Erik Westein

Dr

20032019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 20 Article
  • 5 Review Article
  • 1 Chapter (Book)
  • 1 Comment / Debate
2019

Shear-Dependent Platelet Aggregation: Mechanisms and Therapeutic Opportunities

Rana, A., Westein, E., Niego, B. & Hagemeyer, C. E., 20 Sep 2019, In : Frontiers in Cardiovascular Medicine. 6, 21 p., 141.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Targeting Nanotechnologies for the Treatment of Thrombosis and Cardiovascular Disease

Palazzolo, J. S., Westein, E., Hagemeyer, C. & Wang, T-Y., 15 Oct 2019, (Accepted/In press) In : Seminars in Thrombosis and Hemostasis. 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

Multi-photon microscopy in cardiovascular research

Wu, Z., Rademakers, T., Kiessling, F., Vogt, M., Westein, E., Weber, C., Megens, R. T. A. & van Zandvoort, M., 1 Nov 2017, In : Methods. 130, p. 79-89 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Kraakman, M. J., Lee, M. K. S., Al-Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., Whillas, A., Hanssen, N. M. J., Febbraio, M. A., Westein, E., Fisher, E. A., Chin-Dusting, J., Cooper, M. E., Berger, J. S., Goldberg, I. J., Nagareddy, P. R. & 1 others, Murphy, A. J., 1 Jun 2017, In : Journal of Clinical Investigation. 127, 6, p. 2133-2147 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
46 Citations (Scopus)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., May 2017, In : Journal of Thrombosis and Haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Thrombosis in diabetes: A shear flow effect?

Westein, E., Hoefer, T. & Calkin, A. C., 1 Jun 2017, In : Clinical Science. 131, 12, p. 1245-1260 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)
2015

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

Alt, K. M., Paterson, B. M., Westein, E., Rudd, S., Poniger, S., Jagdale, S., Ardipradja, K., Connell, T. U., Krippner, G. Y., Nair, A. K. N., Wang, X., Tochon-Danguy, H., Donnelly, P. S., Peter, K. & Hagemeyer, C. E., 2015, In : Angewandte Chemie - International Edition. 54, 26, p. 7515 - 7519 5 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Gunawan, S. T., Kempe, K., Bonnard, T. M. E., Cui, J., Alt, K. M., Law, L. S., Wang, X., Westein, E., Such, G. K., Peter, K., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Materials. 27, 35, p. 5153-5157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)
2014

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Westein, E., Goddard, D. M., Ono, A., Yamanashi, Y., Nesbitt, W. S. & Jackson, S., 2014, In : Journal of Biological Chemistry. 289, 8, p. 5051 - 5060 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets

Wang, X., Palasubramaniam, J., Gkanatsas, Y., Hohmann, J. D., Westein, E., Kanojia, R., Alt, K., Huang, D., Jia, F., Ahrens, I., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 2014, In : Circulation Research. 114, 7, p. 1083 - 1093 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2013

A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics

Nesbitt, W. S., Tovar-Lopez, F. J., Westein, E., Harper, I. S. & Jackson, S., 2013, Adhesion Protein Protocols. Coutts, A. S. (ed.). USA: Humana Press, Vol. 1046. p. 39 - 58 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

5 Citations (Scopus)

Destination known: Targeted drug delivery in atherosclerosis and thrombosis

Westein, E., Flierl, U., Hagemeyer, C. E. & Peter, K., 2013, In : Drug Development Research. 74, 7, p. 460-471 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S. M., Ashworth, K. J., Westein, E., Hosseini, E., Salem, H. H., Slattery, R. M., McColl, S. R., Hickey, M. J., Ruggeri, Z. M., Yuan, Y-P. & Jackson, S., 2013, In : Blood. 121, 22, p. 4555 - 4566 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)
2012

Monitoring in vitro thrombus formation with novel microfluidic devices

Westein, E., de Witt, S. S., Lamers, M. M., Cosemans, J. MEM. & Heemskerk, J. W. M., 2012, In : Platelets. 23, 7, p. 501 - 509 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2011

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

Straub, A., Krajewski, S., Hohmann, J. D., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y-P., Nandurkar, H., Jackson, S., Hickey, M. & Peter, K., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 7, p. 1607 - 1616 10 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

Tovar-Lopez, F. J., Rosengarten, G., Khoshmanesh, K., Westein, E., Jackson, S., Nesbitt, W. S. & Mitchell, A., 2011, In : Journal of Biomechanics. 44, 6, p. 1031 - 1039 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2010

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2010, In : Lab on a Chip. 10, 3, p. 291 - 302 12 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Erratum: A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood (Lab on a Chip (2010) 10 (291-302) DOI: 10.1039/b916757a)

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S. P., Mitchell, A. & Nesbitt, W. S., 21 Dec 2010, In : Lab on a Chip. 10, 24, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.

Devi, S., Kuligowski, M. P., Kwan, R. Y. Q., Westein, E., Jackson, S., Kitching, A. R. & Hickey, M. J., 2010, In : American Journal of Pathology. 177, 3, p. 1131 - 1142 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2009

A shear gradient-dependent platelet aggregation mechanism drives thrombus formation

Nesbitt, W. S., Westein, E., Tovar-Lopez, F. J., Tolouei, E., Mitchell, A., Jia, F., Carberry, J. J., Fouras, A. & Jackson, S., 2009, In : Nature Medicine. 15, 6, p. 665 - 673 9 p.

Research output: Contribution to journalArticleResearchpeer-review

497 Citations (Scopus)

Dynamics of platelet thrombus formation

Jackson, S., Nesbitt, W. S. & Westein, E., 2009, In : Journal of Thrombosis and Haemostasis. 7, S1, p. 17 - 20 4 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)
2008

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth

Ono, A., Westein, E., Hsiao, S. T-F., Nesbitt, W. S., Hamilton, J. R., Schoenwaelder, S. M. & Jackson, S., 2008, In : Blood. 112, 1, p. 90 - 99 10 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)
2007

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

Maxwell, M. J., Westein, E., Nesbitt, W. S., Giuliano, S., Dopheide, S. M. & Jackson, S., 2007, In : Blood. 109, 2, p. 566 - 576 11 p.

Research output: Contribution to journalArticleResearchpeer-review

147 Citations (Scopus)
2005

Cysteine-mutations in von Willebrand factor associated with increased clearance

Van Schooten, C. J., Tjernberg, P., Westein, E., Terraube, V., Castaman, G., Van Mourik, J. A., Hollestelle, M. J., Vos, H. L., Bertina, R. M., Van Den Berg, H. M., Eikenboom, J. C. J., Lenting, P. J. & Denis, C. V., 2005, In : Journal of Thrombosis and Haemostasis. 3, 10, p. 2228 - 2237 10 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion

Spijkers, P. P. E. M., da Costa Martins, P., Westein, E., Gahmberg, C. G., Zwaginga, J. J. & Lenting, P. J., 2005, In : Blood. 105, 1, p. 170 - 177 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)
2004

An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation

Lenting, P. J., Westein, E., Terraube, V., Ribba, A-S., Huizinga, E. G., Meyer, D., de Groot, P. G. & Denis, C. V., 2004, In : Journal of Biological Chemistry. 279, 13, p. 12102 - 12109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)
2003

Mapping the collagen-binding site in the von Willebrand factor-A3 domain

Romijin, R. A., Westein, E., Bouma, B., Schiphorst, M. E., Sixma, J. J., Lenting, P. J. & Huizinga, E. G., 2003, In : Journal of Biological Chemistry. 278, 17, p. 15035 - 15039 5 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)