferenceAbstract

Open Access

Positive allosteric modulation of GABAA receptors attenuates high blood pressure in Schlager hypertensive mice

Stevenson, E. R., Johns, E. M. C., Marques, F. Z., Jackson, K. L., Davern, P. J., Evans, R. G. & Head, G. A., Mar 2017, In : Journal of Hypertension. 35, 3, p. 546-557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2016

Effect of Dietary Fibre Intake and the Gut Microbiota in a Model of Heart Failure

Coelho Marques, F., Nelson, E. M., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M. D., Tan, J., Kuruppu, D. M. S., Rajapakse, N., El-Osta, A., Mackay, C. R. & Kaye, D. M., 11 Nov 2016. 1 p.

Research output: Contribution to conferenceAbstract

Epigenetic changes in leukocytes after 8 weeks of resistance exercise training

Denham, J., Marques, F. Z., Bruns, E. L., O’Brien, B. J. & Charchar, F. J., 1 Jun 2016, In : European Journal of Applied Physiology. 116, 6, p. 1245-1253 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Erratum to: Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults (European Archives of Psychiatry and Clinical Neuroscience, (2014), 264, 5, (401-408), 10.1007/s00406-014-0486-8)

de Azeredo, L. A., Rovaris, D. L., Mota, N. R., Polina, E. R., Marques, F. Z., Contini, V., Vitola, E. S., Belmonte-de-Abreu, P., Rohde, L. A., Grevet, E. H. & Bau, C. H. D., 1 Dec 2016, In : European Archives of Psychiatry and Clinical Neuroscience. 266, 8, p. 775-776 2 p.

Research output: Contribution to journalComment / DebateOther

Telomere dynamics during aging in polygenic left ventricular hypertrophy

Marques, F. Z., Booth, S. A., Prestes, P. R., Curl, C. L., Delbridge, L. M. D., Lewandowski, P., Harrap, S. B. & Charchar, F. J., 1 Jan 2016, In : Physiological Genomics. 48, 1, p. 42-49 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The transcardiac gradient of cardio-microRNAs in the failing heart

Marques, F. Z., Vizi, D., Khammy, O., Mariani, J. A. & Kaye, D. M., 1 Aug 2016, In : European Journal of Heart Failure. 18, 8, p. 1000-1008 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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76 Citations (Scopus)

Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22

Prestes, P. R., Marques, F. Z., Lopez-Campos, G., Booth, S. A., McGlynn, M., Lewandowski, P., Delbridge, L. M. D., Harrap, S. B. & Charchar, F. J., 1 May 2016, In : Journal of Hypertension. 34, 5, p. 950-958 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2015

Across the globe in 4 months: Two International Society of Hypertension new investigator symposia in 2014

Veerabhadrappa, P., Burger, D., Brouwers, S., Christofidou, P., Bikai, R. E. L., Hannah-Shmouni, F., Kruger, R., Marques, F. Z., Mian, M. O. R., Montezano, A. C., Romero, C. A., Peña-Silva, R. A., Wainford, R. D., Charchar, F. J., Schutte, A. E. & Tomaszewski, M., 1 Jan 2015, In : Journal of Hypertension. 33, 4, p. 891-893 3 p.

Research output: Contribution to journalEditorialOther

Open Access
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1 Citation (Scopus)

Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise

Denham, J., O'Brien, B. J., Marques, F. Z. & Charchar, F. J., 1 Feb 2015, In : Journal of Applied Physiology. 118, 4, p. 475-488 14 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

MicroRNAs in essential hypertension and blood pressure regulation

Marques, F. Z. & Charchar, F. J., 1 Jan 2015, microRNA: Medical Evidence: From Molecular Biology to Clinical Practice. Santulli, G. (ed.). Switzerland: Springer, Vol. 888. p. 215-235 21 p. (Advances in Experimental Medicine and Biology; vol. 888).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

24 Citations (Scopus)

Signatures of miR-181a on the renal transcriptome and blood pressure

Marques, F. Z., Romaine, S. P. R., Denniff, M., Eales, J., Dormer, J., Garrelds, I. M., Wojnar, L., Musialik, K., Duda-Raszewska, B., Kiszka, B., Duda, M., Morris, B. J., Samani, N. J., Jan Danser, A. H., Bogdanski, P., Zukowska-Szczechowska, E., Charchar, F. J. & Tomaszewski, M., 24 Aug 2015, In : Molecular Medicine. 21, p. 739-748 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

The emerging role of non-coding RNA in essential hypertension and blood pressure regulation

Marques, F. Z., Booth, S. A. & Charchar, F. J., 9 Aug 2015, In : Journal of Human Hypertension. 29, 8, p. 459-467 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

25 Citations (Scopus)
2014

Acute exercise leads to regulation of telomere-associated genes and MicroRNA expression in immune cells

Chilton, W. L., Marques, F. Z., West, J., Kannourakis, G., Berzins, S. P., O'Brien, B. J. & Charchar, F. J., 21 Apr 2014, In : PLoS ONE. 9, 4, 13 p., e92088.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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46 Citations (Scopus)

Exercise: Putting action into our epigenome

Denham, J., Marques, F. Z., O'Brien, B. J. & Charchar, F. J., 1 Feb 2014, In : Sports Medicine. 44, 2, p. 189-209 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

73 Citations (Scopus)

Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: Findings from a sample of adults

De Azeredo, L. A., Rovaris, D. L., Mota, N. R., Polina, E. R., Marques, F. Z., Contini, V., Vitola, E. S., Belmonte-De-Abreu, P., Rohde, L. A., Grevet, E. H. & Bau, C. H. D., 1 Jan 2014, In : European Archives of Psychiatry and Clinical Neuroscience. 264, 5, p. 401-408 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)