Projects per year
Personal profile
Biography
Felix Bennetts is a Research Fellow at the Monash Institute of Pharmaceutical Sciences, Monash University, working under the supervision of Associate Professor David Thal and Dr. Sabatino Ventura. He completed his PhD in October 2024, with a focus on the structural and functional characterisation of the P2X1 receptor. Felix’s current research aims to therapeutically target the P2X1 receptor for the development of non-hormonal, oral male contraceptives. With support from MCI funding, his work contributes to drug discovery efforts focused on identifying potent compounds suitable for future clinical application. In addition to his work on the P2X1 receptor, Felix has a broader interest in membrane proteins, with a focus on using structural biology and pharmacology to identify druggable binding sites and guide the development of small molecule therapeutics.
Research area keywords
- Structural Biology
- Pharmacology
- Male Contraception
- Cryo-EM
- Purinergic Receptors
- P2X1 Receptor
Collaborations and top research areas from the last five years
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Development of a P2X1 receptor antagonist for use as a male contraceptive
Bennetts, F. (Primary Chief Investigator (PCI)), Ventura, S. (Supervisor) & Thal, D. (Supervisor)
17/03/25 → 17/03/27
Project: Research
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Discovery of a lead molecule for development into a non-hormonal male contraceptive
Mobbs, J. (Primary Chief Investigator (PCI)), Ventura, S. (Chief Investigator (CI)), Thal, D. (Chief Investigator (CI)) & Bennetts, F. (Chief Investigator (CI))
1/01/23 → 30/04/24
Project: Research
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Structural insights into the human P2X1 receptor and ligand interactions
Bennetts, F. M., Venugopal, H., Glukhova, A., Mobbs, J. I., Ventura, S. & Thal, D. M., Dec 2024, In: Nature Communications. 15, 1, 14 p., 8418.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
The P2X1 receptor as a therapeutic target
Bennetts, F. M., Mobbs, J. I., Ventura, S. & Thal, D. M., 2022, In: Purinergic Signalling. 18, p. 421–433 13 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access14 Citations (Scopus) -
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice
Retamal, J. S., Grace, M. S., Dill, L. K., Ramirez-Garcia, P., Peng, S., Gondin, A. B., Bennetts, F., Alvi, S., Rajasekhar, P., Almazi, J. G., Carbone, S. E., Bunnett, N. W., Davis, T. P., Veldhuis, N. A., Poole, D. P. & McIntyre, P., Jul 2021, In: Laboratory Investigation. 101, 7, p. 851–864 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive†
Mathiew, M., Dennis, B. M., Bennetts, F., Su, N. N. E., Nguyen, N., Botteon, A., Baell, J. B. & Ventura, S., 4 Aug 2020, In: Biology of Reproduction. 103, 2, p. 323-332 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)