Projects per year
Personal profile
Biography
Dr. Brown completed her PhD in 2013 at the University of Melbourne. During her PhD, Dr. Brown studied the molecular mechanisms underpinning anaemia, including iron deficiency anaemia and beta thalassaemia, the most common causes of anaemia. She then worked as a Research Fellow at Memorial Sloan Kettering Cancer Center in New York, USA, where she studied pathways regulating chemotherapy resistance in acute meloid leukaemia (AML). In 2017, she moved to the Australian Ceneter for Blood Diseases, Monash University based at the Alfred Hospital. Here she is investigating improved targeted therapeutic strategies in AML.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Acute myeloid leukaemia
- resistance dynamics
Network
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Projects
- 2 Active
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A preclinical evaluation to identify novel drug combinations that will improve clinical outcomes in patients treated with AZA + Venetoclax
27/08/20 → 26/08/22
Project: Research
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A translational framework for discovering novel solutions for drug resistance in acute myeloid leukaemia
1/01/20 → 30/06/25
Project: Research
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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Thijssen, R., Diepstraten, S. T., Moujalled, D., Chew, E., Flensburg, C., Shi, M. X., Dengler, M. A., Litalien, V., MacRaild, S., Chen, M., Anstee, N. S., Reljić, B., Gabriel, S. S., Djajawi, T. M., Riffkin, C. D., Aubrey, B. J., Chang, C., Tai, L., Xu, Z., Morley, T. & 16 others, , 20 May 2021, In: Blood. 137, 20, p. 2721-2735 15 p.Research output: Contribution to journal › Article › Research › peer-review
18 Citations (Scopus) -
Author Correction: KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria (Scientific Reports, (2019), 9, 1, (6356), 10.1038/s41598-019-42782-x)
Hortle, E., Starrs, L., Brown, F. C., Jane, S. M., Curtis, D. J., McMorran, B. J., Foote, S. J. & Burgio, G., 1 Dec 2020, In: Scientific Reports. 10, 1, 1 p., 2303.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy
Chua, C. C., Roberts, A. W., Reynolds, J., Fong, C. Y., Ting, S. B., Salmon, J. M., MacRaild, S., Ivey, A., Tiong, I. S., Fleming, S., Brown, F. C., Loo, S., Majewski, I. J., Bohlander, S. K. & Wei, A. H., 20 Oct 2020, In: Journal of Clinical Oncology. 38, 30, p. 3506-3517 12 p.Research output: Contribution to journal › Article › Research › peer-review
48 Citations (Scopus) -
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML
DiNardo, C. D., Tiong, I. S., Quaglieri, A., MacRaild, S., Loghavi, S., Brown, F. C., Thijssen, R., Pomilio, G., Ivey, A., Salmon, J. M., Glytsou, C., Fleming, S. A., Zhang, Q., Ma, H., Patel, K. P., Kornblau, S. M., Xu, Z., Chua, C. C., Chen, X., Blombery, P. & 9 others, , 12 Mar 2020, In: Blood. 135, 11, p. 791-803 13 p.Research output: Contribution to journal › Article › Research › peer-review
167 Citations (Scopus) -
BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals
Srivastava, R., Cao, Z., Nedeva, C., Naim, S., Bachmann, D., Rabachini, T., Gangoda, L., Shahi, S., Glab, J., Menassa, J., Osellame, L., Nelson, T., Fernandez-Marrero, Y., Brown, F., Wei, A., Ke, F., O'Reilly, L., Doerflinger, M., Allison, C., Kueh, A. & 5 others, , 30 Jul 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15469-15474 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile20 Citations (Scopus)