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Personal profile

Biography

Senior Research Fellow

Embryo Implantation Laboratory

Centre for Reproductive Health

Hudson Institute of Medical Research

Biography

Biography

Dr Menkhorst joined Prince Henry’s Institute (now Hudson Institute) in 2007 after completing her PhD at the University of Melbourne in the Department of Zoology. Dr Menkhorst is passionate about the importance of the intrauterine environment for a healthy pregnancy and life-long health of the child.

Dr Menkhorst has a research focus on the molecular mechanisms regulating human implantation which are critical for the establishment of a healthy pregnancy. Impaired implantation leads to infertility, early pregnancy loss and diseases of placental insufficiency including preeclampsia and interuterine growth restriction. Dr Menkhorst’s long-standing research focus is to understand how maternal (uterine and immune) and fetal cells interact during early pregnancy. By understanding the mechanisms underlying implantation and early placentation we aim to identify factors which can be used as biomarkers or therapeutic targets to treat infertility, recurrent pregnancy loss or placental insufficiency.

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Projects 2010 2018

Research Output 2009 2018

An electrical impedance-based assay to examine functions of various placental cell types in vitro

Chollangi, T., Clabault, H., Thibeault, A. A. H., Yong, H. E. J., Narula, S., Menkhorst, E., Sanderson, J. T., Vaillancourt, C. & Murthi, P., 2018, Preeclampsia: Methods and Protocols. Murthi, P. & Vaillancourt, C. (eds.). NY USA: Humana Press, Vol. 1710. p. 267-276 10 p. (Methods in Molecular Biology; vol. 1710).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Galectin‑7 is elevated in endometrioid (type I) endometrial cancer and promotes cell migration

Menkhorst, E., Griffiths, M., van Sinderen, M., Rainczuk, K., Niven, K. & Dimitriadis, E., 1 Oct 2018, In : Oncology Letters. 16, 4, p. 4721-4728 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin 11 blockade during mid to late gestation does not affect maternal blood pressure, pregnancy viability or subsequent fertility in mice

Winship, A., Menkhorst, E., Van Sinderen, M. & Dimitriadis, E., 1 Mar 2018, In : Reproductive BioMedicine Online. 36, 3, p. 250-258 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5

Menkhorst, E. M., Van Sinderen, M. L., Rainczuk, K., Cuman, C., Winship, A. & Dimitriadis, E., 1 Dec 2017, In : Scientific Reports. 7, 1, 11 p., 8690.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mouse double minute homologue 2 (MDM2) downregulation by miR-661 impairs human endometrial epithelial cell adhesive capacity

Winship, A., Ton, A., Van Sinderen, M., Menkhorst, E., Rainczuk, K., Griffiths, M., Cuman, C. & Dimitriadis, E., 29 Aug 2017, In : Reproduction, Fertility and Development. 30, p. 477-486 10 p.

Research output: Contribution to journalArticleResearchpeer-review