Personal profile

Biography

Dr. Brown completed her PhD in 2013 at the University of Melbourne. During her PhD, Dr. Brown studied the molecular mechanisms underpinning anaemia, including iron deficiency anaemia and beta thalassaemia, the most common causes of anaemia. She then worked as a Research Fellow at Memorial Sloan Kettering Cancer Center in New York, USA, where she studied pathways regulating chemotherapy resistance in acute meloid leukaemia (AML). In 2017, she moved to the Australian Ceneter for Blood Diseases, Monash University based at the Alfred Hospital. Here she is investigating improved targeted therapeutic strategies in AML. 

Keywords

  • Acute myeloid leukaemia
  • resistance dynamics

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Research Output 2013 2018

Peptidomimetic blockade of MYB in acute myeloid leukemia

Ramaswamy, K., Forbes, L., Minuesa, G., Gindin, T., Brown, F., Kharas, M. G., Krivtsov, A. V., Armstrong, S. A., Still, E., De Stanchina, E., Knoechel, B., Koche, R. & Kentsis, A. 1 Dec 2018 In : Nature Communications. 9, 1, 110

Research output: Research - peer-reviewArticle

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

Brown, F. C., Cifani, P., Drill, E., He, J., Still, E., Zhong, S., Balasubramanian, S., Pavlick, D., Yilmazel, B., Knapp, K. M., Alonzo, T. A., Meshinchi, S., Stone, R. M., Kornblau, S. M., Marcucci, G., Gamis, A. S., Byrd, J. C., Gonen, M., Levine, R. L. & Kentsis, A. 1 Jan 2017 In : British Journal of Haematology. 176, 1, p. 86-91 6 p.

Research output: Research - peer-reviewArticle

Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown, F., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., Bitoun, M., Robinson, P. J., Kile, B. T., Jane, S. M. & Curtis, D. J. Sep 2017 In : British Journal of Haematology. 178, 4, p. 616 - 628 13 p.

Research output: Research - peer-reviewArticle

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, C. S., Brown, F. C., Collett, M., Saw, J., Chiu, S. K., Sonderegger, S. E., Lucas, S. E., Alserihi, R., Chau, N., Toribio, M. L., McCormack, M. P., Chircop, M., Robinson, P. J., Jane, S. M. & Curtis, D. J. 1 Oct 2016 In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Research - peer-reviewArticle

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J. 2015 In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Research - peer-reviewArticle