Projects per year
Personal profile
Biography
Acinetobacter baumannii is an opportunistic pathogen, and one of the greatest threats to modern medicine. Its currently estimated that as many as 60% of all ventilator associated pneumonia cases are attributed to multidrug resistant A. baumannii, with mortality rates >35%. Our research seeks to address the bacterial mechanisms underlying the success of this pathogen during infection. Using a multifaceted approach, our work explores the genetic regulation and function of different virulence attributes, deciphering the complex network of how this bacterium interacts with, and influences the host immune response. By enhancing our understanding of the mechanisms of disease, our research aims to promote a more rational therapeutic design to combat this deadly pathogen.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Microbiology, PhD, University of Birmingham
Sep 2009 → Sep 2013
Award Date: 27 Sep 2013
Mechanistic Molecular Toxicology, MRes, University of Birmingham
Sep 2008 → Aug 2009
Award Date: 28 Aug 2009
Animal Biology, BSc (Hons) , University of Wolverhampton
Sep 2004 → Jul 2008
Award Date: 31 Jul 2008
Research area keywords
- Acinetobacter baumannii
- Bacterial Pathogenesis
- Virulence
Network
Projects
- 1 Finished
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Targeting outer membrane vesicles of Gram-negative ‘superbug’ Acinetobacter baumannii: A systems and computational approach
2/01/17 → 30/04/18
Project: Research
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LI-Detector: a Method for Curating Ordered Gene-Replacement Libraries
Goodall, E. C. A., Morris, F. C., McKeand, S. A., Sullivan, R., Warner, I. A., Sheehan, E., Boelter, G., Icke, C., Cunningham, A. F., Cole, J. A., Banzhaf, M., Bryant, J. A. & Henderson, I. R., Aug 2022, In: Microbiology Spectrum. 10, 4, 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials
Gordillo Altamirano, F., Forsyth, J. H., Patwa, R., Kostoulias, X., Trim, M., Subedi, D., Archer, S. K., Morris, F. C., Oliveira, C., Kielty, L., Korneev, D., O’Bryan, M. K., Lithgow, T. J., Peleg, A. Y. & Barr, J. J., Feb 2021, In: Nature Microbiology. 6, 2, p. 157-161 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
BamA and BamD Are Essential for the Secretion of Trimeric Autotransporter Adhesins
Rooke, J. L., Icke, C., Wells, T. J., Rossiter, A. E., Browning, D. F., Morris, F. C., Leo, J. C., Schütz, M. S., Autenrieth, I. B., Cunningham, A. F., Linke, D. & Henderson, I. R., 23 Feb 2021, In: Frontiers in Microbiology. 12, 10 p., 628879.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
BonA from Acinetobacter baumannii forms a divisome-localized decamer that supports outer envelope function
Grinter, R., Morris, F. C., Dunstan, R. A., Leung, P. M., Kropp, A., Belousoff, M., Gunasinghe, S. D., Scott, N. E., Beckham, S., Peleg, A. Y., Greening, C., Li, J., Heinz, E. & Lithgow, T., Aug 2021, In: mBio. 12, 4, 18 p., e01480-21.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48 metalloprotease BepA
Bryant, J. A., Cadby, I. T., Chong, Z. S., Boelter, G., Sevastsyanovich, Y. R., Morris, F. C., Cunningham, A. F., Kritikos, G., Meek, R. W., Banzhaf, M., Chng, S. S., Lovering, A. L. & Henderson, I. R., Jan 2021, In: Journal of Bacteriology. 203, 2, 18 p., e00434-20.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus)