Projects per year
Personal profile
Biography
Dr. Donia Moujalled is the Head of the Translational Leukaemia Therapeutics Group at the Australian Centre for Blood Diseases, Monash University. Her laboratory develops and translates novel targeted therapies for children and adults with acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL), with a particular focus on overcoming treatment resistance by targeting apoptotic and metabolic vulnerabilities.
Dr. Moujalled completed her PhD in 2012 at The Walter and Eliza Hall Institute of Medical Research (WEHI) in the Cell Death and Cell Signalling Division under the supervision of Professor David Vaux. Her doctoral and early postdoctoral research defined key molecular mechanisms regulating programmed cell death, including the role of RIPK3 and MLKL in necroptosis.
Following postdoctoral training with Dr Mark Guthridge, Dr. Moujalled joined the laboratory of Professor Andrew Wei, where she established a translational research program investigating BH3 mimetic therapies for acute leukaemia. In 2022, she moved with the Wei laboratory to WEHI, where she expanded her research to include childhood and adult acute leukaemia, establishing integrated preclinical platforms using patient-derived samples and xenograft models to identify therapeutic strategies targeting apoptotic and metabolic dependencies. Her work has advanced several novel combination therapies towards early-phase clinical trials and has established collaborative partnerships with industry to accelerate the translation of laboratory discoveries into new treatments for patients.
Dr. Moujalled was awarded a Victorian Cancer Agency Mid-Career Fellowship (2020–2024), which supported the development of her independent research program investigating mechanisms of therapy resistance in acute leukaemia. She has subsequently secured more than $3.5 million in competitive research funding as Chief Investigator from organisations including Cancer Council NSW, Cancer Council Victoria, Cancer Australia and the Victorian Cancer Agency, and has established industry partnerships to accelerate the development of next-generation targeted therapies.
In 2026, Dr. Moujalled was recruited to Monash University to establish the Translational Leukaemia Therapeutics Group at the Australian Centre for Blood Diseases. Her laboratory combines functional genomics, advanced metabolic profiling, patient-derived models and innovative preclinical platforms to discover and translate new therapies for children and adults with high-risk acute leukaemia.
Dr. Moujalled has authored more than 25 peer-reviewed publications, holds multiple patents in targeted leukaemia therapeutics, and serves on national grant review panels and the editorial boards of international journals. She is a Guest Editor for the International Journal of Molecular Sciences and is committed to mentoring the next generation of scientists through initiatives including the Girls in STEM mentoring program at the Bionics Institute.
External positions
Honorary, Walter and Eliza Hall Institute of Medical Research (WEHI)
2026 → …
Research area keywords
- Acute myeloid leukaemia
- Acute lymphoblastic leukaemia
- apoptosis
- BH3 mimetics
- BCL-2
- MCL1
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Improving outcomes for poor risk acute myeloid leukaemia (AML)
Moujalled, D. (Primary Chief Investigator (PCI))
1/01/21 → 31/12/21
Project: Research
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Targeting Survival programs in Acute Lymphoblastic Leukemia
Moujalled, D. (Primary Chief Investigator (PCI))
1/01/18 → 31/12/20
Project: Research
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Improving outcomes for poor risk acute myeloid leukaemia (AML)
Moujalled, D. (Primary Chief Investigator (PCI))
1/04/20 → 1/06/22
Project: Research
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BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia
Karsa, M., Karsa, A., Spurling, D., Xiao, L., Ronca, E., Bongers, A., Gao, W., Gifford, A. J., El-Ayoubi, A., Cheung, L. C., Kotecha, R. S., Lock, R. B., Teh, C. E., Lessene, G., Norris, M. D., Wei, A., Haber, M., Henderson, M. J., Moujalled, D. M. & Somers, K., 2026, (Accepted/In press) In: British Journal of Haematology. 7 p.Research output: Contribution to journal › Letter › Research › peer-review
Open Access -
NAD Metabolism in Acute Myeloid Leukemia: Biological Rationale and Therapeutic Opportunities
Somers, K., Karsa, M. & Moujalled, D. M., Jul 2026, In: Nutrients. 18, 14, 11 p., 2295.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access -
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
Li, K., Yap, Y. Q., Moujalled, D. M., Sumardy, F., Khakham, Y., Georgiou, A., Jahja, M., Lew, T. E., De Silva, M., Luo, M. X., Gong, J. N., Yuan, Z., Birkinshaw, R. W., Czabotar, P. E., Lowes, K., Huang, D. C. S., Kile, B. T., Wei, A. H., Dewson, G. & van Delft, M. F. & 1 others, , 7 Mar 2025, In: Science Advances. 11, 10, 15 p., eadr8146.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Link opens in a new tab Citations (Scopus) -
Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins
Gong, J. N., Djajawi, T. M., Moujalled, D. M., Pomilio, G., Khong, T., Zhang, L. P., Fedele, P. L., Low, M. S., Anderson, M. A., Riffkin, C. D., White, C. A., Lan, P., Lessene, G., Herold, M. J., Strasser, A., Spencer, A., Grigoriadis, G., Wei, A. H., van Delft, M. F. & Roberts, A. W. & 1 others, , Aug 2025, In: Cell Death and Differentiation. 32, 8, p. 1382-1396 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
CD74 Antibody Conjugated to an MCL1 Inhibitor (S227928) Combines Synergistically with Venetoclax to Enhance Killing of Acute Myeloid Leukemia
Moujalled, D. M., Pomilio, G., Morley, T., Litalien, V., Anstee, N. S., Loo, S., Yeoh, Z. H., Boibessot, C., Bresson, L., Maragno, A. L., Liot, C. & Wei, A., 5 Nov 2024, In: Blood. 144, Supplement 1, 2 p., 4136.Research output: Contribution to journal › Meeting Abstract › peer-review
Prizes
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ACBD best post-doctoral research fellow presentation
Moujalled, D. (Recipient), 2019
Prize: Prize (including medals and awards)
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EMCR Best publication-Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
Moujalled, D. (Recipient), 2019
Prize: Prize (including medals and awards)
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New Directions in Leukemia Research New Investigator Award
Moujalled, D. (Recipient), 2022
Prize: Prize (including medals and awards)
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New Directions in Leukemia Research Post-doctoral Research Fellow Travel award
Moujalled, D. (Recipient), 2020
Prize: Prize (including medals and awards)
Press/Media
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BH3 mimetics as potential treatment for AML
27/11/18
1 Media contribution
Press/Media: Profile/Interview