Florian Wiede

Dr

20092019
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Research Output 2009 2019

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2019

Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells

Twohig, J. P., Cardus Figueras, A., Andrews, R., Wiede, F., Cossins, B. C., Derrac Soria, A., Lewis, M. J., Townsend, M. J., Millrine, D., Li, J., Hill, D. G., Uceda Fernandez, J., Liu, X., Szomolay, B., Pepper, C. J., Taylor, P. R., Pitzalis, C., Tiganis, T., Williams, N. M., Jones, G. W. & 1 others, Jones, S. A., 1 Apr 2019, In : Nature Immunology. 20, 4, p. 458-470 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

Svensson, M. N., Doody, K. M., Schmiedel, B. J., Bhattacharyya, S., Panwar, B., Wiede, F., Yang, S., Santelli, E., Wu, D. J., Sacchetti, C., Gujar, R., Seumois, G., Kiosses, W. B., Aubry, I., Kim, G., Mydel, P., Sakaguchi, S., Kronenberg, M., Tiganis, T., Tremblay, M. L. & 3 others, Ay, F., Vijayanand, P. & Bottini, N., 1 Mar 2019, In : The Journal of clinical investigation. 129, 3, p. 1193-1210 18 p.

Research output: Contribution to journalArticleResearchpeer-review

T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities

Wiede, F., Brodnicki, T. C., Goh, P. K., Leong, Y. A., Jones, G. W., Yu, D., Baxter, A. G., Jones, S. A., Kay, T. W. H. & Tiganis, T., 1 Jun 2019, In : Diabetes. 68, 6, p. 1251-1266 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L., 19 Jun 2018, In : Cell Reports. 23, 12, p. 3512-3524 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Grohmann, M., Wiede, F., Dodd, G. T., Gurzov, E. N., Ooi, G. J., Butt, T., Rasmiena, A. A., Kaur, S., Gulati, T., Goh, P. K., Treloar, A. E., Archer, S., Brown, W. A., Muller, M., Watt, M. J., Ohara, O., McLean, C. A. & Tiganis, T., 15 Nov 2018, In : Cell. 175, 5, p. 1289-1306 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants

Willoughby, L. F., Manent, J., Allan, K., Lee, J. H., Portela, M., Wiede, F., Warr, C., Meng, T-C., Tiganis, T. & Richardson, H. E., Jul 2017, In : FEBS Journal. 284, 14, p. 2231-2250 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses

Reimer, D., Lee, A. Y., Bannan, J., Fromm, P., Kara, E. E., Comerford, I., McColl, S., Wiede, F., Mielenz, D. & Körner, H., 1 Jan 2017, In : Immunology and Cell Biology. 95, 1, p. 33-41 9 p.

Research output: Contribution to journalArticleResearchpeer-review

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

Wiede, F., Sacirbegovic, F., Leong, Y. A., Yu, D. & Tiganis, T., 1 Jan 2017, In : Journal of Autoimmunity. 76, p. 85-100 16 p.

Research output: Contribution to journalArticleResearchpeer-review

PTPN2 regulates T cell lineage commitment and αß versus γδ specification

Wiede, F., Dudakov, J. A., Lu, K-H., Dodd, G. T., Butt, T., Godfrey, D. I., Strasser, A., Boyd, R. L. & Tiganis, T., 4 Sep 2017, In : Journal of Experimental Medicine. 214, 9, p. 2733-2758 26 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Merry, T. L., Tran, M., Dodd, G. T., Mangiafico, S. P., Wiede, F., Kaur, S., McLean, C. L., Andrikopoulos, S. & Tiganis, T., 1 Dec 2016, In : Diabetologia. 59, 12, p. 2632-2644 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Reversed T cell receptor docking on a major histocompatibility class I complex limits involvement in the immune response

Gras, S., Chadderton, J., Del Campo, C. M., Farenc, C., Wiede, F., Josephs, T. M., Sng, X. Y. X., Mirams, M., Watson, K. A., Tiganis, T., Quinn, K. M., Rossjohn, J. & La Gruta, N. L., 18 Oct 2016, In : Immunity. 45, 4, p. 749-760 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Leptin and insulin act on POMC neurons to promote the browning of white fat

Dodd, G. T., Decherf, S. S., Loh, K. Y., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Munzberg, H., Zhang, Z-Y., Kahn, B. B., Neel, B. G., Bence, K. K., Andrews, Z. B., Cowley, M. A. & Tiganis, T., 2015, In : Cell. 160, 1-2, p. 88 - 104 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice

