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Research Output 1994 2019

2019

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 5 Feb 2019, In : Proceedings of the National Academy of Sciences. 116, 6, p. 2265-2273 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis

Rahman, T., Brown, A. S., Hartland, E. L., van Driel, I. R. & Fung, K. Y., 1 Jan 2019, In : Frontiers in Immunology. 10, 10 p., 608.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

Newson, J., Scott, N. E., Chung, I. Y. W., Lung, T. W. F., Giogha, C., Gan, J., Wang, N., Strugnell, R., Brown, N. F., Cygler, M., Pearson, J. & Hartland, E., 1 Jun 2019, In : Molecular & Cellular Proteomics. 18, 6, p. 1138-1156 19 p.

Research output: Contribution to journalArticleResearchpeer-review

The mouse as a model for pulmonary Legionella infection

Ng, G. Z., Solomatina, A., van Driel, I. R. & Hartland, E. L., 1 Jan 2019, Legionella: Methods and Protocols. Buchrieser, C. & Hilbi, H. (eds.). 2nd ed. New York, NY: Humana Press, p. 399-417 19 p. (Methods in Molecular Biology; vol. 1921).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2018

Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology

Kennedy, C. L. & Hartland, E. L., 2018, Methods in Molecular Biology. Jenkins, B. J. (ed.). New York, NY: Humana Press, p. 77-89 13 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Editorial: Biology and pathogenesis of Legionella

Newton, H. J., Hartland, E. L. & MacHner, M. P., 19 Sep 2018, In : Frontiers in Cellular and Infection Microbiology. 8, SEP, 3 p., 328.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

Schuelein, R., Spencer, H., Dagley, L. F., Li, P., Luo, L., Stow, J. L., Abraham, G. C., Naderer, T., Gomez-Valero, L., Buchrieser, C., Sugimoto, C., Yamagishi, J., Webb, A. I., Pasricha, S. & Hartland, E. L., 1 Sep 2018, In : Cellular Microbiology. 20, 9, 44 p., e12852.

Research output: Contribution to journalArticleResearchpeer-review

2017

Bacterial pathogenesis: Legionella phosphoinositide tailoring

Hartland, E. L., 22 Feb 2017, In : Nature Microbiology. 2, 3, 17013.

Research output: Contribution to journalComment / DebateOtherpeer-review

Distinct roles of the antiapoptotic effectors NleB and NleF from enteropathogenic Escherichia coli

Pollock, G. L., Oates, C. V. L., Giogha, C., Lung, T. W. F., Ong, S. Y., Pearson, J. S. & Hartland, E. L., 1 Apr 2017, In : Infection and Immunity. 85, 4, 12 p., e01071-16.

Research output: Contribution to journalArticleResearchpeer-review

Editorial overview: Offence is the best defense: host–pathogen interactions driving evolution of human immunity and the germs we live with

Pellegrini, M. & Hartland, E., 1 Oct 2017, In : Current Opinion in Immunology. 48, p. x-xi 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Pearson, J. S., Giogha, C., Mühlen, S., Nachbur, U., Pham, C. L. L., Zhang, Y., Hildebrand, J. M., Oates, C. V., Lung, T. W. F., Ingle, D. J., Dagley, L. F., Bankovacki, A., Petrie, E. J., Schroeder, G. N., Crepin, V. F., Frankel, G., Masters, S. L., Vince, J., Murphy, J. M., Sunde, M. & 3 othersWebb, A. I., Silke, J. & Hartland, E. L., 13 Jan 2017, In : Nature Microbiology. 2, 16258.

Research output: Contribution to journalArticleResearchpeer-review

Host Innate Immune Factors Influencing Enterohemorrhagic Escherichia coli Pathogenicity

Zhang, Y., Pearson, J. S. & Hartland, E. L., 2017, Foodborne Pathogens : Virulence Factors and Host Susceptibility. Gurtler, J. B., Doyle, M. P. & Kornacki, J. L. (eds.). Cham, Switzerland: Springer, p. 355-373 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori

Srikhanta, Y. N., Gorrell, R. J., Power, P., Tsyganov, K., Boitano, M., Clark, T. A., Korlach, J., Hartland, E. L., Jennings, M. P. & Kwok, T., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16140.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Phasevarion-regulated virulence in the emerging pediatric pathogen Kingella kingae

Srikhanta, Y. N., Fung, K. Y., Pollock, G. L., Bennett-Wood, V., Howden, B. P. & Hartland, E. L., 2017, In : Infection and Immunity. 85, 12, 15 p., e00319-17.

