Donia Moujalled

Research Fellow, Australian Centre for Blood Diseases

Research output per year

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Personal profile

Biography

Dr. Donia Moujalled completed her PhD in 2012 at The Walter and Eliza Hall Institute of Medical Research in the Cell Death and Cell Signaling division, led by Prof. David Vaux. During her PhD, Dr. Moujalled examined the role of receptor interacting protein kinases in cell death induced by tumour necrosis factor receptor 1. She continued to work as a post-doctoral researcher in Prof. Vaux's lab 2012- 2013, recieving funding from The Cancer Austalia Foundation, to characterise RIPK3 and MLKL in necroptosis signaling induced by TNF.

In 2014, she moved to the Austrlian Centre for Blood Diseases, Monash University based at The Alfred Hospital. She joined the Leukemia Research Group, led by A/Prof. Andrew Wei. Her research focus is on developing in vivo pre-clinical models to examine BH3 mimetic compounds targeting pro-survival proteins BCL-2 and MCL1 in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia.

External positions

Honorary, Alfred Hospital

2014 → …

Research area keywords

Acute myeloid leukaemia
Acute lymphoblastic leukaemia
apoptosis
BH3 mimetics
BCL-2
MCL1

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Projects

2 Active

Improving outcomes for poor risk acute myeloid leukaemia (AML)

Moujalled, D.

1/04/20 → 31/03/24

Project: Research

Targeting Survival programs in Acute Lymphoblastic Leukemia

Moujalled, D.

Cancer Council Victoria

1/01/18 → 31/12/20

Project: Research

Research Output

15 Article
2 Comment / Debate

Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Moujalled, D. M., Pomilio, G., Ghiurau, C., Ivey, A., Salmon, J., Rijal, S., Macraild, S., Zhang, L., Teh, T. C., Tiong, I. S., Lan, P., Chanrion, M., Claperon, A., Rocchetti, F., Zichi, A., Kraus-Berthier, L., Wang, Y., Halilovic, E., Morris, E., Colland, F. & 7 others, Segal, D., Huang, D., Roberts, A. W., Maragno, A. L., Lessene, G., Geneste, O. & Wei, A. H., 1 Apr 2019, In : Leukemia. 33, a, p. 905-917 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

29 Citations (Scopus)

AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies

Caenepeel, S., Brown, S. P., Belmontes, B., Moody, G., Keegan, K. S., Chui, D., Whittington, D. A., Huang, X., Poppe, L., Cheng, A. C., Cardozo, M., Houze, J., Li, Y., Lucas, B., Paras, N. A., Wang, X., Taygerly, J. P., Vimolratana, M., Zancanella, M., Zhu, L. & 18 others, Cajulis, E., Osgood, T., Sun, J., Damon, L., Egan, R. K., Greninger, P., McClanaghan, J. D., Gong, J., Moujalled, D., Pomilio, G., Beltran, P., Benes, C. H., Roberts, A. W., Huang, D. C., Wei, A., Canon, J., Coxon, A. & Hughes, P. E., 1 Dec 2018, In : Cancer Discovery. 8, 12, p. 1582-1597 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

68 Citations (Scopus)

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh, T. C., Nguyen, N. Y., Moujalled, D. M., Segal, D., Pomilio, G., Rijal, S., Jabbour, A., Cummins, K., Lackovic, K., Blombery, P., Thompson, E., Ekert, P. G., Lessene, G., Glaser, S. P., Huang, D. C. S., Roberts, A. W., Guthridge, M. A. & Wei, A. H., 1 Feb 2018, In : Leukemia. 32, 2, p. 303-312 10 p.

Research output: Contribution to journal › Article › Research › peer-review

51 Citations (Scopus)

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled, D., Grubman, A., Acevedo, K., Yang, S., Ke, Y. D., Moujalled, D. M., Duncan, C., Caragounis, A., Perera, N. D., Turner, B. J., Prudencio, M., Petrucelli, L., Blair, I., Ittner, L. M., Crouch, P. J., Liddell, J. R. & White, A. R., 1 May 2017, In : Human Molecular Genetics. 26, 9, p. 1732-1746 15 p., ddx093.

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Lalaoui, N., Hänggi, K., Brumatti, G., Chau, D., Nguyen, N. Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 others, Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W. L. & Silke, J., 12 Sep 2016, In : Cancer Cell. 30, 3, p. 499-500 2 p.

Research output: Contribution to journal › Comment / Debate › Other › peer-review

10 Citations (Scopus)