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Research Output 1994 2019

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2019

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 5 Feb 2019, In : Proceedings of the National Academy of Sciences. 116, 6, p. 2265-2273 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis

Rahman, T., Brown, A. S., Hartland, E. L., van Driel, I. R. & Fung, K. Y., 1 Jan 2019, In : Frontiers in Immunology. 10, 10 p., 608.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

Newson, J., Scott, N. E., Chung, I. Y. W., Lung, T. W. F., Giogha, C., Gan, J., Wang, N., Strugnell, R., Brown, N. F., Cygler, M., Pearson, J. & Hartland, E., 1 Jun 2019, In : Molecular & Cellular Proteomics. 18, 6, p. 1138-1156 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

Schuelein, R., Spencer, H., Dagley, L. F., Li, P., Luo, L., Stow, J. L., Abraham, G. C., Naderer, T., Gomez-Valero, L., Buchrieser, C., Sugimoto, C., Yamagishi, J., Webb, A. I., Pasricha, S. & Hartland, E. L., 1 Sep 2018, In : Cellular Microbiology. 20, 9, 44 p., e12852.

Research output: Contribution to journalArticleResearchpeer-review

2017

Distinct roles of the antiapoptotic effectors NleB and NleF from enteropathogenic Escherichia coli

Pollock, G. L., Oates, C. V. L., Giogha, C., Lung, T. W. F., Ong, S. Y., Pearson, J. S. & Hartland, E. L., 1 Apr 2017, In : Infection and Immunity. 85, 4, 12 p., e01071-16.

Research output: Contribution to journalArticleResearchpeer-review

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Pearson, J. S., Giogha, C., Mühlen, S., Nachbur, U., Pham, C. L. L., Zhang, Y., Hildebrand, J. M., Oates, C. V., Lung, T. W. F., Ingle, D. J., Dagley, L. F., Bankovacki, A., Petrie, E. J., Schroeder, G. N., Crepin, V. F., Frankel, G., Masters, S. L., Vince, J., Murphy, J. M., Sunde, M. & 3 othersWebb, A. I., Silke, J. & Hartland, E. L., 13 Jan 2017, In : Nature Microbiology. 2, 16258.

Research output: Contribution to journalArticleResearchpeer-review

Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori

Srikhanta, Y. N., Gorrell, R. J., Power, P., Tsyganov, K., Boitano, M., Clark, T. A., Korlach, J., Hartland, E. L., Jennings, M. P. & Kwok, T., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16140.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Phasevarion-regulated virulence in the emerging pediatric pathogen Kingella kingae

Srikhanta, Y. N., Fung, K. Y., Pollock, G. L., Bennett-Wood, V., Howden, B. P. & Hartland, E. L., 2017, In : Infection and Immunity. 85, 12, 15 p., e00319-17.

Research output: Contribution to journalArticleResearchpeer-review

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)

Scott, N. E., Giogha, C., Pollock, G. L., Kennedy, C. L., Webb, A. I., Williamson, N. A., Pearson, J. S. & Hartland, E. L., 2017, In : Journal of Biological Chemistry. 292, 42, p. 17337-17350 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The type III effector NleD from enteropathogenic Escherichia coli differentiates between host substrates p38 and JNK

Creuzburg, K., Giogha, C., Lung, T. W. F., Scott, N. E., Mühlen, S., Hartland, E. L. & Pearson, J. S., 2017, In : Infection and Immunity. 85, 2, e00620-16.

Research output: Contribution to journalArticleResearchpeer-review

2016

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Brown, A. S., Yang, C., Fung, K. Y., Bachem, A., Bourges, D., Bedoui, S., Hartland, E. L. & van Driel, I. R., 1 Jun 2016, In : PLoS Pathogens. 12, 6, e1005691.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Speir, M., Lawlor, K. E., Glaser, S. P., Abraham, G., Chow, S., Vogrin, A., Schulze, K. E., Schuelein, R., O'Reilly, L. A., Mason, K., Hartland, E. L., Lithgow, T., Strasser, A., Lessene, G., Huang, D. C. S., Vince, J. E. & Naderer, T., 24 Feb 2016, In : Nature Microbiology. 1, 3, 9 p., 15034.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ

