• Monash Institute of Pharmaceutical Sciences, 399 Royal Parade, 404

    3052 Parkville

    Australia

Accepting PhD Students

PhD projects

Novel drug targets for non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma

20052020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Ebru Boslem is a research officer in the Febbraio lab currently investigating the cellular mechanisms behind the reversal of non-alcoholic steatohepatitis (NASH) and prevention of hepatocellular carcinoma in the MuP-uPA mouse model of NASH. Previously in her role as Jenna Goggins Fellow at Sydney based biotech company, EnGeneIc, she was part of the team that characterised the immune response to a new generation of cancer cyto-immuno-therapy created from bacterially derived nanocells. During her time as post-doctoral researcher at the Garvan Institute of Medical Research in Sydney, she characterised mechanisms of lipid-induced apoptosis and pancreatic beta cell failure in the context of Type 2 diabetes. In her role as Young Garvan fellow, Ebru spoke at numerous public events including Garvan tours and public seminars to communicate the Institute's research and facilitated stakeholder meetings. Ebru received her PhD in 2011 from the Garvan/UNSW, working in Professor Trevor Biden's lab on pancreatic beta cell apoptosis.

Research interests

  • cancer immunology
  • mechanistic cell biology behind cancer cell growth and death
  • streamlining AI to probe big data for drug dicovery

Education/Academic qualification

Medicine, PhD, University of New South Wales

Feb 2007May 2011

Award Date: 9 May 2011

Research area keywords

  • Cancer Immunology
  • Cancer Cell Biology
  • non-alcoholic fatty liver disease
  • hepatotoxicity

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

  • 12 Article
  • 2 Review Article
  • 1 Comment / Debate
  • 1 Conference article

Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells

Sagnella, S. M., Yang, L., Stubbs, G. E., Boslem, E., Martino-Echarri, E., Smolarczyk, K., Pattison, S. L., Vanegas, N., St. Clair, E., Clarke, S., Boockvar, J., MacDiarmid, J. A. & Brahmbhatt, H., 16 Mar 2020, In : Cancer Cell. 37, 3, p. 354-370.e7 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Cantley, J., Davenport, A., Vetterli, L., Nemes, N. J., Whitworth, P. T., Boslem, E., Thai, L. M., Mellett, N., Meikle, P. J., Hoehn, K. L., James, D. E. & Biden, T. J., Jan 2019, In : Diabetologia. 62, 1, p. 99-111 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

Pearson, G. L., Mellett, N., Chu, K. Y., Boslem, E., Meikle, P. J. & Biden, T. J., 1 Jun 2016, In : Molecular Metabolism. 5, 6, p. 404-414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

Biden, T. J., Boslem, E., Chu, K. Y. & Sue, N., Aug 2014, In : Trends in Endocrinology & Metabolism. 25, 8, p. 389-398 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

99 Citations (Scopus)

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Boslem, E., Weir, J. M., MacIntosh, G., Sue, N., Cantley, J., Meikle, P. J. & Biden, T. J., 13 Sep 2013, In : The Journal of Biological Chemistry. 288, 37, p. 26569-26582 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
60 Citations (Scopus)

Prizes

Jenna Goggins Memorial Fellowship

Boslem, Ebru (Recipient), 2015

Prize: Competitive Fellowships

Young Garvan Fellow

Boslem, Ebru (Recipient), 2011

Prize: Competitive Fellowships