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Personal profile

Biography

Professor Hartland obtained her B. Sc. (Hons) majoring in microbiology and biochemistry and her Ph.D in microbiology from the University of Melbourne. She has held a Royal Society/NHMRC Howard Florey Fellowship in the Department of Biochemistry, Imperial College London and Lecturer/Senior Lecturer positions at Monash University, Australia. She was an inaugural Australian Research Council Future Fellow at the University of Melbourne and subsequently held the positions of Head of the Department of Microbiology and Immunology, University of Melbourne, Deputy Director of the Doherty Institute for Infection and Immunity and Acting Pro-Vice Chancellor Research Partnerships and External Relations at the University of Melbourne. She is currently the Director and CEO of Hudson Institute of Medical Research in Melbourne and Head of the Department of Molecular and Translational Science at Monash University. Professor Hartland has a long-standing research interest in the pathogenesis of infections caused by Gram-negative pathogens, with a focus on mechanisms of bacterial colonization and immune evasion.

Research interests

Translocated effectors of bacterial pathogens. The subversion of host cell processes by microbial pathogens is an intrinsic part of the host-pathogen interaction. Many bacterial pathogens have the ability to transport virulence proteins, termed effector proteins, into host cells via specialized protein secretion systems. We work on a range of effectors from pathogenic E. coli, Shigella and Salmonella that interfere with host innate immune signaling pathways and block inflammation and cell death. The aim of this work is to investigate the manipulation of host cell signaling by effector protein families to understand their influence on host cell function, inflammatory signaling and the innate immune response. 

Intracellular bacterial pathogens and cell intrinsic immunity. Many bacterial pathogens have acquired the capacity to replicate inside human cells by avoiding cell intrinsic innate immune pathways.Pathogens such as Legionella and Burkholderia are environmental organisms that cause the life threatening opportunistic infections known as Legionnaire’s Disease and melioidosis respectively. A feature of both pathogens is the capacity of the bacteria to replicate within human cells through effector-mediated manipulation of host cell biology. Our goal is to identify and characterize effectors that interact with cell intrinsic innate immune pathways. Ultimately this will allow us to understand the molecular mechanisms by which intracellular bacteria cause disease.

Immune responses in Legionnaire’s disease. Infection with Legionella elicits a strong inflammatory response in the lung. This initial inflammation is important for subsequent recruitment and activation of immune responses necessary to control and clear the infection. We have discovered that certain subsets of monocyte derived cells play a role in limiting bacterial replication in the lung. The aim of this work is to understand the mechanisms by which these contribute to resistance to infection with Legionella and other bacterial pathogens. This work will not only contribute to our understanding of the pathogenesis of Legionnaire’s disease but will also provide novel information on the functions of inflammatory cells in the lung.

Supervision interests

Professor Hartland is an accomplished research supervisor and mentor and has supervised 13 PhD students to completion as primary supervisor. Three of her former students, have won NHMRC Early Career Fellowships and one former student is the recent recipient of an ARC Future Fellowship. Under Professor Hartland’s supervision, former PhD student Dr Pearson was awarded the 2014 University of Melbourne Chancellor's Prize for Excellence in a PhD Thesis and the 2014 Deans Award for Excellence in a PhD Thesis. Dr Pearson also won the 2014 Premier’s Award for Health and Medical Research.

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Projects 2000 2020

Research Output 1994 2018

Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology

Kennedy, C. L. & Hartland, E. L., 2018, Methods in Molecular Biology. Jenkins, B. J. (ed.). New York, NY: Humana Press, p. 77-89 13 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

Schuelein, R., Spencer, H., Dagley, L. F., Li, P., Luo, L., Stow, J. L., Abraham, G. C., Naderer, T., Gomez-Valero, L., Buchrieser, C., Sugimoto, C., Yamagishi, J., Webb, A. I., Pasricha, S. & Hartland, E. L., 1 Sep 2018, In : Cellular Microbiology. 20, 9, 44 p., e12852.

Research output: Contribution to journalArticleResearchpeer-review

Bacterial pathogenesis: Legionella phosphoinositide tailoring

Hartland, E. L., 22 Feb 2017, In : Nature Microbiology. 2, 3, 17013.

Research output: Contribution to journalComment / DebateOtherpeer-review

Distinct roles of the antiapoptotic effectors NleB and NleF from enteropathogenic Escherichia coli

Pollock, G. L., Oates, C. V. L., Giogha, C., Lung, T. W. F., Ong, S. Y., Pearson, J. S. & Hartland, E. L., 1 Apr 2017, In : Infection and Immunity. 85, 4, 12 p., e01071-16.

Research output: Contribution to journalArticleResearchpeer-review

Editorial overview: Offence is the best defense: host–pathogen interactions driving evolution of human immunity and the germs we live with

Pellegrini, M. & Hartland, E., 1 Oct 2017, In : Current Opinion in Immunology. 48, p. x-xi 2 p.

Research output: Contribution to journalEditorialOtherpeer-review