Zhang, Y., Mühlen, S., Oates, C. V., Pearson, J. S. & Hartland, E. L., 16 Sep 2016, In : Journal of Biological Chemistry. 291, 38, p. 20149-20162 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila

Fiene, A., Baqi, Y., Malik, E. M., Newton, P., Li, W., Lee, S. Y., Hartland, E. L. & Müller, C. E., 2016, In : Bioorganic & Medicinal Chemistry. 24, 18, p. 4363-4371 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Rolando, M., Escoll, P., Nora, T., Botti, J., Boitez, V., Bedia, C., Daniels, C., Abraham, G., Stogios, P. J., Skarina, T., Christophe, C., Dervins-Ravault, D., Cazalet, C., Hilbi, H., Rupasinghe, T. W. T., Tull, D., McConville, M. J., Ong, S. Y., Hartland, E. L., Codogno, P. & 4 othersLevade, T., Naderer, T., Savchenko, A. & Buchrieser, C., 16 Feb 2016, In : Proceedings of the National Academy of Sciences. 113, 7, p. 1901-1906 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mutagenesis and functional analysis of the bacterial arginine glycosyltransferase effector NleB1 from enteropathogenic Escherichia coli

Wong Fok Lung, T., Giogha, C., Creuzburg, K., Ong, S. Y., Pollock, G. L., Zhang, Y., Fung, K. Y., Pearson, J. S. & Hartland, E. L., 1 May 2016, In : Infection and Immunity. 84, 5, p. 1346-1360 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2015

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H. J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J. M., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N. & 8 othersMurphy, J. M., Gyrd-Hansen, M., Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In : Nature Communications. 6, 6442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 othersXu, D., 2015, In : Proceedings of the National Academy of Sciences. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Fas regulates neutrophil lifespan during viral and bacterial infection

O’Donnell, J. A., Kennedy, C. L., Pellegrini, M., Nowell, C. J., Zhang, J. G., O’Reilly, L. A., Cengia, L., Dias, S., Masters, S. L., Hartland, E. L., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Feb 2015, In : Journal of leukocyte biology. 97, 2, p. 321-326 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Legionella pneumophila effector LpdA Is a palmitoylated phospholipase D virulence factor

Schroeder, G. N., Aurass, P., Oates, C. V., Tate, E. W., Hartland, E. L., Flieger, A. & Frankel, G., 2015, In : Infection and Immunity. 83, 10, p. 3989-4002 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophilaDot/Icm effector

King, N. P., Newton, P., Schuelein, R., Brown, D. L., Petru, M., Zarsky, V., Dolezal, P., Luo, L., Bugarcic, A., Stanley, A. C., Murray, R. Z., Collins, B. M., Teasdale, R. D., Hartland, E. L. & Stow, J. L., 1 Jun 2015, In : Cellular Microbiology. 17, 6, p. 767-784 18 p.

Research output: Contribution to journalArticleResearchpeer-review

SseK3 is a salmonella effector that binds TRIM32 and modulates the host's NF-κB signalling activity

Yang, Z., Soderholm, A., Lung, T. W. F., Giogha, C., Hill, M., Brown, N. F., Hartland, E. & Teasdale, R. D., 22 Sep 2015, In : PLoS ONE. 10, 9, e0138529.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli

Giogha, C., Wong Fok Lung, T., Mühlen, S., Pearson, J. S. & Hartland, E. L., 1 Dec 2015, In : Cellular Microbiology. 17, 12, p. 1766-1778 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

A horizontally acquired transcription factor coordinates Salmonella adaptations to host microenvironments

Brown, N. F., Rogers, L. D., Sanderson, K. L., Gouw, J. W., Hartland, E. L. & Foster, L. J., 23 Sep 2014, In : mBio. 5, 5, e01727-1.

Research output: Contribution to journalArticleResearchpeer-review

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

Mousnier, A., Schroeder, G. N., Stoneham, C. A., So, E. C., Garnett, J. A., Yu, L., Matthews, S. J., Choudhary, J. S., Hartland, E. L. & Frankel, G., 12 Aug 2014, In : mBio. 5, 4, e01148-14.

