Projects per year
Personal profile
Biography
To Elva science is about imagination and curiosity. Research gives her the opportunity to use her knowledge to decipher the unknown. Her research interest is in regulation of cellular signaling, and how these complex events can translate into human physiology and pathophysiology. Her receptors of interest are called protease-activated receptors (PARs). PARs plays critical role in regulating inflammation and pain signaling. To understand how PARs function at cellular, tissue and whole animal level will provide novel mechanisms in pain transmission and further facilitate the development of new pain therapies.
Selected recent publications
1.Zhao P, Canals M, Murphy JE, Klingler D, Eriksson EM, Pelayo J-C, et al. Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons. J. Biol. Chem. 2013 Sep 6;288(36):25689-700.
2.Zhao P, Cladman W, Van Tol HHM, Chidiac P. Fine-tuning of GPCR signals by intracellular G protein modulators. Prog Mol Biol Transl Sci. 2013;115:421-53.
3.Zhao P, Nguyen CH, Chidiac P. The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function. J. Biol. Chem. 2010 Mar 19;285(12):9008-17.
4.Nunn C, Zhao P, Zou M-X, Summers K, Guglielmo CG, Chidiac P. Resistance to age-related, normal body weight gain in RGS2 deficient mice. Cell. Signal. 2011 Aug;23(8):1375-86.
5.Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, et al. Translational control by RGS2. J. Cell Biol. 2009 Sep 7;186(5):755-65.
6.Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P. The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins. J Cell Biochem. 2013 Jun 15;114(6):1414-23.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Chikungunya virus disease; the role of proteases and their receptors
Suhrbier, A., Bird, P., Prow, N. A. & Zhao, E.
1/01/18 → 23/12/20
Project: Research
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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Deganutti, G., Liang, Y. L., Zhang, X., Khoshouei, M., Clydesdale, L., Belousoff, M. J., Venugopal, H., Truong, T. T., Glukhova, A., Keller, A. N., Gregory, K. J., Leach, K., Christopoulos, A., Danev, R., Reynolds, C. A., Zhao, P., Sexton, P. M. & Wootten, D., 2022, In: Nature Communications. 13, 18 p., 92.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2
Kaiserman, D., Zhao, P., Rowe, C. L., Leong, A., Barlow, N., Joeckel, L. T., Hitchen, C., Stewart, S. E., Hollenberg, M. D., Bunnett, N., Suhrbier, A. & Bird, P. I., Jul 2022, In: PLoS ONE. 17, 7, 16 p., e0270584.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Implications of ligand-receptor binding kinetics on GLP-1R signalling
Zhao, P., Truong, T. T., Merlin, J., Sexton, P. M. & Wootten, D., May 2022, In: Biochemical Pharmacology. 199, 13 p., 114985.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Structural and functional diversity among agonist-bound states of the GLP-1 receptor
Cary, B. P., Deganutti, G., Zhao, P., Truong, T. T., Piper, S. J., Liu, X., Belousoff, M. J., Danev, R., Sexton, P. M., Wootten, D. & Gellman, S. H., Mar 2022, In: Nature Chemical Biology. 18, 3, p. 256-263 8 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors
Lu, J., Piper, S. J., Zhao, P., Miller, L. J., Wootten, D. & Sexton, P. M., 1 Aug 2022, In: International Journal of Molecular Sciences. 23, 15, 38 p., 8069.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus)
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2024 Asian Pacific congress of phaarmacology
Elva Zhao (Organiser)
1 Dec 2024 → 4 Dec 2024Activity: Participating in or organising an event types › Contribution to conference
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Biochemical Journal (Journal)
Elva Zhao (Peer reviewer)
Apr 2022Activity: Publication peer-review and editorial work types › Peer review responsibility
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Nature Communications (Journal)
Elva Zhao (Peer reviewer)
Jan 2022Activity: Publication peer-review and editorial work types › Peer review responsibility
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Cell Metabolism (Journal)
Elva Zhao (Peer reviewer)
Aug 2022Activity: Publication peer-review and editorial work types › Peer review responsibility
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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (Journal)
Elva Zhao (Peer reviewer)
Apr 2022Activity: Publication peer-review and editorial work types › Peer review responsibility