Xi, Y., Liu, S., Bettaieb, A., Matsuo, K., Matsuo, I., Hosein, E., Chahed, S., Wiede, F., Zhang, S., Zhang, Z-Y., Kulkarni, R. N., Tiganis, T. & Haj, F. G., 2015, In : Diabetologia. 58, 1, p. 122 - 131 10 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Beringer, D. X., Kleijwegt, F. S., Wiede, F., Van Der Slik, A. R., Loh, K. K. L., Petersen, J., Dudek, N. L., Duinkerken, G., Laban, S., Joosten, A. M., Vivian, J. P., Chen, Z., Uldrich, A. P., Godfrey, D. I., McCluskey, J., Price, D. A., Radford, K. J., Purcell, A. W., Nikolic, T., Reid, H. H. & 3 others, Tiganis, T., Roep, B. O. & Rossjohn, J., 2015, In : Nature Immunology. 16, 11, p. 1153 - 1161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage

Merry, T., Tran, M., Stathopoulos, M., Wiede, F., Fam, B. C., Dodd, G. T., Clarke, I. J., Watt, M. J., Andrikopoulos, S. & Tiganis, T., 2014, In : Antioxidants and Redox Signaling. 20, 14, p. 2114 - 2129 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis

Bettaieb, A., Xi, Y., Hosein, E., Coggins, N., Bachaalany, S., Wiede, F., Perez, S., Griffey, S. M., Sastre, J., Tiganis, T. & Haj, F. G., 2014, In : Cell Communication and Signaling. 12, 1, p. 1 - 11 11 p., 13.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PTPN2 attenuates T-cell lymphopenia-induced proliferation

Wiede, F., La Gruta, N. L. & Tiganis, T., 2014, In : Nature Communications. 5, (Art. No: 3073), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PTPN2 restrains CD8+ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice

Wiede, F., Ziegler, A. I., Zehn, D. & Tiganis, T., 2014, In : Journal of Autoimmunity. 53, p. 105 - 114 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

Wiede, F., Fromm, P., Comerford, I., Kara, E., Bannan, J., Schuh, W., Ranasinghe, C., Tarlinton, D. M., Winkler, T., McColl, S. R. & Korner, H., 2013, In : Immunology and Cell Biology. 91, 5, p. 335 - 339 5 p.

Research output: Contribution to journalArticleResearchpeer-review

TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers

Shields, B., Wiede, F., Gurzov, E., Wee, K. T. B., Hauser, C., Zhu, H-J., Molloy, T. J., O'Toole, S. A., Daly, R. J., Sutherland, R. L., Mitchell, C. A., McLean, C. A. & Tiganis, T., 2013, In : Molecular and Cellular Biology. 33, 3, p. 557 - 570 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice

Wiede, F., Chew, S. H., van Vliet, C. J., Poulton, I. J., Kyparissoudis, K., Sasmono, T., Loh, K. Y., Tremblay, M. L., Godfrey, D. I., Sims, N. A. & Tiganis, T., 2012, In : PLoS ONE. 7, 5, 15 p., e36703.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2011

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

Loh, K., Fukushima, A., Zhang, X. M., Galic, S., Briggs, D. I., Enriori, P., Simonds, S., Wiede, F., Reichenbach, A., Hauser, C., Sims, N. A., Bence, K. K., Zhang, S., Zhang, Z-Y., Kahn, B., Neel, B., Andrews, Z. B., Cowley, M. A. & Tiganis, T., 2011, In : Cell Metabolism. 14, 5, p. 684 - 699 16 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Wiede, F., Shields, B., Chew, K. S. H., Kyparissoudis, K., van Vliet, C. J., Galic, S., Tremblay, M. L., Russell, S. M., Godfrey, D. I. & Tiganis, T., 2011, In : Journal of Clinical Investigation. 121, 12, p. 4758 - 4774 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis

Fukushima, A., Loh, K., Galic, S., Fam, B., Shields, B., Wiede, F., Tremblay, M. L., Watt, M. J., Andrikopoulos, S. & Tiganis, T., 2010, In : Diabetes. 59, 8, p. 1906 - 1914 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Age-dependent, polyclonal hyperactivation of t cells is reduced in TNF-negative gld/gld mice

Wiede, F., Roomberg, A., Cretney, E., Lechner, A., Fromm, P., Wren, L., Smyth, M. J. & Korner, H., 2009, In : Journal of leukocyte biology. 85, 1, p. 108 - 116 9 p.

Research output: Contribution to journalArticleResearchpeer-review