Research output: Contribution to journalArticleResearchpeer-review

Post-translational Mechanisms of Host Subversion by Bacterial Effectors

Scott, N. E. & Hartland, E. L., 1 Dec 2017, In : Trends in Molecular Medicine. 23, 12, p. 1088-1102 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)

Scott, N. E., Giogha, C., Pollock, G. L., Kennedy, C. L., Webb, A. I., Williamson, N. A., Pearson, J. S. & Hartland, E. L., 2017, In : Journal of Biological Chemistry. 292, 42, p. 17337-17350 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The regulation of acute immune responses to the bacterial lung pathogen Legionella pneumophila

Brown, A. S., Yang, C., Hartland, E. L. & van Driel, I. R., 1 Apr 2017, In : Journal of leukocyte biology. 101, 4, p. 875-886 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The role of mass spectrometry analysis in bacterial effector characterization

Scott, N. E. & Hartland, E. L., 15 Aug 2017, In : Biochemical Journal. 474, 16, p. 2779-2784 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

The type III effector NleD from enteropathogenic Escherichia coli differentiates between host substrates p38 and JNK

Creuzburg, K., Giogha, C., Lung, T. W. F., Scott, N. E., Mühlen, S., Hartland, E. L. & Pearson, J. S., 2017, In : Infection and Immunity. 85, 2, e00620-16.

Research output: Contribution to journalArticleResearchpeer-review

2016

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Brown, A. S., Yang, C., Fung, K. Y., Bachem, A., Bourges, D., Bedoui, S., Hartland, E. L. & van Driel, I. R., 1 Jun 2016, In : PLoS Pathogens. 12, 6, e1005691.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Editorial overview: Host-microbe interactions: Bacteria: Secretion systems, effectors, immunity and metabolism

Hartland, E. L. & Richardson, A. R., 1 Feb 2016, In : Current Opinion in Microbiology. 29, p. v-vii

Research output: Contribution to journalEditorialOtherpeer-review

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Speir, M., Lawlor, K. E., Glaser, S. P., Abraham, G., Chow, S., Vogrin, A., Schulze, K. E., Schuelein, R., O'Reilly, L. A., Mason, K., Hartland, E. L., Lithgow, T., Strasser, A., Lessene, G., Huang, D. C. S., Vince, J. E. & Naderer, T., 24 Feb 2016, In : Nature Microbiology. 1, 3, 9 p., 15034.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ

Zhang, Y., Mühlen, S., Oates, C. V., Pearson, J. S. & Hartland, E. L., 16 Sep 2016, In : Journal of Biological Chemistry. 291, 38, p. 20149-20162 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila

Fiene, A., Baqi, Y., Malik, E. M., Newton, P., Li, W., Lee, S. Y., Hartland, E. L. & Müller, C. E., 2016, In : Bioorganic & Medicinal Chemistry. 24, 18, p. 4363-4371 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Rolando, M., Escoll, P., Nora, T., Botti, J., Boitez, V., Bedia, C., Daniels, C., Abraham, G., Stogios, P. J., Skarina, T., Christophe, C., Dervins-Ravault, D., Cazalet, C., Hilbi, H., Rupasinghe, T. W. T., Tull, D., McConville, M. J., Ong, S. Y., Hartland, E. L., Codogno, P. & 4 othersLevade, T., Naderer, T., Savchenko, A. & Buchrieser, C., 16 Feb 2016, In : Proceedings of the National Academy of Sciences. 113, 7, p. 1901-1906 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mutagenesis and functional analysis of the bacterial arginine glycosyltransferase effector NleB1 from enteropathogenic Escherichia coli

Wong Fok Lung, T., Giogha, C., Creuzburg, K., Ong, S. Y., Pollock, G. L., Zhang, Y., Fung, K. Y., Pearson, J. S. & Hartland, E. L., 1 May 2016, In : Infection and Immunity. 84, 5, p. 1346-1360 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pathogenesis of Legionella pneumophila in Humans

Vogrin, A. J. & Hartland, E. L., 2016, Human Emerging and Re-emerging Infections: Bacterial and Mycotic Infections. Singh, S. K. (ed.). First ed. John Wiley & Sons, Vol. II. p. 575-590 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

The Genetics of Enteropathogenic Escherichia coli Virulence

Pearson, J. S., Giogha, C., Wong Fok Lung, T. & Hartland, E. L., 23 Nov 2016, In : Annual Review of Genetics. 50, p. 493-513 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2015

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H. J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J. M., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N. & 8 othersMurphy, J. M., Gyrd-Hansen, M., Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In : Nature Communications. 6, 6442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 othersXu, D., 2015, In : Proceedings of the National Academy of Sciences. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Fas regulates neutrophil lifespan during viral and bacterial infection

O’Donnell, J. A., Kennedy, C. L., Pellegrini, M., Nowell, C. J., Zhang, J. G., O’Reilly, L. A., Cengia, L., Dias, S., Masters, S. L., Hartland, E. L., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Feb 2015, In : Journal of leukocyte biology. 97, 2, p. 321-326 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Legionella pneumophila effector LpdA Is a palmitoylated phospholipase D virulence factor

Schroeder, G. N., Aurass, P., Oates, C. V., Tate, E. W., Hartland, E. L., Flieger, A. & Frankel, G., 2015, In : Infection and Immunity. 83, 10, p. 3989-4002 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Post-modern pathogens: Surprising activities of translocated effectors from E. coli and Legionella

Pearson, J. S., Zhang, Y., Newton, H. J. & Hartland, E. L., 1 Feb 2015, In : Current Opinion in Microbiology. 23, p. 73-79 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophilaDot/Icm effector

King, N. P., Newton, P., Schuelein, R., Brown, D. L., Petru, M., Zarsky, V., Dolezal, P., Luo, L., Bugarcic, A., Stanley, A. C., Murray, R. Z., Collins, B. M., Teasdale, R. D., Hartland, E. L. & Stow, J. L., 1 Jun 2015, In : Cellular Microbiology. 17, 6, p. 767-784 18 p.

