Projects per year
Personal profile
Biography
Acinetobacter baumannii is an opportunistic pathogen, and one of the greatest threats to modern medicine. Its currently estimated that as many as 60% of all ventilator associated pneumonia cases are attributed to multidrug resistant A. baumannii, with mortality rates >35%. Our research seeks to address the bacterial mechanisms underlying the success of this pathogen during infection. Using a multifaceted approach, our work explores the genetic regulation and function of different virulence attributes, deciphering the complex network of how this bacterium interacts with, and influences the host immune response. By enhancing our understanding of the mechanisms of disease, our research aims to promote a more rational therapeutic design to combat this deadly pathogen.
Education/Academic qualification
Microbiology, PhD, University of Birmingham
Sep 2009 → Sep 2013
Award Date: 27 Sep 2013
Mechanistic Molecular Toxicology, MRes, University of Birmingham
Sep 2008 → Aug 2009
Award Date: 28 Aug 2009
Animal Biology, BSc (Hons) , University of Wolverhampton
Sep 2004 → Jul 2008
Award Date: 31 Jul 2008
Research area keywords
- Acinetobacter baumannii
- Bacterial Pathogenesis
- Virulence
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
- 1 Finished
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Targeting outer membrane vesicles of Gram-negative ‘superbug’ Acinetobacter baumannii: A systems and computational approach
2/01/17 → 30/04/18
Project: Research
Research Output
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Bacteriophages targeting Acinetobacter baumannii capsule induce antimicrobial resensitization
Altamirano, F. G., Forsyth, J. H., Patwa, R., Kostoulias, X., Trim, M., Subedi, D., Archer, S., Morris, F. C., Oliveira, C., Kielty, L., Korneev, D., O’Bryan, M. K., Lithgow, T. J., Peleg, A. Y. & Barr, J. J., 26 Feb 2020, 28 p. bioRxiv.Research output: Other contribution › Research
Open Access -
Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
Domínguez-Medina, C. C., Pérez-Toledo, M., Schager, A. E., Marshall, J. L., Cook, C. N., Bobat, S., Hwang, H., Chun, B. J., Logan, E., Bryant, J. A., Channell, W. M., Morris, F. C., Jossi, S. E., Alshayea, A., Rossiter, A. E., Barrow, P. A., Horsnell, W. G., MacLennan, C. A., Henderson, I. R., Lakey, J. H. & 4 others, , 12 Feb 2020, In : Nature Communications. 11, 1, 11 p., 851.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile7 Citations (Scopus) -
Structure-function analyses of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation
Bryant, JA., Morris, FC., Knowles, TJ., Maderbocus, R., Heinz, E., Boelter, G., Alodaini, D., Colyer, A., Wotherspoon, PJ., Staunton, KA., Jeeves, M., Browning, DF., Sevastsyanovich, YR., Wells, TJ., Bavro, VN., Sridhar, P., Ward, DG., Chong, Z-S., Icke, C., Teo, A. & 7 others, , 2020, (Accepted/In press) 47 p. bioRxiv.Research output: Other contribution › Research
Open Access -
The Mechanisms of Disease Caused by Acinetobacter baumannii
Morris, F. C., Dexter, C., Kostoulias, X., Uddin, M. I. & Peleg, A. Y., 17 Jul 2019, In : Frontiers in Microbiology. 10, 20 p., 1601.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile21 Citations (Scopus) -
Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae
Nang, S. C., Morris, F. C., McDonald, M. J., Han, M., Wang, J., Strugnell, R. A., Velkov, T. & Li, J., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1604-1610 7 p.Research output: Contribution to journal › Article › Research › peer-review
17 Citations (Scopus)