20092020

Research output per year

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Research Output

  • 23 Article
  • 1 Chapter (Book)
  • 1 Comment / Debate
  • 1 Review Article
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Article
2020

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Granzyme A in Chikungunya and Other Arboviral Infections

Schanoski, A. S., Le, T. T., Kaiserman, D., Rowe, C., Prow, N. A., Barboza, D. D., Santos, C. A., Zanotto, P. M. A., Magalhães, K. G., Aurelio, L., Muller, D., Young, P., Zhao, P., Bird, P. I. & Suhrbier, A., 14 Jan 2020, In : Frontiers in Immunology. 10, 14 p., 3083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

Liang, Y. L., Belousoff, M. J., Zhao, P., Koole, C., Fletcher, M. M., Truong, T. T., Julita, V., Christopoulos, G., Xu, H. E., Zhang, Y., Khoshouei, M., Christopoulos, A., Danev, R., Sexton, P. M. & Wootten, D., 6 Feb 2020, In : Molecular Cell. 77, 3, p. 656-668.e5 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2019

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Zhao, P., Pattison, L. A., Jensen, D. D., Jimenez-Vargas, N. N., Latorre, R., Lieu, T., Jaramillo, J. O., Lopez-Lopez, C., Poole, D. P., Vanner, S. J., Schmidt, B. L. & Bunnett, N. W., 5 Jul 2019, In : Journal of Biological Chemistry. 294, 27, p. 10649-10662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination

Liang, Y-L., Zhao, P., Draper-Joyce, C. J., Baltos, J-A., Glukhova, A., Truong, T. T., May, L. T., Christopoulos, A., Wootten, D., Sexton, P. & Furness, S., 2018, In : ACS Pharmacology and Translational Sciences. 1, 1, p. 12-20 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
94 Citations (Scopus)

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

Lei, S., Clydesdale, L., Dai, A., Cai, X., Yang, F., Yang, D., Liang, Y-L., Koole, C., Zhao, P., Coudrat, T., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 24, p. 9370-9387 18 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2016

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Protein kinase D and Gβγ subunits mediate agonist-evoked translocation of protease-activated receptor-2 from the golgi apparatus to the plasma membrane

Jensen, D. D., Zhao, P., Jimenez-Vargas, N. N., Lieu, T., Gerges, M., Yeatman, H. R., Canals, M., Vanner, S. J., Poole, D. P. & Bunnett, N. W., 20 May 2016, In : Journal of Biological Chemistry. 291, 21, p. 11285-11299 15 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2015

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain

Zhao, P., Lieu, T. M., Barlow, N., Sostegni, S., Haerteis, S., Korbmacher, C., Liedtke, W., Jimenez-Vargas, N. N., Vanner, S. & Bunnett, N. W., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13875 - 13887 13 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Regulation of RGS5 GAP activity by GPSM3

Zhao, P. & Chidiac, P., 2015, In : Molecular and Cellular Biochemistry. 405, 1-2, p. 33-40 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2014

Biased signaling of protease-activated receptors

Zhao, P., Metcalf, M. & Bunnett, N. W., 2014, In : Frontiers in Endocrinology. 5, May 2014, p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
112 Citations (Scopus)

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice

Lieu, T. M., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D. D., Grace, M., McIntyre, P., Bron, R., Wilson, Y., Krappitz, M., Haerteis, S., Korbmacher, C., Steinhoff, M. S., Nassini, R., Materazzi, S., Geppetti, P., Corvera, C. U. & Bunnett, N. W., 2014, In : Gastroenterology. 147, 6, p. 1417 - 1428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)
2013

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Zhao, P., Canals, M., Murphy, J. E., Klingler, D., Eriksson, E. M., Pelayo, J-C., Hardt, M., Bunnett, N. W. & Poole, D. P., 2013, In : Journal of Biological Chemistry. 288, 36, p. 25689 - 25700 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins

Zhao, P., Nunn, C., Ramineni, S., Hepler, J. R. & Chidiac, P., 2013, In : Journal of Cellular Biochemistry. 114, 6, p. 1414 - 1423 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2012

RGS2 is a component of the cellular stress response

Nguyen, C. H., Zhao, P., Sobiesiak, A. J. & Chidiac, P., 14 Sep 2012, In : Biochemical and Biophysical Research Communications. 426, 1, p. 129-134 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2011

Resistance to age-related, normal body weight gain in RGS2 deficient mice

Nunn, C., Zhao, P., Zou, M. X., M Summers, K., Guglielmo, C. G. & Chidiac, P., Aug 2011, In : Cellular Signalling. 23, 8, p. 1375-1386 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2010

The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function

Zhao, P., Nguyen, C. H. & Chidiac, P., 19 Mar 2010, In : Journal of Biological Chemistry. 285, 12, p. 9008-9017 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2009

Translational control by RGS2

Nguyen, C. H., Ming, H., Zhao, P., Hugendubler, L., Gros, R., Kimball, S. R. & Chidiac, P., 2009, In : Journal of Cell Biology. 186, 5, p. 755 - 765 11 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)