Projects per year
Personal profile
Biography
Dr. Brown completed her PhD in 2013 at the University of Melbourne. During her PhD, Dr. Brown studied the molecular mechanisms underpinning anaemia, including iron deficiency anaemia and beta thalassaemia, the most common causes of anaemia. She then worked as a Research Fellow at Memorial Sloan Kettering Cancer Center in New York, USA, where she studied pathways regulating chemotherapy resistance in acute meloid leukaemia (AML). In 2017, she moved to the Australian Ceneter for Blood Diseases, Monash University based at the Alfred Hospital. Here she is investigating improved targeted therapeutic strategies in AML.
Keywords
- Acute myeloid leukaemia
- resistance dynamics
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Projects 2020 2024
- 1 Not started
A translational framework for discovering novel solutions for drug resistance in acute myeloid leukaemia
1/01/20 → 31/12/24
Project: Research
Research Output 2013 2019
KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria
Hortle, E., Starrs, L., Brown, F., Jane, S., Curtis, D., McMorran, B. J., Foote, S. J. & Burgio, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 6356.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency
Conway, A., Brown, F. C., Hortle, E. J., Burgio, G., Foote, S. J., Morton, C. J., Jane, S. M. & Curtis, D. J., 21 May 2018, In : Disease Models and Mechanisms. 11, 5, 8 p., dmm034678.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Characterization of Tfrc-mutant mice with microcytic phenotypes
Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M. & Curtis, D. J., 14 Aug 2018, In : Blood Advances. 2, 5, p. 1914-1922 9 p.Research output: Contribution to journal › Article › Research › peer-review
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
Johnson, D. C., Taabazuing, C. Y., Okondo, M. C., Chui, A. J., Rao, S. D., Brown, F. C., Reed, C., Peguero, E., de Stanchina, E., Kentsis, A. & Bachovchin, D. A., 1 Aug 2018, In : Nature Medicine. 24, 8, p. 1151-1156 6 p.Research output: Contribution to journal › Letter › Research › peer-review
MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia
Brown, F. C., Still, E., Koche, R. P., Yim, C. Y., Takao, S., Cifani, P., Reed, C., Gunasekera, S., Ficarro, S. B., Romanienko, P., Mark, W., McCarthy, C., de Stanchina, E., Gonen, M., Seshan, V., Bhola, P., O’Donnell, C., Spitzer, B., Stutzke, C., Lavallée, V. P. & 12 others, 1 Apr 2018, In : Cancer Discovery. 8, 4, p. 478-497 20 p.Research output: Contribution to journal › Article › Research › peer-review