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Fiona Brown

Dr

  • Australian Centre for Blood Diseases Central Clinical School, Monash University Level 1, Walkway via The Alfred Centre, 99 Commercial Road, Melbourne 3004

    Australia

20132018
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Personal profile

Biography

Dr. Brown completed her PhD in 2013 at the University of Melbourne. During her PhD, Dr. Brown studied the molecular mechanisms underpinning anaemia, including iron deficiency anaemia and beta thalassaemia, the most common causes of anaemia. She then worked as a Research Fellow at Memorial Sloan Kettering Cancer Center in New York, USA, where she studied pathways regulating chemotherapy resistance in acute meloid leukaemia (AML). In 2017, she moved to the Australian Ceneter for Blood Diseases, Monash University based at the Alfred Hospital. Here she is investigating improved targeted therapeutic strategies in AML. 

Keywords

  • Acute myeloid leukaemia
  • resistance dynamics

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Research Output 2013 2018

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Conway, A., Brown, F. C., Hortle, E. J., Burgio, G., Foote, S. J., Morton, C. J., Jane, S. M. & Curtis, D. J. 2018 (Accepted/In press) In : Disease Models & Mechanisms. p. 1-8 8 p.

Research output: Contribution to journal › Article

Open Access

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia

Brown, F. C. , Still, E. , Koche, R. P. , Yim, C. Y. , Takao, S. , Cifani, P. , Reed, C. , Gunasekera, S. , Ficarro, S. B. , Romanienko, P. , Mark, W. , McCarthy, C. , de Stanchina, E. , Gonen, M. , Seshan, V. , Bhola, P. , O’Donnell, C. , Spitzer, B. , Stutzke, C. , Lavallée, V. P. & 12 others Hébert, J., Krivtsov, A. V., Melnick, A., Paietta, E. M., Tallman, M. S., Letai, A., Sauvageau, G., Pouliot, G., Levine, R., Marto, J. A., Armstrong, S. A. & Kentsis, A. 1 Apr 2018 In : Cancer Discovery. 8, 4, p. 478-497 20 p.

Research output: Contribution to journal › Article

Peptidomimetic blockade of MYB in acute myeloid leukemia

Ramaswamy, K., Forbes, L., Minuesa, G., Gindin, T., Brown, F., Kharas, M. G., Krivtsov, A. V., Armstrong, S. A., Still, E., De Stanchina, E., Knoechel, B., Koche, R. & Kentsis, A. 1 Dec 2018 In : Nature Communications. 9, 1, 110

Research output: Contribution to journal › Article

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M. & Curtis, D. J. 1 Aug 2017 In : Disease Models & Mechanisms. 10, 8, p. 1005-1013 9 p.

Research output: Contribution to journal › Article

Open Access
File

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

Brown, F. C., Cifani, P., Drill, E., He, J., Still, E., Zhong, S., Balasubramanian, S., Pavlick, D., Yilmazel, B., Knapp, K. M., Alonzo, T. A., Meshinchi, S., Stone, R. M., Kornblau, S. M., Marcucci, G., Gamis, A. S., Byrd, J. C., Gonen, M., Levine, R. L. & Kentsis, A. 1 Jan 2017 In : British Journal of Haematology. 176, 1, p. 86-91 6 p.

Research output: Contribution to journal › Article