20092020
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Personal profile

Biography

To Elva science is about imagination and curiosity. Research gives her the opportunity to use her knowledge to decipher the unknown. Her research interest is in regulation of cellular signaling, and how these complex events can translate into human physiology and pathophysiology. Her receptors of interest are called protease-activated receptors (PARs). PARs plays critical role in regulating inflammation and pain signaling. To understand how PARs function at cellular, tissue and whole animal level will provide novel mechanisms in pain transmission and further facilitate the development of new pain therapies.

Selected recent publications

 

1.Zhao P, Canals M, Murphy JE, Klingler D, Eriksson EM, Pelayo J-C, et al. Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons. J. Biol. Chem. 2013 Sep 6;288(36):25689-700.

2.Zhao P, Cladman W, Van Tol HHM, Chidiac P. Fine-tuning of GPCR signals by intracellular G protein modulators. Prog Mol Biol Transl Sci. 2013;115:421-53.

3.Zhao P, Nguyen CH, Chidiac P. The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function. J. Biol. Chem. 2010 Mar 19;285(12):9008-17.

4.Nunn C, Zhao P, Zou M-X, Summers K, Guglielmo CG, Chidiac P. Resistance to age-related, normal body weight gain in RGS2 deficient mice. Cell. Signal. 2011 Aug;23(8):1375-86.

5.Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, et al. Translational control by RGS2. J. Cell Biol. 2009 Sep 7;186(5):755-65.

6.Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P. The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins. J Cell Biochem. 2013 Jun 15;114(6):1414-23.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2018 2020

Chikungunya virus disease; the role of proteases and their receptors

Suhrbier, A., Bird, P., Prow, N. A. & Zhao, E.

1/01/1823/12/20

Project: Research

Research Output 2009 2019

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Zhao, P., Pattison, L. A., Jensen, D. D., Jimenez-Vargas, N. N., Latorre, R., Lieu, T., Jaramillo, J. O., Lopez-Lopez, C., Poole, D. P., Vanner, S. J., Schmidt, B. L. & Bunnett, N. W., 5 Jul 2019, In : Journal of Biological Chemistry. 294, 27, p. 10649-10662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2015 2015

  • 3 Peer review responsibility

Journal of Clinical Investigation (Journal)

Elva Zhao (Peer reviewer)
2015 → …

Activity: Publication peer-review and editorial work typesPeer review responsibility

British Journal of Pharmacology (Journal)

Elva Zhao (Peer reviewer)
2015 → …

Activity: Publication peer-review and editorial work typesPeer review responsibility

Molecular Pharmacology (Journal)

Elva Zhao (Peer reviewer)
2015 → …

Activity: Publication peer-review and editorial work typesPeer review responsibility