Research output: Contribution to journalArticleResearchpeer-review

A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis

Newton, H. J., Kohler, L. J., McDonough, J. A., Temoche-Diaz, M., Crabill, E., Hartland, E. L. & Roy, C. R., 2014, In : PLoS Pathogens. 10, 7, e1004286.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A surprising sweetener from enteropathogenic Escherichia coli

Pearson, J. S. & Hartland, E. L., 2014, In : Gut Microbes. 5, 6, p. 766-769 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease

Gomez-Valero, L., Rusniok, C., Rolando, M., Neou, M., Dervins-Ravault, D., Demirtas, J., Rouy, Z., Moore, R. J., Chen, H., Petty, N. K., Jarraud, S., Etienne, J., Steinert, M., Heuner, K., Gribaldo, S., Médigue, C., Glöckner, G., Hartland, E. L. & Buchrieser, C., 2014, In : Genome Biology. 15, 11, 505.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic diversity and virulence potential of Shiga toxin-producing Escherichia coli O113: H21 strains isolated from clinical, environmental, and food sources

Feng, P. C. H., Delannoy, S., Lacher, D. W., dos Santos, L. F., Beutin, L., Fach, P., Rivas, M., Hartland, E. L., Paton, A. W. & Guth, B. E. C., 2014, In : Applied and Environmental Microbiology. 80, 15, p. 4757-4763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Sansom, F. M., Ralton, J. E., Sernee, M. F., Cohen, A. M., Hooker, D. J., Hartland, E. L., Naderer, T. & McConville, M. J., 18 Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, 12 p., e3402.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila

Riedmaier, P., Sansom, F. M., Sofian, T., Beddoe, T. C., Schuelein, R., Newton, H. & Hartland, E. L., 2014, In : Biochemical Journal. 462, 2, p. 279 - 289 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Rab8a interacts directly with PI3Kgamma to modulate TLR4-driven PI3K and mTOR signalling

Luo, L., Wall, A. A., Yeo, J. C., Condon, N. D., Norwood, S. J., Schoenwaelder, S. M., Chen, K. W., Jackson, S., Jenkins, B. J., Hartland, E. L., Schroder, K., Collins, B. M., Sweet, M. J. & Stow, J. L., 2014, In : Nature Communications. 5, (Art. No.:4407), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 2014, In : Nature Communications. 5, 10 p., 5887.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The inflammatory response during enterohemorrhagic Escherichia coli infection

Pearson, J. S. & Hartland, E. L., 2014, In : Microbiology spectrum. 2, 4, EHEC-0012-2013.

Research output: Contribution to journalArticleResearchpeer-review

The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection

Pallett, M. A., Berger, C. N., Pearson, J. S., Hartland, E. L. & Frankel, G., 2014, In : Infection and Immunity. 82, 11, p. 4878-4888 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

A type III effector antagonizes death receptor signalling during bacterial gut infection

Pearson, J. S., Giogha, C., Ong, S. Y., Kennedy, C. L., Kelly, M., Robinson, K. S., Lung, T. W. F., Mansell, A. S., Riedmaier, P., Oates, C. VL., Zaid, A., Muhlen, S., Crepin, V. F., Marches, O., Ang, C-S., Williamson, N. A., O'Reilly, L. A., Bankovacki, A., Nachbur, U., Infusini, G. & 5 othersWebb, A. I., Silke, J., Strasser, A., Frankel, G. M. & Hartland, E. L., 2013, In : Nature. 501, 7466, p. 247-251 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the ospz promoter in shigella flexneri and its regulation by virb and h-ns

Basta, D. W., Pew, K. L., Immak, J. A., Park, H. S., Picker, M. A., Wigley, A. F., Hensley, C. T., Pearson, J. S., Hartland, E. L. & Wing, H. J., Jun 2013, In : Journal of Bacteriology. 195, 11, p. 2562-2572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein

Yang, J., Hocking, D. M., Cheng, C., Dogovski, C., Perugini, M. A., Holien, J. K., Parker, M. W., Hartland, E. L., Tauschek, M. & Robins-Browne, R. M., 25 Oct 2013, In : Journal of Biological Chemistry. 288, 43, p. 31115-31126 12 p.