Research output: Contribution to journalArticleResearchpeer-review

SseK3 is a salmonella effector that binds TRIM32 and modulates the host's NF-κB signalling activity

Yang, Z., Soderholm, A., Lung, T. W. F., Giogha, C., Hill, M., Brown, N. F., Hartland, E. & Teasdale, R. D., 22 Sep 2015, In : PLoS ONE. 10, 9, e0138529.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli

Giogha, C., Wong Fok Lung, T., Mühlen, S., Pearson, J. S. & Hartland, E. L., 1 Dec 2015, In : Cellular Microbiology. 17, 12, p. 1766-1778 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

A horizontally acquired transcription factor coordinates Salmonella adaptations to host microenvironments

Brown, N. F., Rogers, L. D., Sanderson, K. L., Gouw, J. W., Hartland, E. L. & Foster, L. J., 23 Sep 2014, In : mBio. 5, 5, e01727-1.

Research output: Contribution to journalArticleResearchpeer-review

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

Mousnier, A., Schroeder, G. N., Stoneham, C. A., So, E. C., Garnett, J. A., Yu, L., Matthews, S. J., Choudhary, J. S., Hartland, E. L. & Frankel, G., 12 Aug 2014, In : mBio. 5, 4, e01148-14.

Research output: Contribution to journalArticleResearchpeer-review

A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis

Newton, H. J., Kohler, L. J., McDonough, J. A., Temoche-Diaz, M., Crabill, E., Hartland, E. L. & Roy, C. R., 2014, In : PLoS Pathogens. 10, 7, e1004286.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A surprising sweetener from enteropathogenic Escherichia coli

Pearson, J. S. & Hartland, E. L., 2014, In : Gut Microbes. 5, 6, p. 766-769 4 p.

Research output: Contribution to journalArticleResearchpeer-review

CD8 subunit expression by plasmacytoid dendritic cells is variable, and does not define stable subsets

Brown, A. S., Bourges, D., Ang, D. K., Hartland, E. L. & Van Driel, I. R., Jan 2014, In : Mucosal Immunology. 7, 1, p. 200-201 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease

Gomez-Valero, L., Rusniok, C., Rolando, M., Neou, M., Dervins-Ravault, D., Demirtas, J., Rouy, Z., Moore, R. J., Chen, H., Petty, N. K., Jarraud, S., Etienne, J., Steinert, M., Heuner, K., Gribaldo, S., Médigue, C., Glöckner, G., Hartland, E. L. & Buchrieser, C., 2014, In : Genome Biology. 15, 11, 505.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Genetic diversity and virulence potential of Shiga toxin-producing Escherichia coli O113: H21 strains isolated from clinical, environmental, and food sources

Feng, P. C. H., Delannoy, S., Lacher, D. W., dos Santos, L. F., Beutin, L., Fach, P., Rivas, M., Hartland, E. L., Paton, A. W. & Guth, B. E. C., 2014, In : Applied and Environmental Microbiology. 80, 15, p. 4757-4763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Sansom, F. M., Ralton, J. E., Sernee, M. F., Cohen, A. M., Hooker, D. J., Hartland, E. L., Naderer, T. & McConville, M. J., 18 Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, 12 p., e3402.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Inhibition of death receptor signaling by bacterial gut pathogens

Giogha, C., Lung, T. W. F., Pearson, J. S. & Hartland, E. L., 2014, In : Cytokine and Growth Factor Reviews. 25, 2, p. 235-243 9 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila

Riedmaier, P., Sansom, F. M., Sofian, T., Beddoe, T. C., Schuelein, R., Newton, H. & Hartland, E. L., 2014, In : Biochemical Journal. 462, 2, p. 279 - 289 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Rab8a interacts directly with PI3Kgamma to modulate TLR4-driven PI3K and mTOR signalling

Luo, L., Wall, A. A., Yeo, J. C., Condon, N. D., Norwood, S. J., Schoenwaelder, S. M., Chen, K. W., Jackson, S., Jenkins, B. J., Hartland, E. L., Schroder, K., Collins, B. M., Sweet, M. J. & Stow, J. L., 2014, In : Nature Communications. 5, (Art. No.:4407), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The cell death response to enteropathogenic Escherichia coli infection

Wong Fok Lung, T., Pearson, J. S., Schuelein, R. & Hartland, E. L., 1 Dec 2014, In : Cellular Microbiology. 16, 12, p. 1736-1745 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 2014, In : Nature Communications. 5, 10 p., 5887.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The inflammatory response during enterohemorrhagic Escherichia coli infection

Pearson, J. S. & Hartland, E. L., 2014, In : Microbiology spectrum. 2, 4, EHEC-0012-2013.

Research output: Contribution to journalArticleResearchpeer-review