Projects per year
Personal profile
Biography
Dr. Evan Healy completed his PhD in 2019 in Prof. Adrian Bracken's lab at Trinity College Dublin, Ireland. His doctoral work focused on defining how specific components of the Polycomb Repressive Complex (PRC) machinery synergise to coordinate genome wide activites. Dr. Healy was recruited to the Biomedicine Discovery Institute at Monash University in November 2021, where he is currently an ARC DECRA Fellow and NHMRC Investigator. His current research focus is to understand the molecular mechanisms underlying chromatin and transcriptional regulation with a particular focus on the role RNA plays in this process.
Research interests
In all multicellular organisms, cellular identity is defined by distinct gene expression programmes that are stably maintained throughout life. Coordination of gene expression is linked to the three-dimensional packaging of genomic DNA into chromatin.
My research interests are focused on the molecular mechanisms underlying chromatin regulation and how this related to gene expression. Mutations in chromatin regulators that control these processes often drive human disease such as cancer and neurodevelopmental syndromes. In particular, I study how chromatin and chromatin regulators are modulated by RNA. The ultimate goal of my research is to leverage basic biological discoveries in this area to uncover novel therapuetic strategies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Genetics, PhD, Understanding the Diverse Roles of Polycomb-like proteins in the Regulation of Chromatin and Transcriptional Landscapes, Trinity College Dublin
1 Sept 2015 → 30 Jan 2019
Award Date: 20 Jun 2019
Research area keywords
- Chromatin biology
- Epigenetics
- Transcriptional Regulation
Collaborations and top research areas from the last five years
Projects
- 2 Active
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How does RNA regulate gene repression?
Healy, E. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/27
Project: Research
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How does RNA regulate gene repression?
Healy, E. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/29
Project: Research
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A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells
McCole, R., Nolan, J., Reck, D. M., Monger, C., Rustichelli, S., Conway, E., Brien, G. L., Wang, C., Deevy, O., Neikes, H. K., Bashore, F. M., Mooney, A., Flavin, R., Vandenberghe, E., Flanigan, S. F., Pasini, D., Davidovich, C., Vermeulen, M., James, L. I. & Healy, E. & 1 others, , 28 Jan 2025, In: Cell Reports. 44, 1, 21 p., 115192.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
PIC-king apart PRC1-mediated repression
Healy, E. & Bracken, A. P., Jan 2025, In: Trends in Genetics. 41, 1, p. 4-5 2 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access -
Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2
Gail, E. H., Healy, E., Flanigan, S. F., Jones, N., Ng, X. H., Uckelmann, M., Levina, V., Zhang, Q. (Leading Author) & Davidovich, C. (Leading Author), Jun 2024, In: Nature Genetics. 56, 6, p. 1193-1202 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion
Healy, E., Zhang, Q., Gail, E. H., Agius, S. C., Sun, G., Bullen, M., Pandey, V., Das, P. P., Polo, J. M. & Davidovich, C., 26 Mar 2024, In: Cell Reports. 43, 3, 13 p., 113858.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus) -
PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1
Glancy, E., Wang, C., Tuck, E., Healy, E., Amato, S., Neikes, H. K., Mariani, A., Mucha, M., Vermeulen, M., Pasini, D. & Bracken, A. P., 4 May 2023, In: Molecular Cell. 83, 9, p. 1393-1411.e7 26 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access33 Citations (Scopus)