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Research Output

2019

Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Moujalled, D. M., Pomilio, G., Ghiurau, C., Ivey, A., Salmon, J., Rijal, S., Macraild, S., Zhang, L., Teh, T. C., Tiong, I. S., Lan, P., Chanrion, M., Claperon, A., Rocchetti, F., Zichi, A., Kraus-Berthier, L., Wang, Y., Halilovic, E., Morris, E., Colland, F. & 7 others, Segal, D., Huang, D., Roberts, A. W., Maragno, A. L., Lessene, G., Geneste, O. & Wei, A. H., 1 Apr 2019, In : Leukemia. 33, a, p. 905-917 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)
2018

AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies

Caenepeel, S., Brown, S. P., Belmontes, B., Moody, G., Keegan, K. S., Chui, D., Whittington, D. A., Huang, X., Poppe, L., Cheng, A. C., Cardozo, M., Houze, J., Li, Y., Lucas, B., Paras, N. A., Wang, X., Taygerly, J. P., Vimolratana, M., Zancanella, M., Zhu, L. & 18 others, Cajulis, E., Osgood, T., Sun, J., Damon, L., Egan, R. K., Greninger, P., McClanaghan, J. D., Gong, J., Moujalled, D., Pomilio, G., Beltran, P., Benes, C. H., Roberts, A. W., Huang, D. C., Wei, A., Canon, J., Coxon, A. & Hughes, P. E., 1 Dec 2018, In : Cancer Discovery. 8, 12, p. 1582-1597 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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55 Citations (Scopus)

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh, T. C., Nguyen, N. Y., Moujalled, D. M., Segal, D., Pomilio, G., Rijal, S., Jabbour, A., Cummins, K., Lackovic, K., Blombery, P., Thompson, E., Ekert, P. G., Lessene, G., Glaser, S. P., Huang, D. C. S., Roberts, A. W., Guthridge, M. A. & Wei, A. H., 1 Feb 2018, In : Leukemia. 32, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)
2017

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled, D., Grubman, A., Acevedo, K., Yang, S., Ke, Y. D., Moujalled, D. M., Duncan, C., Caragounis, A., Perera, N. D., Turner, B. J., Prudencio, M., Petrucelli, L., Blair, I., Ittner, L. M., Crouch, P. J., Liddell, J. R. & White, A. R., 1 May 2017, In : Human Molecular Genetics. 26, 9, p. 1732-1746 15 p., ddx093.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2016

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Lalaoui, N., Hänggi, K., Brumatti, G., Chau, D., Nguyen, N. Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 others, Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W. L. & Silke, J., 12 Sep 2016, In : Cancer Cell. 30, 3, p. 499-500 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

8 Citations (Scopus)

Erratum: TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8 (Journal of Biological Chemistry (2016) 291 (2547))

Gentle, I. E., Wong, W. W. L., Evans, J. M., Bankovacki, A., Cook, W. D., Khan, N. R., Nachbur, U., Rickard, J. A., Anderton, H., Moulin, M., Lluis, J. M., Moujalled, D. M., Silke, J. & Vaux, D. L., 29 Jan 2016, In : Journal of Biological Chemistry. 291, 5, p. 2547 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

3 Citations (Scopus)

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Lalaoui, N., Hanggi, K., Brumatti, G., Chau, D., Nguyen, N-Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 others, Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W-L. & Silke, J., 2016, In : Cancer Cell. 29, 2, p. 145 - 158 14 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Maragno, A. L., Le Toumelin-Braizat, G., Chanrion, M., Kelly, G. L., Gong, J. N., Moujalled, D. M., Bruno, A., Csekei, M., Paczal, A., Szabo, Z. B., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G. & 2 others, Pomilio, G. & Wei, A. H., 2016, In : Nature. 538, 7626, p. 477-482 6 p.

Research output: Contribution to journalArticleResearchpeer-review

328 Citations (Scopus)
2015

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Moujalled, D., James, J. L., Yang, S., Zhang, K., Duncan, C., Moujalled, D. M., Parker, S. J., Caragounis, A., Lidgerwood, G., Turner, B. J., Atkin, J. D., Grubman, A., Liddell, J. R., Proepper, C., Boeckers, T. M., Kanninen, K. M., Blair, I., Crouch, P. J. & White, A. R., 15 Mar 2015, In : Human Molecular Genetics. 24, 6, p. 1655-1669 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)
2014

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

Allam, R., Lawlor, K. E., Yu, E. C-W., Mildenhall, A. L., Moujalled, D. M., Lewis, R. S., Ke, F., Mason, K. D., White, M. J., Stacey, K. J., Strasser, A., O'Reilly, L., Alexander, W., Kile, B. T., Vaux, D. L. & Vince, J. E., 1 Sep 2014, In : EMBO Reports. 15, 9, p. 982-990 9 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Necroptosis induced by RIPK3 requires MLKL but not Drp1

Moujalled, DM., Cook, WD., Murphy, JM. & Vaux, DL., Feb 2014, In : Cell Death and Disease. 5, 7 p., e1086.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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60 Citations (Scopus)

RIPK1-and RIPK3-induced cell death mode is determined by target availability

Cook, WD., Moujalled, DM., Ralph, TJ., Lock, P., Young, SN., Murphy, JM. & Vaux, DL., Oct 2014, In : Cell Death and Differentiation. 21, 10, p. 1600-1612 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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78 Citations (Scopus)
2013

CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)-mediated apoptosis

Lee, Y. Y., Moujalled, D., Doerflinger, M., Gangoda, L., Weston, R., Rahimi, A., De Alboran, I., Herold, M., Bouillet, P., Xu, Q., Gao, X., Du, X. J. & Puthalakath, H., Jul 2013, In : Cell Death and Differentiation. 20, 7, p. 941-952 12 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

Moujalled, DM., Cook, W. D., Okamoto, T., Murphy, J., Lawlor, KE., Vince, JE. & Vaux, DL., 17 Jan 2013, In : Cell Death and Disease. 4, 8 p., e465.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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83 Citations (Scopus)
2011

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8

Gentle, I. E., Wong, W. W. L., Evans, J. M., Bankovacki, A., Cook, W. D., Khan, N. R., Nachbur, U., Rickard, J. A., Anderton, H., Moulin, M., Lluis, J. M., Moujalled, D. M., Silke, J. & Vaux, D. L., 15 Apr 2011, In : Journal of Biological Chemistry. 286, 15, p. 13282-13291 10 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)
2010

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-κB dependent induction of cFLIPL

Lluis, J. M., Nachbur, U., Cook, W. D., Gentle, I. E., Moujalled, D., Moulin, M., Wong, W. W. L., Khan, N., Chau, D., Callus, B. A., Vince, J. E., Silke, J. & Vaux, D. L., 8 Jan 2010, In : PLoS ONE. 5, 1, e8620.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)