Accepting PhD Students

PhD projects

1. Elucidating the Effect of Vitamin E Tocotrienol-Rich Fraction in Preventing Chronic Unpredictable Stress-Induced Male Reproductive Deficit Sprague–Dawley Rat.

2. Elucidating the semen quality and the potential biomarker of young men’s reproductive health: A cross sectional population-based study

20142023

Research activity per year

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Personal profile

Biography

Dr Faizul bin Jaafar is currently an Assistant Lecturer at the Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia since October 2019. His academic journey, marked by a PhD and a Bachelor of Science in Biochemistry from the University Kebangsaan Malaysia (UKM).

His research journey commenced during his honors project, where he delved into the realms of biochemistry and microbial genetics. His project focused on developing non-antibiotic antimicrobials for melioidosis disease.

With a keen interest in diseases, particularly their clinical biochemistry and aging aspects, he pursued a PhD. His research focused on elucidating the role of the vitamin E isomer (tocotrienol) in upregulating protein expression to prevent cell aging. During his PhD, he was invited to conduct part of his PhD research at the Faculty of Pharmaceutical Science, Tokyo University of Science, Japan.

Post-PhD, his dedication to research led him to actively collaborate with researchers from Universiti Malaya (UM) and Universiti Kebangsaan Malaysia (UKM). His research work has centered around age-related diseases and antioxidants, leveraging advanced omics techniques such as genomics, transcriptomics, proteomics, and metabolomics.

Driven by a desire to specialize and focus his research on aging, he joined Monash and underwent specialized training in reproductive neuropeptide. With two years of dedicated training, his current research endeavors revolve around enhancing the understanding of reproductive neuropeptide roles in infertility. He investigates how external factors, specifically stress and nutrient intake, impact reproductive neuropeptides in the infertility process.

Monash teaching commitment

MED 1100/1200 - PBL Year 1 

MED 1100/1200 - Health, Knowledge & Society

MED 1100/1200 - Biochemistry

MED 2100 & MED 2200 - Student project cases 

MED5101 - Applied Studies in Medical Research and Professional Practice/Scholarly Intensive Placement (SIP)

PSY2026 - Biopsychology

NUT1023 - Nutritional Biochemistry and Nutrigenomics (Unit Coordinator)

Research interests

He is currently immersed in groundbreaking research that explores the intricate connection between the brain and reproduction, with a specific emphasis on unraveling the pivotal role of reproductive neuropeptides in fertility. His work delves into how external factors, such as stress and nutrient intake, influence this intricate interplay.

Moreover, he is actively engaged in several exciting projects, including:

  1. The Effect of Neuroinflammation on Oxidative Stress and Reproductive Neuropeptides in The Hypothalamus
  2. Influence of Social Stress on Phoenixin in the Brain of Male Nile tilapia (Oreochromis niloticus).
  3. Elucidating the semen quality and the potential biomarker of young
    men’s reproductive health: A cross-sectional population-based study.
  4. Elucidating the Role of Phoenixin in HPA-HPG Axis in Chronic Unpredictable Stress-Induced Infertility Male Rats
  5. Elucidating the Effect of Vitamin E Tocotrienol-Rich Fraction in Preventing Chronic Unpredictable Stress-Induced Male Reproductive Deficit Sprague–Dawley Rats.
  6. Investigating the effect of spexin on insulin secretion and sensitivity using C2C12 cell line.
  7. Effect of miR-153 overexpression on the inflammation-induced depression-like phenotype.

Additionally, he has been awarded multiple grants, including:

Internal Grant

Project Title: Elucidating the Role of Phoenixin As the Central Regulator of Reproductive and Stress in
Depression-Induced Male Infertility
Role: Principal Investigator
Grant Amount and Type: MYR 20,000.00 / Internal Grant
Duration: 01 October 2022 – 31 December 2022

 

Project Title: Elucidating the Effect of Vitamin E Tocotrienol-Rich Fraction in Preventing Chronic Unpredictable Stress-Induced Male Reproductive Deficit Sprague–Dawley Rat
Role: Principal Investigator
Grant Amount and Type: MYR 10,000.00 / Internal Grant (Seed Grant)
Duration: 01 February 2022 – 31 December 2023

 

Project Title: Genetic Marker and Changes in Reproductive Neuropeptide Genes of Infertile Person (Male and Female) and its Association with Psychological Distress
Role: Principal Investigator
Grant Amount and Type: MYR 20,000.00 / Internal Grant
Duration: 06 July 2020 – 31 October 2023

 

Project Title: Investigating the effect of spexin on insulin secretion and sensitivity using C2C12 cell line
Role: Co-Investigator
Grant Amount and Type: MYR 20,000.00 / Internal Grant
Duration: 1 May 2023 - 30 April 2025

 

Project Title: The role of Phoenixin (PNX), a novel neuropeptide in stress-induced reproductive failures
Role: Co-Investigator
Grant Amount and Type: MYR 20,000.00 / Internal Grant
Duration: 15 July 2021 – 30 Jun 2024

 

External Grant

Project Title: Unravelling Mitochondrial Dysfunction and Alpha-synuclein Pathogenesis of Parkinson's Disease by Phoenixin
Role: Co-Investigator
Grant Amount and Type: RM128,899 / 2023 Fundamental Research Grant Scheme (FRGS)
Duration: 1 October 2023 – 30 September 2025

 

Project Title: Effect of miR-153 overexpression on the inflammation-induced depression-like phenotype
Role: Co-Investigator
Grant Amount and Type: RM23,366.00 / 2022 IBRO Early Career Award
Duration: 1 September 2021 – 30 December 2023

 

 

Supervision interests

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Aging and Antioxidant, Doctor of Philosophy (Biochemistry), Modulation of SIRT1 Expression by Tocotrienol-rich Fraction (TRF) Treatment to Prevent Replicative Senescence of Human Diploid Fibroblast (HDFs), Pusat Perubatan Universiti Kebangsaan Malaysia (University Kebangsaan Malaysia Medical Centre)

Award Date: 10 Nov 2018

Biochemistry, Bachelor of Science with Honours (Biochemistry), ugt-29 Gene Expression in Caenorhabditis elegans Infected by Gram-Positive and Gram-Negative Pathogens, Universiti Kebangsaan Malaysia (National University of Malaysia)

Award Date: 24 Sept 2011

Research area keywords

  • Neuroendocrinology
  • Ageing
  • Infertility
  • Gene expression
  • Signal Transduction

Collaborations and top research areas from the last five years

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  • Gold Award

    Makpol, Suzana (Recipient), Jaafar, Faizul (Recipient) & Mohd Sahardi, Nur Fatin Nabilah (Recipient), Mar 2023

    Prize: Prize (including medals and awards)

    File
  • Gold Medal

    Makpol, Suzana (Recipient), Razak, Azraul Mumtazah (Recipient), Mohd Sahardi, Nur Fatin Nabilah (Recipient), Jaafar, Faizul (Recipient) & Tan, Jen Kit (Recipient), May 2023

    Prize: Prize (including medals and awards)

    File