Research output: Contribution to journalArticleResearchpeer-review

LtpD is a novel legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1

Harding, C. R., Mattheis, C., Mousnier, A., Oates, C. V., Hartland, E. L., Frankel, G. & Schroedera, G. N., Nov 2013, In : Infection and Immunity. 81, 11, p. 4261-4270 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Dot/Icm Effector SdhA Is Necessary for Virulence of Legionella pneumophila in Galleria mellonella and A/J Mice

Harding, C. R., Stoneham, C. A., Schuelein, R., Newton, H., Oates, C. V., Hartland, E. L., Schroeder, G. N. & Frankel, G., Jul 2013, In : Infection and Immunity. 81, 7, p. 2598-2605 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

A method for quantifying pulmonary Legionella pneumophila infection in mouse lungs by flow cytometry

Ang, D. K. Y., Ong, S. Y., Brown, A. S., Hartland, E. L. & Van Driel, I. R., 2012, In : BMC Research Notes. 5, 448.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Discovery of an archetypal protein transport system in bacterial outer membranes

Selkrig, J., Mosbahi, K., Webb, C. T., Belousoff, M. J., Perry, A. J., Wells, T. J., Morris, F. C., Leyton, D. L., Totsika, M., Phan, M-D., Celik, N., Kelly, M., Oates, C., Hartland, E. L., Robins-Browne, R. M., Ramarathinam, S. H., Purcell, A. W., Schembri, M. A., Strugnell, R. A., Henderson, I. R. & 2 othersWalker, D. & Lithgow, T. J., 2012, In : Nature Structural and Molecular Biology. 19, 5 (S 1), p. 506 - 510 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Legionella pneumophila secretes a mitochondrial carrier protein during infection

Dolezal, P., Aili, M., Tong, J., Jiang, J-H., Marobbio, C. MT., Lee, S. F., Schuelein, R., Belluzzo, S., Binova, E., Mousnier, A., Frankel, G. M., Giannuzzi, G., Palmieri, F., Gabriel, K., Naderer, T., Hartland, E. L. & Lithgow, T. J., 2012, In : PLoS Pathogens. 8, 1 (Art. ID: e1002459), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

Pearson, J. S., Riedmaier, P., Marchès, O., Frankel, G. & Hartland, E. L., Apr 2011, In : Molecular Microbiology. 80, 1, p. 219-230 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Enteropathogenic and enterohemorrhagic Escherichia coli type III secretion effector EspV induces radical morphological changes in eukaryotic cells

Arbeloa, A., Oates, C. V., Marchès, O., Hartland, E. L. & Frankel, G., Mar 2011, In : Infection and Immunity. 79, 3, p. 1067-1076 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function

Clements, A., Smollett, K., Lee, S. F., Hartland, E. L., Lowe, M. & Frankel, G., Sep 2011, In : Cellular Microbiology. 13, 9, p. 1429-1439 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Immune control of Legionella infection: An in vivo perspective

Schuelein, R., Ang, D. K. Y., van Driel, I. R. & Hartland, E. L., 2011, In : Frontiers in Microbiology. 2, JUNE

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sculpting the immune response to infection

Hertzog, P., Mansell, A., van Driel, I. R. & Hartland, E., 2011, In : Nature Immunology. 12, 7, p. 579 - 582 4 p.

Research output: Contribution to journalArticleOther

2010

Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease

Cazalet, C., Gomez-Valero, L., Rusniok, C., Lomma, M., Dervins-Ravault, D., Newton, H. J., Sansom, F. M., Jarraud, S., Zidane, N., Ma, L., Bouchier, C., Etienne, J., Hartland, E. L. & Buchrieser, C., Feb 2010, In : PLoS Genetics. 6, 2, e1000851.

Research output: Contribution to journalArticleResearchpeer-review

Binding to Na+/H+ exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH

Martinez, E., Schroeder, G. N., Berger, C. N., Lee, S. F., Robinson, K. S., Badea, L., Simpson, N., Hall, R. A., Hartland, E. L., Crepin, V. F. & Frankel, G. M., 2010, In : Cellular Microbiology. 12, 12, p. 1718 - 1731 14 p.

Research output: Contribution to journalArticleResearchpeer-review