• Australian Centre for Blood Diseases Central Clinical School, Monash University Level 1, Walkway via The Alfred Centre, 99 Commercial Road, Melbourne 3004

    Australia

20132020

Research output per year

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Research Output

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Article

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M. & Curtis, D. J., 1 Aug 2017, In : Disease Models and Mechanisms. 10, 8, p. 1005-1013 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

Srivastava, R., Cao, Z., Nedeva, C., Naim, S., Bachmann, D., Rabachini, T., Gangoda, L., Shahi, S., Glab, J., Menassa, J., Osellame, L., Nelson, T., Fernandez-Marrero, Y., Brown, F., Wei, A., Ke, F., O'Reilly, L., Doerflinger, M., Allison, C., Kueh, A. & 5 others, Ramsay, R., Smith, B. J., Mathivanan, S., Kaufmann, T. & Puthalakath, H., 30 Jul 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15469-15474 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Conway, A., Brown, F. C., Hortle, E. J., Burgio, G., Foote, S. J., Morton, C. J., Jane, S. M. & Curtis, D. J., 21 May 2018, In : Disease Models and Mechanisms. 11, 5, 8 p., dmm034678.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Characterization of Tfrc-mutant mice with microcytic phenotypes

Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M. & Curtis, D. J., 14 Aug 2018, In : Blood Advances. 2, 15, p. 1914-1922 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level

Brown, F., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., Whitelaw, N. C., Whitelaw, E., Kile, B., Jane, S. M. & Curtis, D. J., 2013, In : Blood Cells, Molecules, and Diseases. 50, 2, p. 86-92 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

Brown, F. C., Cifani, P., Drill, E., He, J., Still, E., Zhong, S., Balasubramanian, S., Pavlick, D., Yilmazel, B., Knapp, K. M., Alonzo, T. A., Meshinchi, S., Stone, R. M., Kornblau, S. M., Marcucci, G., Gamis, A. S., Byrd, J. C., Gonen, M., Levine, R. L. & Kentsis, A., 1 Jan 2017, In : British Journal of Haematology. 176, 1, p. 86-91 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Induction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde

He, Y., Rank, G., Zhang, M., Ju, J., Liu, R., Xu, Z., Brown, F., Cerruti, L., Ma, C., Tan, R., Jane, S. M. & Zhao, Q., 2013, In : Journal of Translational Medicine. 11, p. 1 - 7 7 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria

Hortle, E., Starrs, L., Brown, F. C., Jane, S. M., Curtis, D. J., McMorran, B. J., Foote, S. J. & Burgio, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 6356.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown, F., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., Bitoun, M., Robinson, P. J., Kile, B. T., Jane, S. M. & Curtis, D. J., Sep 2017, In : British Journal of Haematology. 178, 4, p. 616 - 628 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, CS., Brown, FC., Collett, M., Saw, J., Chiu, SK., Sonderegger, SE., Lucas, SE., Alserihi, R., Chau, N., Toribio, ML., McCormack, MP., Chircop, M., Robinson, PJ., Jane, SM. & Curtis, DJ., 1 Oct 2016, In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia

Brown, F. C., Still, E., Koche, R. P., Yim, C. Y., Takao, S., Cifani, P., Reed, C., Gunasekera, S., Ficarro, S. B., Romanienko, P., Mark, W., McCarthy, C., de Stanchina, E., Gonen, M., Seshan, V., Bhola, P., O’Donnell, C., Spitzer, B., Stutzke, C., Lavallée, V. P. & 12 others, Hébert, J., Krivtsov, A. V., Melnick, A., Paietta, E. M., Tallman, M. S., Letai, A., Sauvageau, G., Pouliot, G., Levine, R., Marto, J. A., Armstrong, S. A. & Kentsis, A., 1 Apr 2018, In : Cancer Discovery. 8, 4, p. 478-497 20 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Peptidomimetic blockade of MYB in acute myeloid leukemia

Ramaswamy, K., Forbes, L., Minuesa, G., Gindin, T., Brown, F., Kharas, M. G., Krivtsov, A. V., Armstrong, S. A., Still, E., De Stanchina, E., Knoechel, B., Koche, R. & Kentsis, A., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)